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31. 发明授权

US06492565B2 Process for the preparation of polyether polyols 失效
标题翻译：制备聚醚多元醇的方法
公开(公告)号：US06492565B2
公开(公告)日：2002-12-10
申请号：US09827655
申请日：2001-04-06
申请人： Uwe Denninger , Jörg Hofmann , Pramod Gupta
发明人： Uwe Denninger , Jörg Hofmann , Pramod Gupta
IPC分类号： C07C4103
CPC分类号： C08G65/2654 , B01J31/0211 , B01J31/0227 , B01J31/0228 , B01J31/0252 , B01J31/0255 , B01J31/0257 , B01J2231/48 , C07F5/069
摘要： The present invention relates to a process for the preparation of polyether polyols by the reaction of alkylene oxides and compounds containing active hydrogens, in the presence of specific Lewis acid metal compounds as catalysts, novel bis(perfluoroalkylsulfonic acid) compounds of Group 13 of the Periodic Table of the Elements, and to a process for the preparation thereof and the use thereof as catalysts for ring-opening polymerization of cyclic ethers.
摘要翻译：本发明涉及在特定的路易斯酸金属化合物作为催化剂的存在下，通过环氧烷和含有活性氢的化合物的反应制备聚醚多元醇的方法，所述周期的第13族的新的双（全氟烷基磺酸）化合物表格，以及其制备方法及其作为环醚开环聚合的催化剂的用途。

32. 发明授权

US06482993B1 Method for producing long chain polyether polyols without reprocessing 有权
标题翻译：不再加工生产长链聚醚多元醇的方法
公开(公告)号：US06482993B1
公开(公告)日：2002-11-19
申请号：US09673583
申请日：2000-10-18
申请人： Jörg Hofmann , Pramod Gupta
发明人： Jörg Hofmann , Pramod Gupta
IPC分类号： C07C4311
CPC分类号： B01J31/0227 , B01J2231/48 , C08G65/2642 , C08G65/266
摘要： This invention relates to a process for the production of long-chain polyether polyols without working up, in which oligomeric, alkoxylated starter compounds having molecular weights of 200 to 1000 are first obtained by catalysis with perfluoroalkylsulfonates of the metals of group III A of the periodic system of elements (in accordance with the IUPAC convention of 1970) from low molecular weight starters by reaction with alkylene oxides at reaction temperatures of 80 to 200° C. and catalyst concentrations of 5 to 200 ppm, which oligomeric, alkoxylated starter compounds are then converted without working up and removal of the catalyst by means of highly active DMC catalysts at a catalyst concentration of 30 ppm or below, relative to the quantity of polyether polyol to be produced, by reaction with alkylene oxides into higher molecular weight, long-chain polyether polyols.
摘要翻译：本发明涉及一种不加工的长链聚醚多元醇的制备方法，其中分子量为200〜1000的低聚烷氧基化起始化合物首先通过周期性的IIIA族金属的全氟烷基磺酸盐的催化而得到在低分子量起始化合物的反应温度为80〜200℃，催化剂浓度为5〜200ppm的条件下，通过与环氧烷烃反应，从低分子量起始剂中分离出元素系统（按照IUPAC惯例）通过高活性DMC催化剂处理和除去催化剂，催化剂浓度为30ppm或更低，相对于待生产的聚醚多元醇的量，通过与烯化氧反应成较高分子量的长链聚醚多元醇。

33. 发明授权

US06350920B1 Method for preparing polyether polyols 失效
标题翻译：制备聚醚多元醇的方法
公开(公告)号：US06350920B1
公开(公告)日：2002-02-26
申请号：US09485507
申请日：2000-03-20
申请人： Hans-Josef Buysch , Manfred Dietrich , Pramod Gupta , Pieter Ooms
发明人： Hans-Josef Buysch , Manfred Dietrich , Pramod Gupta , Pieter Ooms
IPC分类号： C07C4311
CPC分类号： B01J31/0202 , B01J31/068 , C08G65/2648 , C08G65/2651 , C08G65/30
摘要： Polyether polyols can be prepared by reacting polyols with epoxides in the presence of basic catalysts, by treating the polyether polyols containing the basic catalysts with OH-functional solid compounds of metals of groups III to VIII of the periodic system of the elements (Mendeleyev), the compounds being insoluble in the polyether polyols and having BET surface areas of from 10 to 1000 m2/g, isolating the solid inorganic compounds laden with the basic catalysts from the polyether polyol and using them in the reaction of polyols with epoxides, or bringing the isolated inorganic compounds laden with the basic catalysts into contact with the polyols that are to be used in the reaction with epoxides, separating those polyols from the inorganic compounds and delivering them to the reaction with epoxides.
摘要翻译：聚醚多元醇可以通过在碱性催化剂的存在下使多元醇与环氧化物反应来制备，通过用含有元素（Mendeleyev）的周期体系的III-VIII族金属的OH-官能固体化合物处理含有碱性催化剂的聚醚多元醇，所述化合物不溶于所述聚醚多元醇并具有10至1000m 2 / g的BET表面积，从所述聚醚多元醇中分离含有碱性催化剂的固体无机化合物，并将其用于多元醇与环氧化物的反应，或将分离的无机化合物与碱性催化剂接触，与用于与环氧化物的反应中使用的多元醇接触，将这些多元醇与无机化合物分离并将其输送到与环氧化物反应。

34. 发明授权

US5426126A Liquid, light-colored polyisocyanate mixtures and a process for their production 失效
标题翻译：液体，浅色多异氰酸酯混合物及其生产方法
公开(公告)号：US5426126A
公开(公告)日：1995-06-20
申请号：US998190
申请日：1992-12-30
申请人： Herbert Gebauer , Pramod Gupta , Martin Hoppe , Rolf Wiedermann
发明人： Herbert Gebauer , Pramod Gupta , Martin Hoppe , Rolf Wiedermann
IPC分类号： C08G18/10 , C08G18/48 , C08G18/76 , C08G18/80 , C08G101/00 , C08J9/00
CPC分类号： C08G18/8029 , C08G18/10 , C08G18/4829 , C08G18/7664 , C08G2101/0025
摘要： An isocyanate terminated prepolymer based upon diphenylmethane isocyanates. This prepolymer is the reaction product of a diphenylmethane isocyanate mixture having from about 75 to about 95 wt % binuclear isomers and from about 5 to about 25 wt % polymeric isocyanate with a polyether polyol. The binuclear isomer content is generally from about 15 to about 40 wt % 2,4'-isomer and from about 2 to about 10 wt % 2,2'-isomer. The polyether polyol has a functionality of from about 3 to about 8, an OH number of from about 350 to about 1000 mg KOH/g and a molecular weight of from about 150 to about 1000. These prepolymers are particularly useful as starting materials for the production of light-colored, dimensionally stable rigid polyurethane foams.
摘要翻译：基于二苯基甲烷异氰酸酯的异氰酸酯封端的预聚物。该预聚物是具有约75至约95重量％双核异构体和约5至约25重量％聚异氰酸酯与聚醚多元醇的二苯基甲烷异氰酸酯混合物的反应产物。双核异构体含量通常为约15至约40重量％的2,4'-异构体和约2至约10重量％的2,2'-异构体。聚醚多元醇具有约3至约8的官能度，约350至约1000mg KOH / g的OH数和约150至约1000的分子量。这些预聚物特别可用作生产浅色，尺寸稳定的硬质聚氨酯泡沫。

35. 发明申请

US20070101463A1 Use of porous membrane to support developing conifer somatic embryos 审中-公开
公开(公告)号：US20070101463A1
公开(公告)日：2007-05-03
申请号：US11548937
申请日：2006-10-12
申请人： Pramod Gupta , Diane Holmstrom , Bonnie Larson , Susan Rayfield , Anthony Swanda
发明人： Pramod Gupta , Diane Holmstrom , Bonnie Larson , Susan Rayfield , Anthony Swanda
IPC分类号： C12N5/04 , A01H7/00
CPC分类号： A01H4/001 , A01H4/005 , C12M25/02
摘要： The present invention provides methods for developing conifer cotyledonary somatic embryos. In some embodiments, the methods of the invention include the step of culturing conifer pre-cotyledonary somatic embryos on a porous membrane, that is at least intermittently contacted with liquid development medium, for a period of time sufficient to produce conifer, cotyledonary, somatic embryos from the pre-cotyledonary somatic embryos.

36. 发明申请

US20060280786A1 PHARMACEUTICAL FORMULATIONS FOR MINIMIZING DRUG-DRUG INTERACTIONS 审中-公开
标题翻译：用于最小化药物相互作用的药物制剂
公开(公告)号：US20060280786A1
公开(公告)日：2006-12-14
申请号：US11423491
申请日：2006-06-12
申请人： Barrett Rabinow , Chyung Cook , Pramod Gupta
发明人： Barrett Rabinow , Chyung Cook , Pramod Gupta
IPC分类号： A61K9/127 , A61K9/14
CPC分类号： A61K9/0019 , A61K9/10 , A61K31/496 , A61K31/5517 , A61K31/704 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical combination for minimizing pharmacokinetic drug-drug interaction is described including a first pharmaceutical component having a particular pharmacokinetic profile in a mammal and a second pharmaceutical component formulated for parenteral administration having an altered pharmacokinetic profile different from the unaltered pharmacokinetic profile of the second pharmaceutical component, which would interfere with the pharmacokinetic profile of the first pharmaceutical component. Due to its altered pharmacokinetic profile, the second pharmaceutical component does not substantially affect the pharmacokinetic profile of the first pharmaceutical component.
摘要翻译：描述了用于最小化药代动力学药物 - 药物相互作用的药物组合物，其包括在哺乳动物中具有特定药代动力学特征的第一药物组分和用于非肠道给药的第二药物组分，所述第二药物组分具有不同于第二药物组分的未改变的药代动力学特征的药代动力学特征，其将干扰第一药物组分的药代动力学特征。由于其药代动力学变化的改变，第二药物组分基本上不影响第一药物组分的药代动力学特征。

37. 发明申请

US20050026282A1 Methods and compositions for regrowth of cryopreserved conifer embryos 有权
标题翻译：冷冻针叶树胚胎再生长的方法和组成
公开(公告)号：US20050026282A1
公开(公告)日：2005-02-03
申请号：US10875666
申请日：2004-06-24
申请人： Pramod Gupta , Diane Holmstrom , Bonnie Larson , Doris Budworth
发明人： Pramod Gupta , Diane Holmstrom , Bonnie Larson , Doris Budworth
IPC分类号： A01H20060101 , A01H4/00 , A01N1/02 , A01N3/00 , C12N5/04 , A01H7/00 , C12N15/82
CPC分类号： A01H4/005 , A01H4/008 , A01N1/0226 , Y10T436/108331
摘要： The present invention provides methods for regrowth of conifer embryogenic cells. The methods comprise the steps of (a) contacting cryopreserved conifer embryogenic cells with a liquid transition medium, and (b) culturing the contacted conifer embryogenic cells in a regrowth medium to generate regrowth of the conifer embryogenic cells. Generally, the cryopreserved conifer embryogenic cells are contacted with the liquid transition medium for less than about 24 hours, such as for about one hour.
摘要翻译：本发明提供针叶树胚发生细胞再生长的方法。所述方法包括以下步骤：（a）使冷冻保存的针叶树胚胎发生细胞与液体转移培养基接触，和（b）在再生培养基中培养接触的针叶树胚发生细胞以产生针叶胚胎发生细胞的再生长。通常，冷冻保存的针叶树胚胎发生细胞与液体转移培养基接触少于约24小时，例如约1小时。

38. 发明申请

US20050026281A1 Development and stratification of pine somatic embryos using a liquid system 失效
标题翻译：使用液体系统的松体细胞胚的发育和分层
公开(公告)号：US20050026281A1
公开(公告)日：2005-02-03
申请号：US10875656
申请日：2004-06-24
申请人： Pramod Gupta , Diane Holmstrom , Bonnie Larson , Judith Zucati
发明人： Pramod Gupta , Diane Holmstrom , Bonnie Larson , Judith Zucati
IPC分类号： A01H4/00 , A01H7/00 , C12N5/04 , C12N15/82
CPC分类号： A01H4/005
摘要： The invention provides methods for producing pine somatic embryos using a liquid development medium and/or a liquid stratification medium. In a first aspect, the methods comprise the step of culturing embryogenic cells in, or on, a liquid development medium to produce cotyledonary pine somatic embryos. In another aspect, the methods comprise the step of culturing pine cotyledonary somatic embryos in, or on, a liquid stratification medium to produce stratified cotyledonary somatic embryos. The invention also provides methods for producing pine somatic embryos in bioreactors.
摘要翻译：本发明提供使用液体显影培养基和/或液体分层培养基生产松体细胞胚的方法。在第一方面，所述方法包括在液体显影培养基中或其上培养胚发生细胞以产生子叶松体细胞胚的步骤。另一方面，所述方法包括在液体分层培养基中或其上培养松果子体细胞胚以产生分层的子叶体细胞胚的步骤。本发明还提供了在生物反应器中生产松体细胞胚的方法。

39. 发明申请

US20050003415A1 Media and methods for promoting maturation of conifer somatic embryos 有权
标题翻译：用于促进针叶树体细胞胚成熟的培养基和方法
公开(公告)号：US20050003415A1
公开(公告)日：2005-01-06
申请号：US10861168
申请日：2004-06-04
申请人： Pramod Gupta , Bonnie Larson , Diane Holmstrom
发明人： Pramod Gupta , Bonnie Larson , Diane Holmstrom
IPC分类号： A01H4/00 , C12N5/00 , C12N5/02 , C12Q1/68
CPC分类号： A01H4/005
摘要： In one aspect, the present invention provides methods for producing mature conifer somatic embryos. The methods of the invention comprise the steps of: (a) culturing pre-cotyledonary conifer somatic embryos in, or on, a development medium comprising less than 0.5% of gellan gum to form cotyledonary conifer somatic embryos; and (b) culturing cotyledonary conifer somatic embryos formed in step (a) in, or on, a maturation medium comprising between about 0.5% to about 1.5% of gellan gum to form mature conifer somatic embryos. In some embodiments, the maturation medium further comprises sucrose and/or abscisic acid.
摘要翻译：一方面，本发明提供了生产成熟针叶树体细胞胚的方法。本发明的方法包括以下步骤：（a）在包含少于0.5％吉兰糖胶的显影培养基中或上培养前叶子针叶体细胞胚，以形成子叶针叶体细胞胚; 和（b）在步骤（a）中形成的子叶针叶树体细胞胚在包含约0.5％至约1.5％的结冷糖胶的成熟培养基中或之上培养，以形成成熟的针叶树体细胞胚。在一些实施方案中，成熟培养基还包含蔗糖和/或脱落酸。

40. 发明授权

US06617419B1 Long-chain polyether polyols with a high proportion of primary oh groups 有权
标题翻译：长链聚醚多元醇具有较高比例的原子喔基团
公开(公告)号：US06617419B1
公开(公告)日：2003-09-09
申请号：US10009889
申请日：2002-01-28
申请人： Jörg Hofmann , Pramod Gupta , Manfred Dietrich
发明人： Jörg Hofmann , Pramod Gupta , Manfred Dietrich
IPC分类号： C08G6534
CPC分类号： C08G65/2663 , C08G18/4841 , C08G18/4866
摘要： The invention relates to long-chain polyether polyols having a content of primary OH groups of 40 to 95 mol-% and a total content of oxyethylene units of >25 wt. % as well as a process for their production by DMC-catalysed polyaddition of an ethylene oxide (EO)/propylene oxide (PO) mixture in the weight ratio of 40:60 to 95:5 as an end block to starter compounds having active hydrogen atoms.
摘要翻译：本发明涉及具有40至95摩尔％的伯OH基团的含量和> 25重量％的氧化乙烯单元的总含量的长链聚醚多元醇。％以及通过DMC-催化加成的环氧乙烷（EO）/环氧丙烷（PO）混合物以40:60至95:5的重量比作为末端嵌段生产的方法，其具有活性氢的起始化合物原子

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