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31. 发明申请

US20050245459A1 Method of utilizing physiological activity of rare saccharide and composition containing rare saccharide 有权
标题翻译：利用稀有糖类生物活性的方法和含有稀有糖类的组合物
公开(公告)号：US20050245459A1
公开(公告)日：2005-11-03
申请号：US10515018
申请日：2003-05-22
申请人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
发明人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
IPC分类号： A23L1/09 , A23L1/30 , A61K8/60 , A61K31/7004 , A61Q19/00 , C12N5/08 , A61K31/70 , A61K31/715
CPC分类号： A61Q19/00 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A61K8/60 , A61K31/7004
摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
摘要翻译：利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。细胞是人细胞。组合物是功能性食品，药物或化妆品。罕见的糖是属于醛糖和/或酮糖的稀有糖。醛糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。酮糖是D-psicose，细胞选自趋化因子分泌抑制活性敏感细胞，小胶质细胞迁移抑制活性敏感细胞和低血糖活性敏感细胞。

32. 发明授权

US6037153A L-ribose isomerase, its preparation and uses 失效
标题翻译： L-核糖异构酶，其制备和用途
公开(公告)号：US6037153A
公开(公告)日：2000-03-14
申请号：US122642
申请日：1998-07-27
申请人： Ken Izumori , Keiji Tsusaki
发明人： Ken Izumori , Keiji Tsusaki
IPC分类号： C12N1/21 , C12N9/90 , C12P19/02 , C12P19/24 , C12R1/01 , C12R1/02 , C07H3/02
CPC分类号： C12P19/24 , C12N9/90
摘要： An L-ribose isomerase which isomerizes aldoses such as L-ribose, D-lyxose, D-talose, D-mannose, L-allose and L-gulose into their corresponding ketoses such as L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose. The enzymatic reaction is a reversible equilibrium reaction. The L-ribose isomerase can be obtained from microorganisms of the genus Acinetobacter.
摘要翻译：将L-核糖异构酶如L-核糖，D-赖索糖，D-塔洛糖，D-甘露糖，L-阿洛糖和L-古洛糖异构化成它们相应的酮糖，例如L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝和L-山梨糖。酶反应是可逆平衡反应。 L-核糖异构酶可以从不动杆菌属的微生物获得。

33. 发明授权

US5846804A L-ribose isomerase, its preparation and uses 失效
公开(公告)号：US5846804A
公开(公告)日：1998-12-08
申请号：US856006
申请日：1997-05-14
申请人： Ken Izumori , Keiji Tsusaki
发明人： Ken Izumori , Keiji Tsusaki
IPC分类号： C12N1/21 , C12N9/90 , C12P19/02 , C12P19/24 , C12R1/01 , C12R1/02
CPC分类号： C12P19/24 , C12N9/90
摘要： An L-ribose isomerase which isomerizes aldoses such as L-ribose, D-lyxose, D-talose, D-mannose, L-allose and L-gulose into their corresponding ketoses such as L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose. The enzymatic reaction is a reversible equilibrium reaction. The L-ribose isomerase can be obtained from microorganisms of the genus Acinetobacter.

34. 发明授权

US5679562A D-ketohexose 3-epimerase, and its preparation 失效
标题翻译： D-酮己糖3-差向异构酶及其制备方法
公开(公告)号：US5679562A
公开(公告)日：1997-10-21
申请号：US413937
申请日：1995-03-30
申请人： Ken Izumori , Keiji Tsusaki
发明人： Ken Izumori , Keiji Tsusaki
IPC分类号： A23L27/30 , C12N9/90 , C12P19/02 , C12P19/24 , C12R1/38
CPC分类号： C12P19/24 , C12N9/90
摘要： D-ketohexose 3-epimerase, a novel epimerase, is obtained by cultivating bacteria of the genus Pseudomonas including Pseudomonas cichorii ST-24 (FERM BP-2736). D-Ketohexose 3-epimerase epimerizes D-ketohexose, D-ketopentose and L-ketopentose at their C-3 positions to form their corresponding epimeric counterparts in a high yield at a high conversion rate. Interconversion reaction using D-Ketohexose 3-epimerase yields mixture of intact ketose and its epimeric counterpart which can impart an appropriate sweetness, gloss and improve taste quality when used in foods, beverages, feeds, pet foods, dentifrice, cachou, sublingual agents and internal medicines.
摘要翻译：通过培养包括Pseudomonas cichorii ST-24（FERM BP-2736）在内的假单胞菌属的细菌获得D-酮基己糖3-差向异构酶，一种新的差向异构酶。 D-酮己糖3-差向异构酶在其C-3位置差向分解D-酮己糖，D-酮戊糖和L-酮戊糖，以高转化率以高产率形成其相应的差向异构体对应物。使用D-酮己糖3-差向异构酶的相互转化反应产生完整酮糖和其差向异构体对应物的混合物，当用于食品，饮料，饲料，宠物食品，洁齿剂，cachou，舌下剂和内部物质时，其可以赋予适当的甜度，光泽和改善味觉质量药物。

35. 发明授权

US08420606B2 Method of utilizing physiological activity of rare saccharide and composition containing rare saccharide 有权
标题翻译：利用稀有糖类生物活性的方法和含有稀有糖类的组合物
公开(公告)号：US08420606B2
公开(公告)日：2013-04-16
申请号：US13007058
申请日：2011-01-14
申请人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad A. Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
发明人： Ken Izumori , Masaaki Tokuda , Toshifumi Itano , Osamu Miyamoto , Toshihiko Ishida , Koji Murao , Taizo Tasaka , Gan Muneuchi , Fuminori Yamaguchi , Terukazu Tanaka , Masaaki Ueki , Kazuyuki Hirooka , Tomohiko Taminato , Mohammad A. Hossain , Keiji Tsusaki , Takeo Takahashi , Mitsuhiro Nagata , Yutaka Ishida
IPC分类号： A61K31/7004 , A61K31/70
CPC分类号： A61Q19/00 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A61K8/60 , A61K31/7004
摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
摘要翻译：利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。细胞是人细胞。组合物是功能性食品，药物或化妆品。罕见的糖是属于醛糖和/或酮糖的稀有糖。醛糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。酮糖是D-psicose，细胞选自趋化因子分泌抑制活性敏感细胞，小胶质细胞迁移抑制活性敏感细胞和低血糖活性敏感细胞。

36. 发明申请

US20100167350A1 MICROORGANISM WITH ABILITY TO PRODUCE DEOXY POLYOL DEHYDROGENASE AND USE THEREOF 有权
标题翻译：具有生产脱氧多糖脱氢酶能力的微生物及其用途
公开(公告)号：US20100167350A1
公开(公告)日：2010-07-01
申请号：US12515602
申请日：2007-03-27
申请人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C12P19/00 , C07H3/08 , C12N1/20
CPC分类号： C12R1/01 , A61K8/60 , A61K2800/86 , A61Q19/00 , C12N9/0006 , C12P19/02
摘要： Problem: To provide a microorganism with an ability to produce deoxy polyol dehydrogenase.Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for producing deoxy ketose comprising allowing a culture containing the deoxy polyol dehydrogenase obtained by the culturing of the microorganism of the invention or allowing the deoxy polyol dehydrogenase to react with a solution containing deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol to oxidize deoxy polyol to produce the corresponding deoxy ketose and then collecting the deoxy ketose. The deoxy polyol is 1-deoxy-D-allitol, while the corresponding deoxy ketose is 1-deoxy-L-psicose. Otherwise, the deoxy polyol is L-rhamnitol, while the corresponding deoxy ketose is 1-deoxy-L-fructose.
摘要翻译：问题：提供具有生产脱氧多元醇脱氢酶能力的微生物。解决方法：属于肠杆菌属的微生物，其在位置C2和C3处产生与核糖醇或L-阿托糖醇相同结构的脱氧多羟基化脱氢酶的能力。肠杆菌属细菌细胞IK7（登录号NITE P-271）。一种生产脱氧酮糖酮的方法，包括使含有通过培养本发明的微生物获得的脱氧多元醇脱氢酶的培养物或使脱氧多元醇脱氢酶与位置C2和C3处于相同结构的含有脱氧多羟基化合物的溶液反应，作为核糖醇或L-天冬氨酸氧化脱氧多元醇以产生相应的脱氧酮糖，然后收集脱氧酮糖酮。脱氧多元醇是1-脱氧-D-多糖，而相应的脱氧酮基是1-脱氧-L-精氨酸。否则，脱氧多元醇为L-麦芽糖醇，而相应的脱氧酮糖为1-脱氧-L-果糖。

37. 发明申请

US20100105885A1 DEOXYKETOHEXOSE ISOMERASE AND METHOD FOR PRODUCING DEOXYHEXOSE AND DERIVATIVE THEREOF USING SAME 有权
标题翻译：脱乙酰壳多糖异构体及其制造方法及其衍生物
公开(公告)号：US20100105885A1
公开(公告)日：2010-04-29
申请号：US12515605
申请日：2007-11-20
申请人： Ken Izumori , Masaaki Tokuda , George Fleet , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Masaaki Tokuda , George Fleet , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C07H3/02 , C12N9/90 , C12P19/24
CPC分类号： C07H3/02 , C12N9/92 , C12P19/24
摘要： Providing 1- or 6-deoxy products corresponding to all of aldohexoses, ketohexoses and sugar alcohols, as based on Deoxy-Izumoring, as well as a method for systematically producing those products. A method for producing deoxyketohexose and a derivative thereof using a deoxyketohexose isomerase derived from Pseudomonas cichorii ST-24 (FERM BP-2736), comprising epimerizing 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose at position 3 to produce the individually corresponding 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose as an intended product.
摘要翻译：提供对应于所有醛脱水己酮糖，酮己立糖和糖醇的1-脱氧产物或6-脱氧产物，以脱氧消肿为基础，以及一种系统地生产这些产品的方法。使用衍生自奇异假单胞菌ST-24（FERM BP-2736）的脱氧己糖异构酶生产脱氧己糖及其衍生物的方法，其包括将1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或 6-脱氧L-酮基己糖，以产生单独相应的1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或6-脱氧L-酮己糖作为目标产物。

38. 发明授权

US06294369B1 L-ribose isomerase, its preparation and uses 有权
标题翻译： L-核糖异构酶，其制备和用途
公开(公告)号：US06294369B1
公开(公告)日：2001-09-25
申请号：US09524014
申请日：2000-05-31
申请人： Ken Izumori , Keiji Tsusaki
发明人： Ken Izumori , Keiji Tsusaki
IPC分类号： C12N990
CPC分类号： C12P19/24 , C12N9/90
摘要： An L-ribose isomerase which isomerizes aldoses such as L-ribose, D-lyxose, D-talose, D-mannose, L-allose and L-gulose into their corresponding ketoses such as L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose. The enzymatic reaction is a reversible equilibrium reaction. The L-ribose isomerase can be obtained from microorganisms of the genus Acinetobacter.
摘要翻译：将L-核糖异构酶如L-核糖，D-赖索糖，D-塔洛糖，D-甘露糖，L-阿洛糖和L-古洛糖异构化成它们相应的酮糖，例如L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝和L-山梨糖。酶反应是可逆平衡反应。 L-核糖异构酶可以从不动杆菌属的微生物获得。

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