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31. 发明授权

US07621925B2 Needle assembly for tissue manipulation 有权
标题翻译：用于组织操作的针组件
公开(公告)号：US07621925B2
公开(公告)日：2009-11-24
申请号：US10955243
申请日：2004-09-30
申请人： Vahid Saadat , Chris Rothe , Richard C. Ewers
发明人： Vahid Saadat , Chris Rothe , Richard C. Ewers
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Needle assemblies for tissue manipulation are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. A needle deployment assembly is deployable through the tissue manipulation assembly via a handle assembly, through the tubular member, and into or through tissue. An elongate pusher is translationally disposed within a sheath of the needle deployment assembly and can be urged distally for deploying an anchor assembly from the sheath distal end. The anchor assembly is positioned distally of the pusher within the sheath.
摘要翻译：用于组织操作的针组件在本文中描述。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，组织稳定构件所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。针部署组件可经由手柄组件穿过组织操纵组件展开，穿过管状构件，并且进入或穿过组织。细长的推动器平移地设置在针展开组件的护套内，并且可以向远侧推动以从护套远端展开锚固组件。锚固组件位于鞘内的推动器的远侧。

32. 发明授权

US07347863B2 Apparatus and methods for manipulating and securing tissue 有权
标题翻译：用于操纵和固定组织的装置和方法
公开(公告)号：US07347863B2
公开(公告)日：2008-03-25
申请号：US10955245
申请日：2004-09-29
申请人： Chris Rothe , Richard C. Ewers , Cang C. Lam , Vahid Saadat , Kenneth J. Michlitsch
发明人： Chris Rothe , Richard C. Ewers , Cang C. Lam , Vahid Saadat , Kenneth J. Michlitsch
IPC分类号： A61B17/10 , A61B17/00 , A61B17/08
CPC分类号： A61B1/0014 , A61B17/0401 , A61B17/06066 , A61B17/29 , A61B17/295 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/3488 , A61B2090/037
摘要： Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置和方法。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

33. 发明申请

US20080058650A1 CORONARY SINUS CANNULATION 有权
标题翻译：冠状动脉瘤
公开(公告)号：US20080058650A1
公开(公告)日：2008-03-06
申请号：US11848207
申请日：2007-08-30
申请人： Vahid SAADAT , Chris Rothe , Ruey-Feng Peh , Edmund Tam
发明人： Vahid SAADAT , Chris Rothe , Ruey-Feng Peh , Edmund Tam
IPC分类号： A61B6/00 , A61B5/103 , A61M25/09
CPC分类号： A61B1/042 , A61B1/00089 , A61B1/0051 , A61B1/0676 , A61B1/0684 , A61B5/0084 , A61B5/6853 , A61B17/0057 , A61B17/0401 , A61B17/0487 , A61B17/12045 , A61B17/221 , A61B17/3417 , A61B2017/00221 , A61B2017/00243 , A61B2017/00278 , A61B2017/00296 , A61B2017/00575 , A61B2017/00778 , A61B2017/00884 , A61B2017/00893 , A61B2017/00907 , A61B2017/00986 , A61B2017/12127 , A61B2017/3484 , A61B2017/3488 , A61B2090/373 , A61M25/007 , A61M25/1002 , A61M2025/0058
摘要： Coronary sinus cannulation apparatus and methods relating to tissue visualization catheters that can locate and/or cannulate a morphological feature within a body lumen, such as the coronary sinus, are described. Such devices can also perform a variety of therapeutic tissue treatments under direct in vivo visualization thereafter. Moreover, such apparatus and methods may also be utilized with guidewires to facilitate delivery into the coronary sinus to eliminate repositioning of the device and/or repeating an entire sequence of operations, consequently improving procedure effectiveness and reducing procedure time.
摘要翻译：描述了可以定位和/或插入体腔内的形态特征（例如冠状窦）的冠状窦插管装置和与组织可视化导管相关的方法。这样的装置还可以在其后直接体内可视化下执行各种治疗组织处理。此外，这种装置和方法还可以与引导线一起使用以便于递送到冠状窦以消除装置的重新定位和/或重复整个操作序列，从而提高手术有效性并缩短手术时间。

34. 发明申请

US20080058591A1 TISSUE VISUALIZATION DEVICE AND METHOD VARIATIONS 有权
标题翻译：组织可视化设备和方法变体
公开(公告)号：US20080058591A1
公开(公告)日：2008-03-06
申请号：US11848202
申请日：2007-08-30
申请人： Vahid Saadat , Chris Rothe , Edmund Tam , Ruey-Feng Peh
发明人： Vahid Saadat , Chris Rothe , Edmund Tam , Ruey-Feng Peh
IPC分类号： A61B1/01
CPC分类号： A61B1/00085 , A61B1/0008 , A61B1/00082 , A61B1/00089 , A61B1/00091 , A61B1/00177 , A61B1/005 , A61B1/012 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/02007 , A61B5/6882 , A61B8/12 , A61B17/00234 , A61B17/0057 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/22012 , A61B18/24 , A61B2017/048 , A61B2017/0496
摘要： Tissue visualization devices and variations thereof are described herein where such devices may utilize a variety of methods for facilitating clearing of the device of opaque bodily fluids and sealing between the device and the underlying tissue surface. Additionally, methods and devices for enhancing navigation of the device through a patient body are also described.
摘要翻译：本文描述了组织可视化装置及其变型，其中这样的装置可以利用各种方法来促进不透明体液的装置的清除和装置与下面的组织表面之间的密封。此外，还描述了用于增强穿过患者身体的装置导航的方法和装置。

35. 发明申请

US20080015445A1 TISSUE VISUALIZATION DEVICE AND METHOD VARIATIONS 有权
标题翻译：组织可视化设备和方法变体
公开(公告)号：US20080015445A1
公开(公告)日：2008-01-17
申请号：US11775771
申请日：2007-07-10
申请人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Amir Abolfathi , Chris Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Amir Abolfathi , Chris Rothe
IPC分类号： A61B8/12
CPC分类号： A61B1/005 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/0031 , A61B5/02007 , A61B5/6882 , A61B8/12 , A61B2018/0212
摘要： Tissue visualization device and method variations are described herein where an imaging hood is temporarily sealed against a region of tissue to be treated while under direct visualization. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. The imaging hood is placed against or adjacent to the tissue to be imaged in a body linen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid is pumped into the hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via all imaging element. Temporary sealing against the tissue can be achieved in a number of ways such as circumferential balloons inflatable within the hood or other sealing techniques. A field of view of the imaging element can be expanded by inflating the balloon beyond the imaging hood.
摘要翻译：本文描述了组织可视化装置和方法变化，其中成像罩在直接可视化期间临时密封待处理组织的区域。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。成像罩被放置在通常用不透明的体液如血液填充的身体亚麻织物中或邻近要成像的组织上。半透明或透明流体被泵送到罩中，直到流体移动通过所有成像元件离开要成像的组织的清晰区域的任何血液。可以以多种方式实现对组织的临时密封，例如在罩内充气的周向气囊或其他密封技术。成像元件的视野可以通过使气囊膨胀超过成像罩而扩大。

36. 发明授权

US09510817B2 Apparatus for manipulating and securing tissue 有权
标题翻译：用于操纵和固定组织的装置
公开(公告)号：US09510817B2
公开(公告)日：2016-12-06
申请号：US13491273
申请日：2012-06-07
申请人： Vahid Saadat , Richard C. Ewers , Cang C. Laduca , Robert A. Vaughan , Chris Rothe , Kenneth J. Michlitsch
发明人： Vahid Saadat , Richard C. Ewers , Cang C. Laduca , Robert A. Vaughan , Chris Rothe , Kenneth J. Michlitsch
IPC分类号： A61B17/04 , A61B17/08 , A61B17/10 , A61B17/06 , A61B17/064 , A61B17/29 , A61B17/00 , A61B17/34
CPC分类号： A61F5/0086 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B17/0487 , A61B17/06 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/12013 , A61B17/1285 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably dispose through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置。在组织折叠在患者身体内部时，组织操作组件通常可以具有细长的管状构件，可滑动地配置穿过管状构件的接合构件和适于经由螺旋构件接合组织的远端，组织稳定构件所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

37. 发明授权

US07361180B2 Apparatus for manipulating and securing tissue 有权
标题翻译：用于操纵和固定组织的装置
公开(公告)号：US07361180B2
公开(公告)日：2008-04-22
申请号：US10954666
申请日：2004-09-29
申请人： Vahid Saadat , Richard C. Ewers , Cang C. Lam , Robert A. Vaughan , Chris Rothe , Kenneth J. Michlitsch
发明人： Vahid Saadat , Richard C. Ewers , Cang C. Lam , Robert A. Vaughan , Chris Rothe , Kenneth J. Michlitsch
IPC分类号： A61B17/00 , A61B17/10 , A61B17/08
CPC分类号： A61F5/0086 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B17/0487 , A61B17/06 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/12013 , A61B17/1285 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，组织稳定构件所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

38. 发明申请

US20080015569A1 METHODS AND APPARATUS FOR TREATMENT OF ATRIAL FIBRILLATION 审中-公开
标题翻译：方法和装置治疗椎间盘突出症
公开(公告)号：US20080015569A1
公开(公告)日：2008-01-17
申请号：US11775819
申请日：2007-07-10
申请人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Chris Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Chris Rothe
IPC分类号： A61B18/14 , A61B1/045 , A61M25/00
CPC分类号： A61B1/005 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/0031 , A61B5/02007 , A61B5/6882 , A61B8/12 , A61B2018/0212
摘要： Apparatus and methods for the treatment of atrial fibrillation are described herein where tissue to be ablated may be monitored under direct visualization. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid can be pumped into the imaging hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An ablation probe may be advanced into the contained region where the tissue may be ablated and monitored for changes in color as well as appropriate positioning.
摘要翻译：本文描述了用于治疗房颤的装置和方法，其中可以在直接可视化下监测待消融的组织。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。在使用中，将成像罩放置在通常填充有不透明体液（例如血液）的体腔中的待成像组织上或邻近待成像的组织。半透明或透明流体可被泵送到成像罩中，直到流体移动通过部署导管中的成像元件离开要成像的组织的清晰区域的任何血液。消融探针可以进入包含的区域，其中可以消融组织并监测颜色的变化以及适当的定位。

39. 发明申请

US20070293724A1 VISUALIZATION APPARATUS FOR TRANSSEPTAL ACCESS 审中-公开
标题翻译：可视化设备用于传输接入
公开(公告)号：US20070293724A1
公开(公告)日：2007-12-20
申请号：US11763399
申请日：2007-06-14
申请人： Vahid SAADAT , Amir Abolfathi , Chris Rothe , Kevin Van Bladel
发明人： Vahid SAADAT , Amir Abolfathi , Chris Rothe , Kevin Van Bladel
IPC分类号： A61B1/12
CPC分类号： A61B1/00089 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/005 , A61B1/015 , A61B1/018 , A61B1/04 , A61B1/3137 , A61B5/02007 , A61B8/12 , A61B8/4472
摘要： Visualization apparatus and methods for transseptal access are described herein where intravascular access across a septal wall is facilitated via devices which provide for direct visual viewing of tissue area. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid can be pumped into the imaging hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Any number of therapeutic tools or a guidewire can be passed through the catheter and into the imaging hood for crossing the septal wall and passing the guidewire or instruments therethrough.
摘要翻译：本文描述了可视化装置和用于经常通路的方法，其中通过提供组织区域的直接视觉观察的装置促进通过隔壁的血管内通路。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。在使用中，将成像罩放置在通常填充有不透明体液（例如血液）的体腔中的待成像组织上或邻近待成像的组织。半透明或透明流体可被泵送到成像罩中，直到流体移动通过部署导管中的成像元件离开要成像的组织的清晰区域的任何血液。任何数量的治疗工具或导丝可以通过导管并进入成像罩，用于穿过隔壁并使导丝或器械通过。

40. 发明申请

US20060178562A1 Apparatus and methods for obtaining endoluminal access with a steerable guide having a variable pivot 审中-公开
标题翻译：用于具有可变枢轴的可转向引导件获得腔内通路的装置和方法
公开(公告)号：US20060178562A1
公开(公告)日：2006-08-10
申请号：US11057042
申请日：2005-02-10
申请人： Vahid Saadat , Chris Rothe
发明人： Vahid Saadat , Chris Rothe
IPC分类号： A61B1/00
CPC分类号： A61B17/00234 , A61B1/0055 , A61B1/2736 , A61B17/0643 , A61B17/1114 , A61B2017/003 , A61B2017/00323 , A61B2017/3445
摘要： Methods and apparatus for obtaining endoluminal access are provided comprising a steerable endoluminal guide having a variable pivot for altering steering dynamics. In one variation, variable pivoting is achieved by advancing a member having a hard or substantially rigid section to various depths within a lumen of the guide. The hard section resists deformation, thereby reducing or precluding pivoting of the guide proximal of the distal-most depth of hard section insertion. In another variation, the guide comprises one or more pivot wires that terminate at a segment of the guide disposed proximal of the guide's distal outlet. In such a variation, the steering pivot of the guide may be altered by applying tension to at least one pivot wire, while concurrently applying tension to a steering wire that terminates more distally than the pivot wire, and that is radially offset from the pivot wire about the circumference of the guide. In another variation, one or more stiffening elements are translated over or alongside one or more steering wires to alter the guide's pivot.
摘要翻译：提供了用于获得腔内通路的方法和装置，其包括具有用于改变转向动力学的可变枢轴的可操纵的腔内引导件。在一个变型中，通过将具有硬的或基本上刚性的部分的部件推进到引导件的内腔内的各种深度来实现可变枢转。硬部分抵抗变形，从而减少或排除硬截面插入最远深度的导向件近端枢转。在另一个实施例中，引导件包括一个或多个枢转线，其终止于布置在引导件远端出口附近的引导件的一段。在这种变化中，可以通过向至少一个枢转线施加张力来改变引导件的转向枢轴，同时向远离枢转线的端部延伸的转向线同时施加张力，并且从枢转线径向偏移围绕引导件的圆周。在另一种变型中，一个或多个加强元件在一个或多个转向线上或旁边平移以改变引导件的枢轴。

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