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31. 发明授权

US06834990B2 Impeller for mixing small volumes of reaction materials 有权
标题翻译：用于混合少量反应物料的叶轮
公开(公告)号：US06834990B2
公开(公告)日：2004-12-28
申请号：US10408812
申请日：2003-04-08
申请人： Ralph B. Nielsen
发明人： Ralph B. Nielsen
IPC分类号： B01F700
CPC分类号： B01F13/1022 , B01F7/00033 , B01F7/0015 , B01F7/002 , B01F7/18 , B01F13/1013 , B01J2219/00283 , B01J2219/00306 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , C40B60/14
摘要： Method and apparatus for mixing small volumes of reaction components. In one application, a plurality of removable vessels are placed in a parallel reactor, and reaction components are delivered to each vessel. An impeller is rotated in each vessel to mix the components. Each impeller has a rotary shaft and at least one blade on the shaft for placement in the reaction components. The blade is dimensioned so that one rotation of the impeller causes the blade to sweep out a sweep volume representing a large amount of the fill volume of the vessel.
摘要翻译：用于混合少量反应组分的方法和装置。在一个应用中，将多个可移除的容器放置在平行的反应器中，并将反应组分输送到每个容器。在每个容器中旋转叶轮以混合组分。每个叶轮具有旋转轴和轴上的至少一个叶片，用于放置在反应部件中。叶片的尺寸被设计成使得叶轮的一个旋转使叶片扫出表示容器的大量填充体积的扫掠体积。

32. 发明授权

US06818183B2 Multi-temperature modular reactor and method of using same 有权
标题翻译：多温度模块式反应器及其使用方法
公开(公告)号：US06818183B2
公开(公告)日：2004-11-16
申请号：US10134556
申请日：2002-04-29
申请人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
发明人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
IPC分类号： G01N3348
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28D15/00 , F28D2021/0077 , F28F27/00 , G01K13/00 , G01N21/253 , Y10T436/10 , Y10T436/11 , Y10T436/25
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
摘要翻译：公开了一种用于实施和监测多重反应的进展和性质的装置和方法。该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。此外，该装置可以包括用于独立地控制每个容器中的压力的装置。单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。

33. 发明授权

US06577392B1 Characterization of non-biological polymers using flow-injection analysis with light-scattering detection 有权
标题翻译：使用光散射检测的流动注射分析表征非生物聚合物
公开(公告)号：US06577392B1
公开(公告)日：2003-06-10
申请号：US09728374
申请日：2000-11-28
申请人： Ralph B. Nielsen , Sigrid C. Kuebler , Thomas S. Lee , Adam Safir , Miroslav Petro
发明人： Ralph B. Nielsen , Sigrid C. Kuebler , Thomas S. Lee , Adam Safir , Miroslav Petro
IPC分类号： G01N2100
CPC分类号： B01D15/08 , B01D15/14 , B01D15/1871 , B01D15/1885 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00585 , B01J2219/00587 , B01J2219/00707 , B01J2219/00722 , C40B40/14 , G01N15/0205 , G01N30/02 , G01N30/16 , G01N30/24 , G01N30/30 , G01N30/461 , G01N30/466 , G01N30/54 , G01N30/60 , G01N30/6052 , G01N30/88 , G01N33/44 , G01N33/442 , G01N35/085 , G01N35/1097 , G01N2015/0288 , G01N2015/0294 , G01N2030/324 , G01N2030/625 , B01D15/34
摘要： Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
摘要翻译：公开了聚合物样品的快速表征和筛选以确定平均分子量，分子量分布和其它性质。优选采用快速流动表征系统和方法，包括液相色谱和流动注射分析系统和方法。还公开了高通量，自动采样系统和方法，高温表征系统和方法以及快速，间接校准组合物和方法。所描述的方法，系统和装置在组合聚合物研究和工业过程控制中具有主要应用。

34. 发明授权

US06559255B2 Controlled free radical emulsion and water-based polymerizations and seeded methodologies 失效
公开(公告)号：US06559255B2
公开(公告)日：2003-05-06
申请号：US09520583
申请日：2000-03-08
申请人： Gerrit Klaerner , Adam Safir , Ralph B. Nielsen , Bernd Jandeleit , Peter Huefner , Yunxiao Li
发明人： Gerrit Klaerner , Adam Safir , Ralph B. Nielsen , Bernd Jandeleit , Peter Huefner , Yunxiao Li
IPC分类号： C08F222
CPC分类号： C08F220/58 , C08F4/00 , G01N33/54353
摘要： Nitroxides having an alpha-carbon atom with a destabilizing moiety are effective control agents for emulsion and water-based polymerizations, including the formation of block copolymers from a wide range of monomers. The nitroxide radicals may be used as a free radical or as an adduct with a residue from the initiator. The emulsions have living characteristics, including the re-initiation of polymer chains. Also, a seeded process for emulsions, which includes the step-wise addition of monomer is disclosed, providing access to a wide range of initiator types.

35. 发明授权

US06507945B1 Synthesizing combinatorial libraries of materials 失效
标题翻译：合成材料组合库
公开(公告)号：US06507945B1
公开(公告)日：2003-01-14
申请号：US09305830
申请日：1999-05-05
申请人： William C. Rust , Ralph B. Nielsen
发明人： William C. Rust , Ralph B. Nielsen
IPC分类号： G06F944
CPC分类号： G05B19/0426 , B01J19/0046 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695
摘要： Methods and apparatus for controlling an automated material handling procedure. The method includes receiving a recipe file comprising component information and mapping information; interacting with a user to create a procedure for executing a set of material handling steps; and causing a automated material-handling apparatus to carry out the set of material-handling steps by executing the procedure. The mapping information relates a source component and a destination component. The mapping information defines one or more transfers of at least one source component material to at least one destination component location. The method includes providing to the user an assortment of pre-programmed code objects and receiving from the user a selection and arrangement of the pre-programmed code objects. The procedure is defined by the user's selection and arrangement. The procedure contains at least one first pre-programmed code object operable to read and interpret the recipe file and at least one second pre-programmed code object operable to interpret a mapping read from the recipe file.
摘要翻译：用于控制自动化材料处理程序的方法和装置。该方法包括接收包括组件信息和映射信息的配方文件; 与用户交互以创建用于执行一组材料处理步骤的过程; 并且使自动物料处理装置通过执行该程序来执行一组物料处理步骤。映射信息涉及源组件和目标组件。映射信息将至少一个源组件材料的一个或多个传输定义到至少一个目的地组件位置。该方法包括向用户提供各种预先编程的代码对象并从用户接收预编程代码对象的选择和布置。该过程由用户的选择和安排来定义。该过程包含至少一个第一预编程代码对象，其可操作以读取和解释配方文件，以及至少一个第二预编程代码对象，其可操作以解释从配方文件读取的映射。

36. 发明授权

US06175409B1 Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers 有权
标题翻译：用于表征聚合物的流动注射分析和可变流光散射方法和装置
公开(公告)号：US06175409B1
公开(公告)日：2001-01-16
申请号：US09285335
申请日：1999-04-02
申请人： Ralph B. Nielsen , Sigird C. Kuebler , James Bennett , Adam Safir , Miroslav Petro
发明人： Ralph B. Nielsen , Sigird C. Kuebler , James Bennett , Adam Safir , Miroslav Petro
IPC分类号： G01N1506
CPC分类号： B01D15/08 , B01D15/14 , B01D15/1871 , B01D15/1885 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00585 , B01J2219/00587 , B01J2219/00707 , B01J2219/00722 , C40B40/14 , G01N15/0205 , G01N30/02 , G01N30/16 , G01N30/24 , G01N30/30 , G01N30/461 , G01N30/466 , G01N30/54 , G01N30/60 , G01N30/6052 , G01N30/88 , G01N33/44 , G01N33/442 , G01N35/085 , G01N35/1097 , G01N2015/0288 , G01N2015/0294 , G01N2030/324 , G01N2030/625 , B01D15/34
摘要： Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
摘要翻译：公开了聚合物样品的快速表征和筛选以确定平均分子量，分子量分布和其它性质。优选采用快速流动表征系统和方法，包括液相色谱和流动注射分析系统和方法。还公开了高通量，自动采样系统和方法，高温表征系统和方法以及快速，间接校准组合物和方法。所描述的方法，系统和装置在组合聚合物研究和工业过程控制中具有主要应用。

37. 发明授权

US6151123A Systems and methods for employing optical probes to characterize material properties 失效
标题翻译：使用光学探针来表征材料特性的系统和方法
公开(公告)号：US6151123A
公开(公告)日：2000-11-21
申请号：US112247
申请日：1998-07-08
申请人： Ralph B. Nielsen
发明人： Ralph B. Nielsen
IPC分类号： C07B61/00 , G01N21/25 , G01N21/64 , G01N21/55
CPC分类号： G01N21/6428 , G01N21/6452 , C40B40/00
摘要： Methods and apparatus for screening diverse arrays of materials are provided. In particular, the present invention provides techniques for interrogating organic materials, inorganic materials, or polymers on predefined regions of a substrate, using optical probe molecules to measure properties of these materials. This invention involves the use of environment-sensitive probes, such as dye probes, to enable parallel, rapid and efficient characterization of important material properties, including glass-transition temperatures, polarity, hydrogen bonding and other intermolecular interactions. These methods can be applied to crystalline or amorphous materials, polymeric or small-molecule materials, pure materials or mixtures, and to materials in bulk, particles, thin films, dispersions, emulsions, and solutions.
摘要翻译：提供了筛选各种材料阵列的方法和装置。特别地，本发明提供了使用光学探针分子来测量这些材料的性质来询问有机材料，无机材料或聚合物在基底的预定区域上的技术。本发明涉及使用环境敏感探针，例如染料探针，以使得能够平行，快速和有效地表征重要的材料性质，包括玻璃化转变温度，极性，氢键和其他分子间相互作用。这些方法可以应用于结晶或无定形材料，聚合物或小分子材料，纯材料或混合物，以及本体，颗粒，薄膜，分散体，乳液和溶液中的材料。

38. 发明授权

US5196502A Method for the preparation of multiply-branched aromatic polyesters 失效
标题翻译：多支化芳族聚酯的制备方法
公开(公告)号：US5196502A
公开(公告)日：1993-03-23
申请号：US788070
申请日：1991-11-05
申请人： S. Richard Turner , Brigitte I. Voit , Ralph B. Nielsen
发明人： S. Richard Turner , Brigitte I. Voit , Ralph B. Nielsen
IPC分类号： C08G63/123 , C08G63/06 , C08G63/12 , C08G83/00
CPC分类号： C08G83/003 , C08G63/065 , Y10S424/16
摘要： An improved method for producing multiply-branched polyester comprising condensing a reactant having the general formula Z.sup.1 --Ar--(Z.sup.2).sub.j, wherein j is 2 or 3, Ar is an aryl or heteroaryl group having from 1 to 3, solitary or linked or fused, five or six membered rings, and one of Z.sup.1 and Z.sup.2 is a carboxyl group and the other is a group having the general formula ##STR1## wherein R is an alkyl group having from 1 to 3 carbon atoms, X is selected from the group consisting of fluoro and chloro and g is an integer from 0 to about 7.

39. 发明授权

US06976383B2 Apparatus for high temperature withdrawal or dispensing of fluids 有权
标题翻译：用于高温取出或分配流体的装置
公开(公告)号：US06976383B2
公开(公告)日：2005-12-20
申请号：US10403302
申请日：2003-03-31
申请人： Miroslav Petro , Adam Safir , Ralph B. Nielsen , G. Cameron Dales , Eric D. Carlson , Thomas S. Lee
发明人： Miroslav Petro , Adam Safir , Ralph B. Nielsen , G. Cameron Dales , Eric D. Carlson , Thomas S. Lee
IPC分类号： B01D15/08 , B01D15/26 , B01D15/32 , B01D15/34 , B01J19/00 , B01J19/26 , C40B40/14 , G01N1/00 , G01N15/02 , G01N30/02 , G01N30/16 , G01N30/24 , G01N30/30 , G01N30/32 , G01N30/46 , G01N30/54 , G01N30/60 , G01N30/88 , G01N33/44 , G01N35/02 , G01N35/08 , G01N35/10
CPC分类号： G01N35/1097 , B01D15/08 , B01D15/14 , B01D15/161 , B01D15/26 , B01D15/265 , B01D15/325 , B01D15/34 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00585 , B01J2219/00587 , B01J2219/00707 , B01J2219/00722 , C40B40/14 , G01N15/0205 , G01N30/02 , G01N30/16 , G01N30/24 , G01N30/30 , G01N30/461 , G01N30/466 , G01N30/54 , G01N30/6052 , G01N30/88 , G01N33/44 , G01N33/442 , G01N35/028 , G01N35/085 , G01N2015/0288 , G01N2015/0294 , G01N2030/324 , G01N2030/885 , Y10S210/13
摘要： Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
摘要翻译：公开了聚合物样品的快速表征和筛选以确定平均分子量，分子量分布和其它性质。优选采用快速流动表征系统和方法，包括液相色谱和流动注射分析系统和方法。还公开了高通量，自动采样系统和方法，高温表征系统和方法以及快速，间接校准组合物和方法。所描述的方法，系统和装置在组合聚合物研究和工业过程控制中具有主要应用。

40. 发明授权

US06787112B1 Parallel reactor with internal sensing and method of using same 有权
标题翻译：具有内部感测的并联电抗器及其使用方法
公开(公告)号：US06787112B1
公开(公告)日：2004-09-07
申请号：US09724275
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , William C. Rust
IPC分类号： B01J1900
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译：公开了用于控制和监测多个反应的进展和性质的装置和方法。该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。

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