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31. 发明授权

US08673577B2 Method for examining acute renal disorder 有权
标题翻译：检查急性肾功能障碍的方法
公开(公告)号：US08673577B2
公开(公告)日：2014-03-18
申请号：US13579906
申请日：2011-02-24
申请人： Masanori Hara , Hiroyuki Kurosawa , Shinya Ogasawara , Yoshiaki Hirayama
发明人： Masanori Hara , Hiroyuki Kurosawa , Shinya Ogasawara , Yoshiaki Hirayama
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347
摘要： Provided is a test method for acute kidney injury, including detecting urinary podocalyxin. According to the test method, a subject to be tested who has a higher value for the urinary podocalyxin than a reference value can be assessed to have acute kidney injury. Further, as compared to a conventional method, the test method allows acute kidney injury to be assessed accurately and non-invasively, which allows a physical burden on a patient to be reduced. Thus, the test method is useful.
摘要翻译：提供急性肾损伤的检测方法，包括检测尿球蛋白。根据测试方法，可以评估具有比参考值更高的尿球蛋白含量的被测试患者具有急性肾损伤。此外，与常规方法相比，测试方法允许精确和非侵入性地评估急性肾损伤，这允许减少患者的身体负担。因此，测试方法是有用的。

32. 发明授权

US08628930B2 Use of megalin in urine as marker for detecting renal disorder 有权
标题翻译：在尿液中使用巨蛋白作为检测肾脏疾病的标记物
公开(公告)号：US08628930B2
公开(公告)日：2014-01-14
申请号：US13266397
申请日：2010-04-27
申请人： Akihiko Saito , Yasuhiko Tomino , Katsuhiko Asanuma , Shinya Ogasawara , Hiroyuki Kurosawa , Yoshiaki Hirayama
发明人： Akihiko Saito , Yasuhiko Tomino , Katsuhiko Asanuma , Shinya Ogasawara , Hiroyuki Kurosawa , Yoshiaki Hirayama
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N2800/347
摘要： This invention provides a simple means for detecting a renal disorder, a diagnostic marker for a renal disorder that enables prognostic prediction of a renal disorder (e.g., diabetic nephropathy and IgA nephropathy) and evaluation of the degree of nephropathy at the phase of stage-II diabetic nephropathy by measuring the megalin level in urine associated with a renal disorder used for the detection means, and use of such marker. The invention also provides the use of human megalin obtained from the urine sample of a subject as a marker for detecting a renal disorder.
摘要翻译：本发明提供了一种用于检测肾脏疾病的简单方法，一种能够预测肾病（例如，糖尿病性肾病和IgA肾病）的肾病的诊断标志物，并评估II期阶段的肾病程度通过测量与用于检测手段的肾脏疾病相关的尿液中的巨蛋白水平，以及使用这种标记物，糖尿病性肾病。本发明还提供了从受试者的尿样获得的人巨蛋白作为检测肾病的标记物的用途。

33. 发明申请

US20120040374A1 METHOD FOR DETECTING RENAL DISEASE COMPRISING MEASURING HUMAN MEGALIN IN URINE 有权
标题翻译：检测包含在尿液中测量人类血红蛋白的肾病的方法
公开(公告)号：US20120040374A1
公开(公告)日：2012-02-16
申请号：US13266411
申请日：2010-04-27
申请人： Akihiko Saito , Yasuhiko Tomino , Katsuhiko Asanuma , Shinya Ogasawara , Hiroyuki Kurosawa , Yoshiaki Hirayama
发明人： Akihiko Saito , Yasuhiko Tomino , Katsuhiko Asanuma , Shinya Ogasawara , Hiroyuki Kurosawa , Yoshiaki Hirayama
IPC分类号： G01N21/76 , C07K14/705 , G01N33/577 , G01N33/566
CPC分类号： G01N33/92 , G01N2800/347
摘要： This invention provides a diagnostic kit and a diagnostic marker used for diagnosing a renal disease. This invention also provides a method for detecting a renal disease comprising measuring at least one type of human megalin existing in urine selected from among full-length human megalin and human megalin fragments of (i) to (iii): (i) full-length human megalin; (ii) a human megalin endodomain fragment lacking a human megalin ectodomain; and (iii) a human megalin ectodomain fragment lacking a human megalin endodomain.
摘要翻译：本发明提供了用于诊断肾脏疾病的诊断试剂盒和诊断标记。本发明还提供了一种用于检测肾脏疾病的方法，包括测量存在于选自全身人巨蛋白和（i）至（iii））的人巨蛋白片段中的至少一种类型的人巨蛋白：（i）全长人巨蛋（ii）缺乏人巨蛋白胞外域的人巨蛋白胞质内结构域片段; 和（iii）缺乏人巨蛋白结构域的人巨蛋白胞外域片段。

34. 发明授权

US07955809B2 Method for measuring human megalin 有权
标题翻译：测量人巨蛋白的方法
公开(公告)号：US07955809B2
公开(公告)日：2011-06-07
申请号：US12293992
申请日：2007-03-28
申请人： Shinya Ogasawara , Shuhei Miura , Akihiko Saito , Tetsuro Takeda
发明人： Shinya Ogasawara , Shuhei Miura , Akihiko Saito , Tetsuro Takeda
IPC分类号： G01N33/53
CPC分类号： G01N33/92 , C07K16/28 , G01N33/6893 , G01N2800/00 , G01N2800/347
摘要： This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can also quantify human megalin. This invention also provides a method that enables diagnosis of functional diseases, which are specific to cells, tissues, or organs, in a site-directed manner at an early stage. Measurement of human megalin enables detection of a disease in an organ in which megalin expression is observed.
摘要翻译：本发明提供了一种用于测量人类巨蛋白的方法，其可以在比常规技术可能的更短的时间内以更简单的方式进行，并且还可以定量人巨蛋白。本发明还提供了能够以早期阶段以现场方式诊断功能性疾病的方法，所述功能性疾病特异于细胞，组织或器官。人巨蛋白的测定能够检测观察到巨蛋白表达的器官中的疾病。

35. 发明申请

US20100233738A1 URINE PRETREATMENT AGENT FOR URINARY PROTEIN QUANTITATION, URINE PRETREATMENT METHOD, AND URINARY PROTEIN QUANTITATION METHOD 有权
标题翻译：尿素预处理剂尿素蛋白质定量，尿液预处理方法和尿素蛋白质定量方法
公开(公告)号：US20100233738A1
公开(公告)日：2010-09-16
申请号：US12680479
申请日：2008-09-26
申请人： Masanori Hara , Akihiko Saito , Shinya Ogasawara , Yoshiaki Hirayama , Hiroyuki Kurosawa
发明人： Masanori Hara , Akihiko Saito , Shinya Ogasawara , Yoshiaki Hirayama , Hiroyuki Kurosawa
IPC分类号： G01N33/53 , G01N33/00
CPC分类号： G01N33/6827 , Y10T436/10 , Y10T436/107497 , Y10T436/108331
摘要： The present invention is intended to develop a urine pretreatment agent, a urine pretreatment method, and a urinary protein quantitation method which reduce or cancel the influences of urine pH variations, cancel the influences of precipitates of urinary inorganic salts, and solubilize membrane proteins. The present invention provides: a urine pretreatment agent for urinary protein quantitation, comprising a buffer, a chelating agent, and a surfactant; a urine pretreatment method comprising a step of mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and a urinary protein quantitation method comprising steps of: mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and then measuring the protein concentration.
摘要翻译：本发明旨在开发尿液预处理剂，尿预处理方法和尿蛋白定量方法，其减少或消除尿pH变化的影响，消除尿无机盐沉淀物的影响和溶解膜蛋白。本发明提供了一种尿蛋白定量尿预处理剂，其包含缓冲液，螯合剂和表面活性剂; 尿预处理方法包括将10〜1000质量份本发明的尿预处理剂与100质量份的尿混合的步骤; 和尿蛋白定量方法，其包括以下步骤：将10〜1000质量份的本发明的尿预处理剂与100质量份的尿混合; 然后测量蛋白质浓度。

36. 发明申请

US20100033641A1 IMAGE DISPLAY DEVICE 审中-公开
标题翻译：图像显示设备
公开(公告)号：US20100033641A1
公开(公告)日：2010-02-11
申请号：US12490682
申请日：2009-06-24
申请人： Shinya Ogasawara , Yukihiro Iwata , Takayuki Furukawa
发明人： Shinya Ogasawara , Yukihiro Iwata , Takayuki Furukawa
IPC分类号： H04N5/64
CPC分类号： H04N5/64
摘要： The image display device of the present invention includes a display panel having a front surface for displaying an image and a rear surface facing a side opposite to the front surface, and a chassis to which a circuit-bearing member is attached. The chassis supports the display panel. The chassis has a frame shape that surrounds the display panel from outside in a direction perpendicular to a thickness direction of the display panel, and that allows the rear surface of the display panel to be exposed. Thereby, heat can be radiated to air directly from the rear surface of the display panel.
摘要翻译：本发明的图像显示装置包括具有用于显示图像的前表面和面向与前表面相对的一侧的后表面的显示面板和附接有电路承载构件的底架。机箱支持显示面板。底架具有从垂直于显示面板的厚度方向的方向从外部围绕显示面板的框架形状，并且允许显示面板的后表面露出。由此，可以从显示面板的后表面直接将热量照射到空气中。

37. 发明申请

US20070079310A1 Disk apparatus 有权
标题翻译：磁盘设备
公开(公告)号：US20070079310A1
公开(公告)日：2007-04-05
申请号：US10576378
申请日：2004-10-18
申请人： Yukihiro Araki , Shingo Kage , Shinya Ogasawara , Nobuyuki Miroku
发明人： Yukihiro Araki , Shingo Kage , Shinya Ogasawara , Nobuyuki Miroku
IPC分类号： G11B17/04
CPC分类号： G11B17/0286
摘要： The present invention provides a disk apparatus with a reduced thickness which is realized by reducing the space required for holding a disk between the turn table and the damper as much as possible, while ensuring the space for reliably carrying the inserted disk into the disk apparatus. The disk apparatus of the present invention comprises a floating unit held on a stationary frame through elastic means, and the floating unit comprises a clamping member including a damper which holds the disk-shaped recording medium, and a disk recording/reproducing-driving member including a turn table, and in that a part of the damper and a part of the turn table are fitted in each other, when the disk-shaped recording medium is held between the damper and the turn table.
摘要翻译：本发明提供了一种减小厚度的盘装置，其通过尽可能地减小在转台和阻尼器之间保持盘所需的空间，同时确保用于将插入的盘可靠地携带到盘装置中的空间来实现。本发明的盘装置包括通过弹性装置保持在固定框架上的浮动单元，并且浮动单元包括夹持构件，该夹紧构件包括保持盘状记录介质的阻尼器，以及盘记录/再现驱动构件，旋转台，并且当盘形记录介质保持在阻尼器和转台之间时，阻尼器的一部分和转台的一部分彼此嵌合。

38. 发明申请

US20070074229A1 Disk apparatus 有权
标题翻译：磁盘设备
公开(公告)号：US20070074229A1
公开(公告)日：2007-03-29
申请号：US10576168
申请日：2004-10-18
申请人： Nobuyuki Miroku , Shingo Kage , Yukihiro Araki , Shinya Ogasawara
发明人： Nobuyuki Miroku , Shingo Kage , Yukihiro Araki , Shinya Ogasawara
IPC分类号： G11B17/04 , G11B17/22
CPC分类号： G11B17/051
摘要： The present invention provides a disk apparatus reduced in size and thickness, by reducing the size of a means which detects the insertion of a disk into the disk apparatus. In the disk apparatus of the present invention, an electric circuit board and-disk insertion-detecting levers are provided on the floating unit, and the disk insertion-detecting levers are disposed in the proximity of the disk insertion/extraction port, and are pressed down and rotated by the outer edge of the inserted disk-shaped recording medium, to thereby directly drive a switch which outputs a disk detection signal to the electric circuit board.
摘要翻译：本发明通过减小检测盘插入盘装置的装置的尺寸来提供尺寸和厚度减小的盘装置。在本发明的盘装置中，在浮动单元上设置电路板和盘插入检测杆，并且盘插入检测杆设置在盘插入/拔出口附近，并被按压通过插入的盘形记录介质的外边缘向下并旋转，从而直接驱动向电路板输出盘检测信号的开关。

39. 发明授权

US5224455A Gas discharging device for charcoal canister 失效
标题翻译：炭罐排气装置
公开(公告)号：US5224455A
公开(公告)日：1993-07-06
申请号：US894551
申请日：1992-06-05
申请人： Shinya Ogasawara
发明人： Shinya Ogasawara
IPC分类号： B62D21/02 , B60K15/035 , F02M25/08
CPC分类号： B60K15/03504 , F02M2025/0863
摘要： A discharging device connected to a charcoal canister which is disposed in an engine compartment of an automotive vehicle. The discharging device includes a first hose connected to a bottom portion of the charcoal canister. A second hose is disposed in a space defined by a front side member of the automotive vehicle, and connected to the first hose. The second hose extends from a position in the engine compartment to a position under a passenger compartment of the automotive vehicle. A partition plate is connected to the front side member so as to divide the front side member space into two spaces at the position under the passenger compartment. The second hose passes through the partition plate so that the drained fuel vapor from the charcoal canister is discharged from the second hose passing through the partition plate.
摘要翻译：连接到设置在机动车辆的发动机室中的炭罐的排出装置。排放装置包括连接到炭罐底部的第一软管。第二软管设置在由机动车辆的前侧构件限定的空间中，并连接到第一软管。第二软管从发动机舱中的位置延伸到机动车辆的乘客舱下方的位置。分隔板连接到前侧构件，以将前侧构件空间分成在乘客室下方的两个空间。第二软管通过分隔板，使得来自木炭罐的排出的燃料蒸气从通过分隔板的第二软管排出。

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