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31. 发明授权

US09131885B2 Analyte sensors and methods of manufacturing same 有权
标题翻译：分析物传感器及其制造方法
公开(公告)号：US09131885B2
公开(公告)日：2015-09-15
申请号：US12829318
申请日：2010-07-01
申请人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
发明人： Peter C. Simpson , Robert Boock , Paul V. Neale , Sebastian Bohm , Matthew Wightlin , Jack Pryor , Jason Mitchell , Jeff Jackson , Kaushik Patel , Antonio C. Llevares
IPC分类号： A61B5/05 , A61B5/1473 , A61B5/145 , A61B5/1486 , B05C3/10
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.
摘要翻译：提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

32. 发明授权

US08298142B2 Analyte sensor 有权
公开(公告)号：US08298142B2
公开(公告)日：2012-10-30
申请号：US12267547
申请日：2008-11-07
申请人： Peter C. Simpson , Michael J. Estes , Paul V. Neale , Robert Boock , Jacob S. Leach , Richard C. Yang , Mark Brister
发明人： Peter C. Simpson , Michael J. Estes , Paul V. Neale , Robert Boock , Jacob S. Leach , Richard C. Yang , Mark Brister
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： C12Q1/001 , A61B5/0031 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61B5/7275 , A61B5/743 , A61B2560/0223 , A61B2560/04 , A61B2562/085 , A61M5/14 , A61M5/16804 , A61M5/1723 , A61M25/007 , A61M2005/14296 , A61M2230/201 , C12Q1/006 , G06F19/3468 , G16H40/40 , Y02A90/26
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

33. 发明授权

US08275438B2 Analyte sensor 有权
公开(公告)号：US08275438B2
公开(公告)日：2012-09-25
申请号：US12267545
申请日：2008-11-07
申请人： Peter C. Simpson , Michael J. Estes , Paul V. Neale , Robert Boock , Jacob S. Leach , Richard C. Yang
发明人： Peter C. Simpson , Michael J. Estes , Paul V. Neale , Robert Boock , Jacob S. Leach , Richard C. Yang
IPC分类号： A61B5/00
CPC分类号： C12Q1/001 , A61B5/0031 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61B5/7275 , A61B5/743 , A61B2560/0223 , A61B2560/04 , A61B2562/085 , A61M5/14 , A61M5/16804 , A61M5/1723 , A61M25/007 , A61M2005/14296 , A61M2230/201 , C12Q1/006 , G06F19/3468 , G16H40/40 , Y02A90/26
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

34. 发明授权

US08034003B2 Tissue extraction and collection device 有权
标题翻译：组织提取和收集装置
公开(公告)号：US08034003B2
公开(公告)日：2011-10-11
申请号：US12056637
申请日：2008-03-27
申请人： Robert S. Pesce , Shelby Cook , Kristian DiMatteo , Kevin Ranucci , Robert Boock
发明人： Robert S. Pesce , Shelby Cook , Kristian DiMatteo , Kevin Ranucci , Robert Boock
IPC分类号： A61B10/00
CPC分类号： A61B10/025 , A61B10/0096 , A61B10/0266 , A61B10/0283 , A61B17/1635 , A61B17/32002 , A61B2017/320064 , A61B2090/0807
摘要： Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof. A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue. In many cases, devices disclosed herein can include driving mechanisms that are adapted to drive a tissue harvesting tip such that the tip excises soft tissue, but stops when contacting bone (or soon after contacting bone). In some embodiments, the tissue harvesting tip can be effective to excise viable tissue samples, such that the samples can exhibit desirable proportions of viable cells. Further, in some embodiments, the tissue harvesting tips can excise a tissue sample with tissue particles falling in certain size ranges.
摘要翻译：公开了用于提取和收集组织的方法和装置，其可以用于组织工程和移植应用中。在一个实施例中，装置可以包括外管。旋转轴可以设置在外管内，可以具有形成在其远端上的组织收集尖端，组织收集尖端有效地在旋转时切除组织。可以包括组织收集装置以接收和收集切除的组织，并且组织收集装置可以指示其中收集的组织的量。例如，组织收集装置可以包括收集切除的组织的应变元件和用于评估收集的组织的量的指示器。在一些实施例中，组织收集装置可以平移以指示收集的组织的量。在许多情况下，本文公开的装置可以包括适于驱动组织收集尖端的驱动机构，使得尖端切除软组织，但是当接触骨骼时（或者在接触骨骼之后不久）停止。在一些实施方案中，组织采集尖端可有效地切除活组织样品，使得样品可以显示出所需比例的活细胞。此外，在一些实施例中，组织采集尖端可以用落在一定尺寸范围内的组织颗粒来切除组织样本。

35. 发明申请

US20090287073A1 SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS 有权
标题翻译：用于可植入葡萄糖传感器的硅胶基膜
公开(公告)号：US20090287073A1
公开(公告)日：2009-11-19
申请号：US12511982
申请日：2009-07-29
申请人： Robert Boock , Monica Rixman
发明人： Robert Boock , Monica Rixman
IPC分类号： A61B5/1486
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/6848 , B33Y70/00 , C08G77/12 , C08G77/20 , C08G77/46 , C08L83/04 , C08L2666/14
摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
摘要翻译：介绍了结合有机硅聚合物的膜系统用于可植入分析物传感器。膜系统的一些层可以包括硅氧烷聚合物与亲水性聚合物，例如三嵌段聚（环氧乙烷） - 聚（环氧丙烷） - 聚（环氧乙烷）聚合物的共混物。这种聚合物共混物提供高氧溶解度和水分析物溶解度。

36. 发明授权

US07613491B2 Silicone based membranes for use in implantable glucose sensors 有权
标题翻译：用于植入式葡萄糖传感器的硅基膜
公开(公告)号：US07613491B2
公开(公告)日：2009-11-03
申请号：US11404417
申请日：2006-04-14
申请人： Robert Boock , Monica Rixman
发明人： Robert Boock , Monica Rixman
IPC分类号： A61B5/00 , C08J9/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/6848 , B33Y70/00 , C08G77/12 , C08G77/20 , C08G77/46 , C08L83/04 , C08L2666/14
摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
摘要翻译：介绍了结合有机硅聚合物的膜系统用于可植入分析物传感器。膜系统的一些层可以包括硅氧烷聚合物与亲水性聚合物，例如三嵌段聚（环氧乙烷） - 聚（环氧丙烷） - 聚（环氧乙烷）聚合物的共混物。这种聚合物共混物提供高氧溶解度和水分析物溶解度。

37. 发明申请

US20080033254A1 SYSTEMS AND METHODS FOR REPLACING SIGNAL DATA ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM 有权
标题翻译：用于在葡萄糖传感器数据流中替换信号数据文件的系统和方法
公开(公告)号：US20080033254A1
公开(公告)日：2008-02-07
申请号：US11762638
申请日：2007-06-13
申请人： Apurv Kamath , Aarthi Mahalingam , Ying Li , Mohammad Shariati , James Brauker , Mark Brister , Robert Boock
发明人： Apurv Kamath , Aarthi Mahalingam , Ying Li , Mohammad Shariati , James Brauker , Mark Brister , Robert Boock
IPC分类号： A61B5/00
CPC分类号： A61B5/7203 , A61B5/01 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14865 , A61B5/1495 , A61B5/6848 , A61B5/725 , A61B5/7257 , A61B5/726 , A61B5/743 , A61B5/7475
摘要： Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.
摘要翻译：用于检测噪声发生并响应于此处理分析物传感器数据的系统和方法。在一些实施例中，处理分析物传感器数据包括过滤传感器数据以减少或消除噪声发作对信号的影响。

38. 发明申请

US20060270923A1 Analyte sensor 有权
公开(公告)号：US20060270923A1
公开(公告)日：2006-11-30
申请号：US11439630
申请日：2006-05-23
申请人： James Brauker , Peter Simpson , Robert Boock , Monica Rixman , Mark Brister
发明人： James Brauker , Peter Simpson , Robert Boock , Monica Rixman , Mark Brister
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66 , Y02A50/55 , Y02A50/58
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

39. 发明申请

US20060258761A1 Silicone based membranes for use in implantable glucose sensors 审中-公开
公开(公告)号：US20060258761A1
公开(公告)日：2006-11-16
申请号：US11404418
申请日：2006-04-14
申请人： Robert Boock , Monica Rixman , Mark Tapsak , Mark Shults , Rathbun Rhodes
发明人： Robert Boock , Monica Rixman , Mark Tapsak , Mark Shults , Rathbun Rhodes
IPC分类号： C08J9/00
CPC分类号： C08L83/04 , A61B5/14532 , A61B5/14865 , A61B5/6848 , B01D69/141 , B01D71/54 , B01D71/80 , C08G77/12 , C08G77/20 , C08G77/46 , C12Q1/002 , C08L2666/14
摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

40. 发明申请

US20060085028A1 Vessel occlusion system 审中-公开
标题翻译：血管闭塞系统
公开(公告)号：US20060085028A1
公开(公告)日：2006-04-20
申请号：US10967661
申请日：2004-10-18
申请人： Robert Boock
发明人： Robert Boock
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M25/04 , A61M2025/1052 , A61M2025/1054 , A61M2025/1084
摘要： The present invention relates to a device for occluding vessels or ducts in a living being. The device includes a frame for anchoring the device in a vessel and a expandable core connected to the frame for occluding the vessel.
摘要翻译：本发明涉及一种用于在生活中封闭血管或管道的装置。该装置包括用于将装置固定在容器中的框架和连接到框架以用于封闭容器的可膨胀芯。

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