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31. 发明授权

US08318480B2 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor 有权
标题翻译：腺相关病毒（AAV）血清型8序列，含有其的载体及其用途
公开(公告)号：US08318480B2
公开(公告)日：2012-11-27
申请号：US11981191
申请日：2007-10-31
申请人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
发明人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
IPC分类号： C12N15/63 , C12N15/85
CPC分类号： C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
摘要： Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.
摘要翻译：提供血清型8腺相关病毒和含有这些序列的载体和宿主细胞的序列。还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。

32. 发明申请

US20120189582A1 SIMIAN ADENOVIRUS 41 AND USES THEREOF 有权
标题翻译： SIMIAN ADENOVIRUS 41及其使用
公开(公告)号：US20120189582A1
公开(公告)日：2012-07-26
申请号：US13321985
申请日：2010-05-27
申请人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
发明人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
IPC分类号： A61K35/76 , A61K38/02 , C12N15/34 , C07K14/075 , C12N7/01 , C12N15/63
CPC分类号： C12N15/86 , A61K39/145 , A61K48/00 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2810/6018
摘要： Novel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and a heterologous gene under the control of regulatory sequences are provided. A cell line which expresses simian adenovirus 41 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译：描述了新型猿猴腺病毒41及其两个分离物。提供这些分离物的各种用途，包括构建包含猿猴腺病毒41序列和在调控序列控制下的异源基因的重组载体。还公开了表达猿腺病毒41基因的细胞系。提供了使用载体和细胞系的方法。

33. 发明申请

US20110151434A1 ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES IDENTIFIED THEREBY 有权
标题翻译： ADENO相关病毒（AAV）序列和分离的序列识别
公开(公告)号：US20110151434A1
公开(公告)日：2011-06-23
申请号：US12962793
申请日：2010-12-08
申请人： GUANGPING GAO , James M. Wilson , Mauricio R. Alvira
发明人： GUANGPING GAO , James M. Wilson , Mauricio R. Alvira
IPC分类号： C12Q1/70 , C12Q1/68 , C12N15/63
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： A method for detecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided, which sample contains DNA and proviral AAV. The method involves subjecting the sample containing DNA to amplification via polymerase chain reaction (PCR) using a first set of primers which specifically amplify a first AAV region. The first AAV region is characterized by having at least 250 nucleotides of AAV capsid nucleic acid sequence, a variable sequence flanked by a sequence of at least 18 nucleotides at the 5′ end of the first AAV region and a sequence of at least 18 nucleotides at the 3′ end of the first AAV region. Each of the 5′ and 3′ at least 18 nucleotides is the same over at least 9 consecutive nucleotides relative to corresponding sequences in an alignment of at least two AAV serotypes. Each of the sets of primers consist of a 5′ primer and a 3′ primer. The method is further useful for identifying AAV sequences in the sample by the presence of amplified proviral AAV sequences.
摘要翻译：提供了从组织或细胞获得的DNA样品中检测和分离AAV序列的方法，该样品含有DNA和前病毒AAV。该方法包括使用特异性扩增第一AAV区域的第一组引物通过聚合酶链反应（PCR）使含有DNA的样品进行扩增。第一个AAV区的特征在于具有AAV衣壳核酸序列的至少250个核苷酸，在第一AAV区的5'末端侧接至少18个核苷酸的序列的可变序列和至少18个核苷酸的序列第一个AAV区域的3'端。相对于至少两种AAV血清型的比对中的相应序列，5'和3'至少18个核苷酸中的每一个在至少9个连续核苷酸上相同。每组引物由5'引物和3'引物组成。该方法进一步用于通过扩增的前病毒AAV序列的存在来鉴定样品中的AAV序列。

34. 发明授权

US07860713B2 Reducing time for annotating speech data to develop a dialog application 有权
标题翻译：减少注释语音数据开发对话应用程序的时间
公开(公告)号：US07860713B2
公开(公告)日：2010-12-28
申请号：US12165755
申请日：2008-07-01
申请人： Tirso M. Alonso , Ilana Bromberg , Dilek Z. Hakkani-Tur , Barbara B. Hollister , Mazin G. Rahim , Giuseppe Riccardi , Lawrence Lyon Rose , Daniel Leon Stern , Gokhan Tur , James M. Wilson
发明人： Tirso M. Alonso , Ilana Bromberg , Dilek Z. Hakkani-Tur , Barbara B. Hollister , Mazin G. Rahim , Giuseppe Riccardi , Lawrence Lyon Rose , Daniel Leon Stern , Gokhan Tur , James M. Wilson
IPC分类号： G10L15/14 , G10L15/22
CPC分类号： G10L15/19 , G10L15/063 , G10L15/183 , H04M3/4936
摘要： Systems and methods for annotating speech data. The present invention reduces the time required to annotate speech data by selecting utterances for annotation that will be of greatest benefit. A selection module uses speech models, including speech recognition models and spoken language understanding models, to identify utterances that should be annotated based on criteria such as confidence scores generated by the models. These utterances are placed in an annotation list along with a type of annotation to be performed for the utterances and an order in which the annotation should proceed. The utterances in the annotation list can be annotated for speech recognition purposes, spoken language understanding purposes, labeling purposes, etc. The selection module can also select utterances for annotation based on previously annotated speech data and deficiencies in the various models.
摘要翻译：用于注释语音数据的系统和方法。本发明通过选择最有益的用于注释的话语来减少注释语音数据所需的时间。选择模块使用包括语音识别模型和语言理解模型在内的语音模型来基于诸如由模型产生的置信度得分的标准来识别应当注释的话语。这些话语被放置在注释列表中，以及要为语句执行的注释类型以及注释应该继续执行的顺序。注释列表中的话语可以被注释用于语音识别目的，语言理解目的，标签目的等。选择模块还可以基于先前注释的语音数据和各种模型中的缺陷来选择用于注释的话语。

35. 发明授权

US07560966B2 Method of testing connectivity using dual operational mode CML latch 失效
标题翻译：使用双操作模式CML锁定测试连接的方法
公开(公告)号：US07560966B2
公开(公告)日：2009-07-14
申请号：US12002878
申请日：2007-12-19
申请人： Joseph O. Marsh , Joseph Natonio , James M. Wilson
发明人： Joseph O. Marsh , Joseph Natonio , James M. Wilson
IPC分类号： H03K3/289
CPC分类号： H03K3/356043
摘要： A method of testing connectivity through a plurality of dual purpose current mode logic (“CML”) latch circuits connected in a series is provided. Each of the CML latch circuits are operable to latch at least one output signal at a timing in accordance with at least one clock signal and having a mode control device for operating the CML latch circuit as a buffer amplifier when the at least one clock signal is inactive. The method comprises the steps of activating the mode control devices of each of the CML latches to operate each of the CML latches as a buffer; inputting a first signal to a first CML latch of the series; latching an output signal of a second CML latch of the series, the second CML latch being connected at a point in the series downstream from the first CML latch; and determining whether the output signal changes in accordance with a change in the first signal.
摘要翻译：提供了通过串联连接的多个双用途电流模式逻辑（“CML”）锁存电路来测试连接性的方法。每个CML锁存电路可操作以根据至少一个时钟信号在定时锁存至少一个输出信号，并具有一个模式控制装置，用于当至少一个时钟信号为不活动该方法包括以下步骤：激活每个CML锁存器的模式控制装置，以操作每个CML锁存器作为缓冲器; 向所述系列的第一CML锁存器输入第一信号; 锁存串联的第二CML锁存器的输出信号，第二CML锁存器在第一CML锁存器下游的串联点连接; 以及确定所述输出信号是否根据所述第一信号的改变而改变。

36. 发明授权

US07491508B2 Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses 有权
标题翻译：产生嵌合腺病毒的方法和用于这种嵌合腺病毒的方法
公开(公告)号：US07491508B2
公开(公告)日：2009-02-17
申请号：US10561201
申请日：2004-06-15
申请人： Soumitra Roy , James M. Wilson
发明人： Soumitra Roy , James M. Wilson
IPC分类号： C12N15/63 , C12N15/64 , C12N15/861 , C12N5/10 , A61K48/00 , C12P21/00 , C07H21/04 , C12Q1/68 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K48/00 , A61K2039/5256 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10344 , C12N2710/10351 , C12N2760/14134 , C12N2810/6018
摘要： A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing the left and right termini of the adenovirus with the corresponding termini from an adenovirus which grow efficiently in the desired cell line. At a minimum, the left terminus spans the (5′) inverted terminal repeat, the left terminus spans the E4 region and the (3′) inverted terminal repeat. The resulting chimeric adenovirus contains the internal regions spanning the genes encoding the penton, hexon and fiber from the serotype which does not grow efficiently in the desired cell. Also provided are vectors constructed from novel simian adenovirus sequences and proteins, host cells containing same, and uses thereof.
摘要翻译：描述了从在该细胞系中具有生长能力的所需细胞系中不能有效生长的血清型提供腺病毒的方法。该方法包括用在期望的细胞系中有效生长的腺病毒的相应末端替换腺病毒的左侧和右侧末端。至少，左终点跨越（5'）反向末端重复，左终点跨越E4区域，（3'）反向末端重复。所得到的嵌合腺病毒包含跨越编码来自血清型的五邻体，六邻体和纤维的基因的内部区域，其不能在期望的细胞中有效生长。还提供了由新型猿猴腺病毒序列和蛋白构成的载体，含有其的宿主细胞及其用途。

37. 发明授权

US07282199B2 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor 有权
标题翻译：腺相关病毒（AAV）血清型8序列，含有其的载体及其用途
公开(公告)号：US07282199B2
公开(公告)日：2007-10-16
申请号：US10423704
申请日：2003-04-25
申请人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
发明人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
IPC分类号： C12N15/864 , C12N15/35 , C12N15/63 , C12N15/64 , C12N7/01 , C12P21/00 , C07K14/015 , C12Q1/70 , C12Q1/68
CPC分类号： C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
摘要： Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes, including Factor VIII, is also provided.
摘要翻译：提供血清型8腺相关病毒和含有这些序列的载体和宿主细胞的序列。还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。还提供rAAV8介导的治疗和免疫原性基因的递送，包括因子VIII。

38. 发明授权

US07186552B2 Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same 有权
标题翻译：腺相关病毒血清型1核酸序列，载体和含有它们的宿主细胞
公开(公告)号：US07186552B2
公开(公告)日：2007-03-06
申请号：US10696900
申请日：2003-10-30
申请人： James M. Wilson , Weidong Xiao
发明人： James M. Wilson , Weidong Xiao
IPC分类号： C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12N5/00 , C12N5/02 , C12N15/85 , C12N15/87
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C07K14/505 , C07K14/8125 , C12N7/00 , C12N2750/14042 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2799/025
摘要： The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors.
摘要翻译：提供腺相关病毒（AAV）血清型1的核酸序列，载体和含有这些序列及其功能片段的宿主细胞也是如此。还提供了通过AAV-1衍生的载体递送基因的方法。

39. 发明授权

US07167951B2 Intelligent controller accessed through addressable virtual space 有权
标题翻译：智能控制器通过可寻址的虚拟空间进行访问
公开(公告)号：US07167951B2
公开(公告)日：2007-01-23
申请号：US10263274
申请日：2002-10-02
申请人： Jerry A. Blades , Matthew C. Dewey , Bruce A. Thompson , David J. Van Maren , James M. Wilson
发明人： Jerry A. Blades , Matthew C. Dewey , Bruce A. Thompson , David J. Van Maren , James M. Wilson
IPC分类号： G06F12/00
CPC分类号： G06F3/0664 , G06F3/0607 , G06F3/0643 , G06F3/0679 , G06F12/08
摘要： Mass storage system controller apparatus receives requests for access to files in a data storage system and manages access to the files in the data storage system, the data storage system having a plurality of storage devices and the requests being addressed to the data storage system as a single virtual storage device having addressable Command Regions allocated to controller commands and addressable Mapped Data Regions allocated for data storage. The apparatus includes a file system to manage access to files in the data storage system, the file system having a processor acting as a Command Region processor and acting as a Mapped Data Region processor. A disk emulator responds as a disk drive device to write/read commands and passes the write/read commands addressed to Command Regions of the virtual storage device to the Command Region processor, the write/read commands addressed to Command Regions containing controller commands for the file system. The Command Region processor responds to controller commands in the write/read commands and processes the controller commands to control files in the data storage system. The disk emulator responds as a disk drive device to write/read commands and passes write/read commands addressed to a Mapped Data Region of the virtual storage device to the Mapped Data Region processor. The Mapped Data Region processor responds to a write/read command with a Mapped Data Region address and transfers data to or from the data storage system for files mapped to the Mapped Data Region address.
摘要翻译：大容量存储系统控制器装置接收访问数据存储系统中的文件的请求，并管理对数据存储系统中的文件的访问，数据存储系统具有多个存储装置，并且请求被作为数据存储系统寻址到数据存储系统单个虚拟存储设备具有分配给控制器命令的可寻址命令区域和分配用于数据存储的可寻址映射数据区域。该装置包括用于管理数据存储系统中文件访问的文件系统，该文件系统具有用作命令区域处理器的处理器并用作映射数据区域处理器。磁盘仿真器作为磁盘驱动器设备作为写入/读取命令进行响应，并将寻址到虚拟存储设备的命令区域的写入/读取命令传递到命令区域处理器，写入/读取命令寻址到包含控制器命令的命令区域文件系统。命令区域处理器响应写/读命令中的控制器命令，并处理控制器命令以控制数据存储系统中的文件。磁盘仿真器作为磁盘驱动器设备进行响应，以写/读命令，并将寻址到虚拟存储设备的映射数据区的写/读命令传递给映射数据区处理器。映射数据区域处理器使用映射数据区域地址响应写入/读取命令，并将数据传输到数据存储系统或从映射到映射到映射数据区域地址的文件传输数据。

40. 发明授权

US06887463B2 Methods and compositions for the treatment of defects in lipoprotein metabolism 失效
标题翻译：用于治疗脂蛋白代谢缺陷的方法和组合物
公开(公告)号：US06887463B2
公开(公告)日：2005-05-03
申请号：US10167264
申请日：2002-06-10
申请人： James M. Wilson , Karen Kozarsky , Jerome Strauss, III
发明人： James M. Wilson , Karen Kozarsky , Jerome Strauss, III
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K38/17 , A61K48/00 , A61P3/06 , C07K14/705 , C12N5/10 , C12N7/00 , C12N15/12 , C12N15/861 , C12N15/86 , C12N15/864
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/705 , C12N2710/10344 , C12N2799/022
摘要： The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic cell; and a human VLDL receptor gene operatively linked to regulatory sequences directing its expression. The vector is capable of expressing the normal VLDL receptor gene product in hepatic cells in vivo or in vitro. This viral vector is useful in the treatment of metabolic disorders caused by the accumulation of LDL in plasma, such as familial hypercholesterolemia or familial combined hyperlipidemia.
摘要翻译：本发明提供了一种重组病毒载体，其包含腺病毒基因组的至少一部分的DNA或相当于该部分能够感染肝细胞的DNA; 和与指导其表达的调节序列可操作地连接的人类VLDL受体基因。该载体能够在体内或体外在肝细胞中表达正常的VLDL受体基因产物。该病毒载体可用于治疗血浆中LDL积累引起的代谢紊乱，如家族性高胆固醇血症或家族性高脂血症。

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