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31. 发明授权

US6130440A Image reading apparatus 失效
标题翻译：图像读取装置
公开(公告)号：US6130440A
公开(公告)日：2000-10-10
申请号：US10142
申请日：1998-01-21
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： G01N21/64 , G01T1/00 , G03B42/02 , G03B42/08 , G06T1/00 , G21K4/00 , H04N1/04
CPC分类号： G03B42/08 , G01T1/2012 , H04N1/0281
摘要： An image reading apparatus includes three laser stimulating ray sources for emitting a laser beam, a laser beam scanner for scanning the laser beam, a light detector for photoelectrically detecting light released from an image carrier carrying an image, a scan starting point detector for detecting the laser beam and detecting a scan starting point in a main scanning direction, a laser power adjuster for adjusting power of the laser beam to be projected onto the image carrier in accordance with the kind of the image carrier and a gain switch for switching gain of the scan starting point detector in accordance with the kind of the laser beam and the kind of the image carrier. According to the thus constituted image reading apparatus, it is possible to accurately detect a scan starting point in a main scanning direction of a laser beam to read an image in a radiation diagnosis system, an autoradiographic system, an electron microscope detecting system and a radiation diffraction image detecting system using a stimulable phosphor and a fluorescence detecting system.
摘要翻译：图像读取装置包括用于发射激光束的三个激光刺激射线源，用于扫描激光束的激光束扫描器，用于光电检测从携带图像的图像载体释放的光的光检测器，用于检测激光束的扫描起始点检测器激光束并且在主扫描方向上检测扫描起始点，激光功率调节器，用于根据图像载体的种类调整要投射到图像载体上的激光束的功率，以及增益开关，用于切换扫描起点检测器根据激光束的种类和图像载体的种类。根据这样构成的图像读取装置，能够精确地检测激光束的主扫描方向上的扫描起点，以便在放射线诊断系统，放射自显影系统，电子显微镜检测系统和放射线检测系统中读取图像使用可激发荧光体和荧光检测系统的衍射图像检测系统。

32. 发明授权

US5757022A Image processing apparatus 失效
标题翻译：图像处理装置
公开(公告)号：US5757022A
公开(公告)日：1998-05-26
申请号：US733182
申请日：1996-10-17
申请人： Takashi Kobayashi , Nobuhiko Ogura
发明人： Takashi Kobayashi , Nobuhiko Ogura
IPC分类号： G06T5/40 , H04N1/407 , H04N1/40 , G01N23/20
CPC分类号： H04N1/4074 , G06T5/009 , G06T5/10 , G06T5/40 , G06T2207/10064
摘要： An image processing apparatus includes a histogram producing section for producing a histogram of density signal levels of pixels constituting the image data, a reference density signal level detecting section for detecting from the histogram a density signal level processed by the maximum number of the pixels in a range excluding the maximum value and the minimum value of the density signal levels, a density signal level conversion range determining section for successively comparing the number of the pixels of each density signal level with a threshold value from the density signal level processed by the maximum number of the pixels to lower density signal levels, thereby determining a density signal level lower limit value of density signal levels to be converted and successively comparing the number of the pixels of each density signal level with a threshold value from the maximum value of the density signal level to lower density signal levels, thereby determining a density signal level upper limit value of density signal levels to be converted, a density signal level conversion value calculating section for calculating a conversion value so that density signal levels between the density signal level lower limit value and the density signal level upper limit value can be converted to density signal levels ranging from white to black and a density signal level converting section for converting the density signal levels of the pixels in accordance with the conversion value. According to the thus constituted image processing apparatus, it is possible to reproduce an electron microscope image having a desired gradation.
摘要翻译：图像处理装置包括直方图产生部分，用于产生构成图像数据的像素的浓度信号电平的直方图;参考密度信号电平检测部分，用于从直方图检测由最大数量的像素处理的浓度信号电平密度信号电平转换范围确定部分，用于将密度信号电平的像素数与从最大数目处理的浓度信号电平的阈值连续地比较，从而确定要转换的浓度信号电平的浓度信号电平下限值，并将每个浓度信号电平的像素数与阈值的密度信号从密度信号的最大值相比较电平到较低密度信号电平，从而确定密度信号密度信号电平转换值计算部分，用于计算转换值，使密度信号电平下限值和密度信号电平上限值之间的浓度信号电平可转换为密度信号电平范围从白色到黑色，密度信号电平转换部分根据转换值转换像素的浓度信号电平。根据这样构成的图像处理装置，可以再现具有期望灰度的电子显微镜图像。

33. 发明授权

US5642182A Scanning apparatus with means to control the frequency of vibrations within the scanner 失效
标题翻译：具有控制扫描仪内振动频率的装置的扫描装置
公开(公告)号：US5642182A
公开(公告)日：1997-06-24
申请号：US580184
申请日：1995-12-28
申请人： Yukinori Nishioka , Nobuhiko Ogura
发明人： Yukinori Nishioka , Nobuhiko Ogura
IPC分类号： F16F15/02 , H04N1/04 , H04N1/06 , H04N1/08 , G03B27/52 , G03B27/42 , G03B27/62
CPC分类号： H04N1/0607 , H04N1/0283 , H04N1/0635 , H04N1/0664 , H04N2201/0428
摘要： A scanning apparatus includes a sheet holder for holding a sheet to be scanned in the shape of a segment of a cylinder, a light source for irradiating the sheet with light, a spinner including a converging lens for converging light from the light source on the surface of the sheet, and a light detector for photoelectrically detecting light from the sheet, a spindle motor including a plurality of rolling balls in a bearing for rotating the spinner coaxially with a center axis of the cylinder, and a sub-scanning device for moving the sheet holder relative to the spinner in a direction parallel to the center axis, and the rolling balls are provided so that the vibrational frequency F of the bearing satisfies the formula Fb/6.ltoreq..vertline.F-n1.times.Fb.vertline..ltoreq.Fb/2 wherein Fb is the rotational frequency of the spindle motor and n1 is a positive integer. According to the thus constituted scanning apparatus, it is possible to read an image which contain no visibly recognizable wave-like unevenness even when the image is read at high density at a reduced scanning pitch.
摘要翻译：一种扫描装置，包括用于保持要被扫描的片材的片保持器，其以圆柱体的形式保持，用于用光照射片材的光源，包括会聚透镜的旋转器，用于将来自光源的光会聚在表面上以及用于光电检测来自片材的光的光检测器，包括在用于与所述圆筒的中心轴线同轴旋转所述旋转器的轴承中的多个滚珠的主轴马达和用于使所述滚筒滚动的副扫描装置，片保持器相对于旋转器在平行于中心轴线的方向上设置，并且滚珠被设置成使得轴承的振动频率F满足公式Fb / 6

34. 发明授权

US4823169A Reflection density measuring system 失效
标题翻译：反射密度测量系统
公开(公告)号：US4823169A
公开(公告)日：1989-04-18
申请号：US19402
申请日：1987-02-26
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： G01N21/47
CPC分类号： G01N21/474 , G01N2021/478
摘要： A reflection density measuring system comprises a light source for projecting an irradiation light onto the surface-to-be-measured of a sample and a photodetector which has a photosensor for detecting light reflected by the surface-to-be-measured of the sample to impinge upon the photosensor through a light receiving surface of the photodetector. The distance r between the center of the light receiving surface of the photodetector and the optical axis of the irradiation light is r.sub.o, the distance h between the center of the light receiving surface and the surface-to-be-measured as measured along the optical axis of the irradiation light is h.sub.o, and the angle .theta. which the light receiving surface forms with the surface-to-be-measured is .theta.o, h.sub.o being the value of h at which output I of the photosensor takes a peak value on an output curve representing the change of the output I of the photosensor with the distance h when the distance h is varied under the combination of r.sub.o and .theta.o.
摘要翻译：反射浓度测量系统包括用于将照射光投射到待测样品的表面上的光源和具有光检测器的光电检测器，所述光电传感器用于检测被待测表面被反射的光，通过光电检测器的光接收表面撞击光传感器。光电检测器的光接收表面的中心与照射光的光轴之间的距离r为ro，光接收表面的中心与沿光学测量的待测表面之间的距离h 照射光的轴为ho，光接收表面与待测表面的角度θ为θo，其为光电传感器的输出I在峰值上的值输出曲线表示当距离h在ro和θo的组合下变化时具有距离h的光传感器的输出I的变化。

35. 发明申请

US20130303389A1 METHOD OF CLASSIFYING GENE EXPRESSION STRENGTH IN LUNG CANCER TISSUES 审中-公开
标题翻译：在肺癌组织中分类基因表达强度的方法
公开(公告)号：US20130303389A1
公开(公告)日：2013-11-14
申请号：US13549961
申请日：2012-07-16
申请人： TAKASHI TAKAHASHI , Shuta Tomita , Tetsuya Mitsudomi , Yasushi Yatabe , Nobuhiko Ogura , Masato Some
发明人： TAKASHI TAKAHASHI , Shuta Tomita , Tetsuya Mitsudomi , Yasushi Yatabe , Nobuhiko Ogura , Masato Some
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene in lung cancer tissues isolated from the patient.
摘要翻译：本发明提供一种确认基因表达的方法，该方法可用于决定患者肺癌的5年生存率，并在该方法中使用DNA探针试剂盒。用于决定患有非小细胞肺癌的患者存活率的方法，其包括确认从患者分离的肺癌组织中至少一种基因的表达强度。

36. 发明申请

US20100027005A1 BIOSENSOR DETECTION APPARATUS 审中-公开
标题翻译：生物传感器检测装置
公开(公告)号：US20100027005A1
公开(公告)日：2010-02-04
申请号：US12443632
申请日：2007-09-21
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： G01J3/28 , G01N21/00
CPC分类号： G01N21/253 , G01N2201/0826 , G01N2201/0833
摘要： A biosensor detection apparatus having increased processing power for measurement without complicated structure and increased size. The apparatus includes one or more spectrometers configured to spectrally separate each light beam reflected from each of a plurality of measurement regions defined on a biosensor simultaneously, and one or more optical receivers configured to receive each light beam spectrally separated by the one or more spectrometers simultaneously and to obtain a spectral intensity distribution of each light beam separately.
摘要翻译：一种生物传感器检测装置，其具有增加的测量处理能力，而不需要复杂的结构和增大的尺寸。该装置包括一个或多个光谱仪，其被配置为频谱地分离由在生物传感器上同时定义的多个测量区域中的每一个反射的每个光束;以及一个或多个光学接收器，被配置为接收由一个或多个光谱仪同时光谱分离的每个光束并分别获得每个光束的光谱强度分布。

37. 发明申请

US20060252158A1 Sample recovery method and device 审中-公开
标题翻译：样品回收方法和装置
公开(公告)号：US20060252158A1
公开(公告)日：2006-11-09
申请号：US11418297
申请日：2006-05-05
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： G01N33/558
CPC分类号： G01N35/1095 , G01N21/553
摘要： A surface plasmon resonance (SPR) assay apparatus has a sample recovery device for recovering a bindable sample, which is obtained from a sample by causing a sample fluid of the sample to contact an immobilization film provided with a ligand immobilized thereon, and by binding the sample with the ligand. A recovery stage is loaded with a sensor unit for assay in a removable manner. The sensor unit includes a prism overlaid with the immobilization film, and a flow cell, secured to the prism, and having a flow channel for introducing the sample fluid to the immobilization film. A dispensing head has a pipette assembly for fluid dispensation and aspiration, for accessing the recovery stage, a delivery reservoir for storing the sample fluid, and a collection reservoir for recovering the bindable sample removed from the flow channel.
摘要翻译：表面等离子体共振（SPR）测定装置具有用于回收可从样品获得的可结合样品的样品回收装置，该试样通过使样品的样品流体与固定有固定化剂的配体的固定化膜接触，样品与配体。恢复阶段装载有可拆卸方式的用于测定的传感器单元。传感器单元包括与固定膜重叠的棱镜和固定到棱镜的流动池，并具有用于将样品流体引入固定膜的流动通道。分配头具有用于流体分配和抽吸的移液管组件，用于进入回收阶段，用于存储样品流体的输送储存器和用于回收从流动通道移除的可结合样品的收集容器。

38. 发明申请

US20060127951A1 Screening system 审中-公开
标题翻译：筛选系统
公开(公告)号：US20060127951A1
公开(公告)日：2006-06-15
申请号：US11245222
申请日：2005-10-07
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： C40B40/10 , C40B30/04
CPC分类号： G01N35/1095 , G01N21/553 , G01N33/54373
摘要： Bonding data regarding a great number of combinations of ligands and analytes are obtained within a short amount of time. Management of the bonding data and the corresponding analyte is automatically performed. A ligand solution is supplied to a thin film layer of a measurement unit, prior to measurement by a measuring apparatus that utilizes attenuated total reflection. The measuring unit is held within a mounting space of a ligand immobilizing device, while a ligand in the ligand solution is being immobilized on the measuring unit. A specified analyte solution is removed from an analyte storage section of an analyte library, and supplied to the measuring apparatus prior to measurement. Following measurement, analyte data regarding the specified analyte solution, and bonding data obtained by a bonding data obtaining section are correlated with each other, recorded, and displayed.
摘要翻译：在短时间内获得关于配体和分析物的大量组合的结合数据。自动执行粘合数据和相应分析物的管理。在通过利用衰减的全反射的测量装置测量之前，将配体溶液提供给测量单元的薄膜层。测量单元保持在配体固定装置的安装空间内，而配体溶液中的配体被固定在测量单元上。从分析物库的分析物存储部分去除指定的分析物溶液，并在测量之前提供给测量装置。在测量之后，关于指定的分析物溶液的分析物数据以及由结合数据获取部分获得的结合数据彼此相关，被记录和显示。

39. 发明授权

US06864984B2 Measuring method and apparatus using attenuation in total reflection 失效
标题翻译：在全反射中使用衰减的测量方法和装置
公开(公告)号：US06864984B2
公开(公告)日：2005-03-08
申请号：US09959645
申请日：2001-03-14
申请人： Masayuki Naya , Takashi Kubo , Nobuhiko Ogura , Nobufumi Mori
发明人： Masayuki Naya , Takashi Kubo , Nobuhiko Ogura , Nobufumi Mori
IPC分类号： G01N21/55 , G01N21/27
CPC分类号： G01N21/553
摘要： A plurality of measuring units each comprising a dielectric block, a metal film layer which is formed on a surface of the dielectric block and a sample holder are supported on a support. The support is moved by a support drive means to bring in sequence the measuring units to a measuring portion comprising an optical system which projects a light beam emitted from a light source, and a photodetector which detects attenuation in total internal reflection by detecting the intensity of the light beam which is reflected in total internal reflection at the interface between the dielectric block and the metal film layer. In this measuring apparatus, lots of samples can be measured in a short time.
摘要翻译：多个测量单元，每个测量单元包括介质块，形成在介质块的表面上的金属膜层和样品保持器支撑在支撑体上。支撑体通过支撑驱动装置移动，以将测量单元顺序地调节到包括投影从光源发射的光束的光学系统的测量部分，以及通过检测全部内部反射的强度来检测全内反射的衰减的光电检测器所述光束在介电块和金属膜层之间的界面处被反射在全内反射中。在该测量装置中，可以在短时间内测量许多样品。

40. 发明授权

US06835946B2 Image reading method and apparatus 失效
标题翻译：图像读取方法和装置
公开(公告)号：US06835946B2
公开(公告)日：2004-12-28
申请号：US09996672
申请日：2001-11-30
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： G21N2164
CPC分类号： G01N21/6456 , G01N21/6458 , G01N2021/6439 , G01N2021/6463 , G01N2201/1042
摘要： An image reading apparatus is adapted for irradiating an image carrier including a labeling substance contained in two-dimensionally distributed spots with a stimulating ray and photoelectrically detecting light released from the labeling substance, thereby producing image data, and the image reading apparatus includes at least one stimulating ray source for emitting a stimulating ray, a lens for shaping the stimulating ray emitted from the at least one stimulating ray source into a line beam, a sensor for photoelectrically detecting light released from the labeling substance, and a controller for performing a stimulation and detection step of irradiating the image carrier including the labeling substance contained in the two-dimensionally distributed spots with the line beam of the stimulating ray to stimulate the labeling substance, stopping irradiation with the line beam of the stimulating ray and causing the sensor to photoelectrically detect light released from the labeling substance after the completion of irradiation with the line beam of the stimulating ray. According to the thus constituted image reading apparatus, it is possible to produce low noise image data rapidly and with a simple operation by irradiating an image carrier including two-dimensionally distributed spots of a labeling substance such as a fluorescent substance, a radioactive labeling substance or the like with a stimulating ray to excite the labeling substance and photoelectrically detecting light released from the labeling substance.
摘要翻译：一种图像读取装置适用于用包含在二维分布斑点中的标记物质的图像载体用刺激光线照射和光电检测从标记物质释放的光，从而产生图像数据，图像读取装置包括至少一个用于将从至少一个刺激射线源发射的刺激射线成形为线束的透镜，用于光电检测从标记物质释放的光的传感器，以及用于进行刺激的控制器，以及将包含二维分布斑点中的标记物质的图像载体用刺激射线的线束照射的刺激标记物质的停止检测步骤，停止用刺激射线的线束照射，使传感器进行光电检测光从标签上释放出来在用激发光束的线束照射完成后。根据这样构成的图像读取装置，可以通过照射包含荧光物质，放射性标记物质等标记物质的二维分布的斑点的图像载体，并且通过简单的操作，可以产生低噪声图像数据。其具有刺激性射线以激发标记物质并光电检测从标记物质释放的光。

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