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31. 发明授权

US06945638B2 Method and system for controlling the temperature of a dispensed liquid 有权
标题翻译：用于控制分配液体的温度的方法和系统
公开(公告)号：US06945638B2
公开(公告)日：2005-09-20
申请号：US10284425
申请日：2002-10-29
申请人： Patrick Teung , Michael J. Cima , Timothy J. Pryor , Peter A. Materna
发明人： Patrick Teung , Michael J. Cima , Timothy J. Pryor , Peter A. Materna
IPC分类号： B01L3/02 , B41J2/02 , B41J2/05 , B41J29/377 , G05D23/19 , B41J2/07
CPC分类号： B01L3/0268 , B01L3/0265 , B01L2200/147 , B01L2300/1805 , B01L2300/1827 , B01L2400/0439 , B01L2400/0487 , B01L2400/0633 , B33Y40/00 , B41J2/02 , B41J2/04528 , B41J2/04563 , B41J29/377 , B41J2002/022 , G05D23/1919
摘要： A device for controlling or altering the temperature of a liquid at the point of dispensing. A temperature-altering device is thermally coupled to a dispensing device to compensate for heat dissipated into the liquid as it passes through the dispensing device during dispensing. The dispensing device may be for example, a miniature solenoid valve (microvalve), a piezoelectric printhead, or the like. According to aspects of the invention, a temperature-altering device provides or reduces heat at the point of dispensing in order to alter, control or maintain a constant temperature of the dispensed liquid. As a result, improvement is obtained in the consistency of the fluid regime of the dispensed droplet stream. The temperature-altering device may be a thermoelectric device capable of moving heat either from or to the dispensing structure, or may be a heater. This device may be used beneficially even when the dispensing is performed near room temperature and the liquid does not require heating to maintain its liquid state.
摘要翻译：用于在分配点控制或改变液体的温度的装置。温度改变装置热耦合到分配装置以补偿在分配期间通过分配装置时散失到液体中的热量。分配装置可以是例如微型电磁阀（微型阀），压电打印头等。根据本发明的方面，改变温度的装置在分配点处提供或减少热量，以便改变，控制或维持所分配液体的恒定温度。结果，在分配的液滴流的流体状态的一致性方面获得了改进。温度改变装置可以是能够从分配结构移动热量的热电装置，也可以是加热器。即使当在室温附近进行分配并且液体不需要加热以保持其液体状态时，该装置也可以有利地使用。

32. 发明授权

US06629559B2 Molds for casting with customized internal structure to collapse upon cooling and to facilitate control of heat transfer 有权
标题翻译：用于具有定制内部结构的铸造模具在冷却时塌陷并且便于控制热传递
公开(公告)号：US06629559B2
公开(公告)日：2003-10-07
申请号：US10131001
申请日：2002-04-24
申请人： Emanuel M. Sachs , Won B. Bang , Michael J. Cima
发明人： Emanuel M. Sachs , Won B. Bang , Michael J. Cima
IPC分类号： B22C902
CPC分类号： B22C9/00 , B22C9/04 , B33Y80/00
摘要： A new mold solves problems that arise from differential changes in geometry inherent to casting metal in a ceramic mold, by control of the internal morphology between the surfaces of the mold that face the casting, and that face the external environment. Layered fabrication techniques are used to create a ceramic mold. For example, an internal geometry composed of a cellular arrangement of voids may be created within the mold wall. Structures may be designed and fabricated so that the ceramic mold fails at an appropriate time during the solidification and/or cooling of the casting. Thus, the casting itself is not damaged. The mold fails to avoid rupture, or even distortion, of the casting. A thin shell of ceramic defines the casting cavity. This shell must be thin enough to fail due to the stresses induced (primarily compressive) by the metal next to it and partly adherent to it. A support structure is provided with a morphology that supports the thin shell that defines the casting geometry, yet that also fails as the casting solidifies and/or cools. Typically, the support structure is a skeletal network with voids therebetween. The skeletal elements may be struts, or sheets or both. At least the following two failure mechanisms may be exploited in the design of the support structure: bending in the structure; and under compressive loads, either by buckling of a support member or, breakage under compressive loading. The failure of the support structure may also be due to a combination of bending and compression.
摘要翻译：一种新的模具解决了陶瓷模具中铸造金属固有几何差异变化的问题，通过控制模具表面之间的内部形态以及面对外部环境的内部形态。使用分层制造技术来制造陶瓷模具。例如，可以在模具壁内形成由空隙的细胞布置构成的内部几何形状。可以设计和制造结构，使得陶瓷模具在铸件的凝固和/或冷却期间在适当的时间失效。因此，铸件本身不会损坏。模具不能避免铸件的破裂或甚至变形。陶瓷的薄壳体限定铸造腔体。这种外壳必须足够薄以致由于紧邻其上的金属（部分粘附在其上）的应力引起（主要是压缩）的应力而失效。支撑结构具有支撑限定铸造几何形状的薄壳的形态，但是当铸件固化和/或冷却时也会失效。通常，支撑结构是其间具有空隙的骨架网络。骨架元件可以是支柱或片材或两者。至少在支撑结构的设计中可以利用以下两种故障机构：在结构中弯曲; 并且在压缩载荷下，通过支撑构件的弯曲或在压缩载荷下断裂。支撑结构的故障也可能是由于弯曲和压缩的组合。

33. 发明授权

US06527762B1 Thermally-activated microchip chemical delivery devices 有权
标题翻译：热敏微芯片化学输送装置
公开(公告)号：US06527762B1
公开(公告)日：2003-03-04
申请号：US09638109
申请日：2000-08-11
申请人： John T. Santini, Jr. , Michael J. Cima , Scott Albert Uhland
发明人： John T. Santini, Jr. , Michael J. Cima , Scott Albert Uhland
IPC分类号： A61K911
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , B01L2300/0819 , B01L2400/0677
摘要： Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress. In another preferred embodiment, application of an electric current to a resistor located on or near the reservoir cap causes the cap to expand, contract, or undergo a phase change that results in the rupture of the reservoir cap. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.
摘要翻译：提供Microchip输送装置，其控制释放分子的速率和时间，其中所述装置包括底物，所述基质中含有所述分子的至少一个储存器和位于所述分子上的所述储存器上的储存器盖，其中所述分子在加热或冷却装置或其一部分足以破坏储存器盖时从储存器释放。在优选实施例中，该装置包括集成在储存器中或安装在储存器附近的电阻器，当施加电流通过电阻器时，储存器的至少一个内容物热膨胀，蒸发，相变，或经历热驱动反应，使得储存器盖由于机械应力而破裂。在另一个优选实施例中，将电流施加到位于储存器盖上或附近的电阻器使得盖膨胀，收缩或经历相变，导致储存器盖的破裂。储层可以含有多种药物或其他可变剂量的分子。单个微芯片的每个储存器可以包含不同的分子和/或不同的量和浓度，其可以独立释放。

34. 发明授权

US06491666B1 Microfabricated devices for the delivery of molecules into a carrier fluid 有权
标题翻译：用于将分子输送到载体流体中的微型装置
公开(公告)号：US06491666B1
公开(公告)日：2002-12-10
申请号：US09715493
申请日：2000-11-17
申请人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61M500
CPC分类号： A61K9/0097 , A23L2/52 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61K9/0009 , A61L31/14 , A61L31/16 , A61L2300/416 , A61M5/1407 , A61M15/0031 , A61M15/0045 , A61M15/005 , A61M15/008 , A61M15/0083 , A61M15/009 , A61M2205/8225
摘要： Apparati and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparati include microchip devices which have reservoirs containing the molecules for release. The apparati and methods provide for active or passive controlled release of the molecules. Preferred embodiments include systems for intravenous administration of drugs, wherein drug molecules are released from the microchip devices into a carrier fluid ex vivo, such as a saline solution, forming a drug/saline solution mixture which is then delivered to a patient intravenously.
摘要翻译：提供了通过载体流体将分子递送到部位的方法和方法。该装置包括具有含有释放分子的储存器的微芯片装置。该设备和方法提供分子的主动或被动控制释放。优选的实施方案包括用于静脉内施用药物的系统，其中药物分子从微芯片装置释放到离体的载体液体中，例如盐水溶液，形成药物/盐溶液混合物，然后静脉内递送给患者。

35. 发明授权

US5340656A Three-dimensional printing techniques 失效
标题翻译：三维打印技术
公开(公告)号：US5340656A
公开(公告)日：1994-08-23
申请号：US45632
申请日：1993-04-09
申请人： Emanuel M. Sachs , John S. Haggerty , Michael J. Cima , Paul A. Williams
发明人： Emanuel M. Sachs , John S. Haggerty , Michael J. Cima , Paul A. Williams
IPC分类号： B22F7/04 , B05C19/04 , B22F3/00 , B28B1/32 , B28B7/00 , B29C41/00 , B29C41/12 , B29C41/36 , B29C67/00 , B29C67/02 , B29C67/04 , B29C67/24 , B30B15/30 , B32B27/00 , B41J2/01 , B41J2/085 , B41J2/09 , B65G65/48 , G06T11/00 , H05K3/10 , B22F7/02
CPC分类号： B29C67/0081 , B05C19/04 , B22F3/004 , B22F3/008 , B28B1/001 , B29C41/006 , B29C41/12 , B29C41/36 , B29C67/0059 , B29C67/02 , B29C67/04 , B29C67/243 , B30B15/302 , B41J2/01 , B41J2/085 , B41J2/09 , H05K3/102 , B22F2998/00 , G05B2219/49013 , H05K2203/013 , H05K2203/0522 , Y10T428/12014 , Y10T428/12021
摘要： A process for making a component by depositing a first layer of a powder material in a confined region and then depositing a binder material to selected regions of the layer of powder material to produce a layer of bonded powder material at the selected regions. Such steps are repeated a selected number of times to produce successive layers of selected regions of bonded powder material so as to form the desired component. The unbonded powder material is then removed. In some cases the component may be further processed as, for example, by heating it to further strengthen the bonding thereof.
摘要翻译：一种通过在受限区域中沉积粉末材料的第一层然后将粘合剂材料沉积到粉末材料层的选定区域以在所选择的区域产生粘结的粉末材料层来制备组分的方法。这样的步骤重复选定的次数以产生粘结的粉末材料的选定区域的连续层，以形成所需的组分。然后除去未结合的粉末材料。在一些情况下，可以例如通过加热组分进一步加强其粘合来进一步加工组分。

36. 发明授权

US5231074A Preparation of highly textured oxide superconducting films from MOD precursor solutions 失效
标题翻译：从MOD前置解决方案制备高纹理氧化物超导膜
公开(公告)号：US5231074A
公开(公告)日：1993-07-27
申请号：US510115
申请日：1990-04-17
申请人： Michael J. Cima , Paul McIntyre
发明人： Michael J. Cima , Paul McIntyre
IPC分类号： H01L39/24
CPC分类号： H01L39/2451 , Y10S505/734
摘要： Highly-textured superconductor oxide thin films are prepared on substrates, including lattice matched, non-lattice matThe Government has rights in this invention pursuant to contract Number MDA972-88-K0006 awarded by the U.S. Defense Advance Research Project Agency.
摘要翻译：通过金属有机沉积（MOD）在衬底上制备高纹理超导体氧化物薄膜，包括晶格匹配的，非晶格匹配的惰性和非惰性材料。选择前体溶液组成以及加工温度和气氛以控制瞬态液相的存在。以高度纹理化的形态和完全致密均匀的微观结构为特征的超导体氧化物膜在77°K时能够保持超过104A / cm 2的临界电流密度，当在非晶格匹配衬底上制备时，其临界电流密度超过106A / cm2，当在晶格匹配的基底上制备时。

37. 发明授权

US08721621B2 Systems and methods for deploying devices to genitourinary sites 有权
标题翻译：将设备部署到泌尿生殖网站的系统和方法
公开(公告)号：US08721621B2
公开(公告)日：2014-05-13
申请号：US12879638
申请日：2010-09-10
申请人： Jim Boyko , Grace Kim , Heejin Lee , Michael J. Cima , Jennie Kwo
发明人： Jim Boyko , Grace Kim , Heejin Lee , Michael J. Cima , Jennie Kwo
IPC分类号： A61M31/00 , A61M25/00
CPC分类号： A61L29/16 , A61M25/007 , A61M25/0662 , A61M31/002 , A61M31/007 , A61M2210/1085
摘要： A method delivers an implantable device through the urethra and into the bladder. A deployment instrument is inserted into the urethra, the implantable device is inserted into the deployment instrument, and a stream of fluid is injected into the deployment instrument. The stream of fluid drives the implantable device from the deployment instrument into the bladder. The deployment instrument is removed from the urethra, leaving the implantable device wholly implanted in the bladder.
摘要翻译：一种方法通过尿道递送可植入装置并进入膀胱。将部署仪器插入到尿道中，将可植入装置插入到展开仪器中，并将流体流注入到展开仪器中。流体流将可植入装置从展开器械驱动到膀胱中。将部署仪器从尿道中取出，将可植入装置完全植入膀胱。

38. 发明申请

US20140004503A1 Device and Method for Sampling Bodily Fluid for Medical Analytes in Ultra Low Concentrations 有权
标题翻译：用于超低浓度医用分析物体液取样的装置和方法
公开(公告)号：US20140004503A1
公开(公告)日：2014-01-02
申请号：US13977108
申请日：2011-12-30
申请人： Michael J. Cima , Gregory J. Ekchian , Christophoros C. Vassiliou , Vincent H. Liu , Christoph Wald , Sebastian Flacke , Fredric D. Gordon
发明人： Michael J. Cima , Gregory J. Ekchian , Christophoros C. Vassiliou , Vincent H. Liu , Christoph Wald , Sebastian Flacke , Fredric D. Gordon
IPC分类号： G01N1/34
CPC分类号： G01N1/34 , A61F2/01 , G01N33/5302 , G01N33/5306 , G01N33/54313 , G01N33/56983
摘要： Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.
摘要翻译：提供捕获装置和方法用于捕获血液或其它生物流体中的医学分析物。该装置可以包括结构底物和粘附到结构底物上的结合剂，例如抗体，其中结合剂能够与医学分析物例如病毒颗粒结合或附着，并且该装置被配置用于放置在患者体内的生物腔或血管（含有生物流体）中。可以处于扭曲线圈形状的捕获装置构造成捕获存在于生物流体中的至少一些医学分析物（例如病毒颗粒）。该方法可以包括将捕获装置部署到患者的血管中; 在部署之后一段时间后，将捕获装置从生物腔或血管中取出; 然后分析捕获装置以获得医用分析物的存在。

39. 发明授权

US08604664B2 Electrochemical actuator 有权
标题翻译：电化学执行器
公开(公告)号：US08604664B2
公开(公告)日：2013-12-10
申请号：US13542179
申请日：2012-07-05
申请人： Yet-Ming Chiang , Michael J. Cima , Timothy E. Chin
发明人： Yet-Ming Chiang , Michael J. Cima , Timothy E. Chin
IPC分类号： H01L41/08
CPC分类号： F03G7/005 , H01M10/052
摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.
摘要翻译：本发明提供了涉及电化学致动的系统，装置和相关方法。在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置。

40. 发明申请

US20130324946A1 IMPLANTABLE DRUG DELIVERY DEVICE AND METHODS 审中-公开
标题翻译：可植入药物递送装置和方法
公开(公告)号：US20130324946A1
公开(公告)日：2013-12-05
申请号：US13910730
申请日：2013-06-05
申请人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
发明人： Irene Sophie Tobias , Heejin Lee , Michael J. Cima , Jordan Dimitrakov
IPC分类号： A61L31/06 , A61L31/16
CPC分类号： A61L31/06 , A61K9/0034 , A61L29/06 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/00 , A61M31/002 , C08L83/04 , C08L67/00
摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.
摘要翻译：提供了一种用于将药物局部控制递送至需要治疗的患者的精囊，前列腺，射精管或输精管的方法。在一个实施例中，该方法包括将可再吸收的药物递送装置植入患者的精囊，前列腺，射精管或输精管内。药物递送装置可以包括容纳至少一个含有至少一种药物的药物储存器的弹性装置主体。在优选的实施方案中，该方法还包括以受控的方式将药物从装置释放，通常直接进入精囊，前列腺，射精管或输精管。

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