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31. 发明授权

US08404810B2 Compositions and methods of use for modulators of polypeptides and polynucleotides in treating breast cancer and melanoma 有权
标题翻译：用于治疗乳腺癌和黑素瘤的多肽和多核苷酸调节剂的组合物和方法
公开(公告)号：US08404810B2
公开(公告)日：2013-03-26
申请号：US12279703
申请日：2007-02-20
申请人： Kevin Hestir , Justin Wong
发明人： Kevin Hestir , Justin Wong
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A61K38/00
摘要： This invention relates to the polynucleotides and the encoded polypeptides, including novel sequences, of human or non-human primate genes that are amplified in breast and/or other tumor tissues melanoma, as compared to the corresponding normal tissue. The invention also relates to modulators of such polynucleotides and polypeptides, for example, antibodies, that specifically bind to and/or interfere with the activity of this polypeptide, polynucleotide, its fragments, variants, and antagonists. The invention further relates to compositions containing such a polypeptide, polynucleotide, or modulators thereof and uses of such compositions in methods of treating or preventing cancer, by detecting this polynucleotide, polypeptide, or antibodies thereto in patient samples. The invention also provides diagnostic tests for breast cancer and melanoma, by identifying polypeptides and polynucleotides encoded by the cDNA sequence of the invention that correlate with those disorders.
摘要翻译：本发明涉及与相应的正常组织相比，在乳腺和/或其它肿瘤组织黑素瘤中扩增的人或非人灵长类动物基因的多核苷酸和编码多肽，包括新序列。本发明还涉及这种多核苷酸和多肽的调节剂，例如抗体，其特异性结合和/或干扰该多肽，多核苷酸，其片段，变体和拮抗剂的活性。本发明进一步涉及通过在患者样品中检测该多核苷酸，多肽或其抗体，含有此类多肽，多核苷酸或其调节剂的组合物以及在治疗或预防癌症的方法中的用途。本发明还通过鉴定与本发明的cDNA序列编码的多肽和与这些疾病相关的多核苷酸来提供对乳腺癌和黑素瘤的诊断测试。

32. 发明申请

US20130136740A1 METHODS OF TREATING CANCER 审中-公开
标题翻译：癌症治疗方法
公开(公告)号：US20130136740A1
公开(公告)日：2013-05-30
申请号：US13675255
申请日：2012-11-13
申请人： Thomas Harding , Servando Palencia , Li Long , Kevin Hestir
发明人： Thomas Harding , Servando Palencia , Li Long , Kevin Hestir
IPC分类号： A61K38/17 , A61K45/00 , A61K39/395
CPC分类号： A61K38/179 , A61K39/395 , A61K45/00 , A61K45/06 , C07K14/71 , C07K2319/30 , C12Q1/6813 , C12Q1/686 , G01N33/5005 , A61K2300/00
摘要： Methods of treating cancers comprising FGFR1 gene amplification are provided. In some embodiments, the methods comprise administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule. In some embodiments, the methods comprise administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule in combination with at least one additional therapeutic agent.
摘要翻译：提供了治疗包含FGFR1基因扩增的癌症的方法。在一些实施方案中，所述方法包括施用成纤维细胞生长因子受体1（FGFR1）细胞外结构域（ECD）和/或FGFR1 ECD融合分子。在一些实施方案中，所述方法包括与至少一种另外的治疗剂组合施用成纤维细胞生长因子受体1（FGFR1）细胞外结构域（ECD）和/或FGFR1 ECD融合分子。

33. 发明申请

US20110288024A1 Compositions and Methods for Treating Arthritis and/or Diseases Involving Cartilage Degeneration 有权
标题翻译：治疗涉及软骨退化的关节炎和/或疾病的组合物和方法
公开(公告)号：US20110288024A1
公开(公告)日：2011-11-24
申请号：US12992582
申请日：2009-05-13
申请人： Kalyani Penta , Srinivas Kothakota , Lewis (Rusty) T. Williams , Kevin Hestir , Shannon Marshall , Jeffrey Finer , Yan Wang
发明人： Kalyani Penta , Srinivas Kothakota , Lewis (Rusty) T. Williams , Kevin Hestir , Shannon Marshall , Jeffrey Finer , Yan Wang
IPC分类号： A61K38/17 , A61P19/02 , C07K16/18 , C07K14/435 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.
摘要翻译：本发明提供促进蛋白多糖合成并促进软骨细胞活性，从而治疗关节炎的药物多肽组合物。还提供了提供这些组合物治疗关节炎的方法。

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