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31. 发明授权

US06969388B2 Apparatus for applying energy to biological tissue including the use of tumescent tissue compression 失效
标题翻译：用于向生物组织施加能量的装置，包括使用肿胀组织压缩
公开(公告)号：US06969388B2
公开(公告)日：2005-11-29
申请号：US09841664
申请日：2001-04-23
申请人： Mitchel P. Goldman , Robert A. Weiss , James G. Chandler
发明人： Mitchel P. Goldman , Robert A. Weiss , James G. Chandler
IPC分类号： A61B17/22 , A61B18/14 , G02F1/1343 , G02F1/1362 , G09G3/36 , A61B18/18
CPC分类号： G02F1/134363 , A61B18/1492 , A61B2017/22038 , A61B2017/22051 , A61B2017/22067 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/00488 , A61B2018/00589 , A61B2018/00898 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2090/3782 , A61B2218/002 , G02F1/136213 , G02F1/136259 , G02F2201/12
摘要： An electrode catheter is introduced into a hollow anatomical structure, such as a vein, and is positioned at a treatment site within the structure. Tumescent fluid is injected into the tissue surrounding the treatment site to produce tumescence of the surrounding tissue which then compresses the vein. The solution may include an anesthetic, and may further include a vasoconstrictive drug that shrinks blood vessels. The tumescent swelling in the surrounding tissue causes the hollow anatomical structure to become compressed, thereby exsanguinating the treatment site. Energy is applied by an electrode catheter in apposition with the vein wall to create a heating effect. The heating effect causes the hollow anatomical structure to become molded and durably assume the compressed dimensions caused by the tumescent technique. The electrode catheter can be moved within the structure so as to apply energy to a large section of the hollow anatomic structure. In a further aspect, the location of the electrodes is determined by impedance monitoring. Also, temperature sensors at the treatment site are averaged to determine the site temperature.
摘要翻译：将电极导管引入到诸如静脉的中空解剖结构中，并且位于结构内的治疗部位。将肿胀流体注射到处理部位周围的组织中，以产生周围组织的肿胀，然后压缩静脉。溶液可以包括麻醉剂，并且还可以包括收缩血管的血管收缩药物。周围组织的肿胀肿胀导致中空的解剖结构变得压缩，从而使治疗部位脱垂。能量通过电极导管与静脉壁一起施加以产生加热效果。加热效果使得中空的解剖结构变得模制并且持久地承受由肿胀技术引起的压缩尺寸。电极导管可以在结构内移动，以将能量施加到中空解剖结构的大部分。在另一方面，通过阻抗监测确定电极的位置。此外，将处理部位的温度传感器平均以确定现场温度。

32. 发明授权

US06793888B2 Method and system for sample aliquot storage 有权
标题翻译：样品等分储存方法和系统
公开(公告)号：US06793888B2
公开(公告)日：2004-09-21
申请号：US09908169
申请日：2001-07-18
申请人： Humayun Qureshi , Bernhard Spiess , Robert A. Weiss , Peter G. Werness , Brian D. Wilson , Ronald C. Laska
发明人： Humayun Qureshi , Bernhard Spiess , Robert A. Weiss , Peter G. Werness , Brian D. Wilson , Ronald C. Laska
IPC分类号： G01N100
CPC分类号： G01N35/1002 , G01N35/0092 , Y10T436/11 , Y10T436/113332 , Y10T436/115831
摘要： A method and system of sample aliquot storage for automated immunochemistry or chemistry instruments are provided. The method and system provide a sample aliquot storage unit having a sample storage wheel for storing sample vessels containing sample aliquots in a chilled enclosed environment, which are accessible by both a sample pipettor of a sample aliquoting station and a pick-and-place gripper. The pick-and-place gripper transports the sample vessels containing sample aliquots to multiple independent reagent pipetting stations respectively for sample aspiration of subsequent assay, and thereafter transports the sample vessels containing remaining sample aliquots back to the sample storage wheel to be stored in the chilled environment for reflex testing. When all the tests are completed, the pick-and-place gripper transports the sample vessels to a waste storage area.
摘要翻译：提供了用于自动化免疫化学或化学仪器的样品等分试样储存的方法和系统。该方法和系统提供样品等分存储单元，其具有样品储存轮，用于将含有样品等分试样的样品容器储存在冷藏的封闭环境中，所述样品容器可由样品等分试样台的样品移液器和拾取和放置夹具接近。拾取和夹持器将含有样品等分试样的样品容器分别运送到多个独立的试剂移液站，用于随后测定的样品抽吸，然后将含有剩余样品等分试样的样品容器运送回样品储存轮，以储存在冷藏反射测试环境。当所有测试完成后，拾取和放置夹具将样品容器运送到废物储存区域。

33. 发明授权

US06451007B1 Thermal quenching of tissue 有权
标题翻译：组织的热淬火
公开(公告)号：US06451007B1
公开(公告)日：2002-09-17
申请号：US09364275
申请日：1999-07-29
申请人： Dale E. Koop , Jonathan M. Baumgardner , Robert A. Weiss
发明人： Dale E. Koop , Jonathan M. Baumgardner , Robert A. Weiss
IPC分类号： A61B1818
CPC分类号： A61B18/20 , A61B18/203 , A61B2018/00011 , A61B2018/00041 , A61B2018/00452
摘要： A method for selective heating of subsurface structures in material such as tissue includes a cooling device for thermally quenching or removing heat from the top surface of tissue during or just after delivering pulsed energy to target or subsurface structures or tissue, a preferred embodiment of the invention using dynamic cooling, to quench the thermal energy conducted from the targeted structure into surrounding tissue.
摘要翻译：在诸如组织的材料中选择性加热地下结构的方法包括冷却装置，用于在将脉冲能量递送到目标或地下结构或组织期间或之后将组织的顶表面热热淬火或除去，本发明的优选实施例使用动态冷却，将从目标结构传导的热能猝灭到周围组织。

34. 发明授权

US06258084B1 Method for applying energy to biological tissue including the use of tumescent tissue compression 有权
标题翻译：将能量施加到生物组织的方法，包括使用肿胀组织压缩
公开(公告)号：US06258084B1
公开(公告)日：2001-07-10
申请号：US09267127
申请日：1999-03-10
申请人： Mitchel P. Goldman , Robert A. Weiss , Arthur W. Zikorus , James G. Chandler
发明人： Mitchel P. Goldman , Robert A. Weiss , Arthur W. Zikorus , James G. Chandler
IPC分类号： A61B1804
CPC分类号： G02F1/134363 , A61B18/1492 , A61B2017/22038 , A61B2017/22051 , A61B2017/22067 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/00488 , A61B2018/00589 , A61B2018/00898 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2090/3782 , A61B2218/002 , G02F1/136213 , G02F1/136259 , G02F2201/12
摘要： An electrode catheter is introduced into a hollow anatomical structure, such as a vein, and is positioned at a treatment site within the structure. Tumescent fluid is injected into the tissue surrounding the treatment site to produce tumescence of the surrounding tissue which then compresses the vein. The solution may include an anesthetic, and may further include a vasoconstrictive drug that shrinks blood vessels. The tumescent swelling in the surrounding tissue causes the hollow anatomical structure to become compressed, thereby exsanguinating the treatment site. Energy is applied by an electrode catheter in apposition with the vein wall to create a heating effect. The heating effect causes the hollow anatomical structure to become molded and durably assume the compressed dimensions caused by the tumescent technique. The electrode catheter can be moved within the structure so as to apply energy to a large section of the hollow anatomic structure. In a further aspect, the location of the electrodes is determined by impedance monitoring. Also, temperature sensors at the treatment site are averaged to determine the site temperature.
摘要翻译：将电极导管引入到诸如静脉的中空解剖结构中，并且位于结构内的治疗部位。将肿胀流体注射到处理部位周围的组织中，以产生周围组织的肿胀，然后压缩静脉。溶液可以包括麻醉剂，并且还可以包括收缩血管的血管收缩药物。周围组织的肿胀肿胀导致中空的解剖结构变得压缩，从而使治疗部位脱垂。能量通过电极导管与静脉壁一起施加以产生加热效果。加热效果使得中空的解剖结构变得模制并且持久地承受由肿胀技术引起的压缩尺寸。电极导管可以在结构内移动，以将能量施加到中空解剖结构的大部分。在另一方面，通过阻抗监测确定电极的位置。此外，将处理部位的温度传感器平均以确定现场温度。

35. 发明授权

US6100336A Golf ball cover compositions 失效
公开(公告)号：US6100336A
公开(公告)日：2000-08-08
申请号：US661608
申请日：1996-06-11
申请人： Michael J. Sullivan , Robert A. Weiss
发明人： Michael J. Sullivan , Robert A. Weiss
IPC分类号： A63B37/00 , C08L23/08 , C08F8/42
CPC分类号： C08L23/08 , A63B37/0003 , C08L23/0869 , C08L23/0876 , C08L51/00 , A63B37/0024 , C08L2205/02 , Y10S273/04 , Y10S273/22
摘要： The present invention is directed to golf ball cover compositions containing blends of high or low carboxylic acid based copolymers and ethylene copolymers such as ethylene alkyl acrylates. The carboxylic acid groups of the blends are neutralized with metal cations. Golf balls produced with the cover molded thereon exhibit desired properties of distance and high coefficient of restitution without substantially sacrificing and/or improving characteristics like playability and durability when compared to existing covers comprising ionomeric resin blends.

36. 发明授权

US5422398A Compatibilizer for polymer blends and the polymer blends derived therefrom 失效
标题翻译：用于聚合物共混物的增容剂和由其衍生的聚合物共混物
公开(公告)号：US5422398A
公开(公告)日：1995-06-06
申请号：US291746
申请日：1994-08-17
申请人： Robert A. Weiss
发明人： Robert A. Weiss
IPC分类号： C08L25/18 , C08L67/00 , C08L69/00 , C08L71/12 , C08L77/00 , C08L77/06 , C08L81/06
CPC分类号： C08L71/123 , C08L67/00 , C08L77/00 , C08L25/18 , C08L69/00 , C08L71/12 , C08L77/06 , C08L81/06
摘要： A compatibilizer for polymer blends is presented. The compatibilizer comprises a sulfonated polystyrene and may be used to prepare miscible blends of the sulfonated polystyrene with two or more polymers having polar groups, e.g., polyamides, polyethers, polyesters, polysulfones and polyamines. The sulfonated polystyrene compatibilizer may be used in conjunction with a counterion.
摘要翻译：提出了一种用于聚合物共混物的增容剂。相容剂包括磺化聚苯乙烯，并可用于制备磺化聚苯乙烯与两种或多种具有极性基团的聚合物如聚酰胺，聚醚，聚酯，聚砜和聚胺的可混溶共混物。磺化聚苯乙烯增容剂可以与抗衡离子结合使用。

37. 发明授权

US5239010A Sulfonated block copolymers 失效
标题翻译：磺化嵌段共聚物
公开(公告)号：US5239010A
公开(公告)日：1993-08-24
申请号：US820446
申请日：1992-01-10
申请人： Jaroslav G. Balas , William P. Gergen , Carl L. Willis , Lorelle A. Pottick , Richard Gelles , Robert A. Weiss
发明人： Jaroslav G. Balas , William P. Gergen , Carl L. Willis , Lorelle A. Pottick , Richard Gelles , Robert A. Weiss
IPC分类号： C08F8/36
CPC分类号： C08F8/36
摘要： A thermoplastic polymer which possesses excellent mechanical properties at both room and elevated temperatures is obtained by reacting an acyl sulfate with a block copolymer composed of at least one conjugated diene block and one alkenyl arene block. The block copolymer is first selectively hydrogenated and thereafter modified by grafting sulfonic acid functional groups primarily in the alkenyl arene blocks. The mechanical properties may be varied and controlled by varying the degree of functionalization (amount of sulfonation), and the degree of neutralization of the sulfonic acid groups to metal sulfonate salts.
摘要翻译：通过使酰基硫酸盐与至少一个共轭二烯嵌段和一个链烯基芳烃嵌段组成的嵌段共聚物反应，得到在室温和高温下具有优异机械性能的热塑性聚合物。首先将嵌段共聚物选择性氢化，然后通过主要在烯基芳烃嵌段中接枝磺酸官能团进行改性。可以通过改变官能度（磺化量）和磺酸基与金属磺酸盐的中和度来改变和控制机械性能。

38. 发明授权

US4322317A Composition for chalcogenide electrodes 失效
标题翻译：硫属化物电极的组成
公开(公告)号：US4322317A
公开(公告)日：1982-03-30
申请号：US126688
申请日：1980-03-03
申请人： Bhaskara M. L. Rao , Robert A. Weiss
发明人： Bhaskara M. L. Rao , Robert A. Weiss
IPC分类号： H01M4/58 , H01M4/62 , H01B1/06
CPC分类号： H01M4/581 , H01M4/62
摘要： The present invention is directed to a novel method of fabricating and composition for chalcogenide cathode-active electrodes. The method comprises the steps of:(a) combining the cathode-active material in particulate form with about 0.1 to about 10 percent by weight of a neutralized sulfonated ionomer, based on the total weight of the cathode-active material and the ionomer, and about 10 to about 90 percent by weight of solvent, based on the total weight of the cathode-active material, ionomer and solvent, wherein said solvent is a cosolvent system which includes one or more solvents selected from the group consisting of normal and aromatic hydrocarbons and one or more solvents selected from the group consisting of alcohols, amines, amides, nitriles, nitro-compounds, lactones and acetols;(b) forming the desired electrode configuration with the resulting mixture; and(c) drying the formed electrode so as to volatilize the solvent.The composition consists essentially of(a) a chalcogenide material in a particulate form consisting of one or more compounds selected from a group consisting of the sulfides, selenides and tellurides of titanium, zirconium, hafnium, niobium, tantalum, molybdenum and vanadium; and(b) less than about 10 weight percent of a neutralized sulfonated elastomeric polymer having less than about 6 mole percent neutralized sulfonate groups per 100 grams of said polymer.
摘要翻译：本发明涉及硫族化物阴极活性电极的制造和组成的新方法。该方法包括以下步骤：（a）基于阴极活性材料和离聚物的总重量，将颗粒形式的阴极活性材料与约0.1至约10重量％的中和磺化离聚物混合，以及约10至约90重量％的溶剂，基于阴极活性材料，离聚物和溶剂的总重量，其中所述溶剂是助溶剂体系，其包括一种或多种选自正常和芳族烃的溶剂和一种或多种选自醇，胺，酰胺，腈，硝基化合物，内酯和乙酰胺的溶剂; （b）用所得混合物形成所需的电极构型; 和（c）干燥形成的电极以使溶剂挥发。组合物基本上由（a）由一种或多种选自钛，锆，铪，铌，钽，钼和钒的硫化物，硒化物和碲化物组成的组中的颗粒形式的硫族化物材料组成; 和（b）小于约10重量％的每100克所述聚合物具有小于约6摩尔％中和磺酸盐基团的中和磺化弹性体聚合物。

39. 发明授权

US4255540A Neutralized phosphonated elastomeric polymers 失效
标题翻译：中和膦酸化弹性体聚合物
公开(公告)号：US4255540A
公开(公告)日：1981-03-10
申请号：US31542
申请日：1979-04-19
申请人： Robert A. Weiss
发明人： Robert A. Weiss
IPC分类号： C08F8/00 , C08F8/40 , C08F8/44 , C08L23/32 , C08F8/42
CPC分类号： C08L23/32 , C08F8/44
摘要： This invention relates to a process for the manufacture of a neutralized phosphonated ethylene-propylene copolymer having about 1 to about 150 mmoles of PO.sub.3 H.sub.2 groups which are neutralized with a counterion selected from the group comprising metal cations, ammonium or amines. Elastomeric compositions used for elastomeric articles could include the neutralized phosphonated ethylene-propylene copolymer having about 20 to about 200 parts by weight of a non-polar process oil per 100 parts of the phosphonated copolymer and about 25 to about 300 parts by weight of a filler per 100 parts of the phosphonated copolymer, wherein a preferential plasticizer can also be incorporated into the composition. These blend compositions can be readily processed on conventional plastic fabrication equipment into elastomeric articles having excellent physical properties and desirable rubber characteristics.
摘要翻译：本发明涉及制备中和的具有约1至约150mmol PO 3 H 2基团的中和膦酸化乙烯 - 丙烯共聚物的方法，所述PO 3 H 2基团用选自金属阳离子，铵或胺的抗衡离子中和。用于弹性体制品的弹性体组合物可包括中和的膦酸化乙烯 - 丙烯共聚物，每100份膦酸化共聚物具有约20至约200重量份的非极性加工油，约25至约300重量份的填料每100份膦酸共聚物，其中也可以将优先增塑剂掺入组合物中。这些共混组合物可以容易地在常规塑料制造设备上加工成具有优异的物理性能和期望的橡胶特性的弹性体制品。

40. 发明授权

US09782222B2 System and method for endovenous treatment of varicose veins with mid infrared laser 有权
公开(公告)号：US09782222B2
公开(公告)日：2017-10-10
申请号：US12604815
申请日：2009-10-23
申请人： David R. Hennings , Mitchell P. Goldman , Robert A. Weiss , Eric B. Taylor , Don Johnson
发明人： David R. Hennings , Mitchell P. Goldman , Robert A. Weiss , Eric B. Taylor , Don Johnson
IPC分类号： A61N5/067 , A61B18/24 , A61B17/00 , A61B18/00 , A61B18/22 , A61B90/00
CPC分类号： A61B18/24 , A61B2017/00084 , A61B2018/00005 , A61B2018/00196 , A61B2018/2261 , A61B2090/036
摘要： This invention is an improved method and device for treating varicose veins 200 or the greater saphenous vein 202. The method comprises the use of infrared laser radiation in the region of 1.2 to 1.8 um in a manner from inside the vessel 200 or 202 such that the endothelial cells of the vessel wall 704 are damaged and collagen fibers in the vessel wall 704 are heated to the point where they permanently contract, the vessel 200 or 202 is occluded and ultimately resorbed. The device includes a laser 102 delivered via a fiber optic catheter 300 that may have frosted or diffusing fiber tips 308. A motorized pull-back device 104 is used, and a thermal sensor 600 may be used to help control the power required to maintain the proper treatment temperature.

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