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31. 发明授权

US06955173B2 Device and method for forming a circumferential conduction block in a pulmonary vein 有权
标题翻译：在肺静脉中形成圆周传导阻滞的装置和方法
公开(公告)号：US06955173B2
公开(公告)日：2005-10-18
申请号：US10233158
申请日：2002-08-30
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61B17/00 , A61B17/22 , A61B18/08 , A61B18/14 , A61F2/958 , A61N7/02 , A61B19/00 , A61B18/18 , A61F7/12
CPC分类号： A61B18/10 , A61B18/08 , A61B18/1492 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00369 , A61B2018/00375 , A61B2018/00577 , A61B2018/00642 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2018/1407 , A61B2218/002 , A61M25/1002 , A61M2025/1075 , A61M2210/125 , A61N7/022
摘要： This invention is a method for treating a patient diagnosed with atrial arrhythmia by forming a circumferential conduction block along a circumferential path of tissue in a pulmonary vein wall that circumscribes the pulmonary vein lumen and transects the electrical conductivity of the pulmonary vein such that conduction is blocked along the longitudinal axis of the vein wall and into the left atrial wall. The method is performed to treat a patient with a focal arrythmogenic origin along the pulmonary vein wall by either ablating the focal origin or by isolating the focal origin from the atrial wall with the circumferential conduction block. The circumferential conduction block is also formed in a pulmonary vein in order to bridge the adjacent ends of two linear lesions, wherein each linear lesion is formed to extend between the pulmonary vein and another adjacent pulmonary vein in a less-invasive “maze”-type procedure. A circumferential ablation element in a circumferential ablation device assembly is used in a percutaneous translumenal catheter technique in order to form the circumferential conduction block in the pulmonary vein wall.
摘要翻译：本发明是一种通过沿着肺静脉壁的肺组织周向路径形成圆周传导阻滞来诊断患有心律失常的患者的方法，所述肺静脉壁围绕肺静脉管腔并横切肺静脉的导电性，从而导致阻塞沿着静脉壁的纵向轴线并进入左心房壁。执行该方法以通过消融焦点来源或通过用圆周传导阻滞来将心源起点与心房壁一起沿着肺静脉壁治疗具有局灶性原发性起源的患者。圆周传导阻滞也形成在肺静脉中以便桥接两个线性损伤的相邻端，其中每个线性病变形成为在较小侵入性“迷宫”型的肺静脉和另一相邻的肺静脉之间延伸程序。在经皮腔内导管技术中使用周缘消融装置组件中的圆周消融元件，以便在肺静脉壁中形成圆周传导阻滞。

32. 发明授权

US06652515B1 Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall 有权
公开(公告)号：US06652515B1
公开(公告)日：2003-11-25
申请号：US09435281
申请日：1999-11-05
申请人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
发明人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
IPC分类号： A61B1818
CPC分类号： A61N7/02 , A61B18/00 , A61B18/08 , A61B18/1492 , A61B2017/00243 , A61B2018/00011 , A61B2018/00065 , A61B2018/00101 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/143 , A61B2018/1432 , A61B2218/002 , A61M25/1002
摘要： This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.

33. 发明授权

US06641557B1 Method and apparatus for closing a body lumen 有权
标题翻译：用于闭合体腔的方法和装置
公开(公告)号：US06641557B1
公开(公告)日：2003-11-04
申请号：US09707293
申请日：2000-11-03
申请人： Andrew G. C. Frazier , Erik J. van der Burg , Michael D. Lesh
发明人： Andrew G. C. Frazier , Erik J. van der Burg , Michael D. Lesh
IPC分类号： A61M500
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/12122 , A61B2017/00243 , A61B2017/00292 , A61B2017/00575 , A61B2017/00579 , A61B2017/00632 , A61B2017/00668 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/042 , A61B2017/0437 , A61B2017/0445 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0472 , A61B2017/0477 , A61B2017/048 , A61B2017/0488 , A61B2017/0645 , A61B2017/0647 , A61F2/24 , A61F2/2427 , A61F2/2487 , Y10S606/907
摘要： Disclosed is a closure catheter, for closing a body cavity such as a vessel, or the left atrial appendage of the heart. The closure catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may thereafter be used to draw the tissue radially inwardly, to close the body cavity. Methods are also disclosed.
摘要翻译：公开了一种闭合导管，用于封闭诸如血管的体腔或心脏的左心耳。闭合导管包括多个可展开的组织锚，其可以横向地展开到周围的组织中。然后可以使用锚定件径向向内拉伸组织，以闭合体腔。还公开了方法。

34. 发明授权

US06383151B1 Circumferential ablation device assembly 有权
公开(公告)号：US06383151B1
公开(公告)日：2002-05-07
申请号：US09659477
申请日：2000-09-11
申请人： Chris J. Diederich , Michael D. Lesh , James C. Peacock, III , Michael R. Ross
发明人： Chris J. Diederich , Michael D. Lesh , James C. Peacock, III , Michael R. Ross
IPC分类号： A61B100
CPC分类号： A61B18/1492 , A61B18/00 , A61B2017/00243 , A61B2018/00083 , A61B2018/00148 , A61B2018/00214 , A61M25/1002 , A61M2210/125 , A61N7/02 , A61N7/022
摘要： This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive “maze”-type procedure in the region of the pulmonary vein ostia in the left ventricle. A cylindrical ultrasound transducer is provided on an inner member within the balloon and forms the circumferential ablation member by emitting a radial ultrasound signal which is circumferential to the transducer and highly collimated to the transducer's length. The circumferential ultrasound signal sonically couples to the balloon's outer skin to form the circumferential ablation element that is adapted to ablate a circumferential path of tissue engaged to the balloon.

35. 发明授权

US6012457A Device and method for forming a circumferential conduction block in a pulmonary vein 失效
标题翻译：在肺静脉中形成圆周传导阻滞的装置和方法
公开(公告)号：US6012457A
公开(公告)日：2000-01-11
申请号：US889835
申请日：1997-07-08
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61B17/00 , A61B17/22 , A61B18/08 , A61B18/14 , A61F2/958 , A61N7/02 , A61B19/00 , A61B17/38 , A61F7/00 , A61N1/00
CPC分类号： A61B18/10 , A61B18/1492 , A61M25/1002 , A61B18/08 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00369 , A61B2018/00375 , A61B2018/00577 , A61B2018/00642 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2018/1407 , A61B2218/002 , A61M2025/1075 , A61M2210/125 , A61N7/022
摘要： This is a method for treating a patient diagnosed with atrial arrhythmia by forming a circumferential conduction block along a circumferential path of tissue in a pulmonary vein wall that circumscribes the pulmonary vein lumen and transects the electrical conductivity of the pulmonary vein such that conduction is blocked along the longitudinal axis of the vein wall and into the left atrial wall. The method is performed to treat a patient with a focal arrythmogenic origin along the pulmonary vein wall by either ablating the focal origin or by isolating the focal origin from the atrial wall with the circumferential conduction block. The circumferential conduction block is also formed in a pulmonary vein in order to bridge the adjacent ends of two linear lesions, wherein each linear lesion is formed to extend between the pulmonary vein and another adjacent pulmonary vein in a less-invasive "maze"-type procedure. A circumferential ablation element in a circumferential ablation device assembly is used in a percutaneous translumenal catheter technique in order to form the circumferential conduction block in the pulmonary vein wall.
摘要翻译：这是通过沿肺静脉壁的肺组织周向路径形成圆周传导阻滞来诊断患有心律失常的患者的方法，该肺静脉壁围绕肺静脉管腔并横切肺静脉的导电性，使得导电被阻塞静脉壁的纵向轴线并进入左心房壁。执行该方法以通过消融焦点来源或通过用圆周传导阻滞来将心源起点与心房壁一起沿着肺静脉壁治疗具有局灶性原发性起源的患者。圆周传导阻滞也形成在肺静脉中以便桥接两个线性损伤的相邻端，其中每个线性病变形成为在较小侵入性“迷宫”型的肺静脉和另一相邻的肺静脉之间延伸程序。在经皮腔内导管技术中使用周缘消融装置组件中的圆周消融元件，以便在肺静脉壁中形成圆周传导阻滞。

36. 发明授权

US5921982A Systems and methods for ablating body tissue 失效
标题翻译：用于烧伤身体组织的系统和方法
公开(公告)号：US5921982A
公开(公告)日：1999-07-13
申请号：US846739
申请日：1997-04-30
申请人： Michael D. Lesh , Stuart D. Edwards
发明人： Michael D. Lesh , Stuart D. Edwards
IPC分类号： A61B18/14 , A61B17/36
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00815 , A61B2018/00839 , A61B2018/1425 , A61B2018/1435 , A61B2090/3782 , A61N7/02
摘要： A medical probe device for contacting tissue within the body a catheter tube having a control end and a probe end. The probe end includes a housing having a port. An element is located within the housing that is movable between a first position confined within the housing and a second position extending through the port outside the housing. The element has a distal tip adapted to penetrate a tissue region during movement between the first and second position. The element comprises an electrode for emitting electromagnetic radio frequency energy into the tissue region, or cannula with an interior lumen for conveying fluid to and from the tissue region, or a sensor for sensing temperature conditions in the tissue region.
摘要翻译：一种医疗探针装置，用于使身体内的组织具有具有控制端和探针端的导管。探针端部包括具有端口的壳体。元件位于壳体内，其可在限制在壳体内的第一位置和延伸穿过壳体外部的端口的第二位置之间移动。元件具有适于在第一和第二位置之间移动期间穿透组织区域的远侧末端。该元件包括用于将电磁射频能量发射到组织区域中的电极，或具有用于向组织区域输送流体的内腔的插管或用于感测组织区域中的温度条件的传感器。

37. 发明授权

US5792064A Systems and methods for analyzing cardiac biopotential morphologies by cross-correlation 失效
标题翻译：通过互相关分析心脏生物电位形态的系统和方法
公开(公告)号：US5792064A
公开(公告)日：1998-08-11
申请号：US949287
申请日：1997-10-21
申请人： Dorin Panescu , Michael D. Lesh , David K. Swanson , James G. Whayne
发明人： Dorin Panescu , Michael D. Lesh , David K. Swanson , James G. Whayne
IPC分类号： A61B18/14 , A61N1/362 , A61B5/04
CPC分类号： A61B18/1492 , A61N1/362
摘要： An analog or digital processing element and associated method analyses electrograms or electrocardiograms to locate sites potentially appropriate for ablation. The element and method compares a first number of electrogram or electrocardiogram samples recorded over time during a cardiac event of known diagnosis with a second number of paced electrogram or electrocardiogram samples recorded over time. The comparison cross-correlates the first number of electrogram samples with the second number of paced electrogram samples. The element and method generate an output based upon the cross-correlation. The element and method compare the output to a predetermined value to determine whether a pacing site for the paced electrogram or electrocardiogram samples is near to a potential ablation site.
摘要翻译：模拟或数字处理元件和相关联的方法分析电描记图或心电图以定位潜在适合消融的位置。元件和方法将在已知诊断的心脏事件期间随时间记录的第一数量的电描记图或心电图样本与随时间记录的第二数量的起搏电描记图或心电图样品进行比较。该比较将第一数量的电描记图样本与第二数量的步调电子照相样本相互关联。元素和方法基于互相关产生输出。元件和方法将输出与预定值进行比较，以确定起搏电图或心电图样本的起搏部位是否接近潜在的消融部位。

38. 发明授权

US08845717B2 Coaptation enhancement implant, system, and method 有权
标题翻译：接合增强植入物，系统和方法
公开(公告)号：US08845717B2
公开(公告)日：2014-09-30
申请号：US13099532
申请日：2011-05-03
申请人： Alex Khairkhahan , Michael D. Lesh
发明人： Alex Khairkhahan , Michael D. Lesh
IPC分类号： A61F2/24 , A61F2/00 , A61B17/068 , A61B17/064 , A61B17/12 , A61B17/04 , A61B17/00
CPC分类号： A61F2/246 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12172 , A61B2017/00867 , A61B2017/0412 , A61B2017/0448 , A61B2017/0464 , A61B2017/048 , A61B2017/0649 , A61F2/2454 , A61F2/2457 , A61F2/2466 , A61F2250/0003
摘要： Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.
摘要翻译：植入物，植入物系统和治疗二尖瓣关闭不全的其它瓣膜疾病的方法通常包括接合辅助体，其保持在血流动路径内，因为瓣膜的小叶移动，瓣膜体通常相对较薄（沿着血流路径）和/或适形结构，其从合缝延伸到合缝，允许天然小叶在心脏周期阶段期间在心脏周期阶段期间接合并密封在阀体两侧的大的相对表面上，当心室收缩为空血液室，并允许血液在阀体周围通过，使得血液在心脏周期的充盈阶段期间从心房流向心室。在每个连合处附近单独部署独立的锚杆可以促进示例性三角形阀体的定位和支撑，其中第三锚定部分在心室中。阀体的外表面可以适应组织向内生长或内皮化，而吸入液体的基质可以在引入心脏后膨胀。可以在锚定器部署之后选择阀体形状，并且基于导管的部署系统可以具有期望的低轮廓。

39. 发明授权

US08663273B2 Method of implanting an adjustable occlusion device 有权
标题翻译：植入可调闭塞装置的方法
公开(公告)号：US08663273B2
公开(公告)日：2014-03-04
申请号：US13274380
申请日：2011-10-17
申请人： Alexander K. Khairkhahan , Andrew G. C. Frazier , Alan R. Klenk , Marc S. Kreidler , Stewart M. Kume , Darrell H. Ogi , Chad C. Roue , Erik J. van der Burg , Dino DeCicco , Michael D. Lesh
发明人： Alexander K. Khairkhahan , Andrew G. C. Frazier , Alan R. Klenk , Marc S. Kreidler , Stewart M. Kume , Darrell H. Ogi , Chad C. Roue , Erik J. van der Burg , Dino DeCicco , Michael D. Lesh
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/122 , A61B2017/00243 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00619 , A61B2017/00623 , A61B2017/081 , A61B2017/1205 , A61B2017/12095 , A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0071 , A61F2230/008 , A61M25/10 , A61M2025/1054 , A61M2210/125
摘要： Disclosed is an adjustable occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device is removably carried by a deployment catheter. The device may be enlarged or reduced to facilitate optimal placement or removal. Methods are also disclosed.
摘要翻译：公开了一种用于体腔内的可调闭塞装置，例如左心耳。闭塞装置可移除地由展开导管携带。该装置可以被放大或缩小以便于最佳的放置或移除。还公开了方法。

40. 发明授权

US08535343B2 Method for left atrial appendage occlusion 有权
标题翻译：左心耳闭塞方法
公开(公告)号：US08535343B2
公开(公告)日：2013-09-17
申请号：US13109898
申请日：2011-05-17
申请人： Erik J. van der Burg , Dino De Cicco , Andrew G. C. Frazier , Alex K. Khairkahan , Marc S. Kriedler , Michael D. Lesh , Chad C. Roue
发明人： Erik J. van der Burg , Dino De Cicco , Andrew G. C. Frazier , Alex K. Khairkahan , Marc S. Kriedler , Michael D. Lesh , Chad C. Roue
IPC分类号： A61M29/00
CPC分类号： A61B17/12122 , A61B17/0057 , A61B17/12022 , A61B17/12031 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B17/12195 , A61B17/122 , A61B2017/00243 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00615 , A61B2017/00619 , A61B2017/00632 , A61B2017/00867 , A61B2017/081 , A61B2017/1205 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/0071 , A61F2230/008 , A61M25/10 , A61M2025/1054 , A61M2210/125
摘要： Disclosed is an occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device includes a pumpable injectable material and a retention member having a tissue penetrating shaft which extends from a proximal end of the device to a distal end of the device.
摘要翻译：公开了一种用于体腔内的闭塞装置，例如左心耳。闭塞装置包括可泵送注射材料和具有组织穿透轴的保持构件，所述组织穿透轴从装置的近端延伸到装置的远端。

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