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31. 发明授权

US09062297B2 Yersinia pestis vaccine 有权
标题翻译：耶尔森氏菌疫苗
公开(公告)号：US09062297B2
公开(公告)日：2015-06-23
申请号：US13006072
申请日：2011-01-13
申请人： Roy Curtiss, III , Wei Sun
发明人： Roy Curtiss, III , Wei Sun
IPC分类号： A61K39/00 , A61K39/02 , A61K39/385 , A01N63/00 , C12N1/36 , C07K14/24
CPC分类号： C12N1/36 , A61K39/0291 , A61K2039/522 , C07K14/24 , Y02A50/407
摘要： The present invention encompasses a recombinant Yersinia pestis bacterium and a vaccine comprising a recombinant Yersinia pestis bacterium.
摘要翻译：本发明包括重组耶尔森耶氏酵母菌和包含重组鼠疫耶尔森氏菌的疫苗。

32. 发明授权

US09045742B2 Recombinant Edwardsiella bacterium 有权
标题翻译：重组Edwardsiella细菌
公开(公告)号：US09045742B2
公开(公告)日：2015-06-02
申请号：US12789869
申请日：2010-05-28
申请人： Roy Curtiss, III , Javier Santander
发明人： Roy Curtiss, III , Javier Santander
IPC分类号： A01N63/00 , A01N65/00 , A61K39/02 , C12N1/36 , C07K14/24 , A61K39/00
CPC分类号： C12N1/36 , A61K39/02 , A61K2039/523 , C07K14/24
摘要： The present invention encompasses a recombinant Edwardsiella bacterium, and compositions and methods of use thereof.
摘要翻译：本发明包括重组爱德华氏菌，其组合物及其使用方法。

33. 发明申请

US20130196394A1 COMPOSITIONS AND METHODS FOR BACTERIAL LYSIS AND NEUTRAL LIPID PRODUCTION 有权
标题翻译：用于细菌分析和中性脂生产的组合物和方法
公开(公告)号：US20130196394A1
公开(公告)日：2013-08-01
申请号：US13805733
申请日：2011-07-01
申请人： Roy Curtiss, III , Xinyao Liu
发明人： Roy Curtiss, III , Xinyao Liu
IPC分类号： C12P7/64
CPC分类号： C12P7/6463 , C07K14/195 , C12N9/18 , C12N9/20 , C12N9/2462
摘要： A cyanobactenum that produces neutral lipids or alkanes, such as FAME OR FAEE, which may be used for biofuel production.
摘要翻译：产生中性脂质或烷烃（如FAME OR FAEE）的蓝细菌，可用于生物燃料生产。

34. 发明申请

US20110256177A1 YERSINIA PESTIS VACCINE 有权
公开(公告)号：US20110256177A1
公开(公告)日：2011-10-20
申请号：US13006072
申请日：2011-01-13
申请人： Roy Curtiss, III , Wei Sun
发明人： Roy Curtiss, III , Wei Sun
IPC分类号： A61K39/02 , A61P37/04 , C12N1/21 , A61P31/04
CPC分类号： C12N1/36 , A61K39/0291 , A61K2039/522 , C07K14/24 , Y02A50/407
摘要： The present invention encompasses a recombinant Yersinia pestis bacterium and a vaccine comprising a recombinant Yersinia pestis bacterium.
摘要翻译：本发明包括重组耶尔森耶氏酵母菌和包含重组鼠疫耶尔森氏菌的疫苗。

35. 发明授权

US06780405B1 Regulated antigen delivery system (RADS) 有权
标题翻译：调节抗原递送系统（RADS）
公开(公告)号：US06780405B1
公开(公告)日：2004-08-24
申请号：US09560539
申请日：2000-04-28
申请人： Roy Curtiss, III , Steven A. Tinge
发明人： Roy Curtiss, III , Steven A. Tinge
IPC分类号： A01N6300
CPC分类号： C12N15/74 , A61K2039/523 , A61K2039/53 , C12N15/635
摘要： We describe a regulated antigen delivery system (RADS) that has (a) a vector that includes (1) a gene encoding a desired gene product operably linked to a control sequence, (2) an origin of replication conferring vector replication using DNA polymerase III, and (3) an origin of replication conferring vector replication using DNA polymerase I, where the second origin of replication is operably linked to a control sequence that is repressible by a repressor. The RADS microorganism also has a gene encoding a repressor, operably linked to an activatible control sequence. The RADS described provide high levels of the desired gene product after repression of the high copy number origin of replication is lifted. The RADS are particularly useful as live bacterial vaccines. Also described is a delayed RADS system, in which there is a delay before the high copy number origin is expressed after the repression is lifted. The delayed RADS is also particularly useful for live bacterial vaccines. Also described are several control elements useful for these systems, as well as methods for providing immunity to a pathogen in a vertebrate immunized with the RADS microorganisms.
摘要翻译：我们描述了一种调控抗原递送系统（RADS），其具有（a）载体，其包含（1）编码与控制序列可操作地连接的所需基因产物的基因，（2）使用DNA聚合酶III赋予载体复制的复制起点，和（3）使用DNA聚合酶I赋予载体复制的复制起点，其中第二复制起点可操作地连接于由阻遏物阻抑的控制序列。 RADS微生物还具有编码阻抑物的基因，可操作地连接于活化的对照序列。所述的RADS提供高水平的所需基因产物，在抑制高拷贝数复制起点解除之后。 RADS作为活细菌疫苗是特别有用的。还描述了延迟的RADS系统，其中在压制被解除之后表示高拷贝数原点之前存在延迟。延迟RADS对活细菌疫苗也特别有用。还描述了可用于这些系统的若干控制元件，以及用于用RADS微生物免疫的脊椎动物中的病原体提供免疫的方法。

36. 发明授权

US5855880A Avirulent microbes and uses therefor 失效
标题翻译：无毒微生物及其用途
公开(公告)号：US5855880A
公开(公告)日：1999-01-05
申请号：US596732
申请日：1996-02-05
申请人： Roy Curtiss, III , Sandra M. Kelly
发明人： Roy Curtiss, III , Sandra M. Kelly
IPC分类号： A61K39/04 , C07K14/255 , C07K14/315 , C07K14/35 , C12N1/21 , C12N9/02 , C12N15/00 , C12N15/01 , C12N15/68 , A61K39/02 , A61K39/112
CPC分类号： A61K39/04 , A61K39/0275 , A61K39/099 , C07K14/255 , C07K14/315 , C07K14/35 , C12N15/00 , C12N15/01 , C12N15/68 , C12N9/0008 , C12R1/42 , C12Y102/01011 , A61K2039/522 , A61K2039/523 , A61K2039/552 , Y10S435/879
摘要： This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition.
摘要翻译：本发明提供了用于免疫含脊椎动物或无脊椎动物的免疫原性组合物，其包含伤寒沙利氏菌的无毒性衍生物。具有cya和/或crp和/或cdt基因突变的衍生物。本发明还提供用于免疫脊椎动物和无脊椎动物的免疫原性组合物，其包含上述类型的无毒力衍生物，其能够表达源自所述脊椎动物或无脊椎动物个体的病原体的重组基因以产生能够诱导免疫应答的抗原针对所述病原体。本发明的其它实施方案包括从这些菌株制备免疫原性组合物的方法，以及可用于制备免疫原性组合物的菌株，以及通过施用免疫原性刺激免疫系统对伤寒沙门氏菌的免疫原性抗原作出反应的方法组成。

37. 发明授权

US5840483A Method of maintaining a desired recombinant gene in a genetic population of cells 失效
标题翻译：在细胞遗传群体中维持所需重组基因的方法
公开(公告)号：US5840483A
公开(公告)日：1998-11-24
申请号：US473926
申请日：1995-06-07
申请人： Roy Curtiss, III
发明人： Roy Curtiss, III
IPC分类号： C12N15/09 , A61K39/04 , C07K14/315 , C07K14/35 , C12N1/21 , C12N9/02 , C12N15/00 , C12N15/68 , C12R1/01 , C12R1/19 , C12R1/42 , C12R1/44 , C12Q1/68
CPC分类号： C12N9/0008 , A61K39/04 , C07K14/315 , C07K14/35 , C12N15/00 , C12N15/68 , C12R1/42 , C12Y102/01011 , A61K2039/523
摘要： The invention encompasses methods of maintaining desired recombinant genes in a genetic population of cells expressing the recombinant gene. The methods utilize mutant cells which are characterized by a lack of a functioning native gene encoding an enzyme which is essential for cell survival, wherein this enzyme catalyzes a step in the biosynthesis of an essential cell wall structural component and the presence of a first recombinant gene encoding an enzyme which is a functional replacement for the native enzyme, wherein the first recombinant gene cannot replace the defective chromosomal gene. The first recombinant gene is structurally linked to a second recombinant gene encoding a desired product. Loss of the first recombinant gene causes the cells to lyse when the cells are in an environment where a product due to the expression of the first recombinant gene is absent. The invention also encompasses methods of creating and isolating mutant cells with the above characteristics. The cells of the invention are useful for commercial production of desired products, for components of vaccines for immunizing individuals, and for release into the environment.
摘要翻译：本发明包括在表达重组基因的细胞的遗传群体中维持所需重组基因的方法。该方法利用突变体细胞，其特征在于缺乏编码细胞存活所必需的酶的功能性天然基因，其中该酶催化必需细胞壁结构组分的生物合成和第一重组基因的存在编码作为天然酶的功能性替代物的酶，其中第一重组基因不能代替有缺陷的染色体基因。第一重组基因在结构上与编码所需产物的第二重组基因连接。当细胞处于不存在第一重组基因表达的产物的环境中时，第一重组基因的损失导致细胞裂解。本发明还包括产生和分离具有上述特征的突变细胞的方法。本发明的细胞可用于商业生产所需产品，用于免疫个体的疫苗的组分和用于释放到环境中。

38. 发明授权

US5686079A Oral immunization by transgenic plants 失效
公开(公告)号：US5686079A
公开(公告)日：1997-11-11
申请号：US457563
申请日：1995-06-01
申请人： Roy Curtiss, III , Guy A. Cardineau
发明人： Roy Curtiss, III , Guy A. Cardineau
IPC分类号： A01H5/00 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/09 , A61K39/12 , C07K14/005 , C07K14/195 , C07K14/245 , C07K14/315 , C07K14/41 , C07K19/00 , C12N5/10 , C12N9/10 , C12N9/24 , C12N15/09 , C12N15/31 , C12N15/82 , C12P21/02 , C12P21/08 , G01N33/569
CPC分类号： C12N9/1051 , C07K14/245 , C07K14/315 , C12N15/8258 , C12N9/16 , C12N9/2454 , C12Y301/03001 , C12Y302/01011 , A61K39/00 , C07K2319/00
摘要： The invention is directed to transgenic plants expressing colonization and/or virulence antigens specified by genes from pathogenic microorganisms. It is also directed to the use of such transgenic plants for oral immunization of humans and other animals to elicit a secretory immune response which inhibits colonization of or invasion by such pathogenic microorganisms through a mucosal surface of humans or other animals.

39. 发明授权

US5656488A Recombinant avirulent salmonella antifertility vaccines 失效
标题翻译：重组无毒性沙门氏菌抗生素疫苗
公开(公告)号：US5656488A
公开(公告)日：1997-08-12
申请号：US222182
申请日：1994-04-01
申请人： Roy Curtiss, III , Kenneth S. K. Tung
发明人： Roy Curtiss, III , Kenneth S. K. Tung
IPC分类号： A61K39/00 , C07K14/705 , C07K16/40 , C12N1/21 , C12N9/02 , C12N15/01 , C12N15/53 , A61K45/00
CPC分类号： C12N9/0008 , C07K14/705 , C07K16/40 , C12N15/01 , C12Y102/01011 , A61K39/00 , C07K2319/00
摘要： Avirulent microbes which include a recombinant expression system encoding a gamete-specific antigen, are disclosed. The microbes can be used in compositions to immunize a vertebrate subject against the gamete-specific antigen, thereby preventing or reducing conception rates in the subject to which they are administered.
摘要翻译：公开了包含编码配子特异性抗原的重组表达系统的无毒微生物。这些微生物可用于组合物中，免疫脊椎动物受试者抵抗配子特异性抗原，从而预防或降低受试者的受孕率。

40. 发明申请

US20160251610A1 MICROBES WITH CONTROLLED ADHESIVE PROPERTIES 审中-公开
标题翻译：具有控制粘合性能的微生物
公开(公告)号：US20160251610A1
公开(公告)日：2016-09-01
申请号：US15158343
申请日：2016-05-18
申请人： Michael L. Fisher , Roy Curtiss, III , Rebecca Custer Allen
发明人： Michael L. Fisher , Roy Curtiss, III , Rebecca Custer Allen
IPC分类号： C12N1/20 , C12N15/74
CPC分类号： C12N1/20 , C07K14/195 , C07K14/24 , C07K14/245 , C07K14/405 , C12N15/74 , C12N15/82 , C12N15/8238
摘要： The present invention encompasses a phototrophic microorganism with altered and controlled adhesive properties.
摘要翻译：本发明包括具有改变和控制的粘合性质的光养微生物。

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