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31. 发明授权

US09149617B2 Device, system and methods for the oral delivery of therapeutic compounds 有权
标题翻译：用于口服递送治疗化合物的装置，系统和方法
公开(公告)号：US09149617B2
公开(公告)日：2015-10-06
申请号：US13532589
申请日：2012-06-25
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61M31/00 , A61K9/00 , A61K9/48 , A61K38/21 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/29 , A61M37/00
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/4808 , A61K38/21 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/29 , A61M37/0069
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
摘要翻译：本发明的实施方案提供了可在胃肠道内递送药物和其它治疗剂的吞咽装置，制剂和方法。具体实施方案提供了可吞咽的装置，例如用于将药物输送到肠壁或其它胃肠腔中的胶囊。实施方案还提供了各种药物制剂，其被配置为容纳在胶囊内，从胶囊进入肠壁并在壁内降解以释放药物以产生治疗效果。该制剂可以联接到具有一个或多个气囊或其它可扩张装置的递送机构，所述气囊或其它可扩张装置可响应于小肠或其它GI腔中的状况而扩张，以使制剂从胶囊进入肠壁。本发明的实施方案对于递送胃肠道内吸收不良，耐受和/或降解的药物特别有用。

32. 发明授权

US09118404B2 Apparatus, system and method for underwater signaling of audio messages to a diver 有权
标题翻译：用于向潜水员发送音频消息的水下信令的装置，系统和方法
公开(公告)号：US09118404B2
公开(公告)日：2015-08-25
申请号：US13398718
申请日：2012-02-16
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： H04B11/00
CPC分类号： H04B11/00
摘要： Embodiments of the invention provide a system, apparatus and methods for underwater voice communication between a diver and an underwater electronic device. In many embodiments, the system includes a dive computer which generates audio signals corresponding to spoken messages and a mouthpiece apparatus having an acoustic transducer that conducts sound via conduction through the diver's teeth and skull to the cochlea so as to allow the diver to hear the messages and other sounds and a microphone for sensing the diver's voice. The mouthpiece is adapted to be easily attached to portions of a SCUBA or other underwater breathing apparatus. It may also be attached or integral to a snorkel or similar apparatus.
摘要翻译：本发明的实施例提供了一种用于潜水员和水下电子设备之间的水下语音通信的系统，装置和方法。在许多实施例中，该系统包括产生对应于口语消息的音频信号的潜水计算机和具有声传感器的接口装置，所述声学换能器通过导电通过潜水员的牙齿和头骨将声音传导到耳蜗，以允许潜水员听到消息和其他声音和麦克风，用于感测潜水员的声音。喉舌适于容易地附接到SCUBA或其他水下呼吸器的部分。它也可以附着或与浮潜或类似装置成一体。

33. 发明授权

US09107993B2 Myocardial drug delivery apparatus and method 有权
标题翻译：心肌药物输送装置及方法
公开(公告)号：US09107993B2
公开(公告)日：2015-08-18
申请号：US13681825
申请日：2012-11-20
申请人： Mir Imran , Paul Spehr , Philip F. Morgan , Elmar Fischer
发明人： Mir Imran , Paul Spehr , Philip F. Morgan , Elmar Fischer
IPC分类号： A61N1/00 , A61B18/18 , A61M5/14 , A61M37/00 , A61N1/39 , A61N1/362 , A61B5/00 , A61B5/042
CPC分类号： A61M5/14 , A61B5/0422 , A61B5/4839 , A61B5/6852 , A61B5/6869 , A61M37/0069 , A61N1/362 , A61N1/3962
摘要： Embodiments provide apparatus and methods for delivering solid form drug (SFD) to various locations in the body. In one embodiment, the invention provides an apparatus for treatment of arrhythmia comprising a drug delivery member (DDM) coupled to a drug storage device (DSD). The DSD is configured to store and advance SFD (e.g., drug pellets) through the DDM to a target tissue site (TTS) in or on the heart. A drug advancement member may be used to advance the SFD through the DSD. A capture chamber (CC) may be coupled to the DDM. and is configured to be positioned on a heart surface and allow SFD to dissolve to deliver a drug solution to the heart. The DSD can be implanted subcutaneously e.g., in the pectoral area. Embodiments of the apparatus can be used to store and deliver SFD to the heart or other TTS over an extended period of years.
摘要翻译：实施例提供了将固体形式药物（SFD）递送到身体中的各个位置的装置和方法。在一个实施方案中，本发明提供了一种用于治疗心律失常的装置，其包括联接到药物储存装置（DSD）的药物递送构件（DDM）。 DSD被配置为将SFD（例如，药物颗粒）通过DDM存储并提前到心脏中或心脏上的目标组织部位（TTS）。药物推进会员可用于通过DSD推进SFD。捕获室（CC）可以耦合到DDM。并且被配置为定位在心脏表面上并且允许SFD溶解以将药物溶液递送到心脏。 DSD可以皮下植入，例如在胸部区域。该装置的实施例可以用于在多年的延长时间内将SFD存储并传送到心脏或其他TTS。

34. 发明授权

US09065561B2 System and method for enhancing speech of a diver wearing a mouthpiece 有权
标题翻译：用于增强穿着喉舌的潜水员的演讲的系统和方法
公开(公告)号：US09065561B2
公开(公告)日：2015-06-23
申请号：US13466031
申请日：2012-05-07
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： H04B13/02 , G10L21/0364 , B63C11/26 , H04B11/00 , G10L13/00
CPC分类号： G10L21/0364 , B63C11/26 , G10L13/00 , G10L13/033 , G10L2021/03643 , H04B11/00 , H04B13/005 , H04B13/02 , H04R1/44 , H04R1/46
摘要： Embodiments described herein provide a system, apparatus and methods to enable a diver to communicate more clearly with other divers or locations Embodiments process the speech to add clarity, or otherwise convert speech into an outputted form that is more intelligible e.g. so as to simulate the diver's unhindered speech. Embodiments provide hardware and software for receiving and recognizing hindered speech of a diver (e.g., speech hindered by a mouthpiece) and then augmenting the speech with generated output sounds corresponding to the intended speech sound or generating or replacing at least some of the diver's speech with synthesized words. The output sounds may be in the speaker's own voice or a synthesized voice. Embodiments may be configured to add clarity to and/or augment speech that is hindered by the wearing of a mouthpiece from a snorkel, SCUBA or other diving apparatus.
摘要翻译：本文描述的实施例提供了使潜水员能够与其他潜水员或位置更清楚地通信的系统，装置和方法。实施例处理语音以增加清晰度，或以其他方式将语音转换为更易理解的输出形式。以模拟潜水员不受阻碍的演讲。实施例提供了用于接收和识别潜水员（例如，由喉舌阻碍的语音）的受阻语音的硬件和软件，然后用对应于预期语音的生成的输出声音来增加语音，或者用至少一些潜水员的语音生成或替换合成词。输出声音可能在扬声器自己的声音或合成声音中。实施例可以被配置为增加通过来自浮潜，SCUBA或其它潜水装置的接口管的磨损而妨碍的语音的清晰度和/或增加语音。

35. 发明授权

US09026212B2 Energy harvesting mechanism for medical devices 有权
标题翻译：医疗器械能量采集机构
公开(公告)号：US09026212B2
公开(公告)日：2015-05-05
申请号：US12561159
申请日：2009-09-16
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61N1/00 , A61N1/378
CPC分类号： A61N1/3785 , A61N1/362 , A61N1/3702 , A61N1/3956
摘要： Embodiments of the invention provide apparatus, systems and methods for harvesting energy from bio-kinetic events to power various implanted medical devices. One embodiment provides an energy harvesting mechanism for a cardiac pacemaker comprising an energy converter and a signal path component. The energy converter is positionable inside a human body and configured to generate electric power signals in response to a bio-kinetic event of the human body such as a heart beat, respiration or arterial pulse. The converter can comprise a piezoelectric material which generates electricity in response to mechanical deformation of the converter. The converter can also have a power generation characteristic that is matched to the frequency of the bio-kinetic event. For heart beat powered applications, the power generation characteristic can be matched to the physiologic range of pulse rates.
摘要翻译：本发明的实施例提供了用于从生物动力学事件中收集能量以为各种植入的医疗装置供电的装置，系统和方法。一个实施例提供了一种用于心脏起搏器的能量收集机构，其包括能量转换器和信号路径部件。能量转换器可定位在人体内并且被配置为响应于人体的生物动力学事件（例如心跳，呼吸或动脉脉冲）产生电力信号。转换器可以包括响应于转换器的机械变形而发电的压电材料。转换器还可以具有与生物动力学事件的频率相匹配的发电特性。对于心跳动力应用，发电特性可以与脉搏率的生理范围相匹配。

36. 发明授权

US08986279B2 Methods and architecture for power optimization of iontophoretic transdermal drug delivery 有权
标题翻译：离子电渗透皮药物传递功率优化的方法和架构
公开(公告)号：US08986279B2
公开(公告)日：2015-03-24
申请号：US13024295
申请日：2011-02-09
申请人： Mir Imran , Dean P. Andersen , Vikram Malhotra , George Andrew Mangogna
发明人： Mir Imran , Dean P. Andersen , Vikram Malhotra , George Andrew Mangogna
IPC分类号： A61M31/00 , A61N1/32 , A61N1/04
CPC分类号： A61N1/303 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： Embodiments of the invention provide an architecture, system and methods for optimizing power utilization for transdermal iontophoretic drug delivery which maintain a iontophoretic driving voltage at a reduced or even minimum value to support an iontophoretic delivery current. The reduced voltage reduces the power requirements for a transdermal iontohoretic delivery system during a period of drug delivery. Embodiments of an architecture for implementing this approach can utilize a controller which compares the desired current to the actual current and adjusts the voltage to reduce the amount of power used for iontophoretic drug delivery. The controller can comprise a state machine or microprocessor. Embodiments of the invention are particularly useful for extending the battery life of transdermal iontophoretic drug delivery systems.
摘要翻译：本发明的实施方案提供了用于优化透皮离子电渗药物递送的功率利用的结构，系统和方法，其将离子电渗驱动电压维持在降低或甚至最小值以支持离子电渗疗法输送电流。降低的电压降低了药物递送期间透皮离子电泳递送系统的功率需求。用于实现该方法的体系结构的实施例可以利用将期望电流与实际电流进行比较的控制器，并且调节电压以减少用于离子电渗药物递送的功率量。控制器可以包括状态机或微处理器。本发明的实施方案对于延长透皮离子电渗药物递送系统的电池寿命特别有用。

37. 发明授权

US08903485B2 Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes 有权
标题翻译：用于离子电渗透皮递送用于治疗和药用目的的活性剂的贴片和贴片组件
公开(公告)号：US08903485B2
公开(公告)日：2014-12-02
申请号：US12898671
申请日：2010-10-05
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61M37/00 , A61M2037/0007
摘要： Embodiments of the invention provide patch assemblies for iontophoretic transdermal delivery of therapeutic agents. An embodiment provides a patch assembly comprising a conformable patch for delivery of the agent and having a tissue contacting side including an adhesive. The housing has a bottom surface for engaging a non-tissue contacting side of the patch, a current source such as a battery and a controller for controlling the delivery of the agent. The housing has sufficient flexibility such that when it is engaged with the patch to form the patch assembly and the patch is adhered to a target site on the patient's skin, the assembly has sufficient flexibility to deform with movement of the patient's skin to remain sufficiently adhered to the skin over an extended period of time to transdermally deliver a desired dose of the agent. Embodiments of the assembly may used to deliver a variety of therapeutic agents.
摘要翻译：本发明的实施方案提供了用于治疗剂的离子电渗透皮递送的贴片组件。一个实施方案提供一种贴片组件，其包括用于递送药剂并具有包括粘合剂的组织接触侧的适形贴片。壳体具有用于接合贴片的非组织接触侧的底表面，诸如电池的电流源和用于控制药剂递送的控制器。外壳具有足够的灵活性，使得当其与贴片接合以形成贴片组件并且贴片粘附到患者皮肤上的目标部位时，该组件具有足够的柔性以随着患者皮肤的运动而变形以保持充分粘附在延长的时间段内向皮肤透皮递送所需剂量的试剂。该组件的实施方案可用于递送各种治疗剂。

38. 发明授权

US08846040B2 Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device 有权
标题翻译：包含依那西普的治疗剂制剂，其使用吞咽药物递送装置递送至肠道的内腔
公开(公告)号：US08846040B2
公开(公告)日：2014-09-30
申请号：US13539031
申请日：2012-06-29
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61K39/00 , A61M5/00 , A61M25/10 , A61M31/00
CPC分类号： A61K9/0004 , A61B17/12099 , A61B17/12136 , A61K9/0053 , A61K9/0065 , A61K9/4808 , A61K38/00 , A61K38/1793 , A61K39/3955 , A61K2039/505 , A61K2039/542 , A61K2039/545 , A61M5/00 , A61M25/10 , A61M31/002 , C07K14/70578 , C07K2319/30
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
摘要翻译：本发明的实施方案提供了可在胃肠道内递送药物和其它治疗剂的吞咽装置，制剂和方法。许多实施例提供了用于递送药剂的吞咽装置。具体实施方案提供了可吞咽的装置，例如用于将药物输送到肠壁或其它胃肠腔中的胶囊。实施方案还提供了各种药物制剂，其被配置为容纳在胶囊内，从胶囊进入肠壁并降解以将药物释放到血流中以产生治疗效果。制剂可以可操作地偶联到具有第一构型的输送装置，其中制剂被包含在胶囊中，并且第二配置将制剂从胶囊中推出到肠壁中。本发明的实施方案对于递送胃肠道内吸收不良，耐受和/或降解的药物特别有用。

39. 发明授权

US08764733B2 Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device 有权
标题翻译：用于使用吞咽药物递送装置递送至肠道内腔的治疗剂制剂
公开(公告)号：US08764733B2
公开(公告)日：2014-07-01
申请号：US13538852
申请日：2012-06-29
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61K9/22 , A61K9/20 , A61K38/11 , C07K7/16
CPC分类号： A61K38/08 , A61K9/0053 , A61K9/0097 , A61K9/20 , A61K9/2072 , A61K38/00 , A61K38/11 , A61L29/16 , A61L2300/43 , A61M5/00 , A61M31/002 , C07K7/16
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
摘要翻译：本发明的实施方案提供了可在胃肠道内递送药物和其它治疗剂的吞咽装置，制剂和方法。许多实施例提供了用于递送药剂的吞咽装置。具体实施方案提供了可吞咽的装置，例如用于将药物输送到肠壁或其它胃肠腔中的胶囊。实施方案还提供了各种药物制剂，其被配置为容纳在胶囊内，从胶囊进入肠壁并降解以将药物释放到血流中以产生治疗效果。制剂可以可操作地偶联到具有第一构型的输送装置，其中制剂被包含在胶囊中，并且第二配置将制剂从胶囊中推出到肠壁中。本发明的实施方案对于递送胃肠道内吸收不良，耐受和/或降解的药物特别有用。

40. 发明授权

US08721620B2 Swallowable drug delivery device and methods of drug delivery 有权
标题翻译：吞咽药物输送装置和药物递送方法
公开(公告)号：US08721620B2
公开(公告)日：2014-05-13
申请号：US12978233
申请日：2010-12-23
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61K9/0065 , A61K9/48 , A61K9/4808 , A61K31/155 , A61K38/17 , A61K38/22 , A61K38/2235 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/29 , A61K45/06 , A61M5/14276 , A61M5/168 , A61M5/1723 , A61M5/20 , A61M2005/1401 , A61M2005/14284 , A61M2230/005 , A61K2300/00
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
摘要翻译：本发明的实施方案提供了可在胃肠道内递送药物和其它治疗剂的吞咽装置，制剂和方法。一些实施方案提供了可吞咽的装置，例如用于将药物递送到肠壁或其它胃肠腔的胶囊。该装置包括尺寸被吞咽并通过肠道的胶囊。胶囊可以包括至少一个引导管，定位在引导管中的一个或多个组织穿透构件，输送构件，致动机构和释放元件。释放元件在暴露于肠道中的各种条件时降解，以便释放和致动致动机构。本发明的实施方案对于递送胃肠道内吸收不良，耐受和/或降解的药物特别有用。

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