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31. 发明授权

US08137411B2 Thin collagen tissue for medical device applications 失效
标题翻译：用于医疗器械应用的薄胶原组织
公开(公告)号：US08137411B2
公开(公告)日：2012-03-20
申请号：US13097837
申请日：2011-04-29
申请人： Kemal Schankereli
发明人： Kemal Schankereli
IPC分类号： A61L27/00
CPC分类号： A61L27/3604 , A61K35/34 , Y10S623/922
摘要： This invention relates to processes of preparing heterogeneous graft material from animal tissue. Specifically, the invention relates to the preparation of animal tissue, in which the tissue is cleaned and chemically cross-linked using both vaporized and liquid cross-linking agents, resulting in improved physical properties such as thin tissue and lowered antigenicity, thereby increasing the ease of delivering the tissue during surgery and decreasing the risk of post-surgical complication, respectively.
摘要翻译：本发明涉及从动物组织制备异种移植材料的方法。具体地，本发明涉及动物组织的制备，其中使用蒸发和液体交联剂将组织清洁和化学交联，导致改善的物理性质如薄组织和降低的抗原性，从而增加容易度分别在手术期间输送组织并降低手术后并发症的风险。

32. 发明申请

US20110221096A1 Thin Collagen Tissue for medical device applications 失效
标题翻译：用于医疗器械应用的薄胶原组织
公开(公告)号：US20110221096A1
公开(公告)日：2011-09-15
申请号：US13097837
申请日：2011-04-29
申请人： Kemal Schankereli
发明人： Kemal Schankereli
IPC分类号： B28B3/02
CPC分类号： A61L27/3604 , A61K35/34 , Y10S623/922
摘要： This invention relates to processes of preparing heterogeneous graft material from animal tissue. Specifically, the invention relates to the preparation of animal tissue, in which the tissue is cleaned and chemically cross-linked using both vaporized and liquid cross-linking agents, resulting in improved physical properties such as thin tissue and lowered antigenicity, thereby increasing the ease of delivering the tissue during surgery and decreasing the risk of post-surgical complication, respectively.
摘要翻译：本发明涉及从动物组织制备异种移植材料的方法。具体地，本发明涉及动物组织的制备，其中使用蒸发和液体交联剂将组织清洁和化学交联，导致改善的物理性质如薄组织和降低的抗原性，从而增加容易度分别在手术期间输送组织并降低手术后并发症的风险。

33. 发明授权

US07871639B2 Biocompatible phase invertable proteinaceous compositions and methods for making and using the same 有权
标题翻译：生物相容性相可逆蛋白质组合物及其制备和使用方法
公开(公告)号：US07871639B2
公开(公告)日：2011-01-18
申请号：US11877396
申请日：2007-10-23
申请人： Kemal Schankereli , Ronald Dieck
发明人： Kemal Schankereli , Ronald Dieck
IPC分类号： A61F2/02 , A61F2/06 , A61M5/00
CPC分类号： C09J189/00 , A61K9/0024 , A61K47/42 , A61L24/0021 , A61L24/10 , A61L29/044 , A61L31/043
摘要： Biocompatible phase invertable proteinaceous compositions and methods for making and using the same are provided. The subject phase invertable compositions are prepared by combining a proteinaceous substrate and a cross-linker. The proteinaceous substrate includes one or more proteins and an adhesion modifier, and may also include one or more of: a plasticizer, a carbohydrate, or other modification agent. In certain embodiments, the cross-linker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.
摘要翻译：提供了生物相容性相可逆蛋白质组合物及其制备和使用方法。通过组合蛋白质底物和交联剂制备目标相可逆组合物。蛋白质底物包括一种或多种蛋白质和粘合改性剂，并且还可以包括增塑剂，碳水化合物或其它改性剂中的一种或多种。在某些实施方案中，交联剂是经热处理的二醛，例如经热处理的戊二醛。还提供了用于制备主题组合物的试剂盒。主题组合物，试剂盒和系统可用于各种不同的应用。

34. 发明申请

US20100185278A1 Apical Papillary Msucle Attachment for Left Ventricular Reduction 审中-公开
标题翻译：用于左心室减压的顶端乳头状核附着物
公开(公告)号：US20100185278A1
公开(公告)日：2010-07-22
申请号：US12691591
申请日：2010-01-21
申请人： Kemal Schankereli
发明人： Kemal Schankereli
IPC分类号： A61F2/24
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/0644 , A61B17/1227 , A61B2017/00243 , A61B2017/0409 , A61B2017/0496 , A61F2/2457
摘要： This invention relates to devices and methods for the therapeutic changing of the geometry of the left ventricle of the human heart. Specifically, the invention relates to the apical introduction of an anchoring device to align the papillary muscles.
摘要翻译：本发明涉及用于治疗改变人心脏左心室几何形状的装置和方法。具体而言，本发明涉及一种用于对准乳头肌的锚定装置的顶端引入。

35. 发明申请

US20080096977A1 BIOCOMPATIBLE PHASE INVERTABLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME 有权
标题翻译：生物相容性不可逆蛋白质组合物及其制备和使用方法
公开(公告)号：US20080096977A1
公开(公告)日：2008-04-24
申请号：US11877396
申请日：2007-10-23
申请人： Kemal Schankereli , Ronal Dieck
发明人： Kemal Schankereli , Ronal Dieck
IPC分类号： A61K47/42 , A61K47/26 , A61K47/08
CPC分类号： C09J189/00 , A61K9/0024 , A61K47/42 , A61L24/0021 , A61L24/10 , A61L29/044 , A61L31/043
摘要： Biocompatible phase invertable proteinaceous compositions and methods for making and using the same are provided. The subject phase invertable compositions are prepared by combining a proteinaceous substrate and a cross-linker. The proteinaceous substrate includes one or more proteins and an adhesion modifier, and may also include one or more of: a pasticizer, a carbohydrate, or other modification agent. In certain embodiments, the cross-linker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.
摘要翻译：提供了生物相容性相可逆蛋白质组合物及其制备和使用方法。通过组合蛋白质底物和交联剂制备目标相可逆组合物。蛋白质底物包括一种或多种蛋白质和粘合改性剂，并且还可以包括以下的一种或多种：增塑剂，碳水化合物或其它改性剂。在某些实施方案中，交联剂是经热处理的二醛，例如经热处理的戊二醛。还提供了用于制备主题组合物的试剂盒。主题组合物，试剂盒和系统可用于各种不同的应用。

36. 发明授权

US5782914A Method for preparing heterogeneous tissue grafts 失效
标题翻译：异种组织移植物的制备方法
公开(公告)号：US5782914A
公开(公告)日：1998-07-21
申请号：US764686
申请日：1996-11-29
申请人： Kemal Schankereli
发明人： Kemal Schankereli
IPC分类号： A61L27/36 , A61F2/02
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3687 , Y10S623/901 , Y10S623/915
摘要： A method for preparing heterogeneous graft material from animal tissue in which the harvested tissue is cleaned, chemically cross-linked and then vacuum-dried to remove substantially all moisture therefrom. The vacuum-dried animal tissue is then double-wrapped and subjected to radiation sterilization while in its packaged dry state. Electron beam sterilization is a preferred method. At the time of use, the outer wrap is opened and the inner sterile package is placed in the sterile field in the operating room. When the tissue specimen is removed from its inner wrap, it may be rehydrated in sterile saline to restore its soft, supple hand, or it may be implanted in its dry state at the implanting surgeon's discretion, in which case, the tissue would undergo rehydration with the patient's own body fluids.
摘要翻译：一种用于从动物组织制备异种移植材料的方法，其中采集的组织被清洁，化学交联，然后真空干燥以从其中除去基本上所有的水分。然后将真空干燥的动物组织双包装并在其包装干燥状态下进行辐射灭菌。电子束灭菌是优选的方法。在使用时，打开外部包装，将内部无菌包装放置在手术室中的无菌区域中。当组织样本从其内部包裹物中取出时，可以将其在无菌盐水中再水化以恢复其柔软，柔软的手，或者可以以植入外科医生的判断植入其干燥状态，在这种情况下，组织将进行再水化与患者自己的体液。

37. 发明授权

US5507744A Apparatus and method for sealing vascular punctures 失效
公开(公告)号：US5507744A
公开(公告)日：1996-04-16
申请号：US55634
申请日：1993-04-30
申请人： Sew-Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
发明人： Sew-Wah Tay , Kemal Schankereli , Thomas Holman , Hans Mische
IPC分类号： A61B18/12 , A61B17/00 , A61B17/34 , A61B18/08 , A61B18/14 , A61B19/00 , A61B17/36
CPC分类号： A61B17/0057 , A61B17/3403 , A61B18/082 , A61B18/14 , A61B18/1402 , A61B2090/062 , A61B2090/3937 , A61M2025/0183
摘要： An apparatus for closing and sealing a vascular puncture is connected to an energy supply such that heat is generated in, or thermally conducted to, the tissue, thereby thermally fusing the vascular tissue together. The method for closing and sealing a vascular puncture comprises applying radio frequency or other energy to the tissue, the energy being sufficient to thermally fuse the tissue together, thus sealing the puncture. Embodiments of depth finding and guiding devices, as well as blood vessel occluders, are also disclosed.

38. 发明授权

US4883486A Prosthetic ligament 失效
标题翻译：假肢韧带
公开(公告)号：US4883486A
公开(公告)日：1989-11-28
申请号：US200427
申请日：1988-05-31
申请人： Indu Kapadia , Kemal Schankereli
发明人： Indu Kapadia , Kemal Schankereli
IPC分类号： A61F2/00 , A61F2/08 , A61L27/16
CPC分类号： A61F2/08 , A61L27/16 , A61F2250/0098
摘要： A prosthetic ligament has an outer sheath of permeable PTFE yarn surrounding a core of synthetic filaments with stitching through the sheath and core holding the two firmly together to act as a single integral unit when placed in situ.
摘要翻译：假肢韧带具有可渗透的PTFE纱线的外护套，围绕合成长丝的芯线，其中缝合通过护套和芯部将两者牢固地保持在一起，以在原位放置时用作单个整体单元。

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