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31. 发明授权

US09518982B2 Sequential analysis of biological samples 有权
公开(公告)号：US09518982B2
公开(公告)日：2016-12-13
申请号：US12611299
申请日：2009-11-03
申请人： Anup Sood , Michael Christopher Montalto , Michael Gerdes , Maximilian Lewis Seel , Robert John Filkins
发明人： Anup Sood , Michael Christopher Montalto , Michael Gerdes , Maximilian Lewis Seel , Robert John Filkins
IPC分类号： G01N33/533 , C07H21/04 , C07K16/00 , G01N33/53 , G01N33/542 , G01N33/58 , C12Q1/68
CPC分类号： G01N33/53 , C12Q1/68 , G01N33/542 , G01N33/582 , Y10T436/143333
摘要： Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.

32. 发明授权

US08927732B2 Biotin stannane for HPLC-free radioiodination 有权
标题翻译：生物素锡烷用于无HPLC的放射性碘化
公开(公告)号：US08927732B2
公开(公告)日：2015-01-06
申请号：US13435142
申请日：2012-03-30
申请人： Randall Lee Carter , Bruce Fletcher Johnson , Anup Sood , Michael James Rishel , John Fitzmaurice Valliant , Karin Ann Stephenson , Tao Wu , Yang Yang
发明人： Randall Lee Carter , Bruce Fletcher Johnson , Anup Sood , Michael James Rishel , John Fitzmaurice Valliant , Karin Ann Stephenson , Tao Wu , Yang Yang
IPC分类号： C07F7/22 , C07B59/00
CPC分类号： C07F7/2296 , C07B59/00 , C07F7/2208
摘要： The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include biotin-like substituents useful in such methods.
摘要翻译：本教导提供了能够制备和纯化放射性碘化载体而不需要HPLC纯化的方法，以及包括在这些方法中有用的生物素样取代基的新型前体。

33. 发明授权

US08822147B2 Sequential analysis of biological samples 有权
标题翻译：生物样品的顺序分析
公开(公告)号：US08822147B2
公开(公告)日：2014-09-02
申请号：US13457531
申请日：2012-04-27
申请人： Anup Sood , Michael Christopher Montalto , Michael Gerdes , Maximilian Lewis Seel , Robert John Filkins
发明人： Anup Sood , Michael Christopher Montalto , Michael Gerdes , Maximilian Lewis Seel , Robert John Filkins
IPC分类号： C12Q1/68 , G01N33/58 , G01N33/542 , G01N33/53
CPC分类号： G01N33/53 , C12Q1/68 , G01N33/542 , G01N33/582 , Y10T436/143333
摘要： Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.
摘要翻译：提供了用于检测生物样品中多个靶的方法。所述方法包括使样品与第一探针接触; 将第一探针物理地绑定到第一靶; 观察来自第一探针的第一信号; 施用化学试剂来修饰第一信号; 使样品与第二探针接触; 将第二探针物理地绑定到第二靶上; 并观察来自第二探测器的第二信号。本文公开的方法还提供绑定，观察，信号修改的多次迭代，用于导出关于单个样本中的多个目标的信息。还提供了相关的套件和设备。

34. 发明授权

US08691939B2 Compositions, methods, and kits for assaying complement activation 失效
标题翻译：用于测定补体激活的组合物，方法和试剂盒
公开(公告)号：US08691939B2
公开(公告)日：2014-04-08
申请号：US11811425
申请日：2007-06-08
申请人： Liming Yu , Anup Sood , Mark Felipe Baptista
发明人： Liming Yu , Anup Sood , Mark Felipe Baptista
IPC分类号： A61K38/00
CPC分类号： C07K14/472 , C12Q1/37 , G01N2333/96441
摘要： The present invention provides a fluorogenic composition for assaying complement activation that comprises a substrate for C3 convertase that is linked to a first fluorophore and a second fluorophore, wherein the fluorescence of the first and second fluorophores are mutually substantially quenched when the two fluorophores are present at a distance less than the characteristic distance for the two fluorophores. In one embodiment, the fluorescence of the first fluorophore is substantially quenched by the second fluorophore, and the second fluorophore emits heat upon quenching. The present invention also provides a method for assaying complement activation, wherein the method includes the steps of incubating a biological sample with a polymer to provide a polymeric biological sample, followed by incubating the polymeric biological sample with the fluorogenic composition, and measuring the fluorescence. The method may optionally include the step of measuring the optical properties of the biological sample prior to the incubation steps. The present invention further provides a kit for assaying complement activation that comprises the fluorogenic composition disclosed herein.
摘要翻译：本发明提供了用于测定补体活化的荧光组合物，其包含与第一荧光团和第二荧光团连接的C3转化酶底物，其中当两个荧光团存在于第一荧光团和第二荧光团时，第一和第二荧光团的荧光相互基本上骤冷距离小于两个荧光团的特征距离。在一个实施方案中，第一荧光团的荧光基本上被第二荧光团猝灭，第二荧光团在淬火时发出热。本发明还提供了用于测定补体活化的方法，其中该方法包括以下步骤：用聚合物孵育生物样品以提供聚合生物样品，随后将聚合物生物样品与荧光组合物一起温育，并测量荧光。该方法可以可选地包括在孵育步骤之前测量生物样品的光学性质的步骤。本发明还提供了用于测定补体活化的试剂盒，其包含本文公开的荧光组合物。

35. 发明授权

US08568991B2 Photoactivated chemical bleaching of dyes 有权
标题翻译：光敏化学漂白染料
公开(公告)号：US08568991B2
公开(公告)日：2013-10-29
申请号：US13336409
申请日：2011-12-23
申请人： Arunkumar Natarajan , Anup Sood , Lakshmi Sireesha Kaanumalle , Kwok Pong Chan
发明人： Arunkumar Natarajan , Anup Sood , Lakshmi Sireesha Kaanumalle , Kwok Pong Chan
IPC分类号： G01N33/53 , G01N33/532 , G01N33/533 , G01N21/76
CPC分类号： G01N33/582 , G01N21/64 , G01N21/6428
摘要： Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.
摘要翻译：提供了包括使用光活化化学漂白来检测生物样品中的多个靶的方法。所述方法包括以下步骤：提供含有多个靶标的生物样品，将至少一个探针结合到样品中存在的一个或多个靶，并观察来自探针的信号。该方法还包括以下步骤：将包含结合的探针的样品与电子转移试剂接触并照射样品，从而引发光激活，其通过光活化的化学漂白使探针基本上灭活。该方法还包括将至少一个探针结合到样品中存在的一个或多个靶，并观察来自探针的信号的步骤。结合，观察和漂白的过程可以迭代地重复。

36. 发明申请

US20130261311A1 BIOTIN STANNANE FOR HPLC-FREE RADIOIODINATION 有权
标题翻译：用于HPLC免费放射生物素的生物素
公开(公告)号：US20130261311A1
公开(公告)日：2013-10-03
申请号：US13435142
申请日：2012-03-30
申请人： Randall Lee Carter , Bruce Fletcher Johnson , Anup Sood , Michael James Rishel , John Fitzmaurice Valliant , Karin Ann Stephenson , Tao Wu , Yang Yang
发明人： Randall Lee Carter , Bruce Fletcher Johnson , Anup Sood , Michael James Rishel , John Fitzmaurice Valliant , Karin Ann Stephenson , Tao Wu , Yang Yang
IPC分类号： C07C51/487 , C07F7/22 , C07C67/60
CPC分类号： C07F7/2296 , C07B59/00 , C07F7/2208
摘要： The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include biotin-like substituents useful in such methods.
摘要翻译：本教导提供了能够制备和纯化放射性碘化载体而不需要HPLC纯化的方法，以及包括在这些方法中有用的生物素样取代基的新型前体。

37. 发明申请

US20120252685A1 SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES 有权
标题翻译：生物样品的序列分析
公开(公告)号：US20120252685A1
公开(公告)日：2012-10-04
申请号：US11864098
申请日：2007-09-28
申请人： Thomas Pirrie Treynor , Anup Sood , Michael J. Gerdes , Zhengyu Pang
发明人： Thomas Pirrie Treynor , Anup Sood , Michael J. Gerdes , Zhengyu Pang
IPC分类号： C40B30/04 , C40B40/10 , C40B40/06 , G01N21/64
CPC分类号： G01N33/581 , G01N33/6803
摘要： Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a sample containing multiple targets, binding at least one probe having a binder coupled to an enzyme to one or more target present in the sample, and reacting the bound probe with an enzyme substrate coupled to a fluorescent signal generator. The methods include the steps of observing a signal from the fluorescent signal generator and applying to the sample a solution containing an oxidizing agent that substantially inactivates both the fluorescent signal generator and the enzyme. The methods further include the steps of binding at least one probe having a binder coupled to an enzyme to one or more target present in the sample of step, reacting the bound probe with an enzyme substrate coupled to a fluorescent signal generator; and observing a signal from the fluorescent signal generator. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.
摘要翻译：提供了探测生物样品中多个靶标的方法。所述方法包括以下步骤：提供含有多个靶标的样品，将至少一种具有与酶偶联的结合剂的探针结合至样品中存在的一种或多种靶标，以及使结合的探针与偶联于荧光信号发生器。所述方法包括以下步骤：观察来自荧光信号发生器的信号，并向样品施加含有基本上灭活荧光信号发生器和酶的氧化剂的溶液。所述方法还包括以下步骤：将具有与酶偶联的粘合剂的至少一种探针与步骤样品中存在的一种或多种靶结合，使结合的探针与偶联于荧光信号发生器的酶底物反应; 并观察来自荧光信号发生器的信号。本文公开的方法还提供结合，观察和氧化的多次迭代，用于导出关于单个样本中的多个目标的信息。还提供了相关的套件。

38. 发明申请

US20120114563A1 OPTICAL IMAGING AGENTS 审中-公开
标题翻译：光学成像代理
公开(公告)号：US20120114563A1
公开(公告)日：2012-05-10
申请号：US13257318
申请日：2010-03-19
申请人： Randall Lee Carter , Jason William Castle , Kenneth Michael Fish , Anup Sood , Natalie Anne Staples , Brian Duh-Lan Lee
发明人： Randall Lee Carter , Jason William Castle , Kenneth Michael Fish , Anup Sood , Natalie Anne Staples , Brian Duh-Lan Lee
IPC分类号： A61K49/00 , C07C43/10
CPC分类号： A61K49/0032 , A61K49/0054
摘要： The present invention relates to a method of in vivo optical imaging, of the margins around tumours, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of near-infrared dyes with synthetic polyethylene glycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are optical imaging contrast agents, pharmaceutical compositions and kits.
摘要翻译：本发明涉及一种体内光学成像方法，包括光学成像造影剂，包括肿瘤周围的边缘。光学成像剂包括近红外染料与分子量在15-45kDa范围内的合成聚乙二醇（PEG）聚合物的共轭物。还公开了光学成像造影剂，药物组合物和试剂盒。

39. 发明申请

US20100159572A1 DEVICE AND ASSOCIATED METHOD 审中-公开
标题翻译：装置和相关方法
公开(公告)号：US20100159572A1
公开(公告)日：2010-06-24
申请号：US12340789
申请日：2008-12-22
申请人： Rui Chen , Anping Zhang , Anup Sood , Anthony John Murray
发明人： Rui Chen , Anping Zhang , Anup Sood , Anthony John Murray
IPC分类号： C12M1/34 , B01J19/00 , B05D3/02
CPC分类号： B01J19/0046 , B01J2219/00536 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , G01N33/54353 , G01N33/552
摘要： A microfluidic device for detecting one or more molecules of interest comprising: a non-conductive substrate; wherein the non-conductive substrate is provided with a plurality of thermally active elements is provided. A method for selectively functionalizing a plurality of thermally active elements is also provided.
摘要翻译：一种用于检测一个或多个感兴趣分子的微流体装置，包括：非导电衬底; 其中所述非导电基板设置有多个热活性元件。还提供了一种用于选择性地功能化多个热活性元件的方法。

40. 发明申请

US20070009435A1 Compositions and methods for enhanced delivery to target sites 审中-公开
标题翻译：用于增强传送到目标网站的组合和方法
公开(公告)号：US20070009435A1
公开(公告)日：2007-01-11
申请号：US11175596
申请日：2005-07-06
申请人： Faisal Syud , Nichole Wood , Daniel Kramer , Mark Baillie , Dinko Eduardo Trotter , Anup Sood , Ming Zhao
发明人： Faisal Syud , Nichole Wood , Daniel Kramer , Mark Baillie , Dinko Eduardo Trotter , Anup Sood , Ming Zhao
IPC分类号： A61K51/00 , A61K48/00 , C07H21/02 , C07F9/6533
CPC分类号： C07F9/65586 , A61K49/0002 , A61K51/0491 , A61K51/0495 , C07F9/65616
摘要： A set of compounds that includes an active agent-labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a first oligomeric nucleotide or mimic thereof conjugated to a linker having a first moiety coupled with a diagnostic active agent. The pretargeting conjugate includes a second oligomeric nucleotide or mimic thereof conjugated to a targeting species having a targeting moiety capable of binding to a target or a marker produced by or associated with the target. The second oligomeric nucleotide or mimic thereof has a sequence that is at least partially complementary to a sequence of the first oligomeric nucleotide or mimic thereof. Also disclosed are methods of administering the pretargeting conjugate and active agent-labeled species to a subject for diagnosing a disease condition or assessing the effectiveness of a treatment of the disease condition.
摘要翻译：公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。活性剂标记的物质包括与具有与诊断活性剂偶联的第一部分的接头缀合的第一寡聚核苷酸或其模拟物。预靶向缀合物包括与靶向物质缀合的第二寡聚核苷酸或其模拟物，所述靶向物质具有能够结合靶标的靶向部分或由靶产生或与靶标相关的标记。第二寡聚核苷酸或其模拟物具有与第一寡核苷酸序列至少部分互补的序列或其模拟物。还公开了将预靶向缀合物和活性剂标记物质施用于受试者以诊断疾病状况或评估治疗疾病状况的有效性的方法。

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