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31. 发明申请

US20050131287A1 Detection of premature rupture of the amniotic membrane 审中-公开
标题翻译：检测羊膜早破
公开(公告)号：US20050131287A1
公开(公告)日：2005-06-16
申请号：US10736662
申请日：2003-12-16
申请人： Rosann Kaylor , RameshBabu Boga , Kaiyuan Yang , Shawn Feaster , Curtis Sayre , David Cohen , Ning Wei , Chibueze Chidebelu-Eze , Stephen Quirk
发明人： Rosann Kaylor , RameshBabu Boga , Kaiyuan Yang , Shawn Feaster , Curtis Sayre , David Cohen , Ning Wei , Chibueze Chidebelu-Eze , Stephen Quirk
IPC分类号： A61B5/00 , A61F13/15 , B65D81/00
CPC分类号： A61F13/84 , A61B5/00 , A61F2013/8473 , A61F2013/8491
摘要： The premature rupture of amniotic fluid (PROM) may be discovered through a number of inventive means. Methods of evaluating whether PROM is present include; a) through the testing of the pH of vaginal fluids using an irreversible pH test; b) through the detection of analytes (e.g. enzymes) specific to amniotic fluid in the vaginal fluids; c) though the detection of hydrogen peroxide (H2O2) in the vaginal fluid; and d) through the detection of cholesterol in vaginal fluid. While individually indicative of PROM, it is desirable to combine at least two of these techniques to yield a powerful tool of even greater reliability. Test devices and feminine hygiene pads into which the test methods may be incorporated are also included herein.
摘要翻译：通过许多创造性手段可以发现羊水过早破裂（PROM）。评估PROM是否存在的方法包括： a）通过使用不可逆的pH测试来测试阴道液的pH值; b）通过检测阴道液中特异于羊水的分析物（例如酶）; c）尽管在阴道液中检测过氧化氢（H 2 O 2 O 2）; 和d）通过检测阴道液中的胆固醇。虽然单独指示PROM，但是期望将这些技术中的至少两种组合以产生更大可靠性的强大工具。本文还包括其中可以并入测试方法的测试装置和女性卫生衬垫。

32. 发明授权

US09335972B2 True random number generator 有权
标题翻译：真随机数发生器
公开(公告)号：US09335972B2
公开(公告)日：2016-05-10
申请号：US14093040
申请日：2013-11-29
申请人： Kaiyuan Yang , Dennis Michael Sylvester , David Theodore Blaauw , David Alan Fick , Michael B. Henry , Yoonmyung Lee
发明人： Kaiyuan Yang , Dennis Michael Sylvester , David Theodore Blaauw , David Alan Fick , Michael B. Henry , Yoonmyung Lee
IPC分类号： G06F7/58 , H03K3/84 , H03K3/03
CPC分类号： G06F7/588 , H03K3/0315 , H03K3/84
摘要： A true random number generator comprises a ring oscillator which is triggered to start oscillating in a first mode of oscillation at an oscillation start time. The first mode of oscillation will eventually collapse to a second mode of oscillation dependent on thermal noise. A collapse time from the oscillation start time to the time at which the oscillator collapses to the second mode is measured, and this can be used to determine a random number. The TRNG can be synthesized entirely using standard digital techniques and is able to provide high randomness, good throughput and energy efficiency.
摘要翻译：真正的随机数发生器包括环形振荡器，其在振荡开始时刻被触发以在第一振荡模式下开始振荡。第一种振荡模式最终会依赖于热噪声而崩溃到第二种振荡模式。测量从振荡开始时间到振荡器塌陷到第二模式的时间的崩溃时间，并且这可以用于确定随机数。 TRNG可以使用标准数字技术完全合成，能够提供高随机性，良好的吞吐量和能量效率。

33. 发明授权

US08546638B2 Absorbent article having improved signal member 有权
标题翻译：具有改进的信号元件的吸收制品
公开(公告)号：US08546638B2
公开(公告)日：2013-10-01
申请号：US12646743
申请日：2009-12-23
申请人： Peiguang Zhou , Andrew Mark Long , Dave Allen Soerens , Kaiyuan Yang , James Hongxue Wang , Xuedong Song
发明人： Peiguang Zhou , Andrew Mark Long , Dave Allen Soerens , Kaiyuan Yang , James Hongxue Wang , Xuedong Song
IPC分类号： A61F13/42
CPC分类号： A61F13/42
摘要： An absorbent article comprises a signal element having a body-facing surface, a garment-facing surface, a longitudinal direction, a transverse direction and a z-direction. The signal element includes a water-soluble polymeric buffering film and a stimulation material. The water-soluble polymeric buffering film comprises a water-soluble base polymer. In some aspects, the stimulation material comprises a temperature change agent, and the signal element exhibits a surface temperature change of at least +/−2° C. In some aspects, the signal element exhibits a stimulation effect over at least two aqueous insults.
摘要翻译：吸收性物品包括信号元件，其具有面向身体的表面，面向衣服的表面，纵向方向，横向和z方向。信号元件包括水溶性聚合物缓冲膜和刺激材料。水溶性聚合物缓冲膜包含水溶性基础聚合物。在一些方面，刺激材料包括温度变化剂，并且信号元件表现出至少+/- 2℃的表面温度变化。在一些方面，信号元件对至少两个水质损伤表现出刺激效应。

34. 发明申请

US20130034719A1 Cooling Signal Device For Use In An Absorbent Article 审中-公开
标题翻译：用于吸收物品的冷却信号装置
公开(公告)号：US20130034719A1
公开(公告)日：2013-02-07
申请号：US13195986
申请日：2011-08-02
申请人： Peiguang Zhou , Jun Zhang , Andrew Mark Long , Kaiyuan Yang
发明人： Peiguang Zhou , Jun Zhang , Andrew Mark Long , Kaiyuan Yang
IPC分类号： B32B3/26 , C09J5/00 , B29C47/06 , B32B27/36 , B32B27/00
摘要： A signal device includes a signal composite made with a coextruded film having at least two layers, a polymer skin layer and a stimulation layer. The stimulation layer includes a cooling agent and a polymer binder. The stimulation layer may be about 50 to 98 percent by weight of the signal composite. The signal device may be used in an absorbent article to provide a cooling sensation after a body-fluid insult has taken place.
摘要翻译：信号装置包括由具有至少两层的共挤出膜制成的信号复合材料，聚合物表皮层和刺激层。刺激层包括冷却剂和聚合物粘合剂。刺激层可以是信号复合材料的约50至98重量％。信号装置可以用在吸收制品中，以在发生体液损伤之后提供冷却感。

35. 发明授权

US08287461B2 Vein identification technique 有权
标题翻译：静脉识别技术
公开(公告)号：US08287461B2
公开(公告)日：2012-10-16
申请号：US11939082
申请日：2007-11-13
申请人： John Gavin MacDonald , Kaiyuan Yang , Jaeho Kim , JungMo Kim
发明人： John Gavin MacDonald , Kaiyuan Yang , Jaeho Kim , JungMo Kim
IPC分类号： A61B5/00
CPC分类号： A61B5/445 , A61B5/0077 , A61B5/01 , A61B5/489
摘要： A technique for identifying a vein in a patient is disclosed. The technique involves the application of a thermochromic ink to a venous area on the skin of a patient (e.g., human or animal). The thermochromic ink comprises thermosensitive color-changing microcapsules that contain a proton-accepting chromogen and a desensitizer. The desensitizer possesses a melting point above which the chromogen is capable of becoming protonated, thereby resulting in a color change. Thereafter, the venous area is observed for the color change.
摘要翻译：公开了用于识别患者静脉的技术。该技术涉及将热致变色墨水施加到患者皮肤（例如人或动物）上的静脉区域。热变色油墨包含含有质子接受色原体和脱敏剂的热敏变色微胶囊。脱敏剂具有高于该熔点的色原体能够变质子化，从而导致颜色变化。此后，观察静脉区域的颜色变化。

36. 发明授权

US08158689B2 Hybrid absorbent foam and articles containing it 有权
标题翻译：混合吸收泡沫和含有它的物品
公开(公告)号：US08158689B2
公开(公告)日：2012-04-17
申请号：US11315576
申请日：2005-12-22
申请人： Andrew T. Baker , Timothy James Blenke , Charles W. Colman , Edward A. Colombo , Jeffrey E. Fish , Kaiyuan Yang , Michael Joseph Garvey , Jeffrey Jennings Krueger , Mary Frances Mallory , Joseph E. Pierce , Fred Robert Radwanski , Sridhar Ranganathan , Donald E. Waldroup
发明人： Andrew T. Baker , Timothy James Blenke , Charles W. Colman , Edward A. Colombo , Jeffrey E. Fish , Kaiyuan Yang , Michael Joseph Garvey , Jeffrey Jennings Krueger , Mary Frances Mallory , Joseph E. Pierce , Fred Robert Radwanski , Sridhar Ranganathan , Donald E. Waldroup
IPC分类号： C08J9/00 , B32B3/26
CPC分类号： A61L15/425 , B29C44/5663 , B29K2007/00 , B32B5/14 , B32B5/18 , B32B5/20 , B32B5/245 , B32B5/32 , B32B2266/0207 , B32B2266/0228 , B32B2266/025 , B32B2266/0264 , B32B2266/0292 , B32B2266/06 , B32B2307/54 , B32B2307/5825 , B32B2307/726 , B32B2307/7265 , B32B2432/00 , B32B2437/02 , B32B2555/02 , Y10T428/24504 , Y10T428/249953
摘要： A hybrid absorbent foam includes an integrated hybrid foam layer having an open surface, a closed surface, and a foam body extending between the open and closed surfaces. The integrated hybrid foam layer has an open-cell content of at least 50%, while the closed surface provides a barrier to aqueous liquids. The integrated hybrid foam layer is formed as a single layer, and has a substantially uniform polymer composition throughout its thickness. The integrated hybrid foam layer combines the functions of liquid absorbency, retention, and barrier into a single layer, and is useful in a wide variety of absorbent articles.
摘要翻译：混合吸收泡沫包括具有开放表面，封闭表面和在开放和闭合表面之间延伸的泡沫体的综合混合泡沫层。集成的混合泡沫层具有至少50％的开孔含量，而封闭表面提供了对含水液体的屏障。集成的混合泡沫层形成为单层，并且在其整个厚度上具有基本上均匀的聚合物组成。集成的混合泡沫层将液体吸收性，保留性和阻隔性的功能结合到单层中，并且可用于各种各样的吸收制品。

37. 发明授权

US07858384B2 Flow control technique for assay devices 有权
标题翻译：测定装置的流量控制技术
公开(公告)号：US07858384B2
公开(公告)日：2010-12-28
申请号：US11119394
申请日：2005-04-29
申请人： Shawn Ray Feaster , Kaiyuan Yang
发明人： Shawn Ray Feaster , Kaiyuan Yang
IPC分类号： G01N31/22 , G01N31/00
CPC分类号： G01N33/558 , G01N33/52
摘要： A method for controlling fluid flow in an assay device that employs a membrane is provided. Specifically, one or more recessed regions are formed in the membrane by applying a solvent treatment thereto. The solvent treatment is selected based on its particular dissolving capacity for the material used to form the membrane. For example, an alcohol-based solvent, such as methanol, may be used as a solvent for nitrocellulose membranes. Upon contact with the solvent treatment, a recessed region is formed that may serve a variety of different functions relating to flow control. In one particular embodiment, the recessed region may function as a metering channel that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay.
摘要翻译：提供了一种用于控制采用膜的测定装置中的流体流动的方法。具体地，通过对膜进行溶剂处理，在膜中形成一个或多个凹陷区域。基于其用于形成膜的材料的特定溶解能力来选择溶剂处理。例如，醇类溶剂如甲醇可用作硝酸纤维素膜的溶剂。在与溶剂处理接触时，形成可以用于与流量控制有关的各种不同功能的凹陷区域。在一个具体实施方案中，凹陷区域可用作计量通道，其能够在测定开始时将受控体积的测试样品递送到检测区域。

38. 发明申请

US20100323392A1 Metering Technique for Lateral Flow Assay Devices 有权
标题翻译：侧流测试装置的计量技术
公开(公告)号：US20100323392A1
公开(公告)日：2010-12-23
申请号：US12872225
申请日：2010-08-31
申请人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
发明人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
IPC分类号： C12Q1/04
CPC分类号： G01N33/558 , G01N33/54366
摘要： A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments from about 0.5 to about 25 microliters, and in some embodiments, from about 1 to about 10 microliters. For example, whole blood drops obtained from patients with a lancet typically have a volume of less than about 3 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断测试试剂盒。该套件采用包含膜的侧向流动装置。在膜中形成计量通道，其能够在测定开始时将受控体积的测试样品输送到检测区。这样的计量通道对于其中测试样品具有相对较小体积（例如小于约100微升），在一些实施方案中为约0.5至约25微升，且在一些实施方案中为约1至约10 微升。例如，从具有柳叶刀的患者获得的全血滴通常具有小于约3微升的体积。尽管本发明人的体积小，但是本发明人已经发现，使用侧流检测技术仍然可以精确地分析血液滴定分析物的存在。

39. 发明授权

US07552501B2 Finger wipe with improved seam structure 失效
标题翻译：手指擦拭具有改进的接缝结构
公开(公告)号：US07552501B2
公开(公告)日：2009-06-30
申请号：US11118078
申请日：2005-04-29
申请人： Kaiyuan Yang , Jeffrey E. Fish , Shawn R. Feaster
发明人： Kaiyuan Yang , Jeffrey E. Fish , Shawn R. Feaster
IPC分类号： A41D13/08 , A47L13/18
CPC分类号： A47L21/04 , A45D34/04 , A45D2200/1018 , A45D2200/1063 , A46B5/04 , A46B2200/01 , A46B2200/1046 , A46B2200/1066 , A47L23/10 , A61F13/105 , A61M35/003
摘要： A finger cover, such as a finger wipe that can fit onto a human finger, is provided with an improved seam structure. The cover includes a pocket member having an open end for the insertion of a finger. The pocket member is formed by a first panel attached to a second panel along a flush outwardly facing circumferential edge seam. The seam is less than about 1 millimeter (mm) in width and about 1 mm in height. Additional reinforcing weld points may be provided at various locations along the seam.
摘要翻译：具有改进的接缝结构的手指盖，例如可以适合人的手指的手指擦拭物。盖包括具有用于插入手指的开口端的袋状构件。袋构件由沿着齐平向外的周向边缘接缝附接到第二面板的第一面板形成。接缝宽度小于约1毫米（mm），高度约为1mm。可以在沿着接缝的不同位置处提供附加的加固焊点。

40. 发明申请

US20090124925A1 Vein Identification Technique 有权
标题翻译：静脉识别技术
公开(公告)号：US20090124925A1
公开(公告)日：2009-05-14
申请号：US11939082
申请日：2007-11-13
申请人： J. Gavin MacDonald , Kaiyuan Yang , Jaeho Kim , JungMo Kim
发明人： J. Gavin MacDonald , Kaiyuan Yang , Jaeho Kim , JungMo Kim
IPC分类号： A61B5/01 , B65D69/00
CPC分类号： A61B5/445 , A61B5/0077 , A61B5/01 , A61B5/489
摘要： A technique for identifying a vein in a patient is disclosed. The technique involves the application of a thermochromic ink to a venous area on the skin of a patient (e.g., human or animal). The thermochromic ink comprises thermosensitive color-changing microcapsules that contain a proton-accepting chromogen and a desensitizer. The desensitizer possesses a melting point above which the chromogen is capable of becoming protonated, thereby resulting in a color change. Thereafter, the venous area is observed for the color change.
摘要翻译：公开了用于识别患者静脉的技术。该技术涉及将热致变色墨水施加到患者皮肤（例如人或动物）上的静脉区域。热变色油墨包含含有质子接受色原体和脱敏剂的热敏变色微胶囊。脱敏剂具有高于该熔点的色原体能够变质子化，从而导致颜色变化。此后，观察静脉区域的颜色变化。

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