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31. 发明授权

US08357521B2 Method for producing a biobutanol using a thiolase with improved activity 有权
标题翻译：使用具有改善活性的硫解酶生产生物丁醇的方法
公开(公告)号：US08357521B2
公开(公告)日：2013-01-22
申请号：US13253405
申请日：2011-10-05
申请人： Kyung Jin Kim
发明人： Kyung Jin Kim
IPC分类号： C12P7/16
CPC分类号： C12N9/1029 , C12P7/16 , Y02E50/10
摘要： The present invention relates to a modified thiolase protein with an improved activity, a polynucleotide encoding the modified protein, an expression vector including the polynucleotide, and a transformant, to a composition for producing a biobutanol including the thiolase with an improved activity or a cell expressing the thiolase, and to a method of producing the biobutanol.
摘要翻译：本发明涉及具有改善的活性的修饰的硫硫酸酶蛋白质，编码修饰蛋白质的多核苷酸，包含多核苷酸的表达载体和转化体，涉及用于生产包含具有改善的活性或表达细胞的细胞的硫解酶的生物丁醇的组合物硫解酶，以及生产生物丁醇的方法。

32. 发明申请

US20120064066A1 Monoclonal Antibodies to Hepatocyte Growth Factor 审中-公开
标题翻译：肝细胞生长因子单克隆抗体
公开(公告)号：US20120064066A1
公开(公告)日：2012-03-15
申请号：US13160444
申请日：2011-06-14
申请人： Kyung Jin Kim , Yi-Chi Su
发明人： Kyung Jin Kim , Yi-Chi Su
IPC分类号： A61K39/395 , C12N5/07 , A61P35/04 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N2333/4753
摘要： The present invention is directed toward a neutralizing monoclonal antibody to hepatocyte growth factor, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient.
摘要翻译：本发明涉及对肝细胞生长因子的中和单克隆抗体，包含其的药物组合物，以及包括将这种药物组合物施用于患者的治疗方法。

33. 发明授权

US08101723B2 Monoclonal antibodies to fibroblast growth factor receptor 2 有权
标题翻译：成纤维细胞生长因子受体2的单克隆抗体
公开(公告)号：US08101723B2
公开(公告)日：2012-01-24
申请号：US12614282
申请日：2009-11-06
申请人： Kyung Jin Kim , Wei-meng Zhao , Hangil Park , Maximiliano Vasquez
发明人： Kyung Jin Kim , Wei-meng Zhao , Hangil Park , Maximiliano Vasquez
IPC分类号： C12P21/08 , C07K16/00 , A61K39/00 , A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/565 , C07K2317/92 , G01N33/57492 , G01N2333/71
摘要： The present invention is directed toward a monoclonal antibody to fibroblast growth factor receptor 2, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient.
摘要翻译：本发明涉及对成纤维细胞生长因子受体2的单克隆抗体，包含其的药物组合物，以及治疗方法，包括向患者施用这种药物组合物。

34. 发明申请

US20100174171A1 Neurobiological method for measuring human intelligence and system for the same 有权
标题翻译：用于测量人体智力和系统的神经生物学方法
公开(公告)号：US20100174171A1
公开(公告)日：2010-07-08
申请号：US12376799
申请日：2007-08-09
申请人： Kun Ho Lee , Yu Yong Choi , Kyung Jin Kim , Jong Min Lee
发明人： Kun Ho Lee , Yu Yong Choi , Kyung Jin Kim , Jong Min Lee
IPC分类号： A61B5/055
CPC分类号： A61B5/16 , G01R33/4806 , G06F19/00
摘要： The present invention relates to a method for measuring human intelligence using a neurobiogical model. The invention provides a method which enables neurometric IQ to be measured by processing the MRI and fMRI images of subjects to determine cortical thicknesses and brain activation levels, determining structural IQ (sIQ) and functional IQ (fIQ) from the cortical thicknesses and the brain activation levels, and using the structural IQ (sIQ) and the functional IQ (fIQ) as predictors to measure the neurometric IQ of the subject. According to the present invention, the concept of a neurometric IQ (nIQ) model is established and can assist in easily assessing individual differences in general cognitive ability. These results suggest that general cognitive ability can be explained by two different neural bases or traits: facilitation of neural circuits and accumulation of crystallized knowledge.
摘要翻译：本发明涉及一种使用神经生物学模型测量人类智力的方法。本发明提供一种能够通过处理受试者的MRI和fMRI图像来测量神经测量IQ以确定皮层厚度和脑激活水平，从皮层厚度和脑激活确定结构性IQ（sIQ）和功能IQ（fIQ）的方法水平，并使用结构性IQ（sIQ）和功能IQ（fIQ）作为预测因子来测量受试者的神经测量IQ。根据本发明，建立了神经测量IQ（nIQ）模型的概念，并且可以帮助轻松评估一般认知能力中的个体差异。这些结果表明，一般认知能力可以通过两种不同的神经基础或特征来解释：促进神经回路和结晶化知识的积累。

35. 发明授权

US07314619B2 Inducing apoptosis using anti-Apo-2 antibodies 有权
标题翻译：使用抗Apo-2抗体诱导细胞凋亡
公开(公告)号：US07314619B2
公开(公告)日：2008-01-01
申请号：US10052798
申请日：2001-11-02
申请人： Camellia W. Adams , Avi J. Ashkenazi , Anan Chuntharapai , Kyung Jin Kim
发明人： Camellia W. Adams , Avi J. Ashkenazi , Anan Chuntharapai , Kyung Jin Kim
IPC分类号： A61K39/00 , C07K16/28
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要： Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
摘要翻译：提供了能够调节细胞凋亡的新型多肽，称为Apo-2。还提供了包含Apo-2嵌合体，编码Apo-2的核酸和Apo-2抗体的组合物。

36. 发明授权

US06764679B2 Antibodies to DcR3 Polypeptide, a TNFR Homolog 有权
标题翻译： DcR3多肽的抗体，TNFR同源物
公开(公告)号：US06764679B2
公开(公告)日：2004-07-20
申请号：US09896096
申请日：2001-06-28
申请人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
发明人： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
IPC分类号： C07K1628
CPC分类号： A01K67/0275 , A01K2217/05 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/2875 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C12N2799/026
摘要： A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
摘要翻译：提供了标识为DcR3的TNFR同源物。还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。

37. 发明授权

US06359126B1 Antibodies to &agr;v&bgr;3 integrin 失效
标题翻译：抗体为alphavbeta3整合素
公开(公告)号：US06359126B1
公开(公告)日：2002-03-19
申请号：US08874837
申请日：1997-06-13
申请人： Kyung Jin Kim , Michael A. Horton , Sarah C. Bodary , Anan Chuntharapai
发明人： Kyung Jin Kim , Michael A. Horton , Sarah C. Bodary , Anan Chuntharapai
IPC分类号： C07H2104
CPC分类号： C07K16/2848 , A61K38/00 , Y10S530/867
摘要： The invention relates to monoclonal antibodies to the &agr;v&bgr;3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies recognize unique epitopes on &agr;v&bgr;3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.
摘要翻译：本发明涉及已知在破骨细胞表面上大量表达的α受体α整联蛋白受体的单克隆抗体，因此与骨吸收有关。所公开的单克隆抗体识别出在alphavbeta3上的独特表位，并且可用于治疗与过量骨吸收和/或抑制肿瘤细胞生长相关的病症。

38. 发明授权

US5702946A Anti-IL-8 monoclonal antibodies for treatment of inflammatory disorders 失效
标题翻译：用于治疗炎症性疾病的抗IL-8单克隆抗体
公开(公告)号：US5702946A
公开(公告)日：1997-12-30
申请号：US398611
申请日：1995-03-01
申请人： Claire M. Doerschuk , Sherman Fong , Caroline Alice Hebert , Kyung Jin Kim , Steven R. Leong
发明人： Claire M. Doerschuk , Sherman Fong , Caroline Alice Hebert , Kyung Jin Kim , Steven R. Leong
IPC分类号： C12N15/02 , A61K38/00 , A61K39/395 , A61P29/00 , C07H21/04 , C07K16/24 , C12N15/09 , C12P21/08 , C12N15/00 , C07K16/00
CPC分类号： C07K16/244 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.
摘要翻译：描述了抗IL-8单克隆抗体用于诊断应用和治疗炎症性疾病如炎症性肠病和细菌性肺炎。

39. 发明授权

US5686070A Methods for treating bacterial pneumonia 失效
标题翻译：治疗细菌性肺炎的方法
公开(公告)号：US5686070A
公开(公告)日：1997-11-11
申请号：US398612
申请日：1995-03-01
申请人： Claire M. Doerschuk , Sherman Fong , Caroline Alice Hebert , Kyung Jin Kim , Steven R. Leong
发明人： Claire M. Doerschuk , Sherman Fong , Caroline Alice Hebert , Kyung Jin Kim , Steven R. Leong
IPC分类号： C12N15/02 , A61K38/00 , A61K39/395 , A61P29/00 , C07H21/04 , C07K16/24 , C12N15/09 , C12P21/08 , C07K16/00 , C07K16/18
CPC分类号： C07K16/244 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.
摘要翻译：描述了抗IL-8单克隆抗体用于诊断应用和治疗炎症性疾病如炎症性肠病和细菌性肺炎。

40. 发明授权

US5668003A Nucleic acid encoding monoclonal antibodies to leukemia inhibitory factor 失效
标题翻译：核酸编码白血病抑制因子的单克隆抗体
公开(公告)号：US5668003A
公开(公告)日：1997-09-16
申请号：US438455
申请日：1995-05-10
申请人： Kyung Jin Kim
发明人： Kyung Jin Kim
IPC分类号： A61K38/00 , C07K16/24 , C12P21/08 , C07H21/04 , C07K16/18 , C12N15/13 , C12N15/85
CPC分类号： C07K16/244 , A61K38/00 , C07K2317/74
摘要： The invention relates to nucelic acids encoding monoclonal antibodies to human leukemia inhibitory factor. The disclosed monoclonal antibodies are believed to recognize unique epitopes on hLIF and are useful in the treatment of conditions wherein the presence of hLIF causes or contributes to undesirable pathological effects, such as cachexia, dysregulated calcium metabolism, or excessive bone cell proliferation, and in the detection of hLIF, for example, in clinical samples or specimens.
摘要翻译：本发明涉及编码人白血病抑制因子单克隆抗体的营养酸。所公开的单克隆抗体被认为在hLIF上识别出独特的表位，并且可用于治疗其中hLIF的存在引起或有助于不期望的病理学作用，例如恶病质，调节钙代谢或过度骨细胞增殖的病症，并且在检测hLIF，例如临床样本或标本。

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