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31. 发明授权

US07662569B2 Methods of assessing Crohn's disease patient phenotype by I2 serologic response 有权
标题翻译：通过I2血清学反应评估克罗恩病患者表型的方法
公开(公告)号：US07662569B2
公开(公告)日：2010-02-16
申请号：US10413501
申请日：2003-04-11
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53 , G01N33/542 , G01N33/00
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

32. 发明授权

US06884590B1 Methods of screening for ulcerative colitis and crohn's disease 失效
标题翻译：筛查溃疡性结肠炎和克罗恩病的方法
公开(公告)号：US06884590B1
公开(公告)日：2005-04-26
申请号：US09419408
申请日：1999-10-15
申请人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
发明人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
IPC分类号： C07K14/705 , C07K16/28 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , C07K14/70525 , C07K16/2821 , C12Q2600/156
摘要： A novel association between IBD and a polymorphism at amino acid residue 241 of ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive with ICAM-1 encoded by, R241 allele and kits which exploit the inventive methods.
摘要翻译：已经发现了IBD与ICAM-1氨基酸残基241之间的多态性的新型关联。根据本发明，提供了筛选IBD的方法，用于治疗IBD的方法，与由R241等位基因编码的ICAM-1特异性反应的抗体以及利用本发明方法的试剂盒。

33. 发明申请

US20100240077A1 METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2 SEROLOGIC RESPONSE 有权
标题翻译：通过I2感染反应评估冠心病患者的方法
公开(公告)号：US20100240077A1
公开(公告)日：2010-09-23
申请号：US12645394
申请日：2009-12-22
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

34. 发明授权

US5681699A Methods of diagnosing ulcerative colitis and Crohn's disease 失效
标题翻译：诊断溃疡性结肠炎和克罗恩病的方法
公开(公告)号：US5681699A
公开(公告)日：1997-10-28
申请号：US196003
申请日：1994-02-11
申请人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
发明人： Jerome I. Rotter , Stephan R. Targan , Huiying Yang , Arthur L. Beaudet , Devendra Vora
IPC分类号： C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C07K16/2821 , C07K14/70525 , C12Q1/6883 , C12Q2600/156
摘要： A novel association between IBD and a polymorphism at amino acid residue 241 of ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive wish ICAM-1 encoded by R241 allele and kits which exploit the inventive methods.
摘要翻译：已经发现了IBD与ICAM-1氨基酸残基241之间的多态性的新型关联。根据本发明，提供了筛选IBD的方法，用于治疗IBD的方法，由R241等位基因编码的抗体特异性反应性愿望ICAM-1和利用本发明方法的试剂盒。

35. 发明申请

US20100015156A1 DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE IN CHILDREN 审中-公开
标题翻译：诊断儿童中的炎症性皮肤病
公开(公告)号：US20100015156A1
公开(公告)日：2010-01-21
申请号：US12529106
申请日：2008-03-06
申请人： Marla Dubinsky , Stephan R. Targan , Jerome I. Rotter
发明人： Marla Dubinsky , Stephan R. Targan , Jerome I. Rotter
IPC分类号： A61K39/395 , C12Q1/68 , A61P1/00 , A61P29/00 , A61P37/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156
摘要： This invention provides methods of diagnosing and predicting disease progression of Crohn's disease. In one embodiment, a method of the invention is practiced by determining the presence or absence of CARD15 variants R702W, G908R, and/or 1007insC in a pediatric individual. In another embodiment, a method of the invention is practiced by determining the presence or absence of anti-Cbir1, anti-OmpC, ASCA, and/or pANCA in a pediatric individual
摘要翻译：本发明提供了诊断和预测克罗恩病疾病进展的方法。在一个实施方案中，通过在儿科个体中确定CARD15变体R702W，G908R和/或1007insC的存在或不存在来实施本发明的方法。在另一个实施方案中，本发明的方法通过确定儿科个体中抗Cbir1，抗OmpC，ASCA和/或pANCA的存在或不存在来实施

36. 发明授权

US06534263B1 Methods of screening for Crohn's disease using TNF microsatellite alleles 有权
标题翻译：使用TNF微卫星等位基因筛选克罗恩病的方法
公开(公告)号：US06534263B1
公开(公告)日：2003-03-18
申请号：US09419406
申请日：1999-10-15
申请人： Scott E. Plevy , Jerome I. Rotter , Stephan R. Targan , Hiroo Toyoda , Huiying Yang
发明人： Scott E. Plevy , Jerome I. Rotter , Stephan R. Targan , Hiroo Toyoda , Huiying Yang
IPC分类号： C12Q1568
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presence or absence of nucleic acid of a subject encoding TNF microsatellite alleles associated with Crohn's disease, wherein the presence of nucleic acid encoding three or more of the alleles is indicative of Crohn's disease. Kits useful for screening for Crohn's disease are also provided which comprise nucleic acid encoding TNF microsatellite alleles associated with Crohn's disease.
摘要翻译：已经发现了某些肿瘤坏死因子微卫星等位基因与克罗恩病之间的关联。根据本发明，提供了用于筛选克罗恩病的方法，包括检测编码与克罗恩病相关的TNF微卫星等位基因的受试者的核酸的存在或不存在，其中编码三个或更多个等位基因的核酸的存在表明克罗恩病。还提供了用于筛选克罗恩病的试剂盒，其包含编码与克罗恩病相关的TNF微卫星等位基因的核酸。

37. 发明授权

US06376176B1 Methods of using a major histocompatibility complex class III haplotype to diagnose Crohn's disease 失效
公开(公告)号：US06376176B1
公开(公告)日：2002-04-23
申请号：US09395345
申请日：1999-09-13
申请人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang
发明人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang
IPC分类号： C12Q168
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides a method of diagnosing or predicting susceptibility to an autoimmune disease in an individual by determining the presence or absence in the individual of a 2-2-4 haplotype at the Notch4, HSP70-HOM and D6S273 loci, where the presence of the haplotype diagnoses or predicts susceptibility to the autoimmune disease. The methods of the invention can be particularly useful for diagnosing or predicting susceptibility to Crohn's disease, rheumatoid arthritis or type I diabetes mellitus. In a preferred embodiment, a method of the invention is used to diagnose or predict susceptibility to Crohn's disease in an individual of Ashkenazi Jewish ethnicity.

38. 发明申请

US20120088245A1 METHODS OF DIAGNOSING INSULIN RESISTANCE AND SENSITIVITY 审中-公开
标题翻译：诊断胰岛素抵抗和敏感性的方法
公开(公告)号：US20120088245A1
公开(公告)日：2012-04-12
申请号：US13126695
申请日：2009-10-30
申请人： Jerome I. Rotter , Kent D. Taylor , Xiuqing Guo , Mark O. Goodarzi , Yii-Der I. Chen , Leslie Raffel , Thomas A. Buchanan , Anny Xiang
发明人： Jerome I. Rotter , Kent D. Taylor , Xiuqing Guo , Mark O. Goodarzi , Yii-Der I. Chen , Leslie Raffel , Thomas A. Buchanan , Anny Xiang
IPC分类号： C12Q1/68
CPC分类号： G01N33/6875 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G01N33/6893 , G01N2333/92 , G01N2800/042
摘要： Methods of diagnosing susceptibility to metabolic insulin resistance and other related conditions are disclosed. The method provides means of diagnosing susceptibility to insulin resistance in Hispanic Americans by determining the presence of a risk haplotype at the LPL locus, the LPIN1 locus, and/or elevated levels of gamma-glutamyl transferase.
摘要翻译：公开了诊断代谢性胰岛素抵抗的易感性及其他相关病症的方法。该方法通过确定在LPL基因座，LPIN1基因座和/或γ-谷氨酰转移酶水平升高的风险单倍型的存在来提供诊断西班牙裔美国人胰岛素抵抗的易感性的方法。

39. 发明授权

US06348316B1 Genetic testing for determining the risk of pouchitis development 有权
标题翻译：用于确定囊泡发育风险的遗传测试
公开(公告)号：US06348316B1
公开(公告)日：2002-02-19
申请号：US09556868
申请日：2000-04-12
申请人： Kent D. Taylor , Huiyang Yang , Jerome I. Rotter , Phillip R. Fleshner
发明人： Kent D. Taylor , Huiyang Yang , Jerome I. Rotter , Phillip R. Fleshner
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention provides a method of determining a risk of pouchitis development following a surgical procedure where an internal pouch is created in a patient with ulcerative colitis. The method is practiced by determining in the patient the presence or absence of a pouchitis-associated allele linked to an interferon &ggr; receptor locus, where the presence of the pouchitis-associated allele indicates an increased risk of pouchitis development. The interferon &ggr; receptor locus to which the pouchitis-associated allele is linked can be, for example, an interferon &ggr; receptor 1 gene. A pouchitis-associated allele useful in the invention can be, for example, an allele located within the sixth intron of the interferon &ggr; receptor 1 gene, such as a FA1 microsatellite 171 allele.
摘要翻译：本发明提供了一种确定在具有溃疡性结肠炎的患者中产生内部小袋的外科手术后的囊泡炎发展风险的方法。该方法通过在患者中确定是否存在与干扰素γ受体基因座连接的绒球菌相关等位基因来实现，其中与肠道炎相关等位基因的存在表明增加的囊肿发展的风险。与脑膜炎相关的等位基因连接的干扰素γ受体位点可以是例如干扰素γ受体1基因。可用于本发明的囊泡炎相关等位基因可以是例如位于干扰素γ受体1基因第六内含子内的等位基因，例如FA1微卫星171等位基因。

40. 发明授权

US08178294B2 Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes 有权
标题翻译：用于确定发展胰岛素抵抗，冠状动脉疾病和其他表型的风险的基于单倍型的遗传分析方法
公开(公告)号：US08178294B2
公开(公告)日：2012-05-15
申请号：US11564243
申请日：2006-11-28
申请人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi , Yii-Der Ida Chen
发明人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi , Yii-Der Ida Chen
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a human subject for certain biological conditions, which may be related to coronary artery disease.
摘要翻译：公开了一种确定用于人类亚群体的感兴趣的基因组参考序列内用于大规模遗传分析的单元型的方法。该方法可以应用于统计学评估受试者与感兴趣的表型（例如胰岛素抵抗或冠状动脉疾病）的任何统计学显着相关性的基因型。因此，还公开了一种检测人类受试者在某些生物学条件下的遗传易感性的方法，其可能与冠状动脉疾病有关。

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