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31. 发明申请

US20090152454A1 METHOD AND APPARATUS FOR AUTOMATED SPECTRAL CALIBRATION 有权
标题翻译：自动光谱校准的方法和装置
公开(公告)号：US20090152454A1
公开(公告)日：2009-06-18
申请号：US12273169
申请日：2008-11-18
申请人： Matthew P. Nelson , Patrick J. Treado
发明人： Matthew P. Nelson , Patrick J. Treado
IPC分类号： G01D18/00
CPC分类号： G01J3/28 , A61B5/0059 , A61B2560/0223 , G01J2003/2866
摘要： The disclosure generally relates to a method and apparatus for automated spectral calibration of a spectroscopy device. In one embodiment, the disclosure relates to a method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.
摘要翻译：本发明一般涉及一种用于光谱设备的自动光谱校准的方法和装置。在一个实施方案中，本公开涉及通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱。

32. 发明授权

US07474395B2 System and method for image reconstruction in a fiber array spectral translator system 有权
标题翻译：光纤阵列光谱转换系统中图像重建的系统和方法
公开(公告)号：US07474395B2
公开(公告)日：2009-01-06
申请号：US11674552
申请日：2007-02-13
申请人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
发明人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
IPC分类号： G01J3/00
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0221 , G01J3/28 , G01J3/2803 , G01J3/2823 , G01N21/255 , G01N21/274 , G01N2201/0833
摘要： The disclosure relates generally to methods and apparatus for spectral calibration of a spectroscopic system which includes a fiber array spectral translator. One embodiment relates to a method for obtaining a first image of a known substance using a photon detector and a fiber array spectral translator having plural fibers, wherein the first image comprises at least one pixel; providing a second image of the substance wherein the second image comprises at least one pixel; comparing the first image with the second image; and adjusting at least one pixel of the first image based on the comparison of images to thereby obtain an adjusted image.
摘要翻译：本公开一般涉及包括光纤阵列光谱转换器的光谱系统的光谱校准的方法和装置。一个实施例涉及一种使用光子检测器和具有多个光纤的光纤阵列光谱转换器获得已知物质的第一图像的方法，其中第一图像包括至少一个像素; 提供所述物质的第二图像，其中所述第二图像包括至少一个像素; 将第一图像与第二图像进行比较; 以及基于图像的比较来调整第一图像的至少一个像素，从而获得调整后的图像。

33. 发明申请

US20120150028A1 System and Method of Chemical Imaging Using Puled Laser Excitation and Time-Gated Detection to Determine Tissue Margins During Surgery 审中-公开
标题翻译：使用激光激光和时间门控检测技术测定手术中的组织边缘的化学成像系统和方法
公开(公告)号：US20120150028A1
公开(公告)日：2012-06-14
申请号：US13316703
申请日：2011-12-12
申请人： Patrick J. Treado , John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
发明人： Patrick J. Treado , John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , A61B5/4064 , G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/65 , G01N2021/6484 , G01N2201/08
摘要： System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
摘要翻译：使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。

34. 发明申请

US20120120393A1 TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR 审中-公开
标题翻译：时间和空间分辨率高分辨率高分辨率激光雷达探测器
公开(公告)号：US20120120393A1
公开(公告)日：2012-05-17
申请号：US13290174
申请日：2011-11-07
申请人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
发明人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
IPC分类号： G01J3/44 , G01B11/24
CPC分类号： G01J3/36 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/44 , G01N21/359 , G01N21/6456 , G01N21/65 , G01N21/718 , G01N2021/1738 , G01N2021/174 , G01N2021/1744
摘要： A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
摘要翻译：爆炸物和爆炸物残留物检测的系统和方法。激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。第一光学系统将光引导到目标区域。视频采集装置输出目标区域的动态图像。第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列。光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

35. 发明申请

US20100148073A1 System and Method for Structured Illumination and Collection for Improved Optical Confocality of Raman Fiber Array Spectral Translator Imaging and Interactive Raman Probing 有权
标题翻译：用于拉曼光纤阵列光谱转换成像和交互式拉曼探测的改进光学谐振的结构照明和采集系统和方法
公开(公告)号：US20100148073A1
公开(公告)日：2010-06-17
申请号：US12632187
申请日：2009-12-07
申请人： Matthew P. Nelson , Patrick J. Treado
发明人： Matthew P. Nelson , Patrick J. Treado
IPC分类号： G01T1/28 , G01J1/58 , G01N21/65 , G01N21/64 , G01J3/44
CPC分类号： G01J3/2803 , G01J3/0221 , G01J3/44 , G01N21/474 , G01N21/55 , G01N21/645 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2021/6484 , G01N2201/0833 , G01N2201/0846 , G02B6/06
摘要： The disclosure relates generally to methods and apparatus for using telescope optics and a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.
摘要翻译：本公开一般涉及用于使用望远镜光学器件的方法和装置以及用于改进样品的成像，光谱分析和交互式探测的光纤阵列光谱转换器（“FAST”）光谱系统。在一个实施例中，通过使用结构化照明和/或光子的结构化收集来提高基于光纤阵列光谱转换器的光谱系统的共焦度。可以接收用户输入并执行操作以允许用户以实时和/或接近实时的方式进行交互式查看和分析样本的特定区域。

36. 发明授权

US07692775B2 Time and space resolved standoff hyperspectral IED explosives LIDAR detection 有权
标题翻译：时间和空间解决了高光谱IED爆炸物LIDAR检测
公开(公告)号：US07692775B2
公开(公告)日：2010-04-06
申请号：US11450149
申请日：2006-06-09
申请人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
发明人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
IPC分类号： G01N21/00
CPC分类号： G01J3/36 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/44 , G01N21/359 , G01N21/6456 , G01N21/65 , G01N21/718 , G01N2021/1738 , G01N2021/174 , G01N2021/1744
摘要： A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
摘要翻译：爆炸物和爆炸物残留物检测的系统和方法。激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。第一光学系统将光引导到目标区域。视频采集装置输出目标区域的动态图像。第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列。光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

37. 发明授权

US07551821B2 Chemical imaging fiberscope 有权
标题翻译：化学成像纤维镜
公开(公告)号：US07551821B2
公开(公告)日：2009-06-23
申请号：US11744797
申请日：2007-05-04
申请人： Patrick J. Treado , Matthew P. Nelson , Scott A. Keitzer , Ryan D. Smith
发明人： Patrick J. Treado , Matthew P. Nelson , Scott A. Keitzer , Ryan D. Smith
IPC分类号： G02B6/06 , G01J3/44 , A61B1/06
CPC分类号： G02B6/06 , A61B1/00165 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0227 , G01J3/024 , G01J3/0256 , G01J3/0262 , G01J3/0286 , G01J3/44 , G01J2003/1213
摘要： A fiberscope device is disclosed which is suitable for video imaging, laser Raman spectroscopy and laser Raman spectroscopic (i.e. chemical) imaging. The fiberscope design minimizes fiber background interference arising from the laser delivery fiber optic and the coherent fiber optic light gathering bundle while maintaining high light throughput efficiency through the use of integrated spectral filters. In the fiberscope design, the laser delivery fiber optic is offset from the coherent fiber optic light gathering bundle. The laser delivery field is captured entirely by the light gathering field of view of the coherent fiber bundle. The fiberscope incorporates spectral filter optical elements that provide environmental insensitivity, particularly to temperature and moisture. The fiberscope is suited to the analysis of a wide range of condensed phase materials (solids and liquids), including the analysis of biological materials such as breast tissue lesions and arterial plaques, in such a manner to delineate abnormal from normal tissues.
摘要翻译：公开了适用于视频成像，激光拉曼光谱和激光拉曼光谱（即化学）成像的纤维内窥镜装置。纤维镜设计可以最大限度地减少激光传输光纤和相干光纤采集光束产生的光纤背景干扰，同时通过使用集成光谱滤波器保持高光通量效率。在纤维镜设计中，激光传输光纤与相干光纤聚光束偏移。激光输送场完全由相干光纤束的聚光场捕获。纤维镜包含光谱滤光器光学元件，其提供环境不敏感性，特别是对温度和湿度。纤维内窥镜适用于分析各种凝聚相材料（固体和液体），包括分析生物材料如乳房组织损伤和动脉斑块，以便从正常组织中描绘异常。

38. 发明申请

US20070188747A1 SYSTEM AND METHOD FOR IMAGE RECONSTRUCTION IN A FIBER ARRAY SPECTRAL TRANSLATOR SYSTEM 有权
标题翻译：一种光纤阵列传输系统中图像重构的系统与方法
公开(公告)号：US20070188747A1
公开(公告)日：2007-08-16
申请号：US11674552
申请日：2007-02-13
申请人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
发明人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
IPC分类号： G01D18/00 , G01J3/00 , G01C19/00
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0221 , G01J3/28 , G01J3/2803 , G01J3/2823 , G01N21/255 , G01N21/274 , G01N2201/0833
摘要： The disclosure relates generally to methods and apparatus for spectral calibration of a spectroscopic system which includes a fiber array spectral translator. One embodiment relates to a method for obtaining a first image of a known substance using a photon detector and a fiber array spectral translator having plural fibers, wherein the first image comprises at least one pixel; providing a second image of the substance wherein the second image comprises at least one pixel; comparing the first image with the second image; and adjusting at least one pixel of the first image based on the comparison of images to thereby obtain an adjusted image.
摘要翻译：本公开一般涉及包括光纤阵列光谱转换器的光谱系统的光谱校准的方法和装置。一个实施例涉及一种使用光子检测器和具有多个光纤的光纤阵列光谱转换器获得已知物质的第一图像的方法，其中第一图像包括至少一个像素; 提供所述物质的第二图像，其中所述第二图像包括至少一个像素; 将第一图像与第二图像进行比较; 以及基于图像的比较来调整第一图像的至少一个像素，从而获得调整后的图像。

39. 发明授权

US06954667B2 Method for Raman chemical imaging and characterization of calcification in tissue 有权
标题翻译：拉曼化学成像方法和组织钙化表征
公开(公告)号：US06954667B2
公开(公告)日：2005-10-11
申请号：US10185090
申请日：2002-06-28
申请人： Patrick J. Treado , Matthew P. Nelson
发明人： Patrick J. Treado , Matthew P. Nelson
IPC分类号： A61B5/00 , G01N21/65 , A61B6/00
CPC分类号： A61B5/0091 , A61B5/4312 , G01N21/65
摘要： Apparatus and methods for spatially resolved Raman detection of calcification in tissues are disclosed. A region of soft non-arterial biological tissue is illuminated with monochromatic light. A spatially organized first area of calcified tissue is then detected in the region by detecting a Raman shifted light signal. The Raman shifted light signal is spatially resolved in at least one direction.
摘要翻译：公开了用于组织中钙化的空间分辨拉曼检测的装置和方法。柔软的非动脉生物组织的区域用单色光照射。然后通过检测拉曼偏移的光信号在该区域中检测空间组织的钙化组织的第一区域。拉曼移动的光信号在至少一个方向上被空间分辨。

40. 发明申请

US20080300826A1 FORENSIC INTEGRATED SEARCH TECHNOLOGY WITH INSTRUMENT WEIGHT FACTOR DETERMINATION 有权
标题翻译：威信集成搜索技术与仪器重量因子确定
公开(公告)号：US20080300826A1
公开(公告)日：2008-12-04
申请号：US12017445
申请日：2008-01-22
申请人： Robert C. SCHWEITZER , Patrick J. Treado
发明人： Robert C. SCHWEITZER , Patrick J. Treado
IPC分类号： G06F17/18
CPC分类号： G06K9/00536 , G06F19/703 , G06F19/709 , H01J49/0036
摘要： A system and method to search spectral databases and to identify unknown materials from multiple spectroscopic data in the databases. The methodology may be substantially automated and is configurable to determine weights to be accorded to spectroscopic data from different spectroscopic data generating instruments for improved identification of unknown materials. Library spectra from known materials are divided into training and validation sets. Initial, instrument-specific weighting factors are determined using a weight grid or weight scale. The training and validation spectra are weighted with the weighting factors and indicator probabilities for various sets of “coarse” weighting factors are determined through an iterative process. The finally-selected set of coarse weighting factors is further “fine tuned” using a weight grid with finer values of weights. The instrument-specific finer weight values may be applied to test data sets (or spectra) of an unknown material as well as to the library spectra from corresponding spectroscopic instruments. Instrument-specific weights for each class of samples may also be computed for additional customization and accuracy.
摘要翻译：一种用于搜索光谱数据库并从数据库中的多个光谱数据中识别未知物质的系统和方法。该方法可以基本上是自动化的，并且可配置为确定要与来自不同光谱数据生成装置的光谱数据一致的权重，以改进未知材料的识别。已知材料的谱图谱分为训练和验证集。使用权重网格或权重量表确定初始的仪器特定加权因子。训练和验证光谱通过加权因子加权，并且通过迭代过程确定各组“粗”加权因子的指标概率。最终选择的粗加权系数集合使用具有更精确的权重值的权重网格进一步“精细调整”。仪器特定的更精细的重量值可以应用于未知材料的测试数据集（或光谱）以及来自相应光谱仪的文库光谱。也可以计算每类样品的仪器特定重量，以获得额外的定制和准确性。

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