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31. 发明申请

US20120065185A1 SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE 有权
标题翻译：取代的烷基胺衍生物及其使用方法
公开(公告)号：US20120065185A1
公开(公告)日：2012-03-15
申请号：US13297213
申请日：2011-11-15
申请人： Guoqing CHEN , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
发明人： Guoqing CHEN , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
IPC分类号： A61K31/4436 , A61K31/4709 , A61K31/4725 , A61P3/00 , A61P7/00 , A61P35/00 , A61P31/00 , A61K31/444 , A61K31/5377
CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.
摘要翻译：所选择的杂环化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。

32. 发明授权

US08088794B2 Substituted amide derivatives and methods of use 有权
标题翻译：取代的酰胺衍生物和使用方法
公开(公告)号：US08088794B2
公开(公告)日：2012-01-03
申请号：US12945575
申请日：2010-11-12
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/47 , C07D453/02
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

33. 发明授权

US08026241B2 Vanilloid receptor ligands and their use in treatments 失效
标题翻译：香草素受体配体及其在治疗中的应用
公开(公告)号：US08026241B2
公开(公告)日：2011-09-27
申请号：US12367352
申请日：2009-02-06
申请人： Chenera Balan , Yunxin Bo , Celia Dominguez , Christopher H. Fotsch , Vijay K. Gore , Vu Van Ma , Mark H. Norman , Vassil I. Ognyanov , Yi-xin Qian , Xianghong Wang , Ning Xi , Shimin Xu
发明人： Chenera Balan , Yunxin Bo , Celia Dominguez , Christopher H. Fotsch , Vijay K. Gore , Vu Van Ma , Mark H. Norman , Vassil I. Ognyanov , Yi-xin Qian , Xianghong Wang , Ning Xi , Shimin Xu
IPC分类号： A61K31/497 , C07D403/04 , C07D401/04
CPC分类号： C07D401/04 , C07D235/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotizing agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：治疗性苯并咪唑和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经痛维持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道，泌尿生殖道，胃肠道或血管区内脏运动紊乱，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病，胃溃疡十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

34. 发明申请

US20100093727A1 COMPOUNDS AND METHODS OF USE 有权
标题翻译：化合物和使用方法
公开(公告)号：US20100093727A1
公开(公告)日：2010-04-15
申请号：US12576375
申请日：2009-10-09
申请人： Ning Xi
发明人： Ning Xi
IPC分类号： A61K31/5377 , C07D403/14 , A61K31/444 , A61K31/4709 , C07D471/04 , A61K31/437 , C07D413/14 , A61P35/04
CPC分类号： A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D471/04 , C07D491/107 , C07D493/10 , C07D495/04 , C07D498/04 , C07D519/00
摘要： The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
摘要翻译：本发明提供了可用于调节蛋白酪氨酸激酶活性和调节细胞间和/或细胞内信号传导的新化合物。本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗哺乳动物，特别是人类中过度增殖性疾病的方法。

35. 发明授权

US07435823B2 Compounds and methods of use 有权
标题翻译：化合物和使用方法
公开(公告)号：US07435823B2
公开(公告)日：2008-10-14
申请号：US11042634
申请日：2005-01-24
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , Gregory J. Habgood , David C. McGowan , Douglas A. Whittington , Daniel La , Vinod F. Patel
IPC分类号： C07D215/38 , C07D265/34
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

36. 发明申请

US20080221101A1 Calcium receptor modulating agents 有权
标题翻译：钙受体调节剂
公开(公告)号：US20080221101A1
公开(公告)日：2008-09-11
申请号：US11977777
申请日：2007-10-25
申请人： Thomas S. Coulter , Adam James Davenport , Christopher H. Fotsch , Chiara Ghiron , Paul E. Harrington , Michael Gerard Kelly , Steve Fong Poon , Andrew Tasker , Ning Xi , Qing Ping Zeng
发明人： Thomas S. Coulter , Adam James Davenport , Christopher H. Fotsch , Chiara Ghiron , Paul E. Harrington , Michael Gerard Kelly , Steve Fong Poon , Andrew Tasker , Ning Xi , Qing Ping Zeng
IPC分类号： A61K31/5377 , C07C211/29 , A61K31/137 , A61P13/12 , A61P9/00 , C07D401/04
CPC分类号： C07D261/18 , C07C211/29 , C07C217/58 , C07C233/43 , C07C233/44 , C07C233/80 , C07C271/28 , C07C311/37 , C07C317/32 , C07C323/32 , C07C2601/08 , C07C2601/16 , C07D207/06 , C07D207/09 , C07D207/48 , C07D211/22 , C07D211/62 , C07D213/30 , C07D213/38 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/60 , C07D235/06 , C07D237/14 , C07D239/42 , C07D249/08 , C07D261/08 , C07D263/24 , C07D263/34 , C07D271/06 , C07D285/06 , C07D295/088 , C07D295/185 , C07D295/205 , C07D295/26 , C07D307/68 , C07D317/58 , C07D333/38 , C07D333/40 , C07D409/04 , C07D413/12 , C07D417/04
摘要： The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.
摘要翻译：本发明一般涉及式I所示的化合物，包含它们的药物组合物以及治疗与钙敏感受体的功能有关的疾病或病症的方法。本发明还涉及制备这些化合物和在这些方法中有用的中间体的方法。

37. 发明授权

US07406859B2 Adaptable end effector for atomic force microscopy based nano robotic manipulators 失效
标题翻译：适用于基于原子力显微镜的纳米机器人操纵器的末端执行器
公开(公告)号：US07406859B2
公开(公告)日：2008-08-05
申请号：US11399690
申请日：2006-04-06
申请人： Ning Xi , Guangyong Li , Jiangbo Zhang
发明人： Ning Xi , Guangyong Li , Jiangbo Zhang
IPC分类号： G01B5/28
CPC分类号： B82B3/00 , G01Q10/065 , G01Q60/38 , G01Q80/00
摘要： An improved nanomanipulation system is provided for performing nanomanipulation operations in relation to a sample surface. The system includes: an atomic force microscope having a probe for performing nanomanipulation operations on the sample surface, where the probe includes a cantilever having a layer of piezoelectric material; a position detector configured to ascertain deformation of the cantilever during a nanomanipulation operation; and an adaptable end effector controller adapted to receive data indicative of the deformation from the position detector and implements a control scheme based on the deformation data. The control scheme produces a control signal that is applied to the piezoelectric material of the cantilever, thereby maintaining the straight shape of the cantilever during the nanomanipulation operation.
摘要翻译：提供改进的纳米操纵系统用于相对于样品表面进行纳米操纵操作。该系统包括：原子力显微镜，具有用于对样品表面进行纳米操作操作的探针，其中探针包括具有一层压电材料的悬臂; 位置检测器，其构造成在纳米操作操作期间确定所述悬臂的变形; 以及可适应的末端执行器控制器，其适于接收表示来自位置检测器的变形的数据，并且基于变形数据实现控制方案。控制方案产生施加到悬臂的压电材料的控制信号，从而在纳米操作操作期间保持悬臂的直线形状。

38. 发明申请

US20080108172A1 DETERMINISTIC PROCESS FOR CONSTRUCTING NANODEVICES 失效
标题翻译：用于构建纳米器件的确定方法
公开(公告)号：US20080108172A1
公开(公告)日：2008-05-08
申请号：US11546499
申请日：2006-10-11
申请人： Ning Xi , Guangyong Li , Jiangbo Zhang , Hoyin Chan
发明人： Ning Xi , Guangyong Li , Jiangbo Zhang , Hoyin Chan
IPC分类号： H01L51/40
CPC分类号： H01L51/0048 , B82Y10/00 , H01L51/0587 , Y10S977/70
摘要： A method is provided for constructing a nanodevice. The method includes: fabricating an electrode on a substrate; forming a nanogap across the electrode; dispersing a plurality of nanoobjects onto the substrate using electrophoresis; and pushing one of the nanoobjects onto the electrode using a tip of an atomic force microscope, such that the nanoobject lies across the nanogap formed in the electrode. In addition, remaining nanoobjects may also be pushed away from the electrode using the atomic force microscope, thereby completing construction of a nanodevice.
摘要翻译：提供了一种构造纳米器件的方法。该方法包括：在基板上制造电极; 在电极上形成纳米隙; 使用电泳将多个纳米对象分散到基底上; 并使用原子力显微镜的尖端将一个纳米对象推到电极上，使得纳米对象位于电极中形成的纳米隙上。此外，还可以使用原子力显微镜将剩余的纳米对象推离电极，从而完成纳米器件的构造。

39. 发明申请

US20070176100A1 Automated nanoassembly 有权
标题翻译：自动纳米组装
公开(公告)号：US20070176100A1
公开(公告)日：2007-08-02
申请号：US11205201
申请日：2005-08-16
申请人： Ning Xi , Guangyong Li , Heping Chen
发明人： Ning Xi , Guangyong Li , Heping Chen
IPC分类号： G01N23/00
CPC分类号： B82B3/00 , G01Q30/04 , G01Q80/00
摘要： An automated nanomanipulation system is provided for manufacturing a nanoscale structure. The system includes: a design model for the nanoscale structure; image data of a sample surface upon which the nanoscale structure is to be manufactured; a movable member configured to perform a nanomanipulation operation on the sample surface; and a path planning subsystem adapted to receive the design model and the image data. The path planning subsystem generates path data indicative of a path for traversing the movable member along the sample surface such that the movable member manipulates one or more randomly distributed nanoobjects in accordance with the design model.
摘要翻译：提供了一种用于制造纳米尺度结构的自动化纳米操纵系统。该系统包括：纳米尺度结构的设计模型; 要制造纳米尺度结构的样品表面的图像数据; 被配置为对所述样品表面执行纳米操作操作的可移动部件; 以及适于接收设计模型和图像数据的路径规划子系统。路径规划子系统产生路径数据，其指示沿着样本表面横穿可移动构件的路径，使得可移动构件根据设计模型操纵一个或多个随机分布的纳米对象。

40. 发明申请

US20060252777A1 Substituted heterocycles and methods of use 有权
标题翻译：取代的杂环和使用方法
公开(公告)号：US20060252777A1
公开(公告)日：2006-11-09
申请号：US11289659
申请日：2005-11-29
申请人： Tae-Seong Kim , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Matthew Lee , Longbin Liu , Elizabeth Rainbeau , Aaron Siegmund , Andrew Tasker , Ning Xi , Yuan Cheng
发明人： Tae-Seong Kim , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Matthew Lee , Longbin Liu , Elizabeth Rainbeau , Aaron Siegmund , Andrew Tasker , Ning Xi , Yuan Cheng
IPC分类号： A61K31/519 , A61K31/517 , A61K31/513 , A61K31/4709 , A61K31/4745 , C07D403/04 , C07D487/02 , C07D471/02
CPC分类号： C07D401/14 , C07D215/233 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

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