专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US09354155B2 Cell counting systems and methods 有权
标题翻译：细胞计数系统和方法
公开(公告)号：US09354155B2
公开(公告)日：2016-05-31
申请号：US13483771
申请日：2012-05-30
申请人： Daniel Chu , Eli A. Hefner , Yann Jouvenot
发明人： Daniel Chu , Eli A. Hefner , Yann Jouvenot
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1463 , G01N2015/1006
摘要： An automated system captures multiple digital images of a sample, from different viewing areas of the sample. The images are analyzed and a test result may be reported based on the count of cells in all of the digital images. The system may be especially applicable to the testing of samples having low cell concentrations, as the variability between tests may be reduced as compared with a system that bases its test results on only a single image of the sample. The system may count the cells in a first digital image of the sample, and may capture or analyze one or more additional digital images only when it is recognized that additional measurements are needed to ensure adequate accuracy and repeatability of the test.
摘要翻译：自动化系统从样品的不同观察区域捕获样品的多个数字图像。分析图像，并且可以基于所有数字图像中的单元的计数来报告测试结果。该系统可能特别适用于具有低细胞浓度的样品的测试，因为与将其测试结果仅基于样品的单个图像的系统相比，可以减少测试之间的可变性。系统可以对样本的第一数字图像中的单元进行计数，并且可以仅在认识到需要额外的测量以确保测试的足够的精度和可重复性时才捕获或分析一个或多个附加的数字图像。

32. 发明申请

US20130272048A1 SELF-DISABLING CHIP ENABLE INPUT 有权
公开(公告)号：US20130272048A1
公开(公告)日：2013-10-17
申请号：US13995172
申请日：2011-09-01
申请人： Daniel Chu
发明人： Daniel Chu
IPC分类号： G11C5/06 , H03K19/00
CPC分类号： G11C5/06 , G11C7/109 , G11C7/20 , H01L24/73 , H01L2224/05554 , H01L2224/32145 , H01L2224/32245 , H01L2224/48147 , H01L2224/48247 , H01L2224/49175 , H01L2224/73265 , H01L2225/06562 , H03K19/00 , H01L2924/00012 , H01L2224/48145
摘要： A multi-die memory package may have separate chip enable inputs for the respective memory dice. Individual chip enable inputs may be separated by other chip connections such as power and ground. The memory dice may include multiple chip enable inputs to allow easy wire bonding of the individual chip enable inputs to a die without requiring any jumpers within the package. Circuitry may be included so that undriven chip enable inputs are masked and driven chip enable inputs may be propagated to the memory die to enable memory accesses while a single chip enable input is only connected to the capacitance of a single bonding pad.

33. 发明授权

US08541403B2 Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency 有权
公开(公告)号：US08541403B2
公开(公告)日：2013-09-24
申请号：US13020619
申请日：2011-02-03
申请人： Daniel Chu , Bing Wang , Ying Feng , Yuqiao Shen , Leonard Edwin Post
发明人： Daniel Chu , Bing Wang , Ying Feng , Yuqiao Shen , Leonard Edwin Post
IPC分类号： A01N43/00 , A01N43/58 , A01N43/60 , A61K31/55 , A61K31/535 , A61K31/50 , A61K31/495 , C07D413/00
CPC分类号： A61K31/5377 , A61K31/5025 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D487/06
摘要： A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

34. 发明申请

US20130137144A1 THERMAL BLOCK WITH BUILT-IN THERMOELECTRIC ELEMENTS 审中-公开
标题翻译：具有内置热电元件的热块
公开(公告)号：US20130137144A1
公开(公告)日：2013-05-30
申请号：US13487414
申请日：2012-06-04
申请人： Daniel Chu , Paul Patt
发明人： Daniel Chu , Paul Patt
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/025 , B01L2300/0816 , B01L2300/0829 , B01L2300/1822
摘要： Rapid and uniform temperature changes in the wells of a microplate or any thin-walled plate that contains an array of reaction wells, or in the channels of a multi-channel microfluidics device, are achieved by the use of a thermal block with thermoelectric heating/cooling elements built into the block, or by the use of a thermal block with wedges protruding from its lower surface, with thermoelectric elements placed in surface contact with the angled sides of each wedge.
摘要翻译：在微孔板或包含反应孔阵列的任何薄壁板或多通道微流体装置的通道中的孔中的快速和均匀的温度变化通过使用具有热电加热/ 或者通过使用具有从其下表面突出的楔形物的热块，其中热电元件与每个楔形物的倾斜侧面表面接触。

35. 发明申请

US20130053365A1 DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) 审中-公开
标题翻译：聚（ADP-RIBOSE）聚合酶（PARP）的二氢吲哚哒嗪酮抑制剂
公开(公告)号：US20130053365A1
公开(公告)日：2013-02-28
申请号：US13598392
申请日：2012-08-29
申请人： Bing Wang , Daniel Chu
发明人： Bing Wang , Daniel Chu
IPC分类号： A61K31/55 , C07D498/06 , A61K31/551 , A61P35/02 , A61P35/00 , A61P25/00 , A61P29/00 , C07D487/06 , A61K31/553
CPC分类号： C07D487/06 , C07D471/06 , C07D498/06
摘要： Provided are inhibitors of poly(ADP-ribose)polymerase according to Formula (M): where A, B, Y, Z, D, E, R1, R2, R3, and R4 are as defined herein. Also described are pharmaceutical compositions, methods of preparing, and methods of using a compound of Formula M to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
摘要翻译：提供根据式（M）的聚（ADP-核糖）聚合酶的抑制剂：其中A，B，Y，Z，D，E，R 1，R 2，R 3和R 4如本文所定义。还描述了药物组合物，制备方法和使用式M化合物治疗通过抑制PARP活性而改善的疾病，病症和病症的方法。

36. 发明授权

US08012976B2 Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) 有权
标题翻译：聚（ADP-核糖）聚合酶（PARP）的二氢吡喃并酞嗪酮抑制剂
公开(公告)号：US08012976B2
公开(公告)日：2011-09-06
申请号：US12510096
申请日：2009-07-27
申请人： Bing Wang , Daniel Chu
发明人： Bing Wang , Daniel Chu
IPC分类号： C07D237/36 , A01N43/60 , A61K31/50
CPC分类号： A61K31/5025 , A61K31/282 , A61K31/4745 , A61K31/495 , A61K31/5377 , A61K33/24 , A61N5/10 , A61N2005/1098 , C07D471/06
摘要： A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
摘要翻译：具有式（I）和式（II）所示结构的化合物：其中取代基Y，Z，A，B，R 1，R 2，R 3，R 4和R 5如本文所定义。本文提供了聚（ADP-核糖）聚合酶活性的抑制剂。本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗通过抑制PARP活性而改善的疾病，病症和病症的药物组合物。

37. 发明申请

US20060235019A1 Substituted quinazolinone compounds 失效
标题翻译：取代喹唑啉酮化合物
公开(公告)号：US20060235019A1
公开(公告)日：2006-10-19
申请号：US10515434
申请日：2003-05-23
申请人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith
发明人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith
IPC分类号： A61K31/53 , A61K31/525 , A61K31/519 , C07D487/02 , C07D475/02
CPC分类号： C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要： A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。该化合物可用于治疗MC4-R介导的疾病。化合物具有式（IA），（IB）或（IC）的结构：其中变量的值在本文中定义。

38. 发明申请

US20050101548A1 Antimicrobial derivatives 审中-公开
标题翻译：抗微生物衍生物
公开(公告)号：US20050101548A1
公开(公告)日：2005-05-12
申请号：US10940900
申请日：2004-09-13
申请人： Xiaodong Lin , Daniel Chu
发明人： Xiaodong Lin , Daniel Chu
IPC分类号： A61K31/7048 , A61P31/04 , C07H17/08
CPC分类号： C07H17/08
摘要： Antimicrobial compounds are provided having the formula (Q): as well as tautomers, stereoisomers, pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译：提供具有式（Q）的抗微生物化合物：以及互变异构体，立体异构体，其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

39. 发明申请

US20050009764A1 Pyridyl substituted ketolide antibiotics 失效
标题翻译：吡啶基取代的酮内酯抗生素
公开(公告)号：US20050009764A1
公开(公告)日：2005-01-13
申请号：US10831749
申请日：2004-04-23
申请人： Matthew Burger , Georgia Carroll , Daniel Chu , Xiaodong Lin , Jacob Plattner , Alice Rico
发明人： Matthew Burger , Georgia Carroll , Daniel Chu , Xiaodong Lin , Jacob Plattner , Alice Rico
IPC分类号： A61P31/04 , C07H17/08 , A61K31/7052
CPC分类号： C07H17/08
摘要： Antimicrobial macrolide and ketolide compounds are provided having formulas XII: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译：提供抗微生物大环内酯和酮内酯化合物，其具有式XII：及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

40. 发明授权

US06756359B2 C12 modified erythromycin macrolides and ketolides having antibacterial activity 失效
标题翻译： C12改性红霉素大环内酯类和具有抗菌活性的酮内酯
公开(公告)号：US06756359B2
公开(公告)日：2004-06-29
申请号：US10190431
申请日：2002-07-03
申请人： Daniel Chu , Matthew Burger , Xiaodong Lin , Georgia Law Carroll , Jacob Plattner , Alice Rico
发明人： Daniel Chu , Matthew Burger , Xiaodong Lin , Georgia Law Carroll , Jacob Plattner , Alice Rico
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译：提供具有式II的抗微生物大环内酯类化合物及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式