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31. 发明授权

US07645504B1 Coatings for implantable medical devices comprising hydrophobic and hydrophilic polymers 有权
标题翻译：用于可植入医疗器械的涂层包括疏水性和亲水性聚合物
公开(公告)号：US07645504B1
公开(公告)日：2010-01-12
申请号：US10606711
申请日：2003-06-26
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： B32B7/02 , B32B27/00 , B32B27/36 , A61F2/24 , A61L33/00
CPC分类号： A61L31/10 , A61L2420/08 , Y10T428/13 , Y10T428/24942 , Y10T428/3154 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935
摘要： Coatings for implantable medical devices and methods for fabricating thereof are disclosed. The coatings include a layer comprising a hydrophobic polymer and a layer comprising a hydrophilic or amphiphilic polymer.
摘要翻译：公开了用于可植入医疗器械的涂层及其制造方法。涂层包括包含疏水性聚合物的层和包含亲水性或两亲性聚合物的层。

32. 发明申请

US20090299007A1 BIOLOGICALLY ABSORBABLE COATINGS FOR IMPLANTABLE DEVICES BASED ON POLYESTERS AND METHODS FOR FABRICATING THE SAME 有权
标题翻译：基于聚酯的可植入装置的生物吸收性涂料及其制造方法
公开(公告)号：US20090299007A1
公开(公告)日：2009-12-03
申请号：US12488250
申请日：2009-06-19
申请人： Stephen D. Pacetti , Yiwen Tang
发明人： Stephen D. Pacetti , Yiwen Tang
IPC分类号： C08G63/183
CPC分类号： C08G63/181 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/416 , C08G2230/00 , C08L67/02
摘要： Polymers containing polyesters and, optionally, agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol and a polycarboxylic acid.
摘要翻译：公开了含有聚酯和任选的用于医疗制品的试剂的聚合物及其制造方法。医疗制品通常包括具有涂层的可植入基底，并且该涂层含有包含含有多元醇和多元羧酸的反应的聚合产物的聚合物。

33. 发明申请

US20090269479A1 Method For Biostable Inclusion Of A Biobeneficial Agent On An Outermost Surface Of An Implantable Medical Device 有权
标题翻译：生物稳定剂包含生物有益剂在可植入医疗器械的最外表面上的方法
公开(公告)号：US20090269479A1
公开(公告)日：2009-10-29
申请号：US12108440
申请日：2008-04-23
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： A61L33/00
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61L2420/08 , C08L27/16
摘要： The current invention is directed to a method of protecting UV or visible light sensitive drugs from the effects of UV or visible radiation used to form covalent bonds between a biobeneficial material and the outermost surface of an implantable medical device in order to lessen the foreign body response to the device.
摘要翻译：本发明涉及一种保护UV或可见光敏感药物免受UV或可见辐射的影响的用途，用于在生物有益材料和可植入医疗器械的最外表面之间形成共价键的作用，以减少异物反应到设备。

34. 发明授权

US07604818B2 Polymers of fluorinated monomers and hydrocarbon monomers 有权
标题翻译：氟化单体和烃单体的聚合物
公开(公告)号：US07604818B2
公开(公告)日：2009-10-20
申请号：US11021775
申请日：2004-12-22
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： A61K45/00
CPC分类号： A61L31/048 , A61K31/436 , A61L31/10 , A61L31/16 , A61L2300/416 , C08F214/18 , C08F295/00 , C09D127/16 , C08L27/12 , A61K31/10
摘要： A polymer of fluorinated monomers and hydrocarbon monomers is provided. It is also provided a polymer blend that contains a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. The polymer or polymer blend described herein and optionally a bioactive agent can form an implantable device such as a stent or a coating on an implantable device such as a drug-delivery stent, which can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译：提供氟化单体和烃单体的聚合物。还提供了包含由氟化单体和烃单体形成的聚合物和另一种生物相容性聚合物的聚合物共混物。本文所述的聚合物或聚合物共混物和任选的生物活性剂可以在诸如药物递送支架的可植入装置上形成可植入装置，例如支架或涂层，其可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖，胆管阻塞，输尿管梗阻，肿瘤阻塞或其组合。

35. 发明申请

US20090248146A1 COATINGS FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：可植入医疗器械的涂层
公开(公告)号：US20090248146A1
公开(公告)日：2009-10-01
申请号：US12484040
申请日：2009-06-12
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61N1/0565
摘要： Coatings for implantable medical devices comprising non-fouling moieties or polymers chemically bonded to the surface of the device via chelating structures, and methods of fabricating the coatings are disclosed.
摘要翻译：公开了用于可植入医疗器械的涂层，其包括非结垢部分或通过螯合结构化学结合到器件表面的聚合物，以及制造涂层的方法。

36. 发明授权

US07538180B2 Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same 有权
标题翻译：基于聚（酯酰胺）的可植入装置的生物可吸收涂层及其制造方法
公开(公告)号：US07538180B2
公开(公告)日：2009-05-26
申请号：US11728209
申请日：2007-03-22
申请人： Stephen D. Pacetti , Jessica R. DesNoyer
发明人： Stephen D. Pacetti , Jessica R. DesNoyer
IPC分类号： C08G73/16 , C08F6/00
CPC分类号： A61L31/10 , Y10T428/31725 , Y10T428/31768 , C08L77/12
摘要： Coatings for an implantable medical devices such as stents and methods of fabricating thereof are disclosed. The coatings comprise a biologically absorbable poly(ester amide), which is a polymeric product of a reaction between a diol-diamine and a dicarboxylic acid.
摘要翻译：公开了用于诸如支架的可植入医疗装置的涂层及其制造方法。涂层包含生物可吸收的聚（酯酰胺），其是二醇 - 二胺和二羧酸之间的反应的聚合产物。

37. 发明申请

US20090012606A1 BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS 有权
标题翻译：生物聚酰胺/聚乙烯甘油聚合物与药物治疗
公开(公告)号：US20090012606A1
公开(公告)日：2009-01-08
申请号：US12207419
申请日：2008-09-09
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： A61F2/82 , A61L33/00 , C08G73/10 , C08G69/08 , C08G63/688 , C08G63/66 , C08G67/00 , C08G73/00
CPC分类号： C08G69/44 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/606 , Y10T428/31551 , Y10T428/31725
摘要： This disclosure provides a method device and a method of forming the medical device. The medical device comprises a coating comprising a polymer. The polymer comprises at least two different blocks, at least one L1 block with the formula and at least one L2 block with the formula Medical devices comprising these polymers, mixtures of these polymers with therapeutic agents, and methods of making these polymers and mixtures are within the scope of this disclosure.
摘要翻译：本公开提供了一种形成医疗装置的方法装置和方法。医疗装置包括包含聚合物的涂层。聚合物包含至少两个不同的嵌段，至少一个具有下式的L1嵌段和至少一个具有下式的L2嵌段：包含这些聚合物的医疗器件，这些聚合物与治疗剂的混合物，以及制备这些聚合物和混合物的方法在本公开的范围。

38. 发明申请

US20090012243A1 BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS 有权
标题翻译：生物聚酰胺/聚乙烯甘油聚合物与药物治疗
公开(公告)号：US20090012243A1
公开(公告)日：2009-01-08
申请号：US12207424
申请日：2008-09-09
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： C08L77/00
CPC分类号： C08G69/44 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/606 , Y10T428/31551 , Y10T428/31725
摘要： This disclosure covers polymers, which are useful in medical device applications. The polymers comprise at least two different blocks, at least one L1 block with the formula and at least one L2 block with the formula Medical devices comprising these polymers, mixtures of these polymers with therapeutic agents, and methods of making these polymers and mixtures are within the scope of this disclosure. Some of these medical devices are implantable within a mammalian body, such as in a body lumen.
摘要翻译：本公开涉及聚合物，其可用于医疗器械应用。聚合物包含至少两个不同的嵌段，至少一个具有下式的L1嵌段和至少一个具有下式的L2嵌段：包含这些聚合物的医疗器件，这些聚合物与治疗剂的混合物，以及制备这些聚合物和混合物的方法在本公开的范围。这些医疗装置中的一些可植入哺乳动物体内，例如在体腔中。

39. 发明申请

US20080286332A1 Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties 审中-公开
标题翻译：具有磷酸胆碱丙烯酸酯聚合物的顶涂层的植入式医疗装置，用于减少血栓形成，并改善机械性能
公开(公告)号：US20080286332A1
公开(公告)日：2008-11-20
申请号：US11803651
申请日：2007-05-14
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： A61F2/06 , A61K9/00 , A61P9/00 , A61P9/10
CPC分类号： A61L27/54 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/08
摘要： The present invention relates to implantable medical devices coated with phosphoryl choline acrylate polymer topcoat layer, an acrylate copolymer layer containing a therapeutic agent, and their use in the treatment of vascular diseases.
摘要翻译：本发明涉及涂覆有磷酸胆碱丙烯酸酯聚合物顶涂层的可植入医疗装置，含有治疗剂的丙烯酸酯共聚物层及其在治疗血管疾病中的用途。

40. 发明申请

US20080230000A1 Stent Spin Coating Apparatus 有权
标题翻译：支架旋涂装置
公开(公告)号：US20080230000A1
公开(公告)日：2008-09-25
申请号：US12132543
申请日：2008-06-03
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： B05C11/08
CPC分类号： B05D1/005
摘要： A system or device for spin coating an implantable medical device, such as a stent, is disclosed. The device includes a coating table to support the stent, the stent being positioned on top of the coating table and supported on the table by a support fixture. The coating table has an axis of rotation. The axis of rotation of the table can intersect a center of the mass of the stent. A driving means can be provided for rotating the stent about the longitudinal axis of the stent and for rotating the coating table about the axis of rotation.
摘要翻译：公开了用于旋涂可植入医疗装置（例如支架）的系统或装置。该装置包括用于支撑支架的涂层，支架位于涂层台的顶部，并通过支撑夹具支撑在工作台上。涂层表具有旋转轴。工作台的旋转轴线可以与支架质量的中心相交。可以提供驱动装置，用于围绕支架的纵向轴线旋转支架，并且用于围绕旋转轴线旋转涂布台。

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