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31. 发明申请

US20140046186A1 BONE SURFACE IMAGE RECONSTRUCTION USING ULTRASOUND 审中-公开
标题翻译：使用超声波的骨表面图像重建
公开(公告)号：US20140046186A1
公开(公告)日：2014-02-13
申请号：US14113672
申请日：2012-04-25
申请人： F. William Mauldin, JR. , John A. Hossack , Kevin Owen
发明人： F. William Mauldin, JR. , John A. Hossack , Kevin Owen
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/0875 , A61B8/0841 , A61B8/4245 , A61B8/4254 , A61B8/4433 , A61B8/4455 , A61B8/4466 , A61B8/4483 , A61B8/466 , A61B8/483 , A61B34/20 , A61B2017/3413 , A61B2034/2048 , A61B2034/2051 , A61B2034/2055 , A61B2090/378 , A61B2090/3937 , G01S7/52073 , G01S7/5208 , G01S15/60 , G01S15/8915 , G01S15/899
摘要： An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4λ2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about ½λ, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.
摘要翻译：超声波换能器元件可以被配置为产生被引导到对象的组织中的超声能量，并且被配置为接收由位于组织内的目标反射的超声能量的一部分。超声波换能器可以包括被配置为提供或接收超声能量的表面，该表面包括大于或等于约4λ2的面积，或者超声波换能器元件可以被包括在具有至少两个相邻超声波之间的间隔的阵列中小于或等于约1/2的元件，并且该阵列包括在两个轴线上至少近似对称的孔。可以经由显示器呈现目标的至少一部分的位置，形状或取向中的一个或多个的三维表示。

32. 发明授权

US08622911B2 System for treatment and imaging using ultrasonic energy and microbubbles and related method thereof 有权
标题翻译：使用超声波能量和微泡进行治疗和成像的系统及其相关方法
公开(公告)号：US08622911B2
公开(公告)日：2014-01-07
申请号：US12739128
申请日：2008-10-24
申请人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov
发明人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov
IPC分类号： A61B8/00 , A61M31/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/445 , A61B8/481 , A61B17/2202 , A61B2017/22088 , A61B2017/22089 , A61B2090/3782 , A61K41/0028 , A61K49/223 , A61M37/0092
摘要： A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.
摘要翻译：用于在受试者的一个或多个位置（例如脉管系统）向治疗部位提供治疗的方法和相关系统，例如狭窄或其它脉管系统疾病。该方法包括：将超声导管推进到受试者的治疗部位或其附近; 将微泡注入或接近治疗部位; 并从超声导管输送超声波能量。超声波能量可以适于：对治疗部位进行成像，将微泡翻译成治疗部位或其附近和/或破裂微泡。

33. 发明授权

US07756304B2 Medical diagnostic ultrasonic imaging method and system for displaying multi-phase, multi-frame images 有权
标题翻译：医学诊断超声成像方法和显示多相，多帧图像的系统
公开(公告)号：US07756304B2
公开(公告)日：2010-07-13
申请号：US09369510
申请日：1999-08-06
申请人： John A. Hossack , Linyong Pang , Thilaka S. Sumanaweera
发明人： John A. Hossack , Linyong Pang , Thilaka S. Sumanaweera
IPC分类号： G06K9/00
CPC分类号： A61B8/08 , A61B8/0883 , A61B8/483 , A61B8/543 , G01S7/52034 , G01S7/52065 , G01S7/52087 , G01S15/8993 , G06F19/00 , G06F19/321 , G16H40/63 , G16H50/50 , Y10S128/922
摘要： A medical diagnostic ultrasonic imaging system acquires image data for at least two frames at each of multiple positions, each frame identified with a respective phase of a physiological cycle. A multiphase 3-D or extended field of view data set is constructed from the image data. Then a plurality of images are generated from the multiphase data set. Each image is associated with a respective phase of the physiological cycle, and these images are displayed in sequence to a user.
摘要翻译：医疗诊断超声成像系统在多个位置的每一个处获取至少两帧的图像数据，每个帧用生理周期的相应相位标识。从图像数据构建多相3-D或扩展视场数据集。然后，从多相数据集生成多个图像。每个图像与生理周期的相应相关联，并且这些图像依次显示给用户。

34. 发明授权

US06511426B1 Medical diagnostic ultrasound system and method for versatile processing 有权
公开(公告)号：US06511426B1
公开(公告)日：2003-01-28
申请号：US09328113
申请日：1999-06-08
申请人： John A. Hossack , Jeffrey S. Hastings , Jeffrey M. Greenberg , Samuel H. Maslak
发明人： John A. Hossack , Jeffrey S. Hastings , Jeffrey M. Greenberg , Samuel H. Maslak
IPC分类号： A61B800
CPC分类号： G01S15/899 , A61B8/483 , A61B8/5276 , G01S7/52034 , G01S7/52077 , G01S15/8981 , G01S15/8993 , G01S15/8995
摘要： A method and system for reducing speckle for two and three-dimensional images is disclosed. For two-dimensional imaging, a one and a half or a two-dimensional transducer is used to obtain sequential, parallel or related frames of elevation spaced data. The frames are compounded to derive a two-dimensional image. For three-dimensional imaging, various pluralities of two-dimensional frames of data spaced in elevation are compounded into one plurality of spaced two-dimensional frames of data. The frames of data are then used to derive a three dimensional set of data, such as by interpolation. Alternatively, the various pluralities are used to derive a three-dimensional set of data. An anisotropic filter is applied to the set of data. The anisotropic filter filters at least along the elevation dimension. In either situation, various displays may be generated from the final three-dimensional set of data. A method and system for adjustably generating two and three-dimensional representations is also disclosed. For three-dimensional imaging, at least two sets of three-dimensional data corresponding respectively to two types of Doppler or B-mode data are generated. The sets of data are then combined. An image or a quantity may be obtained from the combined data. By combining after generating the three-dimensional sets of data, the same data (sets of data) may be combined multiple times pursuant to different relationships. Thus, a user may optimize the image or quantity. Likewise, frames of data may be combined pursuant to different persistence parameters, such as different finite impulse response filter size and coefficients. The frames of data may then be re-combined pursuant to different persistence parameters. Original ultrasound data may also be used to re-generate an imaging using the same ultrasound image processes as used for a previous image.

35. 发明授权

US06436046B1 Diagnostic ultrasound imaging method and system with improved frame rate 有权
标题翻译：诊断超声成像方法和系统，帧率提高
公开(公告)号：US06436046B1
公开(公告)日：2002-08-20
申请号：US09698995
申请日：2000-10-27
申请人： David J. Napolitano , Christopher R. Cole , Gregory L. Holley , John A. Hossack , Charles E. Bradley , Patrick Phillips
发明人： David J. Napolitano , Christopher R. Cole , Gregory L. Holley , John A. Hossack , Charles E. Bradley , Patrick Phillips
IPC分类号： A61B800
CPC分类号： G01S15/8963 , A61B8/00 , G01S7/52039 , G01S7/52046 , G01S7/52085 , G01S7/52095 , G01S15/8927 , G01S15/8959 , G01S15/8977
摘要： A medical diagnostic ultrasonic imaging system acquires receive beams from spatially distinct transmit beams. The receive beams alternate in type between at least first and second types across the region being imaged. The first and second types of receive beams differ in at least one scan parameter other than transmit and receive line geometry, and can for example differ in transmit phase, transmit or receive aperture, system frequency, transmit focus, complex phase angle, transmit code or transmit gain. Receive beams associated with spatially distinct ones of the transmit beams (including at least one beam of the first type and at least one beam of the second type) are then combined. In this way, many two-pulse techniques, including, for example, phase inversion techniques, synthetic aperture techniques, synthetic frequency techniques, and synthetic focus techniques, can be used while substantially reducing the frame rate penalty normally associated with such techniques.
摘要翻译：医疗诊断超声成像系统从空间上不同的发射波束获取接收波束。接收波束在被成像的区域之间在至少第一和第二类型之间交替类型。第一和第二类型的接收波束在除发射和接收线几何之外的至少一个扫描参数不同，并且例如可以在发射相位，发射或接收孔径，系统频率，发射焦点，复相位角，发射码或传输增益。然后组合与空间上不同的发射波束（包括第一类型的至少一个波束和第二类型的至少一个波束）相关联的接收波束。以这种方式，可以使用许多双脉冲技术，包括例如相位反转技术，合成孔径技术，合成频率技术和合成焦点技术，同时显着降低通常与这种技术相关联的帧速率损失。

36. 发明授权

US6122222A Ultrasonic transmit and receive system 有权
标题翻译：超声波发射和接收系统
公开(公告)号：US6122222A
公开(公告)日：2000-09-19
申请号：US307491
申请日：1999-05-07
申请人： John A. Hossack , Jian-Hua Mo
发明人： John A. Hossack , Jian-Hua Mo
IPC分类号： G01N29/24 , G01N29/26 , G01N29/34 , G01N29/40 , G01N29/42 , G01N29/46 , G01S7/52 , G01S15/89 , G10K11/34 , G03B42/06
CPC分类号： G01N29/343 , G01N29/2456 , G01N29/2462 , G01N29/262 , G01N29/348 , G01N29/40 , G01N29/42 , G01N29/46 , G01S15/8909 , G01S15/895 , G01S7/52034 , G01S7/52036 , G01S7/52038 , G01S7/52039 , G01S7/52046 , G01S7/52047 , G10K11/341 , G10K11/343 , G01N2291/012 , G01N2291/015 , G01N2291/106
摘要： A transmit beamformer includes multiple transducers, each responsive to a respective transmit waveform to produce a respective transducer waveform. A transmit waveform generator generates the transmit waveforms, and the transmit waveforms each include multiple frequency components. Progressively higher frequency components of the transmit waveforms are timed to cause corresponding progressively higher frequency components of the transducer waveforms to focus along a line at progressively shorter ranges. In this way, a frequency dependent line focus is achieved.
摘要翻译：发射波束形成器包括多个换能器，每个换能器响应相应的发射波形以产生相应的换能器波形。发送波形发生器产生发送波形，并且发送波形各自包括多个频率分量。发射波形的逐渐更高的频率分量被定时，以使得相应的逐渐更高的频率分量的换能器波形在逐渐更短的范围内沿着一条线聚焦。以这种方式，实现了频率相关的线焦点。

37. 发明授权

US06045508A Ultrasonic probe, system and method for two-dimensional imaging or three-dimensional reconstruction 失效
标题翻译：超声波探头，二维成像或三维重建的系统和方法
公开(公告)号：US06045508A
公开(公告)日：2000-04-04
申请号：US807384
申请日：1997-02-27
申请人： John A. Hossack , John W. Eaton
发明人： John A. Hossack , John W. Eaton
IPC分类号： A61B8/12 , G01S15/89 , A61B8/00
CPC分类号： A61B8/12 , A61B8/145 , A61B8/4488 , G01S15/8915 , G01S15/892 , G01S15/8993 , G01S7/52074
摘要： An ultrasonic probe that includes at least two ultrasonic arrays and allows three dimensional images to be constructed of the region examined by the probe in a precise and facile manner.
摘要翻译：一种超声波探头，其包括至少两个超声波阵列，并允许以精确和容易的方式由探头检查的区域构成三维图像。

38. 发明授权

US6042545A Medical diagnostic ultrasound system and method for transform ultrasound processing 有权
标题翻译：医学诊断超声系统及其变换超声处理方法
公开(公告)号：US6042545A
公开(公告)日：2000-03-28
申请号：US200021
申请日：1998-11-25
申请人： John A. Hossack , Samuel H. Maslak
发明人： John A. Hossack , Samuel H. Maslak
IPC分类号： G01S15/89 , A61B8/00
CPC分类号： G01S15/8977
摘要： The preferred embodiment includes a method and system for processing ultrasound data during or after compression. Various compression algorithms, such as JPEG compression, are used to transfer ultrasound data. The ultrasound data may include image (i.e. video data) or data obtained prior to scan conversion, such as detected acoustic line data or data complex in form. Compression algorithms typically include a plurality of steps to transform and quantize the ultrasound data. Various processes in addition to compression may be performed as part of one or more of the compression steps. Furthermore, various ultrasound system processes typically performed on uncompressed ultrasound data may be performed using compressed or partially compressed ultrasound data. Operation on compressed or partially compressed data may more efficiently provide processed data for generation of an image. Fewer operations are required by one or more processors when operating on compressed or partially compressed data than for uncompressed or non-compressed data. In one embodiment, partially compressed data may be input into a look-up table for contrast enhancement. In another embodiment, partially compressed data is high passed filtered.
摘要翻译：优选实施例包括用于在压缩期间或之后处理超声数据的方法和系统。使用各种压缩算法（例如JPEG压缩）来传送超声数据。超声数据可以包括图像（即视频数据）或扫描转换之前获得的数据，例如检测到的声线数据或形式的数据复合体。压缩算法通常包括多个步骤来变换和量化超声数据。作为一个或多个压缩步骤的一部分，可以执行除压缩之外的各种处理。此外，可以使用压缩或部分压缩的超声数据来执行通常在未压缩超声数据上执行的各种超声系统处理。在压缩或部分压缩的数据上的操作可以更有效地提供用于生成图像的处理数据。当对压缩或部分压缩的数据进行操作时，一个或多个处理器需要更少的操作，而不是未压缩或非压缩数据。在一个实施例中，可以将部分压缩的数据输入到用于对比度增强的查找表中。在另一个实施例中，部分压缩的数据被高通过滤。

39. 发明授权

US5947904A Ultrasonic method and system for imaging blood flow including disruption or activation of a contrast agent 有权
标题翻译：超声波血流成像方法及系统
公开(公告)号：US5947904A
公开(公告)日：1999-09-07
申请号：US190581
申请日：1998-11-12
申请人： John A. Hossack , Paul E. Chandler
发明人： John A. Hossack , Paul E. Chandler
IPC分类号： A61B8/00 , A61B8/06 , A61B8/14
CPC分类号： A61B8/481 , A61B8/06 , A61B8/145 , A61B8/463
摘要： An ultrasonic imaging system uses first and second perpendicular arrays. The first array is operated at high power to selectively destroy contrast agent suspended in flowing blood in discrete regions. The second array is used to image the alternating bands of contrast agent depleted blood and contrast image containing blood in order to allow blood flow characteristics to be assessed.
摘要翻译：超声波成像系统使用第一和第二垂直阵列。第一阵列以高功率运行，以选择性地破坏悬浮在离散区域中流动血液中的造影剂。第二阵列用于对包含血液的造影剂耗尽的血液和造影剂图像的交替条带进行成像，以便评估血流特性。

40. 发明授权

US5944666A Ultrasonic method for imaging blood flow including disruption or activation of contrast agent 失效
标题翻译：用于成像血流的超声波方法，包括造影剂的破坏或激活
公开(公告)号：US5944666A
公开(公告)日：1999-08-31
申请号：US916163
申请日：1997-08-21
申请人： John A. Hossack , Paul E. Chandler
发明人： John A. Hossack , Paul E. Chandler
IPC分类号： A61B8/00 , A61B8/06
CPC分类号： A61B8/481 , A61B8/06 , A61B8/145 , A61B8/463
摘要： An ultrasonic imaging system uses first and second perpendicular arrays. The first array is operated at high power to selectively destroy contrast agent suspended in flowing blood in discrete regions. The second array is used to image the alternating bands of contrast agent depleted blood and contrast image containing blood in order to allow blood flow characteristics to be assessed.
摘要翻译：超声波成像系统使用第一和第二垂直阵列。第一阵列以高功率运行，以选择性地破坏悬浮在离散区域中流动血液中的造影剂。第二阵列用于对包含血液的造影剂耗尽的血液和造影剂图像的交替条带进行成像，以便评估血流特性。

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