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31. 发明授权

US08957026B2 Beta-catenin targeting peptides and uses thereof 有权
标题翻译： β-连环蛋白靶向肽及其用途
公开(公告)号：US08957026B2
公开(公告)日：2015-02-17
申请号：US13825709
申请日：2011-09-22
申请人： Gregory L. Verdine , Tom N. Grossmann , Tsung-Han Johannes Yeh
发明人： Gregory L. Verdine , Tom N. Grossmann , Tsung-Han Johannes Yeh
IPC分类号： C07K7/08 , C07K14/47 , C07K1/113 , A61K38/00
CPC分类号： C07K14/4705 , A61K38/00 , C07K1/113 , C07K7/08 , C07K14/47 , C07K14/4702 , C07K14/4703
摘要： The invention relates to β-catenin targeting peptides comprising an α-helical segment that are optionally stapled or stitched, and pharmaceutical compositions thereof. Uses of the inventive β-catenin targeting polypeptides including methods for treatment of disease, such as diseases associated with aberrant Wnt signaling, including cancer, are also provided.
摘要翻译：本发明涉及包含可选择性地缝合或缝合的α-螺旋区段的β-连环蛋白靶向肽及其药物组合物。还提供了本发明的β-连环蛋白靶向多肽的用途，包括治疗疾病的方法，例如与异常Wnt信号传导相关的疾病，包括癌症。

32. 发明申请

US20140235549A1 STABILIZED POLYPEPTIDES AS REGULATORS OF RAB GTPASE FUNCTION 有权
标题翻译：稳定的多糖作为RAB蛋白功能的调节剂
公开(公告)号：US20140235549A1
公开(公告)日：2014-08-21
申请号：US14126642
申请日：2012-06-15
申请人： Raymond E. Moellering , Gregory L. Verdine
发明人： Raymond E. Moellering , Gregory L. Verdine
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/4702
摘要： The present invention provides inventive polypeptides comprising a C terminal RAB binding domain (RabBD) of RAB family interacting proteins (FIPs) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating RAB function comprising contacting an inventive stapled polypeptide with a RAB protein, and methods of treatment associated with modulation of RAB activity. The present invention also provides methods of making the inventive stapled polypeptides by ring closing metathesis of unstapled polypeptide precursors.
摘要翻译：本发明提供了包含通过肽缝合稳定的RAB家族相互作用蛋白（FIPs）的C末端RAB结合结构域（RabBD）的本发明多肽及其药物组合物。还提供了用于调节RAB功能的方法，包括使本发明的缝合多肽与RAB蛋白质接触，以及与调节RAB活性相关的治疗方法。本发明还提供了通过闭合未经取代的多肽前体的复分解制备本发明的缝合多肽的方法。

33. 发明申请

US20130245101A1 Liver Targeted Conjugates 有权
标题翻译：肝靶向共轭体
公开(公告)号：US20130245101A1
公开(公告)日：2013-09-19
申请号：US13869917
申请日：2013-04-24
申请人： Gregory L. Verdine , Yoshihiko Norimine , Lourdes Gude-Rodriguez
发明人： Gregory L. Verdine , Yoshihiko Norimine , Lourdes Gude-Rodriguez
IPC分类号： A61K47/48
CPC分类号： A61K47/48061 , A61K31/22 , A61K31/405 , A61K47/549 , A61K47/55 , C07D209/28 , C07D309/30 , C07D405/12 , C07D405/14
摘要： Therapeutic conjugates containing a statin or a modified statin (collectively “statin”) linked to a therapeutic agent (also referred to as a drug herein) are targeted to the liver by the statin or modified statin and thereby deliver the therapeutic agent to liver cells
摘要翻译：与治疗剂（也称为本药物）连接的含有他汀类药物或改良的他汀类药物（统称“他汀类”）的治疗性缀合物通过他汀类药物或经修饰的他汀类药物靶向肝脏，从而将治疗剂递送至肝细胞

34. 发明申请

US20120316224A1 NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF 有权
标题翻译：新型核酸产品及其使用方法
公开(公告)号：US20120316224A1
公开(公告)日：2012-12-13
申请号：US13381323
申请日：2010-07-06
申请人： Gregory L. Verdine , Meena Meena , Naoki Iwamoto
发明人： Gregory L. Verdine , Meena Meena , Naoki Iwamoto
IPC分类号： A61K31/7084 , A61K31/711 , A61P35/00 , C07H21/04
CPC分类号： A61K31/70 , C07F9/65515 , C07H21/00
摘要： Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.
摘要翻译：本文描述的是包含手性磷部分的核酸前药和核酸前药。本文还描述了制备和使用包含手性磷部分的核酸前药和核酸前药的方法。

35. 发明申请

US20110257251A1 TELOMERASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： TELOMERASE抑制剂及其使用方法
公开(公告)号：US20110257251A1
公开(公告)日：2011-10-20
申请号：US13123123
申请日：2009-10-07
申请人： Lourdes Gude-Rodriguez , Gregory L. Verdine , Shaunna Syu-Mei Stanton
发明人： Lourdes Gude-Rodriguez , Gregory L. Verdine , Shaunna Syu-Mei Stanton
IPC分类号： A61K31/7105 , C12N9/99 , A61P35/00 , C07H21/02
CPC分类号： A61K31/7105 , C12N15/1137 , C12N2310/11 , C12Y207/07049
摘要： One object of the present invention is to provide methods and compositions for inhibiting human telomerase, by providing inhibitors that bind to the CR4-CR5 or pseudoknot/template domains of the RNA component of human telomerase.
摘要翻译：本发明的一个目的是通过提供与人端粒酶的RNA组分的CR4-CR5或假骨/模板结构域结合的抑制剂来提供用于抑制人端粒酶的方法和组合物。

36. 发明授权

US07786072B2 Stabilized compounds having secondary structure motifs 有权
标题翻译：具有二级结构基序的稳定化合物
公开(公告)号：US07786072B2
公开(公告)日：2010-08-31
申请号：US11148976
申请日：2005-06-09
申请人： Gregory L. Verdine , Christian E. Schafmeister
发明人： Gregory L. Verdine , Christian E. Schafmeister
IPC分类号： C07K14/00 , C07K4/00
CPC分类号： C07K1/00 , A61K38/00 , A61K38/02 , C07K1/04 , C07K1/047 , C07K1/10 , C07K1/113 , C07K14/001 , C07K14/4746 , C12N15/1093
摘要： The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involves (1) synthesizing a peptide from a selected number of natural or non-natural amino acids, wherein said peptide comprises at least two moieties capable of undergoing reaction to promote carbon-carbon bond formation; and (2) contacting said peptide with a reagent to generate at least one crosslinker and to effect stabilization of a secondary structure motif. The present invention, in a preferred embodiment, provides stabilized p53 donor helical peptides. Additionally, the present invention provides methods for disrupting the p53/MDM2 binding interaction comprising (1) providing a crosslinked stabilized α-helical structure; and (2) contacting said crosslinked stabilized α-helical structure with MDM2.
摘要翻译：本发明提供具有二级结构基序的新型稳定化交联化合物，这些新化合物的文库，以及合成这些化合物文库的方法。这些新型稳定化合物的合成涉及（1）从选定数量的天然或非天然氨基酸合成肽，其中所述肽包含至少两个能够进行促进碳 - 碳键形成反应的部分; 和（2）使所述肽与试剂接触以产生至少一种交联剂并实现二级结构基序的稳定化。本发明在优选的实施方案中提供稳定的p53供体螺旋肽。另外，本发明提供了破坏p53 / MDM2结合相互作用的方法，其包括（1）提供交联的稳定的α-螺旋结构; 和（2）使所述交联的稳定的α-螺旋结构与MDM2接触。

37. 发明申请

US20080269152A1 Nucleic acid binding oligonucleotides 审中-公开
标题翻译：核酸结合寡核苷酸
公开(公告)号：US20080269152A1
公开(公告)日：2008-10-30
申请号：US11904612
申请日：2007-09-26
申请人： Gregory L. Verdine , Webster Santos
发明人： Gregory L. Verdine , Webster Santos
IPC分类号： A61K31/7088 , C40B40/06 , C40B40/08 , C40B60/12 , A61P31/12 , C40B50/00 , C40B30/04
CPC分类号： C12Q1/6876 , C07H21/00 , C12Q1/6811 , C12Q1/6837 , Y02A50/54 , C12Q2565/501 , C12Q2525/204 , C12Q2525/205
摘要： The present application pertains to products and methods related to the ability of short nucleotide oligomers to bind the tertiary or globular structure of nucleic acids. This application discloses libraries of short oligomers and methods for using these libraries.
摘要翻译：本申请涉及与短核苷酸寡聚体结合核酸的叔或球状结构的能力相关的产品和方法。本申请公开了短寡聚体的文库和使用这些文库的方法。

38. 发明授权

US07223888B2 Mu opioid receptor ligands: methods of use and synthesis 有权
标题翻译： Mu阿片受体配体：使用和合成方法
公开(公告)号：US07223888B2
公开(公告)日：2007-05-29
申请号：US10683756
申请日：2003-10-10
申请人： Bryce A. Harrison , Tiffany M. Gierasch , Gregory L. Verdine , Zhangjie Shi
发明人： Bryce A. Harrison , Tiffany M. Gierasch , Gregory L. Verdine , Zhangjie Shi
IPC分类号： C07C233/30 , C07C535/34 , C07C535/32
CPC分类号： C07C237/22 , C07C235/34 , C07C237/20 , C07C327/22
摘要： Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications, including modulation of disease or disease symptoms in a subject (e.g., mammal, human, dog, cat, horse). The compounds are useful as modulators of the mu opioid receptor (MOR) through their binding affinity with that receptor.
摘要翻译：本文描述了包括这些化合物的新型化合物和组合物，以及使用和制备化合物的方法。该化合物可用于治疗应用，包括对受试者（例如哺乳动物，人，狗，猫，马）中疾病或疾病症状的调节。通过与该受体的结合亲和力，这些化合物可用作μ阿片受体（MOR）的调节剂。

39. 发明授权

US07115372B2 Methods for targeting RNA molecules 失效
公开(公告)号：US07115372B2
公开(公告)日：2006-10-03
申请号：US10256987
申请日：2002-09-26
申请人： Ling X. Shen , Gregory L. Verdine , James P. Basilion , Vincent P. Stanton, Jr.
发明人： Ling X. Shen , Gregory L. Verdine , James P. Basilion , Vincent P. Stanton, Jr.
IPC分类号： C12Q1/68 , G01N33/53 , C12P19/00 , C07G3/00 , A61K31/70
CPC分类号： G01N33/5008 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2320/11 , G01N2500/04
摘要： Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.

40. 发明授权

US06566059B1 Method for analyzing polynucleotides 有权
公开(公告)号：US06566059B1
公开(公告)日：2003-05-20
申请号：US09394467
申请日：1999-09-10
申请人： Vincent P. Stanton, Jr. , Jia Liu Wolfe , Gregory L. Verdine
发明人： Vincent P. Stanton, Jr. , Jia Liu Wolfe , Gregory L. Verdine
IPC分类号： C12Q168
CPC分类号： C07H19/10 , C07H19/14 , C07H19/20 , C07H21/00 , C12N9/1252 , C12N15/11 , C12P19/34 , C12Q1/6827 , C12Q1/6872 , C12Q2565/627 , C12Q2525/101 , C12Q2523/107
摘要： The present invention relates to methods for the analysis of polynucleotides including detection of variance in nucleotide sequence without the need for full sequence determination, full sequence determination of a polynucleotide, genotyping of DNA and labeling a polynucleotide fragment during the process of cleaving it into fragments.

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