专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20070160657A1 Targeting and intestinal-absorption controlled liposome having sugar chain and therapeutic drug for cancer and diagnostic drug containing the liposome 审中-公开
标题翻译：具有糖链的靶向和肠道吸收控制的脂质体和用于癌症的治疗药物和含有脂质体的诊断药物
公开(公告)号：US20070160657A1
公开(公告)日：2007-07-12
申请号：US10566566
申请日：2004-07-30
申请人： Noboru Yamazaki , Hideo Tsurushima , Shuuji Kojima
发明人： Noboru Yamazaki , Hideo Tsurushima , Shuuji Kojima
IPC分类号： A61K9/127 , A61K31/739 , C08B37/00
CPC分类号： A61Q19/00 , A61K8/14 , A61K9/1273 , A61K2800/57 , A61Q5/00 , A61Q7/00
摘要： An object of the present invention is to provide a liposome having a sugar chain bonded thereto, the sugar chain having an activity of specifically binding to various lectins (sugar chain recognizing proteins) present on the cell surfaces of various tissues and thus being capable of actually distinguishing a cell and a tissue in vivo, thereby efficiently delivering a medicinal drug or a gene.
摘要翻译：本发明的目的是提供一种具有与其结合的糖链的脂质体，所述糖链具有与各种组织的细胞表面上存在的各种凝集素（糖链识别蛋白）特异性结合的活性，因此能够实际上在体内区分细胞和组织，从而有效地递送药物或基因。

32. 发明申请

US20060193906A1 Sugar-modified liposome and products comprising the liposome 审中-公开
公开(公告)号：US20060193906A1
公开(公告)日：2006-08-31
申请号：US11350962
申请日：2006-02-10
申请人： Noboru Yamazaki , Shuji Kojima
发明人： Noboru Yamazaki , Shuji Kojima
IPC分类号： A61K9/127 , A61K38/37 , A61K31/739
CPC分类号： A61K8/14 , A61K9/1271 , A61K9/1272 , A61K47/6911 , A61Q19/00
摘要： The present invention provides a sugar-modified liposome having a sugar chain bonded to its membrane surface, preferably through a linker protein, and having excellent absorption qualities, particularly in the intestine. The molecular structure and quantity of the sugar chain is selectively varied to allow the liposome to be delivered in a targeted manner to selected cells and tissues. The liposome is applicable to medicinal drugs, cosmetics and other various products in the medical/pharmaceutical fields, and it is especially useful in a therapeutic drug delivery system that recognizes target cells and tissues, such as cancer cells, and in the delivery of drugs or genes locally to a selected region, or in a diagnostic cell/tissue sensing probe.

33. 发明授权

US06636031B1 Method and device for detecting pinholes in organic film on concrete surface 失效
标题翻译：混凝土表面有机薄膜针孔检测方法及装置
公开(公告)号：US06636031B1
公开(公告)日：2003-10-21
申请号：US09679899
申请日：2000-10-05
申请人： Fukio Kenmochi , Takao Tsurudome , Masaaki Houki , Noboru Yamazaki
发明人： Fukio Kenmochi , Takao Tsurudome , Masaaki Houki , Noboru Yamazaki
IPC分类号： G01R104
CPC分类号： G01M3/40 , G01N27/205 , G01N27/24
摘要： A technique for detecting whether or not a pinhole is present in an organic film on a concrete surface, by detecting the conductivity of the concrete in advance. In the bottom portion of a measuring means body having a high-frequency oscillator accommodated therein, there are disposed electrodes which are insulated from each other through an insulating plate. Two electrodes are provided in parallel and are placed in contact with the surface of the lining film coating the surface of the concrete body. Thus, the electrodes are held in contact with the surface of the lining film, and a high-frequency signal is fed from the high-frequency oscillator to between the electrodes. Then, by detecting the specific dielectric, constant of the concrete body or the base body indirectly from the surface layer of the organic film without breaking the organic film formed on the surface to expose the surface of the concrete body, the conductivity of the concrete can be examined from the correlation between the specific dielectric constant and the water content, as investigated in advance, and the correlation between the water content and the electric resistance.
摘要翻译：通过预先检测混凝土的导电性来检测混凝土表面的有机膜中是否存在针孔的技术。在其中容纳有高频振荡器的测量装置本体的底部中，设置有通过绝缘板彼此绝缘的电极。两个电极平行设置，并且与涂覆在混凝土体表面上的衬膜的表面接触。因此，电极被保持与衬膜的表面接触，并且高频信号从高频振荡器馈送到电极之间。然后，通过从有机膜的表面层间接地检测混凝土体或基体的比电介质，常数，而不破坏形成在表面上的有机膜，露出混凝土体的表面，混凝土的导电性从预先研究的比介电常数和含水量之间的相关性，以及水含量和电阻之间的相关性进行检查。

34. 发明授权

US4366328A Indene compound and novel process for producing indene compounds 失效
标题翻译：茚化合物和新颖的茚化合物生产方法
公开(公告)号：US4366328A
公开(公告)日：1982-12-28
申请号：US97147
申请日：1979-11-26
申请人： Satoshi Numata , Kiyoshi Nakatani , Noboru Yamazaki , Teruo Yuasa
发明人： Satoshi Numata , Kiyoshi Nakatani , Noboru Yamazaki , Teruo Yuasa
IPC分类号： C07C37/52 , C07C39/23
CPC分类号： C07C37/52 , C07C2102/08
摘要： Indene compounds of the formula ##STR1## wherein X represents a hydrogen atom, a halogen atom, a hydroxyl group or a methyl group, andy is 0 or an integer of 1 to 3,are produced by either heat-decomposing indene compounds of the formula ##STR2## wherein X and y are as defined, in the presence of an acid or alkaline catalyst; or heat-decomposing isopropenyl phenols of the formula ##STR3## wherein X and y are as defined,or oligomers or polymers thereof in the presence of an acid catalyst. 5-Hydroxy-1,1,3-trimethyl-2-indene corresponding to formula (III) is a novel compound.
摘要翻译：其中X表示氢原子，卤素原子，羟基或甲基，y为0或1〜3的整数的式（III）的茚化合物是通过热分解茚在酸或碱性催化剂的存在下，其中X和y如上所定义的式（II）的化合物; 或其中X和y如上所定义的式（IV）的热分解异丙烯基酚或其酸催化剂存在下的低聚物或聚合物。对应于式（III）的5-羟基-1,1,3-三甲基-2-茚是新化合物。

35. 发明授权

US4339590A Cyclic sulfur compounds 失效
标题翻译：环状硫化合物
公开(公告)号：US4339590A
公开(公告)日：1982-07-13
申请号：US226834
申请日：1981-01-21
申请人： Noboru Yamazaki , Seiichi Nakahama , Kazuo Yamaguchi
发明人： Noboru Yamazaki , Seiichi Nakahama , Kazuo Yamaguchi
IPC分类号： C07D327/06 , C07D327/00 , C07D341/00
CPC分类号： C07D327/00
摘要： A cyclic sulfur compound represented by the formula, ##STR1## wherein R is --CH.sub.2 CH.sub.2 O).sub.n CH.sub.2 CH.sub.2 --, m is an integer of 2 to 4 and n is an integer of 1 to 3 is novel and can be used as a crosslinking agent instead of sulfur per se and also as a monomer for preparing polysulfide polymer. Said cyclic sulfur compound can be produced by reacting a metal sulfide represented by the formula, ##STR2## wherein R is the same as defined above, R' and R" are independently selected from alkyl groups and aryl groups and M is silicon or tin, with a halogen, sulfur dichloride or sulfur monochloride.
摘要翻译：由下式表示的环状硫化合物，其中R为-CH 2 CH 2 O，n为CH 2 CH 2 - ，m为2〜4的整数，n为1〜3的整数，可以作为交联剂代替的硫本身以及作为制备多硫化物聚合物的单体。所述环状硫化合物可以通过使由式表示的金属硫化物，其中R与上述定义相同，R'和R“独立地选自烷基和芳基，M是硅或锡与卤素，二氯化硫或一氯化硫。

36. 发明授权

US4253341A Water meter comprising a ferromagnetic magnetoresistor coupled to a rotatable permanent magnet 失效
标题翻译：水表包括耦合到可旋转永磁体的铁磁磁阻电阻器
公开(公告)号：US4253341A
公开(公告)日：1981-03-03
申请号：US33027
申请日：1979-04-24
申请人： Mamoru Ikeda , Noboru Yamazaki , Jun Fukui , Kazuhiko Shirai , Takesh Yano
发明人： Mamoru Ikeda , Noboru Yamazaki , Jun Fukui , Kazuhiko Shirai , Takesh Yano
IPC分类号： G01F1/06 , G01F1/075 , G01F15/07 , G01F15/075 , G01P3/487 , G01P13/04
CPC分类号： G01F15/0755 , G01F1/075
摘要： A water meter eliminates the usual conversion gear trains by using a permanent magnet which rotates in proportion to the volume of water to be measured. A magnetic field sensor, comprising a ferromagnetic magnetoresistor, produces a sensor signal which varies as a function of the rotation of the magnet. A wave shaper forms the sensor signal into a sequence of pulses which drive a totalizer for producing a signal indicative of the volume of the water used. The output of the totalizer is supplied to an indicator device which displays the total amount of water passing through the meter, in terms of a predetermined unit of measure. Preferably, the sensor comprises at least two magnetoresistors for producing two sensor signals with a phase difference therebetween. The wave shaper then produces two pulse sequences for identifying a normal and an inverse flow of water, respectively. These two sequences cause the totalizer to count up or down, respectively.
摘要翻译：水表通过使用与要测量的水的体积成比例地旋转的永久磁铁来消除通常的转换齿轮系。包括铁磁性磁阻电阻器的磁场传感器产生作为磁体旋转的函数而变化的传感器信号。波形整形器将传感器信号形成为脉冲序列，其驱动累加器以产生指示所使用的水的体积的信号。累积器的输出被提供给指示装置，其以预定的测量单位显示通过流量计的水的总量。优选地，传感器包括至少两个用于产生其间具有相位差的传感器信号的磁阻。然后，波形整形器分别产生用于识别水的正常和逆流的两个脉冲序列。这两个序列使得累加器分别向上或向下计数。

37. 发明授权

US4201877A Process for producing a linear trimer of paraisopropenyl phenol 失效
标题翻译：对映异丙苯酚的线性三聚体的制备方法
公开(公告)号：US4201877A
公开(公告)日：1980-05-06
申请号：US961451
申请日：1978-11-16
申请人： Noboru Yamazaki , Teruo Yuasa , Yoshio Morimoto , Kunio Aoi , Tsutomu Takase
发明人： Noboru Yamazaki , Teruo Yuasa , Yoshio Morimoto , Kunio Aoi , Tsutomu Takase
IPC分类号： C07C27/00 , C07C37/11 , C07C37/14 , C07C37/52 , C07C39/21 , C07C67/00 , C07D303/24 , C08G59/32 , C08G59/62 , C07C37/00
CPC分类号： C08G59/3218 , C07C37/11 , C07C37/14 , C07C37/52 , C07C39/21 , C07D303/24 , C08G59/621
摘要： A novel trimer of p-isopropenyl phenol of the structure ##STR1## which is useful as a material or a curing agent for epoxy resins. The linear trimer includes a cis-isomer (m.p. 225.5.degree.-227.degree. C.) and a trans-isomer (m.p. 167.degree.-168.degree. C.). It is prepared by reacting p-isopropenyl phenol or its linear polymer in the presence of an acid catalyst such as sulfuric acid, boron fluoride or activated clay in an aromatic hydrocarbon, halogenated hydrocarbon, substituted aromatic hydrocarbon or aprotic polar solvent (e.g., benzene, carbon tetrachloride, nitrobenzene or dioxane).
摘要翻译：可用作环氧树脂的材料或固化剂的结构“IMAGE”的对异丙烯基苯酚的新型三聚体。线性三聚体包括顺式异构体（熔点225.5℃-227℃）和反式异构体（熔点167-116℃）。在酸性催化剂如硫酸，氟化硼或活性粘土存在下，在芳族烃，卤代烃，取代芳烃或非质子极性溶剂（如苯，四氯化碳，硝基苯或二恶烷）。

38. 发明授权

US4087019A Plug arrangement for a container 失效
标题翻译：容器的插头布置
公开(公告)号：US4087019A
公开(公告)日：1978-05-02
申请号：US658062
申请日：1976-02-13
申请人： Noboru Yamazaki
发明人： Noboru Yamazaki
IPC分类号： B65D39/04 , B65D51/22
CPC分类号： B65D39/04
摘要： A two-part plug arrangement for a container includes an outer plug of soft resilient material and a mating inner plug of deformable material. The inner plug is seated within the outer plug, and the mating plugs are together seated within an opening of a wall of the container. Such opening has an annular turned-over wall along its circumference, and the outer plug has an annular flange adapted to engage such turned-over wall. The plugs are retained in place by being distorted radially outwardly whereby the outer plug sealingly engages the container opening and the two plugs are in sealing engagement with one another. One of the two plugs has a blind bottom, and upon the removal of the inner plug, the outer plug assumes its initial relaxed shape for removal thereof and reuse if desired.
摘要翻译：用于容器的两部分插头装置包括柔性弹性材料的外塞和可变形材料的配合内塞。内塞子位于外部塞子内，并且配合塞子一起位于容器壁的开口内。这种开口沿其圆周具有环形翻转壁，并且外塞具有适于接合这种翻转壁的环形凸缘。插头通过径向向外变形而保持在适当的位置，由此外部插头密封地接合容器开口并且两个插头彼此密封接合。两个插头中的一个具有盲底，并且在移除内塞时，外插头呈现其初始松弛形状以便移除并且如果需要重新使用。

39. 发明授权

US3974219A Phosphonium salt and its use 失效
标题翻译：鏻盐及其用途
公开(公告)号：US3974219A
公开(公告)日：1976-08-10
申请号：US475877
申请日：1974-06-03
申请人： Noboru Yamazaki , Fukuji Higashi
发明人： Noboru Yamazaki , Fukuji Higashi
IPC分类号： C07K1/08 , C07C103/04
CPC分类号： C07K1/082 , C07K1/08
摘要： The amidation and esterification of carboxylic acids with amines and hydroxyl group-containing compounds, respectively, are effected without incurring the drawbacks of reaction equilibrium by the reaction of the reactants, one of which has been activated in the reactive group by contact with a phosphonium salt obtained by reacting a phosphorous ester or phosphorous monoester salt with an organic base such as pyridine and an oxidizing agent such as halogens and mono or divalent meercury halide or acetate. The amidation can be applied to the preparation of peptides by the reaction of amino acids and/or peptides in which one of the reactive groups have been protected.
摘要翻译：羧酸与胺和含羟基化合物的酰胺化和酯化反应分别在不引起反应平衡的缺点的情况下进行，反应物的反应已经通过与鏻盐的接触活化在反应性基团中通过使磷酯或磷单酯盐与有机碱如吡啶和氧化剂如卤素和一价或二价卤化银或乙酸酯反应而获得。酰胺化可以通过其中一个反应性基团被保护的氨基酸和/或肽的反应应用于肽的制备。

40. 发明申请

US20110119633A1 Audio Apparatus 有权
标题翻译：音响设备
公开(公告)号：US20110119633A1
公开(公告)日：2011-05-19
申请号：US12837812
申请日：2010-07-16
申请人： Takeru Mishima , Noboru Yamazaki
发明人： Takeru Mishima , Noboru Yamazaki
IPC分类号： G06F3/048 , G06F17/30
CPC分类号： G06F17/30749 , G06F17/30775
摘要： An audio apparatus contains a plurality of playable files stored in a database and organized in folders. The folders can be listed in a manner understandable at a glance even when viewed on a small display area and when the hierarchical structure shows a minimum level of detail. A folder selection section selects a folder from a database, and a directly-under-folder detection section detects if a playable file exists directly under a folder selected. A folder-under-folder detection section detects if a playable file exists directly under any folder located under the selected folder assuming no playable file exists directly under the selected folder.
摘要翻译：音频装置包含存储在数据库中并被组织在文件夹中的多个可播放文件。即使在小显示区域上观看时，以及当层次结构显示最小细节时，文件夹也可以一目了然的方式列出。文件夹选择部分从数据库中选择一个文件夹，并且直接在文件夹下的检测部分检测可直接存在于所选文件夹之下的可播放文件。文件夹下文件夹检测部分，假定在所选择的文件夹下没有直接存在可播放文件，则检测是否可以直接存在于所选文件夹下的任何文件夹下的可播放文件。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式