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31. 发明申请

US20060088193A1 Method and system for generating a combined retina/iris pattern biometric 有权
标题翻译：用于生成组合视网膜/虹膜图案生物识别的方法和系统
公开(公告)号：US20060088193A1
公开(公告)日：2006-04-27
申请号：US11087205
申请日：2005-03-23
申请人： David Muller , Gregory Heacock , David Usher
发明人： David Muller , Gregory Heacock , David Usher
IPC分类号： G06K9/00
CPC分类号： G06K9/00597
摘要： A method and system generates correlated biometric information by capturing an image of a retinal vessel pattern and simultaneously capturing an image of an iris minutia pattern. Retinal biometric data and iris biometric data are generated from the images. The retinal biometric data and the iris biometric data are then combined or linked to maintain the correlation between the two biometrics.
摘要翻译：方法和系统通过捕获视网膜血管图案的图像并同时捕获虹膜细节图案的图像来生成相关生物信息。从图像生成视网膜生物特征数据和虹膜生物特征数据。然后组合或连接视网膜生物特征数据和虹膜生物特征数据以维持两个生物特征之间的相关性。

32. 发明申请

US20070092115A1 Method and system for detecting biometric liveness 审中-公开
标题翻译：检测生物识别活性的方法和系统
公开(公告)号：US20070092115A1
公开(公告)日：2007-04-26
申请号：US11258749
申请日：2005-10-26
申请人： David Usher , John Marshall , David Muller , Gregory Heacock
发明人： David Usher , John Marshall , David Muller , Gregory Heacock
IPC分类号： G06K9/00
CPC分类号： G06K9/00597 , G06K9/00906
摘要： A method and system captures a sequence of images of a biometric wherein the images include a common reference. The system aligns the images represented by the image data with respect to the common reference. Thereafter, the system analyzes an attribute of the biometric represented in the sequence of images to determine whether the attribute changes in the sequence of images in accordance with a living source.
摘要翻译：方法和系统捕获生物特征图像序列，其中图像包括公共参考。系统将由图像数据表示的图像相对于公共参考对齐。此后，系统分析在图像序列中表示的生物特征的属性，以确定属性是否根据生物来源改变图像序列。

33. 发明申请

US20210046111A1 EYE TREATMENTS EMPLOYING SERUM FROM WHOLE BLOOD 有权
公开(公告)号：US20210046111A1
公开(公告)日：2021-02-18
申请号：US17086454
申请日：2020-11-01
申请人： David Muller
发明人： David Muller
IPC分类号： A61K35/16 , A61K9/00 , A61K38/13
摘要： Eye drops for treating dry eye include serum extracted from whole blood. An example method includes collecting whole blood from one or more donors (e.g., allogenic whole blood); separating the whole blood to obtain a serum; applying radiation to the serum for viral inactivation; and adding one or more additives to the serum to produce eye drops.

34. 发明申请

US20160325499A1 SYSTEMS AND METHODS FOR PRODUCING AND APPLYING TISSUE-RELATED STRUCTURES 审中-公开
标题翻译：用于生产和应用组织相关结构的系统和方法
公开(公告)号：US20160325499A1
公开(公告)日：2016-11-10
申请号：US15109731
申请日：2015-01-05
申请人： David Muller
发明人： David Muller
IPC分类号： B29C67/00 , A61L27/38 , A61F2/14 , A61L27/36
CPC分类号： A61L27/3641 , A61F2/142 , A61F9/013 , A61F2240/002 , A61L27/3804 , A61L2430/16 , B29C64/112 , B29C64/20 , B29C64/386 , B29K2071/02 , B29K2105/0058 , B29K2105/24 , B29K2995/0056 , B29L2031/7532
摘要： Embodiments produce and apply tissue-related structures in connection with various medical treatments. Such structures can be applied, as grafts, implants, scaffolds, etc., to replace, modify, or engineer tissue in the body. For example, such structures can be employed to reshape the cornea in order to correct vision. One example includes a tissue cell source including tissue cells in a fluid and a printer configured to deposit the tissue cells in a three-dimensional arrangement to form a tissue cell-based structure. Another example includes a source including a photoreactive liquid precursor, an application system configured to deposit the photoreactive liquid precursor in one or more applications to form a three-dimensional polymer-based structure, and an illumination system configured to deliver light to the photoreactive liquid precursor deposited by the application system and to solidify the photoreactive liquid precursor into the three-dimensional polymer-based structure.
摘要翻译：实施例生产并应用与各种医疗治疗有关的组织相关结构。这样的结构可以作为移植物，植入物，支架等应用来代替，改变或设计身体中的组织。例如，可以使用这种结构来重塑角膜以矫正视力。一个实例包括包括流体中的组织细胞的组织细胞源和被配置为以三维排列沉积组织细胞以形成基于组织细胞的结构的打印机。另一个实例包括源包括光反应性液体前体，配置成在一个或多个应用中沉积光反应性液体前体以形成基于三维聚合物的结构的施加系统，以及被配置为将光传递到光反应性液体前体的照明系统通过应用系统沉积并将光反应性液体前体固化成基于三维聚合物的结构。

35. 发明授权

US08668727B2 Systems and methods for treating pathogenic infection 有权
标题翻译：用于治疗病原性感染的系统和方法
公开(公告)号：US08668727B2
公开(公告)日：2014-03-11
申请号：US13592883
申请日：2012-08-23
申请人： Anthony Natale , David Muller
发明人： Anthony Natale , David Muller
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61N5/0603 , A61N5/0624 , A61N2005/063 , A61N2005/0661
摘要： An internal anatomic target that is infected by pathogenic microorganisms is treated using an applicator configured for delivering a therapeutic solution thereto and an UV light-emitting device transmits UV light thereon.
摘要翻译：用致病微生物感染的内部解剖靶标，使用配置用于将治疗溶液输送到其上的施用器进行处理，并且UV发光装置在其上透射UV光。

36. 发明授权

US08460278B2 Eye therapy system 失效
标题翻译：眼科治疗系统
公开(公告)号：US08460278B2
公开(公告)日：2013-06-11
申请号：US12572019
申请日：2009-10-01
申请人： David Muller
发明人： David Muller
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B2018/00005 , A61B2018/00755 , A61B2018/00875 , A61F9/0079 , A61F9/013
摘要： A system includes a conducting element that conducts energy from an energy source to apply therapy to an eye. The system includes a covering configured to be removably attached to the conducting element. The covering has an interface surface that is positionable at an eye. At least a portion of the interface surface includes one or more dielectric materials. Energy is deliverable to the eye through the interface surface. In one aspect, the covering provides an electrical insulator to minimize the concentration of electrical current in the area of contact with the eye. In another aspect, the covering allows the eye to be cooled during the application of energy without directly applying coolant to the eye. In another aspect, the covering includes a dielectric layer that may provide varying impedances that allow different patterns for energy delivery. In another aspect, the sheath promotes hygienic use of the conducting element.
摘要翻译：一种系统包括从能量源传导能量以将治疗应用于眼睛的导电元件。该系统包括构造成可移除地附接到导电元件的覆盖物。覆盖物具有可在眼睛处定位的界面。界面表面的至少一部分包括一种或多种介电材料。能量通过界面可传递给眼睛。在一个方面，覆盖物提供电绝缘体以最小化与眼睛接触的区域中的电流的浓度。另一方面，覆盖物允许眼睛在施加能量期间被冷却，而不直接将冷却剂施加到眼睛。在另一方面，覆盖物包括可提供允许不同图案用于能量输送的变化阻抗的介电层。另一方面，护套促进卫生使用导电元件。

37. 发明申请

US20090275936A1 SYSTEM AND METHOD FOR APPLYING THERAPY TO AN EYE USING ENERGY CONDUCTION 审中-公开
标题翻译：使用能量诱导将眼部应用于眼睛的系统和方法
公开(公告)号：US20090275936A1
公开(公告)日：2009-11-05
申请号：US12113672
申请日：2008-05-01
申请人： David Muller
发明人： David Muller
IPC分类号： A61F9/007 , A61B18/18
CPC分类号： A61F9/00 , A61B18/18 , A61B18/1815 , A61F9/0079 , A61F9/013
摘要： Thermokeratoplasty is applied to achieve a customized reshaping of a cornea, especially, for the treatment of astigmatism. Energy is applied to the cornea in a customized pattern using a specific configuration of two conductors. In one embodiment, an outer conductor and an outer conductor are separated by a gap. When a conducting element is applied to the corneal surface the area of the cornea at the periphery of the inner conductor is subject to an energy pattern with substantially the same shape and dimension as the gap between the inner and outer conductors. The inner and outer conductors may be positioned and shaped to form a gap having any desirable size and/or shape, including non-annular and asymmetrical shapes. The gap may be configured by altering the spatial relationships between the inner conductor and the outer conductor, by altering the size, shape, and/or position of the inner and/or outer conductors, or by forming one or more indentations or protrusions in or on the inner conductor and/or the outer conductor. Additionally or alternatively, energy is applied to the cornea in a customized pattern defined by a specific arrangement of one or more dielectric materials providing varying impedance.
摘要翻译： Thermokeratoplasty应用于实现角膜的定制重塑，特别是用于治疗散光。使用两个导体的特定配置，以定制的模式将角能量施加到角膜。在一个实施例中，外部导体和外部导体被间隙隔开。当将导电元件施加到角膜表面时，内导体周围的角膜的区域经受与内导体和外导体之间的间隙基本相同的形状和尺寸的能量图案。内导体和外导体可以定位和成形以形成具有任何期望的尺寸和/或形状的间隙，包括非环形和非对称形状。可以通过改变内导体和/或外导体的尺寸，形状和/或位置，或者通过在内导体和/或外导体中形成一个或多个凹陷或突起来改变内导体和外导体之间的空间关系来构造间隙在内部导体和/或外部导体上。附加地或替代地，以由提供变化的阻抗的一个或多个介电材料的特定布置限定的定制图案将能量施加到角膜。

38. 发明授权

US10449090B2 Corneal implant systems and methods 有权
公开(公告)号：US10449090B2
公开(公告)日：2019-10-22
申请号：US15055614
申请日：2016-02-28
申请人： David Muller
发明人： David Muller
IPC分类号： A61F9/008 , B23K26/00 , B23K26/361 , B23K26/12 , B23K26/38 , B23K26/402 , A61F2/14 , B23K103/00
摘要： A system for forming a corneal implant includes a cutting apparatus, which includes a laser source that emits a laser and optical elements that direct the laser. The system includes a controller implemented with at least one processor and at least one data storage device. The controller generates a sculpting plan for modifying a first shape of a lenticule formed from corneal tissue and achieving a second shape for the lenticule to produce a corneal implant with a refractive profile to reshape a recipient eye. The sculpting plan is determined from measurements relating to the lenticule having the first shape and information relating to a refractive profile for a corneal implant. The controller controls the cutting apparatus to direct, via the one or more optical elements, the laser from the laser source to sculpt the lenticule according to the sculpting plan to produce the corneal implant with the refractive profile.

39. 发明授权

US09044308B2 Systems and methods for reshaping an eye feature 有权
标题翻译：重塑眼睛特征的系统和方法
公开(公告)号：US09044308B2
公开(公告)日：2015-06-02
申请号：US13480127
申请日：2012-05-24
申请人： David Muller , Vance Thompson
发明人： David Muller , Vance Thompson
IPC分类号： A61B18/18 , A61F9/013 , A61F9/008
CPC分类号： A61F9/013 , A61F9/00804 , A61F9/00836 , A61F2009/00853 , A61F2009/00872
摘要： Systems and methods include a cutting instrument that creates incisions in selected areas of the cornea; an eye therapy system that applies reshaping forces to the cornea; and a controller that determines the selected areas of the cornea for the incisions and the reshaping forces from the eye therapy system, such that the reshaping forces and the incisions combine to achieve corrective reshaping of the cornea. Other systems and methods include measuring an eye to determine a required amount of reshaping of a cornea; determining one or more doses of cross-linking agent and one or more corresponding doses of photoactivating light according to the required amount of reshaping; applying the cross-linking agent to the cornea; and delivering, from a light source, the photoactivating light to the area of the eye, the photoactivating light combining with the cross-linking agent to induce the corrective reshaping of the cornea.
摘要翻译：系统和方法包括在角膜的选定区域中产生切口的切割工具; 一种将矫正力应用于角膜的眼科治疗系统; 以及控制器，其确定角膜的选择区域用于切口和来自眼部治疗系统的重塑力，使得重塑力和切口结合以实现角膜的矫正重塑。其他系统和方法包括测量眼睛以确定角膜重塑的所需量; 根据所需的重塑量确定一种或多种剂量的交联剂和一种或多种相应剂量的光活化光; 将交联剂施用于角膜; 以及从光源将光活化光输送到眼睛的区域，所述光活化光与交联剂结合以引起角膜的矫正重塑。

40. 发明授权

US08409189B2 System and method for reshaping an eye feature 失效
标题翻译：用于重塑眼睛特征的系统和方法
公开(公告)号：US08409189B2
公开(公告)日：2013-04-02
申请号：US12018457
申请日：2008-01-23
申请人： David Muller
发明人： David Muller
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B18/18 , A61B18/1815 , A61B2018/00017 , A61B2018/00035 , A61B2090/065 , A61F9/0079 , A61F9/009 , A61F9/013 , A61F2009/00853 , A61F2009/00872
摘要： A system for applying therapy to an eye includes an applicator having a conducting element configured to direct energy from an energy source to an application end of the conducting element, where the application end has an eye contact portion. A positioning system receives the applicator and positions the eye contact portion in stable engagement with the surface of an eye. In some embodiments, the conducting element is disposed within a housing for the applicator and an adjustment system is employed to move the conducting element relative to the housing. The adjustment system enables controlled movement of the conducting element and the eye contact portion against the corneal surface. In particular embodiments, sufficient contact between the applicator and the cornea is determined by causing applanation of the cornea. In other embodiments, a physical measurement device, such as a strain gauge, is employed to determine when sufficient contact has been established.
摘要翻译：用于对眼睛施加治疗的系统包括具有导电元件的施加器，该导电元件被配置为将能量从能量源引导到导电元件的施加端，其中施加端具有眼睛接触部分。定位系统接收施加器并将眼睛接触部分定位成与眼睛的表面稳定接合。在一些实施例中，导电元件设置在用于施用器的壳体内，并且使用调节系统相对于壳体移动导电元件。调节系统使得导电元件和眼睛接触部分能够相对于角膜表面受控地运动。在特定实施例中，施加器和角膜之间的充分接触是通过引起角膜的扁平化来确定的。在其它实施例中，使用诸如应变计的物理测量装置来确定何时建立了足够的接触。

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