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31. 发明申请

US20050191361A1 Hydrogel particle formation 审中-公开
标题翻译：水凝胶颗粒形成
公开(公告)号：US20050191361A1
公开(公告)日：2005-09-01
申请号：US11102705
申请日：2005-04-11
申请人： Barbara O'Connor , Terry Burkoth , Steven Prestrelski , Yuh-Fun Maa , Andrew Muddle , Roderick Hafner
发明人： Barbara O'Connor , Terry Burkoth , Steven Prestrelski , Yuh-Fun Maa , Andrew Muddle , Roderick Hafner
IPC分类号： A61K9/00 , A61K9/16 , A61K9/19 , C12N15/89 , A61K48/00 , A61K9/14
CPC分类号： A61K9/19 , A61K9/0021 , A61K9/006 , A61K9/1652 , C12N15/895
摘要： New compositions formed from the combination of an active substance with a hydrogel carrier moiety are provided. The compositions are suitable for use in high-velocity transdermal particle injection techniques. Methods of providing the new compositions are also provided. In addition, methods for administering pharmacologically active agent to a subject are provided. These methods are useful for delivering drugs, biopharmaceuticals, vaccines and diagnostics agents.
摘要翻译：提供了由活性物质与水凝胶载体部分的组合形成的新组合物。该组合物适用于高速透皮颗粒注射技术。还提供了提供新组合物的方法。此外，提供了向受试者施用药理活性剂的方法。这些方法可用于递送药物，生物制药，疫苗和诊断试剂。

32. 发明申请

US20080038356A1 Spray freeze-dried compositions 审中-公开
标题翻译：喷雾冷冻干燥组合物
公开(公告)号：US20080038356A1
公开(公告)日：2008-02-14
申请号：US11797089
申请日：2007-04-30
申请人： Yuh-Fun Maa , Steven Prestrelski , Terry Burkoth
发明人： Yuh-Fun Maa , Steven Prestrelski , Terry Burkoth
IPC分类号： A61K9/14 , A61K39/00 , A61K39/02 , A61K39/12
CPC分类号： A61K9/1694 , A61K9/0021 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K39/00
摘要： A process for producing a powder comprises spray freeze-drying an aqueous solution or suspension comprising a pharmaceutical agent, said solution or suspension having a solids content of 20% by weight or more. The spray freeze-dried powder may be administered to a subject via a needleless syringe.
摘要翻译：制备粉末的方法包括将包含药剂，所述溶液或悬浮液的固体含量为20重量％以上的水溶液或悬浮液喷雾冷冻干燥。可以通过无针注射器将喷雾冷冻干燥的粉末施用于受试者。

33. 发明申请

US20060280644A1 Method for terminal sterilization of transdermal delivery devices 审中-公开
标题翻译：透皮给药装置终末灭菌方法
公开(公告)号：US20060280644A1
公开(公告)日：2006-12-14
申请号：US11446530
申请日：2006-06-01
申请人： Scott Sellers , Yuh-Fun Maa
发明人： Scott Sellers , Yuh-Fun Maa
IPC分类号： A61L2/00
CPC分类号： A61K9/0021 , A61K41/0019 , A61L2/081 , A61L2/087 , A61L2/206 , A61M37/00 , A61M37/0015 , A61M2037/0046 , A61M2037/0061
摘要： A method and system for providing a terminally sterilized transdermal influenza vaccine delivery device. A microprojection member having a plurality of stratum corneum-piercing microprojections is coated with an influenza vaccine-formulation and exposed to sufficient radiation to sterilize the microprojection member while retaining sufficient potency of the influenza vaccine. Preferably, the microprojection member is sealed in packaging, such as a foil pouch. Also preferably, a retainer ring and adhesive are included within the packaging. The sterilizing radiation can be gamma radiation or e-beam, preferably delivered in a dose in the range of approximately 7-21 kGy. Also preferably, the irradiation is performed from −78.5-25° C. In preferred embodiments, the radiation is delivered at a rate greater than 3.0 kGy/hr.
摘要翻译：一种用于提供终末灭菌的经皮流感疫苗递送装置的方法和系统。具有多个角质层穿孔微突出物的微突出物构件涂覆有流感疫苗制剂并且暴露于足够的辐射以在保持足够的流感疫苗的效力的同时对微突出物构件进行灭菌。优选地，微喷射构件被密封在包装中，例如箔袋。还优选地，保持环和粘合剂包括在包装内。灭菌辐射可以是γ辐射或电子束，优选以约7-21kGy的剂量递送。还优选地，照射从-78.5-25℃进行。在优选的实施方案中，以大于3.0kGy / hr的速率递送辐射。

34. 发明申请

US20050220854A1 Apparatus and method for transdermal delivery of influenza vaccine 审中-公开
标题翻译：用于流感疫苗透皮递送的装置和方法
公开(公告)号：US20050220854A1
公开(公告)日：2005-10-06
申请号：US11084631
申请日：2005-03-18
申请人： Yuh-Fun Maa , Scott Sellers , James Matriano , Asha Ramdas
发明人： Yuh-Fun Maa , Scott Sellers , James Matriano , Asha Ramdas
IPC分类号： A61K9/19 , A61K9/70 , A61K39/02 , A61K39/12 , A61K39/145 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/26 , A61M31/00 , A61M37/00 , C12Q1/70
CPC分类号： A61K39/12 , A61K9/0021 , A61K9/19 , A61K39/145 , A61K47/10 , A61K47/186 , A61K47/20 , A61K47/26 , A61K2039/54 , A61K2039/545 , A61K2039/55511 , A61K2039/55583 , A61K2039/70 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： An apparatus and method for transdermally delivering an immunologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers, the microprojection member having a biocompatible coating disposed thereon that includes the immunologically active agent. Preferably, the biocompatible coating is formed from a vaccine coating formulation.
摘要翻译：一种用于透皮递送免疫活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括适于穿透角质层进入下面的表皮层的多个微突出物（或阵列），或表皮和真皮层，所述微突出物构件具有设置在其上的包含免疫活性剂的生物相容性涂层。优选地，生物相容性涂层由疫苗涂层制剂形成。

35. 发明授权

US06737101B2 Particle formation 失效
标题翻译：颗粒形成
公开(公告)号：US06737101B2
公开(公告)日：2004-05-18
申请号：US10397329
申请日：2003-03-27
申请人： Yuh-Fun Maa
发明人： Yuh-Fun Maa
IPC分类号： B01J1300
CPC分类号： A61K9/1676 , A61K9/0021
摘要： Spray-coated pharmaceutical powder compositions for transdermal administration using a needleless syringe comprise seed particles coated with a pharmaceutical composition, the said coated seed particles having an average size of about 10 to 100 &mgr;m and having an envelope density ranging from about 0.1 to about 25 g/cm3.
摘要翻译：使用无针注射器进行透皮给药的喷涂药物粉末组合物包括用药物组合物涂覆的种子颗粒，所述涂覆的种子颗粒具有约10至100μm的平均尺寸并且具有约0.1至约25g的包络密度 / cm 3。

36. 发明授权

US06613360B1 Particle formation 失效
标题翻译：颗粒形成
公开(公告)号：US06613360B1
公开(公告)日：2003-09-02
申请号：US09410692
申请日：1999-10-01
申请人： Yuh-Fun Maa
发明人： Yuh-Fun Maa
IPC分类号： A61K916
CPC分类号： A61K9/1676 , A61K9/0021
摘要： Spray-coated pharmaceutical powder compositions for transdermal administration using a needleless syringe comprise seed particles coated with a pharmaceutical composition, the said coated seed particles having an average size of about 10 to 100 &mgr;m and having an envelope density ranging from about 0.1 to about 25 g/cm3.
摘要翻译：使用无针注射器进行透皮给药的喷涂药物粉末组合物包括用药物组合物涂覆的种子颗粒，所述涂覆的种子颗粒具有约10至100μm的平均尺寸并且具有约0.1至约25g的包络密度 / cm 3。

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