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31. 发明授权

US08445416B2 Solid stick compositions comprising vinyl ester 有权
标题翻译：包括乙烯基酯的固体棒组合物
公开(公告)号：US08445416B2
公开(公告)日：2013-05-21
申请号：US11698046
申请日：2007-01-26
申请人： John Cotter , Annette Ueckert , Xin Lu , Donald Eadie
发明人： John Cotter , Annette Ueckert , Xin Lu , Donald Eadie
IPC分类号： C10M125/08 , C10M125/02 , C10M123/04
CPC分类号： B61K3/00 , C08L63/00 , C10M169/04 , C10M2201/041 , C10M2201/0413 , C10M2201/061 , C10M2201/0613 , C10M2201/065 , C10M2201/0653 , C10M2201/066 , C10M2201/0663 , C10M2201/087 , C10M2201/0873 , C10M2205/04 , C10M2207/1253 , C10M2207/127 , C10M2209/062 , C10M2209/0625 , C10M2209/102 , C10M2209/1023 , C10M2209/103 , C10M2209/1033 , C10M2215/06 , C10N2210/08 , C10N2230/06 , C10N2210/06 , C10N2210/03 , C10N2260/08
摘要： A solid stick composition for use on steel surfaces that are in sliding or rolling-sliding contact. The solid stick composition comprises a vinyl ester resin, for example, from about 20 to about 80 weight percent vinyl ester resin, a solid lubricant, for example from about 0 to about 80 weight percent lubricant, and optionally a friction modifier, for example from about 0 to about 40% weight percent friction modifier, or a combination of a solid lubricant and a friction modifier. The solid stick comprises at least one of the lubricant or the friction modifier. A method of controlling friction between a metal surface and a second metal surface by applying the solid stick composition to one or more than one of the metal surfaces is also disclosed as well as a method of reducing lateral force in a rail system comprising applying the solid stick composition onto a wheel or rail surface.
摘要翻译：用于滑动或滚动滑动接触的钢表面的固体棒组合物。固体棒组合物包括乙烯基酯树脂，例如约20至约80重量％的乙烯基酯树脂，固体润滑剂，例如约0至约80重量％的润滑剂，以及任选的摩擦改进剂，例如来自约0至约40重量％的摩擦改进剂，或固体润滑剂和摩擦改进剂的组合。固体棒包括润滑剂或摩擦改性剂中的至少一种。还公开了一种通过将固体棒组合物施加到一个或多于一个金属表面来控制金属表面和第二金属表面之间的摩擦的方法，以及减少轨道系统中的横向力的方法，包括施加固体将组合物粘贴到轮或轨道表面上。

32. 发明申请

US20130008585A1 COATED SHEET-LIKE PLASTIC MATERIAL WITH REDUCED TENDENCY TO COLONIZATION BY ALGAE, PROCESS FOR THE IN-LINE PRODUCTION THEREOF AND USE 有权
标题翻译：涂层薄片材料，通过ALGAE降低结合度，对其进行在线生产和使用的工艺
公开(公告)号：US20130008585A1
公开(公告)日：2013-01-10
申请号：US13635452
申请日：2011-03-02
申请人： Thomas Hasskerl , Wolfgang Scharnke , Martin Berkenkopf , Jann Schmidt , Xin Lu , Uwe Schneider
发明人： Thomas Hasskerl , Wolfgang Scharnke , Martin Berkenkopf , Jann Schmidt , Xin Lu , Uwe Schneider
IPC分类号： B32B9/04 , B05D3/00 , E04F13/00 , B32B5/16
CPC分类号： C09D1/00 , B01J21/063 , B01J21/08 , B01J35/004 , B01J35/023 , B01J37/0215 , B05D7/04 , B05D2451/00 , C02F2303/20 , C08J7/045 , Y10T428/24364 , Y10T428/24372 , Y10T428/24413 , Y10T428/256 , B05D2401/10 , B05D2401/32
摘要： A coated sheet-like plastics material comprising a) as base, a thermoplastic substrate; and b) on the base, a photocatalytically active coating comprising a water-spreading layer which involves either a sol-adhesion-promoter layer, layer b1+2), comprising an adhesion promoter and a colloid sol, or a colloid-sol layer b2) arranged on an adhesion-promoter layer b1) applied on the substrate a), and a photocatalytically active layer b3) arranged on the water-spreading layer b1+2) or b2), where b3) is obtainable through application and drying of a mixture comprising, based on the solids content of the mixture in percent by weight b31) from 1 to 25% of titanium dioxide and b32) from 75 to 99% of silicon dioxide and/or of a metal oxide which is not soluble in water or of an anionically modified silicon dioxide or metal oxide; where the titanium dioxide is particulate with an average primary-particle size smaller than 10 nm. In-line process for producing said material, and also use as roofing material or as glazing material, preferably in areas with moist conditions. The coated sheet-like plastics material of the invention combines water-spreading properties with photocatalytic activity, without any damage to the thermoplastic substrates. The coated sheet-like plastics substrate of the invention is produced in a relatively uncomplicated, inexpensive and fast in-line process and, in use, provides impressive substrate stability and impressive effectiveness of the coating in resisting initial algal growth.
摘要翻译：一种涂覆的片状塑料材料，其包含：a）作为基底，热塑性基材; 和b）在基材上，包含包含粘合促进剂和胶体溶胶的胶体粘附促进剂层b1 + 2的水分散层或胶体 - 溶胶层b2的光催化活性涂层）和布置在水扩散层b1 + 2）上的光催化活性层b3）或b2），其中b3）可通过施加和干燥a 混合物，其包含基于混合物的固体含量，以重量比b31），1至25％的二氧化钛和b32）75至99％的二氧化硅和/或不溶于水的金属氧化物的阴离子改性二氧化硅或金属氧化物; 其中二氧化钛是平均一次粒径小于10nm的颗粒。用于生产所述材料的在线方法，并且还用作屋顶材料或玻璃材料，优选地在具有潮湿条件的区域中。本发明的涂覆片状塑料材料将水分散性与光催化活性相结合，对热塑性基材没有任何损害。本发明的涂覆的片状塑料基材以相对简单，廉价和快速的在线方法生产，并且在使用中提供令人印象深刻的基材稳定性和涂层在抵抗初始藻类生长中令人印象深刻的有效性。

33. 发明申请

US20070269846A1 Organic cation transporter preferentially expressed in hematopoietic cells and leukemias and uses thereof 有权
标题翻译：有机阳离子转运蛋白优先在造血细胞和白血病中表达及其用途
公开(公告)号：US20070269846A1
公开(公告)日：2007-11-22
申请号：US11521487
申请日：2006-09-15
申请人： Jeffrey Moscow , Xin Lu , Craig Jordan
发明人： Jeffrey Moscow , Xin Lu , Craig Jordan
IPC分类号： G01N33/574 , C12Q1/02
CPC分类号： G01N33/6872 , G01N2500/10
摘要： A novel organic cation transporter (OCT) gene, OCT 6, and use thereof is described. The OCT6 gene is preferentially expressed in human hematopoietic tissues, including CD34+ cells and leukemia cells. Its narrow tissue distribution, substrate specificity, and close homology to other cell membrane transporters make OCT6 an attractive target for the treatment of myeloid diseases.
摘要翻译：描述了一种新颖的有机阳离子转运蛋白（OCT）基因，OCT6及其用途。 OCT6基因优先在人造血组织中表达，包括CD34 +细胞和白血病细胞。其窄的组织分布，底物特异性和与其他细胞膜转运蛋白的密切同源性使OCT6成为治疗骨髓疾病的有吸引力的靶标。

34. 发明申请

US20070128157A1 Tumour suppressor protein 有权
标题翻译：肿瘤抑制蛋白
公开(公告)号：US20070128157A1
公开(公告)日：2007-06-07
申请号：US10582316
申请日：2004-08-13
申请人： Xin Lu , Elizabeth Slee
发明人： Xin Lu , Elizabeth Slee
IPC分类号： A61K38/19 , A61K48/00 , C12Q1/68 , C07H21/04 , C07K14/525 , C07K16/24
CPC分类号： C07K14/4702 , C07K14/525 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178 , Y10S530/828
摘要： We describe a polypeptide which binds and modulates the activity of a tumour suppressor polypeptide, for example p53; a nucleic acid molecule encoding said protein and screening methods which modulate the binding activity of said polypeptide for its target polypeptide(s).
摘要翻译：我们描述了结合和调节肿瘤抑制多肽的活性的多肽，例如p53; 编码所述蛋白质的核酸分子和调节所述多肽对其靶多肽的结合活性的筛选方法。

35. 发明申请

US20070032389A1 Modified friction control compositions 有权
标题翻译：改性摩擦控制组合物
公开(公告)号：US20070032389A1
公开(公告)日：2007-02-08
申请号：US11198163
申请日：2005-08-08
申请人： Don Eadie , Xin Lu , John Cotter
发明人： Don Eadie , Xin Lu , John Cotter
IPC分类号： C10M169/04
CPC分类号： C10M173/02 , B61K3/00 , C08K5/0008 , C10M169/04 , C10M2201/02 , C10M2201/041 , C10M2201/062 , C10M2201/066 , C10M2201/08 , C10M2201/081 , C10M2201/084 , C10M2201/102 , C10M2201/103 , C10M2201/1036 , C10M2201/105 , C10M2201/18 , C10M2205/04 , C10M2207/022 , C10M2207/026 , C10M2207/04 , C10M2209/04 , C10M2209/084 , C10M2209/10 , C10M2209/101 , C10M2209/108 , C10M2209/11 , C10M2209/12 , C10M2213/02 , C10M2213/04 , C10M2215/064 , C10M2217/028 , C10M2217/044 , C10M2217/045 , C10M2219/06 , C10M2219/085 , C10N2210/01 , C10N2210/02 , C10N2210/03 , C10N2210/08 , C10N2230/06 , C10N2240/00 , C10N2250/08 , C10N2250/10 , C10N2250/121 , C10M2205/08
摘要： The present invention provides a friction control composition comprising a binder a rheological control agent, and optionally a lubricant. The liquid friction control composition may also comprise other components a wetting agent, a consistency modifier, and a preservative. The liquid friction control compositions may be used to modify the interfacial friction characteristics in sliding and rolling-sliding contact such as steel wheel-rail systems including mass transit and freight systems. A method of reducing lateral force, reducing energy consumption, or controlling friction between a metal surface and a second metal surface by applying the composition to metal surface, for example a top of rail or wheel, is also provided. The composition may be sprayed onto the rail surface.
摘要翻译：本发明提供一种摩擦控制组合物，其包含粘合剂流变控制剂和任选的润滑剂。液体摩擦控制组合物还可以包含其它组分润湿剂，稠度调节剂和防腐剂。液体摩擦控制组合物可用于改变滑动和滚动滑动接触中的界面摩擦特性，例如包括公共运输和货运系统的钢轮轨道系统。还提供了一种通过将组合物施加到金属表面，例如轨道或车轮的顶部来减小横向力，降低能量消耗或控制金属表面和第二金属表面之间的摩擦力的方法。组合物可以喷涂到轨道表面上。

36. 发明申请

US20060149504A1 System and method for testing liquid crystal displays 审中-公开
标题翻译：用于测试液晶显示器的系统和方法
公开(公告)号：US20060149504A1
公开(公告)日：2006-07-06
申请号：US11189939
申请日：2005-07-26
申请人： Kuan-Hong Hsieh , Zhong-Wu Tian , Xin Lu , Xiao-Guang Li
发明人： Kuan-Hong Hsieh , Zhong-Wu Tian , Xin Lu , Xiao-Guang Li
IPC分类号： G21C17/00
CPC分类号： G08C23/04 , G09G3/006
摘要： A system for testing Liquid Crystal Displays (LCDs), includes: a controlling computer, an encoder, an IR transmitter, an IR receiver, and a decoder. The controlling computer is for transmitting a test instruction. The encoder is for receiving the test instruction via a port, and encoding the test instruction into an infrared (IR) signal. The IR transmitter is for transmitting the IR signal. The IR receiver is for receiving the IR signal. The decoder is for decoding the IR signal into a Visual Graphic Array (VGA) signal, and transmitting the VGA signal via a VGA port. A related method for testing LCDs is also provided.
摘要翻译：一种用于测试液晶显示器（LCD）的系统，包括：控制计算机，编码器，IR发送器，IR接收器和解码器。控制计算机用于发送测试指令。编码器用于通过端口接收测试指令，并将测试指令编码为红外（IR）信号。 IR发送器用于发送IR信号。 IR接收机用于接收IR信号。解码器用于将IR信号解码为视觉图形阵列（VGA）信号，并通过VGA端口传输VGA信号。还提供了一种用于测试LCD的相关方法。

37. 发明申请

US20060127401A1 Screening method 审中-公开
标题翻译：筛选方法
公开(公告)号：US20060127401A1
公开(公告)日：2006-06-15
申请号：US10530450
申请日：2003-10-03
申请人： Xin Lu
发明人： Xin Lu
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/567 , A61K39/395 , G01N33/53
CPC分类号： G01N33/6896 , G01N2500/10
摘要： The invention relates to a screening method to determine the susceptibility of a mammal, preferably a human, to abnormal development of the nervous system and including therapeutic methods and compositions for the treatment of neurodegenerative conditions which result in abnormal expression of a family of polypeptides which induce the apoptotic function of p53.
摘要翻译：本发明涉及确定哺乳动物，优选人类对神经系统异常发展的易感性的筛选方法，包括用于治疗导致诱导的多肽家族异常表达的神经变性病症的治疗方法和组合物 p53的凋亡功能。

38. 发明申请

US20060069997A1 Device and method for processing information 失效
标题翻译：用于处理信息的设备和方法
公开(公告)号：US20060069997A1
公开(公告)日：2006-03-30
申请号：US11227480
申请日：2005-09-15
申请人： Kuan-Hong Hsieh , Xin Lu , Xiao-Guang Li
发明人： Kuan-Hong Hsieh , Xin Lu , Xiao-Guang Li
IPC分类号： G06F3/00 , G11B27/00
CPC分类号： G11B27/34 , G06F3/04815 , G06F3/0482 , G06F2203/04802
摘要： A method for processing information includes steps of: classifying a plurality of files into a plurality of groups, and each group is represented by one or more displayable images; designating each group according to a hierarchy of the groups; displaying images of one or more groups in a same level of the hierarchy in the form of a first virtual ellipse; locating centers of the displayed first virtual ellipses along a path of a second virtual ellipse; wherein a selected one of the groups in the same level of the hierarchy has its first virtual ellipse displayed in a size larger than that of any other displayed first virtual ellipse, a selected one of the images of the first virtual ellipse of the selected group is displayed in an active area of the first virtual ellipse of the selected group.
摘要翻译：一种用于处理信息的方法包括以下步骤：将多个文件分类成多个组，并且每个组由一个或多个可显示图像表示; 根据组的层次来指定每个组; 在第一虚拟椭圆形式的层次结构的相同级别中显示一个或多个组的图像; 沿着第二虚拟椭圆的路径定位所显示的第一虚拟椭圆的中心; 其中所述层级的相同级别中的所选组中的所选择的一个组具有以比任何其他显示的第一虚拟椭圆大的大小显示的第一虚拟椭圆，所选择的组的所述第一虚拟椭圆的所选择的一个图像是显示在所选组的第一虚拟椭圆的活动区域中。

39. 发明申请

US20060064768A1 Murine Pten null prostate cancer model 审中-公开
标题翻译：小鼠Pten无效前列腺癌模型
公开(公告)号：US20060064768A1
公开(公告)日：2006-03-23
申请号：US10946894
申请日：2004-09-21
申请人： Hong Wu , Xin Lu , Shunyou Wang
发明人： Hong Wu , Xin Lu , Shunyou Wang
IPC分类号： A01K67/027
CPC分类号： C12N9/16 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509 , C12N2800/30 , C12N2830/008
摘要： The invention provides a transgenic mouse and cell lines with a homozygous disruption of a chromosomal PTEN gene in prostate cells. The mouse progresses from hyperplasia to metastatic cancer and can be used to identify prostate cancer therapeutics and genes that are differentially regulated during androgen dependent and androgen independent prostate cancer progression.
摘要翻译：本发明提供了转基因小鼠和在前列腺细胞中染色体PTEN基因纯合破坏的细胞系。小鼠从增生进展到转移性癌症，并且可以用于鉴定在雄激素依赖性和雄激素依赖性前列腺癌进展期间差异调节的前列腺癌治疗剂和基因。

40. 发明授权

US09371305B2 Deuterated benzopyran compounds and application thereof 有权
标题翻译：氘化苯并吡喃化合物及其应用
公开(公告)号：US09371305B2
公开(公告)日：2016-06-21
申请号：US14401600
申请日：2012-08-10
申请人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
发明人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
IPC分类号： C07D311/58
CPC分类号： A61K31/353 , A61K31/382 , A61K31/47 , C07D311/58
摘要： The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
摘要翻译：本发明公开了具有式（I）所示结构特征的氘代苯并吡喃化合物或其药学上可接受的盐或立体异构体或其前药分子。具有优异的抗炎和镇痛作用和抑制肿瘤细胞生长的能力，这些化合物是新型的COX-2选择性抑制剂。本申请公开的化合物及其药学上可接受的盐可用于制备用于治疗或预防肿瘤的抗炎和镇痛药物和药物。

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