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31. 发明授权

US06514241B1 Apparatus and method for treating glaucoma using a gonioscopic laser trabecular ablation procedure 失效
标题翻译：使用前房激光小梁消融手术治疗青光眼的装置和方法
公开(公告)号：US06514241B1
公开(公告)日：2003-02-04
申请号：US09456219
申请日：1999-12-07
申请人： James C. Hsia , Shlomo Melamed , Joseph A. Lowery
发明人： James C. Hsia , Shlomo Melamed , Joseph A. Lowery
IPC分类号： A61B1820
CPC分类号： A61F9/00802 , A61B2017/00181 , A61B2017/00194 , A61F9/00821 , A61F9/009 , A61F2009/00868 , A61F2009/00891
摘要： A non-invasive apparatus and method for treating open angle glaucoma in a human eye comprises thermally ablating a targeted region of the trabecular meshwork of a human eye by irradiating the region with a beam of pulsed laser radiation. The beam of pulsed radiation has a wavelength between 350 and 1300 nanometers, energy of 10 to 500 millijoules per pulse, and pulse duration of 0.1 to 50 microseconds. The beam is non-invasively delivered gonioscopically through the cornea onto a targeted region of the trabecular meshwork. The targeted region of the trabecular meshwork is illuminated at a spot size of between 50 and 300 microns in diameter.
摘要翻译：用于治疗人眼中的开角型青光眼的非侵入性装置和方法包括通过用脉冲激光辐射束照射该区域来热切割人眼小梁网的目标区域。脉冲辐射束具有350和1300纳米之间的波长，每脉冲10至500毫焦耳的能量，以及0.1至50微秒的脉冲持续时间。梁被非侵入性地通过角膜递送到小梁网的目标区域上。小梁网的目标区域以直径在50至300微米的点尺寸照射。

32. 发明授权

US5599342A Method for treating pigmentation abnormalities using pulsed laser radiation with an elongated cross-section and apparatus for providing same 失效
标题翻译：使用细长截面的脉冲激光辐射治疗色素沉着异常的方法和用于提供它的装置
公开(公告)号：US5599342A
公开(公告)日：1997-02-04
申请号：US379776
申请日：1995-01-27
申请人： James C. Hsia , Robert Schlier
发明人： James C. Hsia , Robert Schlier
IPC分类号： A61B17/00 , A61B18/20 , A61N5/067 , A61N5/06
CPC分类号： A61B18/203 , A61B2017/00756 , A61B2018/00452 , A61B2018/00458 , A61N2005/067
摘要： A method for treating pigmentation abnormalities in human skin involves the use of a beam of laser radiation having an elongated cross-sectional area. The beam of pulsed laser radiation having an elongated cross-section is produced using a pulsed laser and a delivery system. An elongated area on the skin including a pigmentation abnormality is irradiated with the laser beam. The laser pulse parameters are tailored to the specific type of pigmentation abnormality (e.g., vascular lesions or tattoos) being treated. The beam may have a cross-sectional area characterized by an aspect ratio of greater than two. Also, the beam may have an elliptical cross-sectional area.
摘要翻译：用于治疗人皮肤色素沉着异常的方法涉及使用具有细长横截面积的激光束辐射。使用脉冲激光和输送系统产生具有细长横截面的脉冲激光辐射束。用激光束照射皮肤上包含着色异常的细长区域。激光脉冲参数是针对正在治疗的特定类型的色素沉着异常（例如，血管病变或纹身）而定制的。梁可以具有以大于2的纵横比为特征的横截面。此外，梁可以具有椭圆形横截面积。

33. 发明授权

US5530553A Fiber optic probe apparatus and method 失效
标题翻译：光纤探头装置及方法
公开(公告)号：US5530553A
公开(公告)日：1996-06-25
申请号：US349629
申请日：1994-12-05
申请人： James C. Hsia , Rafael A. Sierra , Michael G. Clancy
发明人： James C. Hsia , Rafael A. Sierra , Michael G. Clancy
IPC分类号： G01N15/04 , G01N21/59 , G01N21/85
CPC分类号： G01N15/042 , G01N21/8507 , G01N2021/5969 , G01N2201/08
摘要： A fiber optic probe comprises a pair of substantially parallel optical fibers separated by a gap and positioned in a centrifuge tube which contains a stratified medium. The pair of fibers includes a transmit fiber for directing light from a light source into a substantially undisturbed portion of the stratified medium disposed in the gap. Light traversing the portion of the stratified medium in the gap is collected by a receive fiber and provides an indication of a light property of the portion of the stratified medium disposed in the gap. The pair of fibers are adapted to be moved in the stratified medium without significantly disturbing the stratification of the medium. As the fibers are moved, light property measurements can be obtained in other substantially undisturbed portions of the stratified medium.
摘要翻译：光纤探针包括一对基本平行的光纤，其间隔开并定位在包含分层介质的离心管中。一对光纤包括用于将来自光源的光引导到布置在间隙中的分层介质的基本上未受干扰的部分中的发射光纤。穿过间隙中的分层介质的部分的光由接收光纤收集，并提供设置在间隙中的分层介质部分的光特性的指示。这对纤维适于在分层介质中移动，而不会明显地扰乱介质的分层。当纤维移动时，可以在分层介质的其他基本上未受干扰的部分中获得光特性测量。

34. 发明授权

US5312395A Method of treating pigmented lesions using pulsed irradiation 失效
标题翻译：使用脉冲照射治疗色素沉着病变的方法
公开(公告)号：US5312395A
公开(公告)日：1994-05-17
申请号：US933873
申请日：1992-08-21
申请人： Oon T. Tan , James C. Hsia , Horace Furumoto
发明人： Oon T. Tan , James C. Hsia , Horace Furumoto
IPC分类号： A61N5/06 , A61B18/20 , A61N5/067
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61N2005/067
摘要： A cutaneous pigmented lesion is treated by irradiation with laser light of between 345 and 600 nm and preferably about 500 nm wavelength. The fluence is between 1 and 10 J/Cm.sup.2 and preferably between 2 and 4 J/cm.sup.2 . The pulse duration is less than 1 .mu.sec and preferably less than 500 nsec. A 3 mm diameter spot is illuminated.
摘要翻译：皮肤色素沉着病变通过在345和600nm之间的激光照射并且优选地约500nm的波长来进行治疗。注量为1〜10J / Cm 2，优选为2〜4J / cm 2。脉冲持续时间小于1μsec，优选小于500nsec。直径3毫米的点被照亮。

35. 发明授权

US4977571A Dye laser solution circulation system 失效
标题翻译：染料激光溶液循环系统
公开(公告)号：US4977571A
公开(公告)日：1990-12-11
申请号：US174729
申请日：1988-03-29
申请人： Horace W. Furumoto , Harry L. Ceccon , James C. Hsia
发明人： Horace W. Furumoto , Harry L. Ceccon , James C. Hsia
IPC分类号： H01S3/02
CPC分类号： H01S3/022
摘要： A dye laser fluid dye solution replenishment system in which the portion of the lasing fluid passing through the laser head which has been activated to a lasing condition is separated from the remainder of the unactivated dye solution and is separately restored before being recombined into the fluid flow path. The thus separated and degraded dye solution, representing only the degraded component of the flowing dye solution, is filtered to remove the degradation products and restored to the desired dye solution component concentrations. The thus restored solution is reinserted into the fluid flow path through the laser head.
摘要翻译：一种染料激光流体染料溶液补充系统，其中通过已激活到激光条件的激光头的激光弹射部分与未活化的染料溶液的其余部分分离，并在再次混合到流体流中之前分别还原路径。过滤分离和降解的染料溶液，其仅代表流动染料溶液的降解组分，以除去降解产物并恢复到所需的染料溶液组分浓度。将如此恢复的溶液重新插入到通过激光头的流体流动路径中。

36. 发明授权

US4817107A Laser plasma chamber 失效
标题翻译：激光等离子体室
公开(公告)号：US4817107A
公开(公告)日：1989-03-28
申请号：US803165
申请日：1985-12-02
申请人： James C. Hsia
发明人： James C. Hsia
IPC分类号： H01S3/03 , H01S3/038 , H01S3/0971
CPC分类号： H01S3/03 , H01S3/038 , H01S3/09716
摘要： The invention is described as embodied in a plasma chamber for use in gas lasers. A sealed nitrogen gas laser is provided with a pair of capacitance coupled, symmetrically positioned pre-ionizer elements in the form of a pair of insulated wire loops extending from one electrode to the region adjacent the other electrode. All parts of the plasma chamber accessible to ultraviolet radiation or ionized gases and are formed entirely of inorganic materials, such as ceramic and quartz, eliminating previously unrecognized difficulties resulting from the use of plastic or other organic materials in the chamber construction, thus making possible a sealed low-power nitrogen laser having a relatively long life. The pre-ionizer elements, which may be used in lasers of other types, both sealed and unsealed, produce a pre-ionization current that is limited to the capacitance displacement current, and are symmetrically positioned with respect to the adjacent negative electrode so that the laser beam is not distorted by the pre-ionization currents.
摘要翻译：本发明被描述为体现在用于气体激光器的等离子体室中。密封的氮气激光器设置有一对电容耦合的对称位置的预电离器元件，其为从一个电极延伸到邻近另一个电极的区域的一对绝缘线环形式。等离子体室的所有部分都可通过紫外线辐射或离子化气体进入，并且完全由诸如陶瓷和石英的无机材料形成，从而消除了在室结构中使用塑料或其它有机材料造成的以前未被认识到的困难，从而使得密封的低功率氮激光器具有较长的使用寿命。可以用于其他类型的激光器的预电除去器元件被密封和非密封，产生限于电容位移电流的预电离电流，并且相对于相邻的负极对称地定位，激光束不被预电离电流扭曲。

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