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31. 发明授权

US06413716B1 Method for detection of human parvovirus and reagent therefor 失效
标题翻译：检测人细小病毒及其试剂的方法
公开(公告)号：US06413716B1
公开(公告)日：2002-07-02
申请号：US08665377
申请日：1996-06-18
申请人： Fumihiro Takakura , Hiroyuki Sato , Yoshiaki Maeda
发明人： Fumihiro Takakura , Hiroyuki Sato , Yoshiaki Maeda
IPC分类号： C12Q170
CPC分类号： G01N33/56983 , Y10T436/11 , Y10T436/116664 , Y10T436/117497
摘要： A method for detection of human parvovirus B19, comprising the steps of: (1) bringing a sample into contact with fixed P-antigen positive red cells in a medium at pH 5.6±0.6; and (2) determining whether or not hemagglutination occurs; and a reagent for detecting human parvovirus B19, wherein the reagent comprises fixed P-antigen positive red cells.
摘要翻译：一种检测人细小病毒B19的方法，包括以下步骤：（1）在pH 5.6±0.6的培养基中使样品与固定的P-抗原阳性红细胞接触; 和（2）确定血细胞凝集是否发生; 以及用于检测人细小病毒B19的试剂，其中所述试剂包含固定的P-抗原阳性红细胞。

32. 发明授权

US5194586A Anti-ATLA antibody binding peptides 失效
标题翻译：抗ATA抗体结合肽
公开(公告)号：US5194586A
公开(公告)日：1993-03-16
申请号：US596081
申请日：1990-10-11
申请人： Yoshiaki Maeda , Hiroshi Shiraki , Yukiko Washitani , Naotaka Kuroda , Kyoko Yamada , Kiichiro Oka , Toshihiko Namba
发明人： Yoshiaki Maeda , Hiroshi Shiraki , Yukiko Washitani , Naotaka Kuroda , Kyoko Yamada , Kiichiro Oka , Toshihiko Namba
IPC分类号： A61K38/00 , A61K39/21 , A61P31/12 , A61P35/02 , C07K7/08 , C07K14/15 , G01N33/574
CPC分类号： C07K14/005 , G01N33/57426 , G01N33/57488 , C12N2740/14022
摘要： A peptide of the general formula:H-X-A-Ywherein A is a peptide fragment comprising 6 to 50 amino acids, X is a peptide fragment comprising 1 to 10 Lys, and Y is hydroxy or amino group, said peptide being capable of specifically binding to an antibody having a specificity against an adult T cell leukemia associated antigen, a reagent for measuring an antibody having a specificity against an adult T cell leukemia associated antigen which comprises the peptide, and an adsorbent for an antibody having a specificity against an adult T cell leukemia associated antigen which comprises the peptide immobilized on a carrier.

33. 发明授权

US08770046B2 Autosampler with control unit for performing a cleaning operation 有权
标题翻译：具有执行清洁操作的控制单元的自动进样器
公开(公告)号：US08770046B2
公开(公告)日：2014-07-08
申请号：US13382499
申请日：2010-09-01
申请人： Yoshiaki Maeda , Kenichi Yasunagi , Takafumi Nakamura
发明人： Yoshiaki Maeda , Kenichi Yasunagi , Takafumi Nakamura
IPC分类号： G01N1/22
CPC分类号： G01N30/24 , G01N30/18 , G01N30/20 , G01N35/1097 , G01N2030/202
摘要： An autosampler is provided with a needle, a measuring pump which sucks and discharges liquid through the needle, a movement mechanism for the needle, and an injection port which has a needle sealing surface. A sample liquid is sucked into the needle and then the sample liquid discharged with the tip of the needle pressed to the needle sealing surface. When cleaning the needle sealing surface, a cleaning liquid within the injection port is sucked and then the cleaning liquid is discharged and sucked into the injection port at a position at which the tip of the needle does not make contact with the needle sealing surface. Alternatively, after the cleaning liquid is discharged into the injection port, the needle may be caused to perform an up and down motion such that the tip of the needle contacts the needle sealing surface and then is lifted.
摘要翻译：自动进样器具有针，通过针吸液排出的测量泵，针的移动机构和具有针密封面的注射口。将样品液体吸入针中，然后用针尖排出的样品液压到针密封表面。当清洁针密封面时，吸入注射口内的清洗液，然后将清洗液排出并吸引到针头未与针密封面接触的位置处的注射口。或者，在将清洁液排出到注入口之后，可以使针进行上下运动，使得针的尖端接触针密封面，然后被提起。

34. 发明授权

US08522627B2 Automatic sampler for liquid chromatograph 有权
标题翻译：液相色谱自动取样器
公开(公告)号：US08522627B2
公开(公告)日：2013-09-03
申请号：US13035036
申请日：2011-02-25
申请人： Yoshiaki Maeda
发明人： Yoshiaki Maeda
IPC分类号： G01N30/20
CPC分类号： G01N30/24
摘要： A pump portion for taking in and discharging solutions includes a first plunger pump with a small capacity and a second plunger pump with a large capacity. Intake ports of both the plunger pumps are connected in parallel to a common port of a switching valve with a first three-way valve interposed therebetween. The first three-way valve connects the intake port of one of the plunger pumps to the switching valve. Discharge ports of both the plunger pumps are connected in parallel to one port of the switching valve with a second three-way valve interposed therebetween. The second three-way valve connects the discharge port of one of the plunger pumps to the switching valve.
摘要翻译：用于吸入和排出溶液的泵部分包括具有小容量的第一柱塞泵和具有大容量的第二柱塞泵。柱塞泵的进气端口并联连接到切换阀的公共端口，其中插入有第一三通阀。第一个三通阀将一个柱塞泵的进气口连接到切换阀。柱塞泵的排出口与切换阀的一个端口并联连接，其间插入第二三通阀。第二个三通阀将一个柱塞泵的排出口连接到切换阀。

35. 发明申请

US20120118141A1 PLUNGER-TYPE MEASURING PUMP 审中-公开
标题翻译： PLUNGER型测量泵
公开(公告)号：US20120118141A1
公开(公告)日：2012-05-17
申请号：US13387547
申请日：2009-07-27
申请人： Yoshiaki Maeda , Masami Tomita
发明人： Yoshiaki Maeda , Masami Tomita
IPC分类号： F04B13/00
CPC分类号： F04B53/164
摘要： A plunger-type measuring pump in which a pump head 9 can be correctly attached to a pump body 1 with a reduced amount of time and labor is provided. The plunger-type measuring pump according to the present invention includes: a pump body 1 supporting a plunger 2 while allowing a reciprocating motion of the plunger 2; a cylindrical head-attachment portion 82 provided at one end of the pump body 1, the head-attachment portion 82 having a male-thread portion 83 formed on an outer circumference thereof; a pump head 9 having a pump chamber 91 inside, the pump head 9 being designed to be attached to the head-attachment portion 82 with a seal 4 therebetween; and a sleeve-like fixing part 7 to be fitted onto the outer circumference of the pump head 9, the sleeve-like fixing part 7 having an inner circumferential wall on which an engaging portion 74 to be engaged with the pump head 9 and a female-thread portion 72 to be screwed onto the male-thread portion 83 are formed. Since a single sleeve-like fixing part 7 is used to fix the pump head 9 to the cylindrical head-attachment portion 82 provided on the pump body 1, it is unnecessary to pay attention to the evenness in the tightening force applied to bolts 6.
摘要翻译：提供了一种柱塞式测量泵，其中泵头9可以以较少的时间和人力来正确地附接到泵体1。根据本发明的柱塞式测量泵包括：泵体1，其支撑柱塞2，同时允许柱塞2的往复运动; 设置在泵体1的一端的圆柱形头部附接部分82，头部附接部分82具有形成在其外圆周上的阳螺纹部分83; 泵头9内部具有泵室91，泵头9被设计成在头部附接部分82上安装有密封件4; 以及套筒状的固定部7，其安装在泵头9的外周上，套筒状的固定部7具有内周壁，与该泵头9配合的卡合部74与母头形成螺纹连接在阳螺纹部83上的螺纹部72。由于使用单个套筒状固定部7将泵头9固定在设置在泵体1上的圆筒形头部安装部82上，因此不需要注意施加于螺栓6的紧固力的均匀性。

36. 发明申请

US20120024048A1 LIQUID CHROMATOGRAPH 有权
标题翻译：液相色谱
公开(公告)号：US20120024048A1
公开(公告)日：2012-02-02
申请号：US13259915
申请日：2010-04-07
申请人： Yoshiaki Maeda
发明人： Yoshiaki Maeda
IPC分类号： G01N30/84
CPC分类号： G01N30/24 , G01N30/20 , G01N30/32
摘要： In injecting a sample sucked into a sample loop in an autosampler from an injection needle into an analytical flow path via an injection port by a mobile phase, a sending flow rate of the mobile phase is reduced from a certain flow rate determined in an analysis condition to reduce pressure applied on a joint section between the needle and the injection port to thereby reduce the sample remaining in the injection port.
摘要翻译：将吸入自动进样器中的样品回路中的样品从注射针注射到通过流动相的注射口的分析流路中时，流动相的发送流量从在分析条件中确定的一定流量下降以减少施加在针和注射口之间的接合部分上的压力，从而减少留在注射口中的样品。

37. 发明申请

US20110247405A1 Sample Injection Port and Auto-Sampler Having the Same 有权
标题翻译：样品注入口和具有相同的自动进样器
公开(公告)号：US20110247405A1
公开(公告)日：2011-10-13
申请号：US13124367
申请日：2008-10-16
申请人： Kenichi Yasunaga , Masami Tomita , Yoshiaki Maeda
发明人： Kenichi Yasunaga , Masami Tomita , Yoshiaki Maeda
IPC分类号： G01N30/24
CPC分类号： G01N30/18 , G01N30/24 , G01N35/1097 , G01N2030/185
摘要： A sample injection port 10 for injecting a sample into a chromatograph or other devices is composed of a body 13 made of an inelastic material, a first seal member 14 made of an elastic material and attached to one end of the body part 13, and a second seal member 15 made of an elastic material and attached to the other end of the body part 13. A first through hole formed in the first seal member 14, a second through hole formed in the second seal member 15 and a third through hole formed in the body part 13 are coaxially connected to form an introduction hole for sample injection. With this construction, a sample injection port which has a small inner diameter, is easy to manufacture, and yet capable of achieving a high pressure resistance can be provided.
摘要翻译：用于将样品注入色谱仪或其他装置的样品注入口10由非弹性材料制成的主体13，由弹性材料制成并附接到主体部分13的一端的第一密封构件14和第二密封构件15，其由弹性材料制成并且附接到主体部分13的另一端。形成在第一密封构件14中的第一通孔，形成在第二密封构件15中的第二通孔和形成的第三通孔在主体部分13中同轴连接以形成用于样品注入的引入孔。通过这种结构，可以容易地制造具有小内径的样品注入口，并且能够实现高耐压性。

38. 发明授权

US07980119B2 Auto-sampler cleaning mechanism 有权
标题翻译：自动进样器清洗机构
公开(公告)号：US07980119B2
公开(公告)日：2011-07-19
申请号：US11942516
申请日：2007-11-19
申请人： Yoshiaki Maeda , Nobuyuki Tatsumi
发明人： Yoshiaki Maeda , Nobuyuki Tatsumi
IPC分类号： G01N30/02
CPC分类号： G01N35/1097 , G01N35/1004
摘要： An auto-sampler cleaning mechanism is provided, which is capable of maintaining the supply of a liquid in a non-time-consuming manner when a cleaning solution is supplied. The auto-sampler cleaning mechanism of the present invention includes: a sample-metering sample loop 14 having a sample-injecting needle 15 at a front end thereof, a metering pump 24, a multi-ported valve 11a, a multi-position valve 11b, and a liquid-supply valve 11c. A diaphragm pump 25 is disposed between the port of the multi-position valve 11a and the port of the liquid-supply valve 11b, and used to supply a cleaning solution 26 or a mobile phase 20 to the sample loop 14.
摘要翻译：提供了一种自动取样器清洁机构，当提供清洁溶液时，其能够以非耗时的方式维持液体的供应。本发明的自动进样器清洗机构包括：样品计量样品回路14，其前端具有试样注射针15，计量泵24，多孔阀11a，多位置阀11b ，以及液体供给阀11c。隔膜泵25设置在多位置阀11a的端口和供液阀11b的端口之间，用于将清洗液26或流动相20提供给样品环14。

39. 发明申请

US20100008971A1 CHEWING COMPOSITION COMPRISING COENZYME Q10 审中-公开
标题翻译：包含COENZYME的CHEWING组合物Q10
公开(公告)号：US20100008971A1
公开(公告)日：2010-01-14
申请号：US12296586
申请日：2007-04-11
申请人： Hideyuki Orikoshi , Yoshiaki Maeda , Taisuke Nakamura , Takumi Tokumoto , Masaki Yanazaki
发明人： Hideyuki Orikoshi , Yoshiaki Maeda , Taisuke Nakamura , Takumi Tokumoto , Masaki Yanazaki
IPC分类号： A61K9/68 , A61P35/00 , A61P9/10
CPC分类号： A61K31/122 , A23G4/12 , A23L33/10 , A23V2002/00 , A61K8/355 , A61K8/738 , A61K9/0056 , A61K9/0058 , A61K47/26 , A61K47/36 , A61K47/40 , A61K47/6951 , A61K2800/56 , A61Q11/00 , B82Y5/00 , A23V2200/224 , A23V2250/5112 , A23V2250/314
摘要： An object of the invention is to provide a chewing composition containing Coenzyme Q10 with improved release properties in the oral cavity. Another object is to provide a process for improving the release properties of Coenzyme Q10 in the oral cavity.Coenzyme Q10 is encapsulated in cyclodextrin, and the resulting inclusion complex is used as a Coenzyme Q10 component. The content of Coenzyme Q10 in the inclusion complex is preferably low. It is preferably 40 wt % or less, and more preferably 20 wt %.
摘要翻译：本发明的目的是提供一种含有辅酶Q10的咀嚼组合物，其具有改善口腔释放性能。另一个目的是提供一种用于改善口腔内辅酶Q10释放特性的方法。辅酶Q10封装在环糊精中，所得的包合物用作辅酶Q10组分。辅酶Q10在包合物中的含量优选低。优选为40重量％以下，更优选为20重量％。

40. 发明申请

US20070130748A1 Method of forming a needle for auto-sampler 有权
标题翻译：自动进样器针形成方法
公开(公告)号：US20070130748A1
公开(公告)日：2007-06-14
申请号：US11648640
申请日：2007-01-03
申请人： Masami Tomita , Yoshiaki Maeda
发明人： Masami Tomita , Yoshiaki Maeda
IPC分类号： B21G1/08
CPC分类号： G01N35/1097 , B01L3/0275 , B01L2300/161 , G01N30/24 , G01N35/1004 , G01N2035/00277 , Y10T29/49391 , Y10T29/49982
摘要： In a method of forming a needle for an auto-sampler successively collecting liquid samples from plural sample containers, a parent material forming the needle is coated with a coating material having a chemical activity small than that of the needle. Then, the coated parent material is polished so that the surface has an average roughness of 10 to 20 nm.
摘要翻译：在从多个样品容器中连续收集液体样品的自动采样器的针形成方法中，形成针的母材涂覆有比针的化学活性小的涂料。然后，对涂覆的母材进行抛光，使得表面的平均粗糙度为10〜20nm。

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