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31. 发明授权

US5731439A Piperidine containing aminobornic acids 失效
标题翻译：含哌啶的氨基硼酸
公开(公告)号：US5731439A
公开(公告)日：1998-03-24
申请号：US409303
申请日：1995-03-24
申请人： David John Carini , Joseph Cacciola , Celia Dominguez , John Matthew Fevig
发明人： David John Carini , Joseph Cacciola , Celia Dominguez , John Matthew Fevig
IPC分类号： A61K38/00 , C07F5/02 , C07K5/06 , C07F5/04 , C07F5/05
CPC分类号： C07F5/025 , C07F5/02 , C07K5/06191 , A61K38/00
摘要： The present invention relates generally to .alpha.-aminoboronic acids and corresponding peptide analogs in which the .alpha.-carbon is substituted with an optionally functionalized piperidine containing alkyl group. These compounds are useful as inhibitors of trypsin-like serine protease enzymes.
摘要翻译：本发明一般涉及α-氨基硼酸和相应的肽类似物，其中α-碳被任选官能化的含哌啶烷基取代。这些化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂。

32. 发明申请

US20140163009A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF 有权
标题翻译：组织脱乙酰酶抑制剂及其组合物及其使用方法
公开(公告)号：US20140163009A1
公开(公告)日：2014-06-12
申请号：US13981107
申请日：2012-01-23
申请人： Christopher A Luckhurst , Alen F Haughan , Perla Breccia , Andrew J Stott , Roland W Burli , Samantha J Hughes , Ignacio Munoz-Sanjuan , Celia Dominguez
发明人： Christopher A Luckhurst , Alen F Haughan , Perla Breccia , Andrew J Stott , Roland W Burli , Samantha J Hughes , Ignacio Munoz-Sanjuan , Celia Dominguez
IPC分类号： C07D487/04 , C07D471/04 , C07D231/12 , C07D409/08 , C07D233/64 , C07D267/14 , C07D401/06
CPC分类号： C07D401/06 , C07C259/08 , C07C311/14 , C07C2601/02 , C07C2601/14 , C07D205/04 , C07D207/10 , C07D209/44 , C07D209/46 , C07D209/82 , C07D211/58 , C07D211/70 , C07D213/56 , C07D213/74 , C07D215/18 , C07D231/12 , C07D233/61 , C07D233/64 , C07D237/08 , C07D239/26 , C07D263/32 , C07D265/36 , C07D267/14 , C07D277/30 , C07D295/155 , C07D317/46 , C07D319/18 , C07D401/04 , C07D409/08 , C07D413/04 , C07D417/08 , C07D471/04 , C07D487/04 , C07D491/10
摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
摘要翻译：提供式I的组蛋白脱乙酰酶（HDAC）抑制剂，其组合物及其使用方法。

33. 发明授权

US08642624B2 Substituted alkylamine derivatives and methods of use 有权
标题翻译：取代的烷基胺衍生物和使用方法
公开(公告)号：US08642624B2
公开(公告)日：2014-02-04
申请号：US13297213
申请日：2011-11-15
申请人： Guoqing Chen , Jeffrey A. Adams , Jean E. Bemis , Shon Booker , Guolin Cai , Lucian V. DiPietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael K. Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander S. Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian M. Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael D. Croghan
发明人： Guoqing Chen , Jeffrey A. Adams , Jean E. Bemis , Shon Booker , Guolin Cai , Lucian V. DiPietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael K. Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander S. Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian M. Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael D. Croghan
IPC分类号： A01N43/40 , A61K31/44 , A01N43/38 , A61K31/40 , A61K31/405
CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.
摘要翻译：所选择的杂环化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。

34. 发明授权

US07652009B2 Substituted heterocycles and methods of use 有权
标题翻译：取代的杂环和使用方法
公开(公告)号：US07652009B2
公开(公告)日：2010-01-26
申请号：US11289659
申请日：2005-11-29
申请人： Tae-Seong Kim , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Matthew Lee , Longbin Liu , Elizabeth Rainbeau , Aaron C. Siegmund , Andrew Tasker , Ning Xi , Yuan Cheng
发明人： Tae-Seong Kim , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Matthew Lee , Longbin Liu , Elizabeth Rainbeau , Aaron C. Siegmund , Andrew Tasker , Ning Xi , Yuan Cheng
IPC分类号： A61K31/506 , C07D401/02 , C07D239/22
CPC分类号： C07D401/14 , C07D215/233 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

35. 发明申请

US20090143575A1 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 失效
标题翻译： VANILLOID受体配体及其在治疗中的应用
公开(公告)号：US20090143575A1
公开(公告)日：2009-06-04
申请号：US12367352
申请日：2009-02-06
申请人： Chenera Balan , Yunxin Bo , Celia Dominguez , Christopher H. Fotsch , Vijay K. Gore , Vu Van Ma , Mark H. Norman , Vassil I. Ognyanov , Yi-xin Qian , Xianghong Wang , Ning Xi , Shimin Xu
发明人： Chenera Balan , Yunxin Bo , Celia Dominguez , Christopher H. Fotsch , Vijay K. Gore , Vu Van Ma , Mark H. Norman , Vassil I. Ognyanov , Yi-xin Qian , Xianghong Wang , Ning Xi , Shimin Xu
IPC分类号： C07D413/14 , C07D471/04 , C07D401/14
CPC分类号： C07D401/04 , C07D235/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotizing agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：治疗性苯并咪唑和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经痛维持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道，泌尿生殖道，胃肠道或血管区内脏运动紊乱，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病，胃溃疡十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

36. 发明授权

US07332511B2 Vanilloid receptor ligands and their use in treatments 失效
公开(公告)号：US07332511B2
公开(公告)日：2008-02-19
申请号：US11195159
申请日：2005-08-01
申请人： Elizabeth M. Doherty , Jiawang Zhu , Markian Stec , Mark H. Norman , Hui-Ling Wang , Christopher H. Fotsch , Ning Chen , Partha P. Chakrabarti , Celia Dominguez , James Richard Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil I. Ognyanov , Liping H. Pettus , Robert Michael Rzasa
发明人： Elizabeth M. Doherty , Jiawang Zhu , Markian Stec , Mark H. Norman , Hui-Ling Wang , Christopher H. Fotsch , Ning Chen , Partha P. Chakrabarti , Celia Dominguez , James Richard Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil I. Ognyanov , Liping H. Pettus , Robert Michael Rzasa
IPC分类号： C07D213/30 , C07D213/32 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/4427 , A61P19/02 , A61P35/00
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

37. 发明授权

US07105682B2 Substituted amine derivatives and methods of use 有权
公开(公告)号：US07105682B2
公开(公告)日：2006-09-12
申请号：US10046622
申请日：2002-01-10
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/14 , A61K31/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , Y02A50/401
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

38. 发明授权

US07049318B2 Substituted heterocyclic compounds and methods of use 失效
公开(公告)号：US07049318B2
公开(公告)日：2006-05-23
申请号：US10897884
申请日：2004-07-23
申请人： Celia Dominguez , Timothy Scot Harvey , Longbin Liu , Aaron Siegmund
发明人： Celia Dominguez , Timothy Scot Harvey , Longbin Liu , Aaron Siegmund
IPC分类号： A61K31/505
CPC分类号： C07D401/14 , C07D401/04 , C07D487/04
摘要： The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted; and R2 is a substituted C1-6alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

39. 发明申请

US20050277631A1 Vanilloid receptor ligands and their use in treatments 有权
公开(公告)号：US20050277631A1
公开(公告)日：2005-12-15
申请号：US11195134
申请日：2005-08-01
申请人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
发明人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
IPC分类号： A61P29/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/549 , A61K31/501 , C07D417/02 , C07D43/02
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

40. 发明授权

US06552042B2 Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor Xa 有权
标题翻译：苯并咪唑啉酮，苯并恶唑啉酮，苯并二嗪酮，茚满酮及其衍生物作为因子Xa的抑制剂
公开(公告)号：US06552042B2
公开(公告)日：2003-04-22
申请号：US09772303
申请日：2001-01-29
申请人： Qi Han , Celia Dominguez , Eugene C. Amparo , Jeongsook M. Park , Mimi L. Quan , Karen A. Rossi
发明人： Qi Han , Celia Dominguez , Eugene C. Amparo , Jeongsook M. Park , Mimi L. Quan , Karen A. Rossi
IPC分类号： C07D23526
CPC分类号： C07D263/58 , C07D209/34 , C07D235/26 , C07D241/44
摘要： The present application describes inhibitors of factor Xa of formula I: or pharmaceutically acceptable salt forms thereof, wherein W, W1, W2, and W3 may be N or C and J, Ja, and Jb combine to form a substituted carbocycle or heterocycle.
摘要翻译：本申请描述了式I的因子Xa或其药学上可接受的盐形式的抑制剂，其中W，W 1，W 2和W 3可以是N或C并且J，J a和J b结合形成取代的碳环或杂环。

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