专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US4232031A Process for preparation of piperidyl-indoles 失效
标题翻译：哌啶基 - 吲哚的制备方法
公开(公告)号：US4232031A
公开(公告)日：1980-11-04
申请号：US100909
申请日：1979-12-06
申请人： Claude Dumont , Jacques Guillaume , Lucien Nedelec
发明人： Claude Dumont , Jacques Guillaume , Lucien Nedelec
IPC分类号： C07D401/04 , A61K20060101 , A61K31/40 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/475 , A61P1/08 , A61P25/00 , A61P25/18 , A61P25/20 , B01J23/04 , C07D20060101 , C07D209/04 , C07D211/68 , C07D211/70 , C07D401/02
CPC分类号： C07D401/04
摘要： A novel process for the preparation of piperidylindoles of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms and X is selected from the group consisting of hydrogen, nitro, fluorine, bromine, chlorine and alkoxy of 1 to 3 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts thereof by reacting an indole of the formula ##STR2## with 4-piperidone hydrochloride in an alkaline medium to obtain the compound of formula I which is optionally salified and the novel product, 5-nitro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and its non-toxic, pharmaceutically acceptable acid addition salts.
摘要翻译：一种制备式Ia的哌啶子基吲哚的新方法，其中R选自氢和1至3个碳原子的烷基，X选自氢，硝基，氟，溴，氯和具有1至3个碳原子的烷氧基以及它们的无毒的药学上可接受的酸加成盐，其通过使式II的吲哚与4-哌啶酮盐酸盐在碱性介质中反应，得到式I化合物，其为任选地盐化，并且新产物5-硝基-3-（1,2,3,6-四氢吡啶-4-基）-1H-吲哚及其无毒的药学上可接受的酸加成盐。

32. 发明授权

US4177292A Novel 5H-benzocyclohepten-7-amines 失效
标题翻译：新的5H-苯并环庚烯-7-胺
公开(公告)号：US4177292A
公开(公告)日：1979-12-04
申请号：US959943
申请日：1978-11-13
申请人： Lucien Nedelec , Daniel Frechet , Claude Dumont , Peter Hunt
发明人： Lucien Nedelec , Daniel Frechet , Claude Dumont , Peter Hunt
IPC分类号： A61K31/135 , A61K20060101 , A61K9/20 , A61K31/04 , A61P25/24 , A61P25/26 , B01J23/00 , B01J23/44 , C07B61/00 , C07C20060101 , C07C67/00 , C07C213/00 , C07C217/52 , C07C91/16 , C07C91/28 , C07C91/40
CPC分类号： C07C217/52 , C07C2102/12
摘要： Novel 5H-benzocyclohepten-7-amines of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and methyl, R.sub.2 and R.sub.3 are individually selected from the group consisting of hydrogen, fluorine, chlorine, bromine, nitro, amino, --CF.sub.3 and methoxy, X is selected from the group consisting of hydrogen and halogen, and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable in vivo and in vitro inhibiting properties for the capture of serotonine and their preparation.
摘要翻译：新颖的式“IMAGE”I'的5H-苯并环庚烯-7-胺其中R 1选自氢和甲基，R 2和R 3分别选自氢，氟，氯，溴，硝基，氨基，-CF 3和甲氧基，X选自氢和卤素，及其无毒的药学上可接受的酸加成盐，其具有显着的体内和体外抑制5-羟色胺的捕获性质及其制备。

33. 发明授权

US4175136A N-Phenethyl-N-propyl-3,4-dihydroxyphenethylamines and salts thereof 失效
标题翻译： N-苯乙基-N-丙基-3,4-二羟基苯乙胺及其盐
公开(公告)号：US4175136A
公开(公告)日：1979-11-20
申请号：US905535
申请日：1978-05-12
申请人： Lucien Nedelec , Daniel Frechet , Claude Dumont
发明人： Lucien Nedelec , Daniel Frechet , Claude Dumont
IPC分类号： A61K31/135 , A61P25/02 , A61P25/26 , C07C20060101 , C07C67/00 , C07C213/00 , C07C215/52 , A01N9/20 , A01N9/24 , C07C91/32
CPC分类号： C07D213/38
摘要： N-phenethyl-N-propyl-3,4-dihydroxyphenethylamine and its non-toxic, pharmaceutically acceptable acid addition salts possessing dopaminergic properties.
摘要翻译： N-苯乙基-N-丙基-3,4-二羟基苯乙胺及其无毒的药学上可接受的具有多巴胺能性质的酸加成盐。

34. 发明授权

US4136179A 2,2-Dimethyl-19-nor-steroids 失效
标题翻译： 2,2-二甲基-19-非 - 异唑烷酮
公开(公告)号：US4136179A
公开(公告)日：1979-01-23
申请号：US831254
申请日：1977-09-07
申请人： Lucien Nedelec , Vesperto Torelli , Robert Fournex
发明人： Lucien Nedelec , Vesperto Torelli , Robert Fournex
IPC分类号： A61K31/57 , A61P5/38 , A61P9/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J17/00 , C07J43/00 , A61K31/56
CPC分类号： C07J17/00 , C07J43/003 , C07J5/0015 , C07J7/002 , C07J9/00
摘要： 2,2-DIMETHYL-19-NOR-STEROIDS OF THE FORMULA ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, ##STR2## and R.sub.2 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 17 carbon atoms and the dotted lines indicate the optional presence of a double bond in 9(10) and 11(12) positions having antialdosteronic activity and an increased sodium diuresis with conservation of organic potassium and their preparation and novel intermediates.

35. 发明授权

US4130658A Novel phenethylamines 失效
标题翻译：新型苯乙胺
公开(公告)号：US4130658A
公开(公告)日：1978-12-19
申请号：US809810
申请日：1977-06-24
申请人： Lucien Nedelec , Daniel Frechet , Claude Dumont
发明人： Lucien Nedelec , Daniel Frechet , Claude Dumont
IPC分类号： A61K31/135 , A61K20060101 , A61K31/165 , A61K31/215 , A61K31/22 , A61P25/00 , C07C20060101 , C07C67/00 , C07C69/02 , C07C69/78 , C07C213/00 , C07C215/52 , C07C219/28 , C07C87/28
CPC分类号： A61K31/195
摘要： Novel phenethylamines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, acyl of an aliphatic carboxylic acid of 2 to 6 carbon atoms and benzoyl and Y is selected from the group consisting of hydrogen and --OX and their non-toxic, pharmaceutically acceptable acid addition salts having dopaminergic stimulating activity and their preparation and novel intermediates.
摘要翻译：下式的新型苯乙胺其中X选自氢，2至6个碳原子的脂族羧酸的酰基和苯甲酰基，Y选自氢和-OX，具有多巴胺能刺激活性的药学上可接受的酸加成盐及其制备和新型中间体。

36. 发明授权

US4100278A Novel benzazepines 失效
标题翻译：新型苯并氮杂
公开(公告)号：US4100278A
公开(公告)日：1978-07-11
申请号：US782747
申请日：1977-03-30
申请人： Lucien Nedelec , Daniel Frechet , Claude Dumont , Marie-Helene Kannengiesser
发明人： Lucien Nedelec , Daniel Frechet , Claude Dumont , Marie-Helene Kannengiesser
IPC分类号： A61K31/55 , A61P25/24 , A61P25/26 , C07D223/16
CPC分类号： C07D223/16
摘要： Novel benzazepines of the formula ##STR1## wherein n is 0 or 1 and R and R.sub.1 are individually selected from the group consisting of hydrogen and methyl with the proviso that when R.sub.1 is methyl, R is also methyl and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive activity and novel intermediates and processes for the preparation of the said compounds.
摘要翻译：式其中n为0或1的新的苯并氮杂，R和R 1分别选自氢和甲基，条件是当R 1是甲基时，R也是甲基，它们是无毒的，药学上具有抗抑郁活性的可接受的酸加成盐和用于制备所述化合物的新中间体和方法。

37. 发明授权

US4078059A Novel 2,2-dimethyl steroids 失效
标题翻译：新型2,2-二甲基类固醇
公开(公告)号：US4078059A
公开(公告)日：1978-03-07
申请号：US719138
申请日：1976-08-31
申请人： Lucien Nedelec , Vesperto Torelli , Robert Fournex
发明人： Lucien Nedelec , Vesperto Torelli , Robert Fournex
IPC分类号： A61K31/57 , A61P9/00 , A61P9/12 , C07J5/00 , C07J7/00 , C07J17/00 , C07J31/00 , A61K31/56
CPC分类号： C07J5/0015 , C07J17/00 , C07J31/003 , C07J7/002
摘要： Novel 2,2-dimethyl steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, --OH and ##STR2## R.sub.1 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 17 carbon atoms Z is selected from the group consisting of hydrogen and ##STR3## in the .alpha.-position, R.sub.2 is alkyl of 1 to 4 carbon atoms and the dotted line in the B ring indicates the optional presence of a double bond in the 6(7) position having antialdosterone activity and increasing sodium diuresis while conserving organic potassium.
摘要翻译：式（Ⅰ）所示的新型2,2-二甲基类固醇，其中R选自氢，-OH和R 1选自氢和1至17个碳原子的烃基Z是选自α位中的氢和，R2是1至4个碳原子的烷基，B环中的虚线表示在6（7）位任选存在双键，抗肿瘤活性和增加钠利尿，同时保护有机钾。

38. 发明授权

US4009273A Substituted 10,11-dihydro-5,10-imino-[5H] dibenzo (a,d)-cycloheptene 失效
标题翻译：取代的10,11-二氢-5,10-亚氨基 - {8H- {9 {0-二苯并（a，d） - 环庚烯
公开(公告)号：US4009273A
公开(公告)日：1977-02-22
申请号：US568148
申请日：1975-04-14
申请人： Lucien Nedelec , Daniel Frechet
发明人： Lucien Nedelec , Daniel Frechet
IPC分类号： C07D451/00 , C07D221/02 , C07D451/02 , C07D471/02 , C07F9/6561 , C07D471/08
CPC分类号： C07D451/02 , C07F9/6561
摘要： Racemates and optically active isomers of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, lower alkyl optionally substituted with a member of the group consisting of hydroxy and halogen, lower alkenyl, lower alkynyl, --(CH.sub.2).sub.n -- COCH.sub.3 where n is 0 or 1, ##STR2## wherein X is selected from the group consisting of lower alkyl and optionally substituted phenyl, aralkyl or 7 to 8 carbon atoms, acyl of an organic carboxylic acid of 1 to 6 carbon atoms optionally substituted with ##STR3## where m is an integer from 0 to 6 and X.sub.1 is selected from the group consisting of hydrogen and lower alkyl, ##STR4## where p is an integer from 1 to 6 and X.sub.1 is as before and ##STR5## wherein X.sub.2 is lower alkyl and R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl and dilower alkylamino and the non-toxic, pharmaceutically acceptable acid addition and quaternary ammonium salts thereof which have a stimulating effect on the central nervous system while possessing at the same time anticonvulsant activity and their preparation.
摘要翻译：选自下列化合物的化合物的外消旋物和光学活性异构体：其中R选自氢，任选被羟基和卤素组成的基团取代的低级烷基，低级烯基，低级炔基， - （CH 2）n -COCH 3，其中n为0或1，其中X选自低级烷基和任选取代的苯基，芳烷基或7至8个碳原子， 1至6个碳原子的有机羧酸，任选被取代，其中m是0至6的整数，X 1选自氢和低级烷基，其中p是1至6的整数 X 1如前所述，其中X 2是低级烷基，R 1和R 2分别选自氢，卤素，低级烷基，低级烷氧基，三氟甲基和二元烷基氨基和无毒的药学上可接受的酸加成其具有对中枢神经系统的刺激作用，同时具有抗惊厥活性及其制备。

39. 发明授权

US5336686A 17 Methylene lactones of steroids 失效
标题翻译： 17类固醇的亚甲基内酯
公开(公告)号：US5336686A
公开(公告)日：1994-08-09
申请号：US20053
申请日：1993-02-19
申请人： Lucien Nedelec , Francois Nique , Daniel Philibert
发明人： Lucien Nedelec , Francois Nique , Daniel Philibert
IPC分类号： A61K31/585 , A61P3/10 , A61P5/24 , A61P5/36 , A61P9/08 , A61P9/12 , A61P13/02 , A61P15/00 , A61P19/10 , A61P25/04 , A61P25/20 , A61P37/04 , C07J1/00 , C07J21/00 , C07J31/00 , C07J41/00 , A61K31/335 , C07D307/33
CPC分类号： C07J31/006 , C07J21/003 , C07J41/0083
摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the application having antiglucocorticoid and antiprogestomimetic properties and a process and intermediates for their preparation.
摘要翻译：选自下式的化合物的化合物，其中取代基如本申请中所定义，具有抗糖皮质激素和止吐模拟性质，以及其制备方法和中间体。

40. 发明授权

US5302719A N,N,N',N'-6-(1-piperazinyl)-2,5-pyridinediamines 失效
标题翻译： N，N，N'，N'-6-（1-哌嗪基）-2,5-吡啶基亚胺
公开(公告)号：US5302719A
公开(公告)日：1994-04-12
申请号：US990729
申请日：1992-12-15
申请人： Andre Claussner , Jacques LeClaire , Lucien Nedelec , Daniel Philibert
发明人： Andre Claussner , Jacques LeClaire , Lucien Nedelec , Daniel Philibert
IPC分类号： C07D213/74 , C07J43/00 , C07D401/00
CPC分类号： C07D213/74 , C07J43/003
摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.A, R.sub.A.sup.1, R.sub.B R.sub.B.sup.1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms or R.sub.A and R.sub.A.sup.1 or R.sub.B and R.sub.B.sup.1 together with the nitrogen atom to which they are attached form a 5- to 6-member heterocycle optionally substituted with alkyl of 1 to 3 carbon atoms and Y is hydrogen or ##STR2## wherein R.sub.6 is selected from the group consisting of hydrogen, --CH.sub.3, --F and --Cl, R.sub.9 and R.sub.11 form a second bond at 9(11) or R.sub.9 is hydrogen or --F and R.sub.11 is hydrogen, --OH or .dbd.0, R.sub.16 is --CH.sub.3 or hydrogen, R.sub.17 is hydrogen, --OH or acyloxy, the dotted lines indicate the possible presence of a second bond at 1(2) and 6(7)-positions and the wavy line indicates the .alpha.- and .beta.-position and their non-toxic, pharmaceutically acceptable acid addition salts having anti-inflammatory and antioxidant activity.
摘要翻译：选自下列化合物的化合物其中RA，RA1，RB RB1分别选自氢和1至4个碳原子的烷基或RA和RA1或RB和RB1在一起的化合物与它们所连接的氮原子形成任选被1至3个碳原子的烷基取代的5至6元杂环，Y是氢或其中R 6选自氢，-CH 3， -F和-Cl，R 9和R 11在9（11）处形成第二个键，或者R 9是氢或-F，R 11是氢，-OH或= 0，R 16是-CH 3或氢，R 17是氢，-OH或酰氧基，虚线表示在1（2）和6（7） - 位上可能存在第二个键，并且波浪线表示α和β-位及其无毒的药学上可接受的具有抗氧化剂的酸加成盐炎症和抗氧化活性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式