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31. 发明授权

US06525174B1 Precerebellin-like protein 失效
标题翻译：类似前脑苷脂的蛋白质
公开(公告)号：US06525174B1
公开(公告)日：2003-02-25
申请号：US09205258
申请日：1998-12-04
申请人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
发明人： Paul Young , John M. Greene , Ann M. Ferrie , Steven M. Ruben , Craig A. Rosen , Jing-Shan Hu , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , Charles Florence , Kimberly Florence , David W. Lafleur , Jian Ni , Ping Fan , Ying-Fei Wei , Carrie L. Fischer , Daniel R. Soppet , Yi Li , Zhizhen Zeng , Hla Kyaw , Guo-Liang Yu , Ping Feng , Patrick J. Dillon , Gregory A. Endress , Kenneth C. Carter
IPC分类号： C07K1447
CPC分类号： G01N33/68 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

32. 发明授权

US06476195B1 Secreted protein HNFGF20 失效
标题翻译：分泌蛋白HNFGF20
公开(公告)号：US06476195B1
公开(公告)日：2002-11-05
申请号：US09489847
申请日：2000-01-24
申请人： George Komatsoulis , Craig A. Rosen , Steven M. Ruben , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Ying-Fei Wei , Jian Ni , Kimberly A. Florence , Paul Young , Laurie A. Brewer , Daniel R. Soppet , Gregory A. Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
发明人： George Komatsoulis , Craig A. Rosen , Steven M. Ruben , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Ying-Fei Wei , Jian Ni , Kimberly A. Florence , Paul Young , Laurie A. Brewer , Daniel R. Soppet , Gregory A. Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
IPC分类号： C07K500
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel human secreted protein (HNFGF20). Polypeptides of the invention are duseful in dianosis and treatment of disorders affecting the immune system.
摘要翻译：本发明涉及新型人分泌蛋白（HNFGF20）。本发明的多肽对于影响免疫系统的紊乱的脓毒症和治疗是有益的。

33. 发明授权

US5424923A Quick release vehicle headlamp arrangement 失效
标题翻译：快速车辆前照灯安排
公开(公告)号：US5424923A
公开(公告)日：1995-06-13
申请号：US323307
申请日：1994-10-14
申请人： Paul Young , Randall J. Smith , William E. Nagengast , Brian E. Witte
发明人： Paul Young , Randall J. Smith , William E. Nagengast , Brian E. Witte
IPC分类号： B60Q1/068 , B60Q1/06
CPC分类号： B60Q1/0683
摘要： A vehicle headlamp assembly is provided which includes a bulb; a reflector housing mounting the bulb; at least one rod pivotally connected to the housing; an adjuster body encircling the rod and threadably engaged therewith, the adjuster body having an insertion end generally opposite the reflector housing and a slot on the insertion end; a vehicle panel with an aperture for receipt of the adjuster body insertion end; and a slider mounted for relative movement with respect to the panel. The slider has an aperture with a first dimension for receipt of the insertion end of the adjuster body, and the slider aperture has a second end with a smaller dimension for encircling the adjuster body adjacent the slot. Thus, movement of the slider from a first position aligning the slot aperture first end with the panel aperture allows insertion or removal of the insertion end of the adjuster body, and movement of the slider to a second position allowing the slider aperture second end to align with the panel aperture retains the adjuster body with the vehicle panel, thereby attaching the reflector body to the vehicle.
摘要翻译：提供一种车头灯组件，其包括灯泡; 安装灯泡的反射器壳体; 至少一个杆枢转地连接到壳体; 所述调节器主体环绕所述杆并与其螺纹接合，所述调节器主体具有大致与所述反射器壳体相对的插入端和所述插入端上的狭槽; 具有用于接收调节器主体插入端的孔的车辆面板; 以及安装成相对于面板相对运动的滑块。滑块具有用于接收调节器主体的插入端的第一尺寸的孔，并且滑动器孔具有具有较小尺寸的第二端，用于围绕调节器本体邻近槽。因此，滑块从第一位置的移动使第一端与定位孔对准，允许插入或移除调节器主体的插入端，以及滑块移动到允许滑块孔第二端对准的第二位置其中面板孔将车辆面板的调节器主体固定，从而将反射器主体附接到车辆上。

34. 发明授权

US5219380A Trenching apparatus 失效
标题翻译：沟渠设备
公开(公告)号：US5219380A
公开(公告)日：1993-06-15
申请号：US859348
申请日：1992-03-27
申请人： Paul Young , Richard A. Ryerson
发明人： Paul Young , Richard A. Ryerson
IPC分类号： E02F3/08 , E02F3/10 , E02F7/02
CPC分类号： E02F7/02 , E02F3/082 , E02F3/086 , E02F3/10
摘要： A trenching machine having a tractor unit and a trenching bar mounted for transverse sliding movement on the rear end portion of the tractor unit to any desired location within the transverse confines of the tractor unit. Spoil generated by the trenching bar is deposited on either of a pair of transverse conveyors which are operable either to transport spoil transversely outwardly to the side of the trenching machine or transversely inwardly to a central hopper. A longitudinal conveyor located on the center line of the trencher extends from a low position at the rear-end portion of the tractor unit at the bottom of the hopper forwardly and upwardly to a high position forwardly of the tractor unit. A swinging conveyor is mounted for pivotal movement about both a vertical and horizontal axis forwardly of the tractor unit and below the output of the longitudinal conveyor. Spoil transported on the longitudinal conveyor is deposited on the swinging conveyor which transports it for deposit outside the transverse confines or forwardly of the tractor unit.

35. 发明授权

US4791508A Magnetic disc memory unit 失效
标题翻译：磁盘存储单元
公开(公告)号：US4791508A
公开(公告)日：1988-12-13
申请号：US96978
申请日：1987-09-14
申请人： James A. Augeri , Carl Bolz , Bruce Bickford , Paul Young , David Johnson
发明人： James A. Augeri , Carl Bolz , Bruce Bickford , Paul Young , David Johnson
IPC分类号： G11B5/54 , G11B5/55 , G11B19/20 , G11B33/08 , G11B33/14 , G11B17/02 , G11B21/08 , G11B21/22
CPC分类号： G11B19/2009 , G11B33/08 , G11B33/1406 , G11B5/54 , G11B5/5521 , G11B33/1493
摘要： A magnetic disc memory unit is presented wherein a pair of read/write heads are attached to and driven by a continuous belt driven by a stepper motor. The read/write heads move linearly, and they retract to a landing position fully off the disc when the unit is shut down. The heads carriage structure is counterbalanced by a counterbalance assembly to allow operation at all altitudes and minimize vibration and shock problems.
摘要翻译：提出了一种磁盘存储单元，其中一对读/写头附接到由步进电动机驱动的连续带并由其驱动。读/写头线性移动，当本机关闭时，读/写头完全退回到盘片的着陆位置。头架结构通过平衡组件平衡，以允许在所有高度操作并且最小化振动和冲击问题。

36. 发明授权

US07979347B1 Automated online sales risk management 有权
标题翻译：自动在线销售风险管理
公开(公告)号：US07979347B1
公开(公告)日：2011-07-12
申请号：US09714315
申请日：2000-11-16
申请人： Sharon Greener , Mark Higgins , Effie Konstantine Anagnostopoulos , Paul Young , Dan Rothman , John Godfrey , Mel Gunewardena
发明人： Sharon Greener , Mark Higgins , Effie Konstantine Anagnostopoulos , Paul Young , Dan Rothman , John Godfrey , Mel Gunewardena
IPC分类号： G06Q40/00
CPC分类号： G06Q40/08 , G06Q20/10 , G06Q20/381 , G06Q20/4016
摘要： The present invention contemplates a risk management system for facilitating an e-commerce transaction wherein the participants to the transaction engage in commerce using different currencies. An automated sales risk management system facilitates a transaction by providing a price of a transaction which incorporates aggregated costs related to the transaction into a price made available to the participants. A currency risk management system can receive an amount relating to a deliverable involved in a transaction and determines an aggregated cost of the transaction. Aggregated cost can include a cost of credit, a cost for exchange of currency, a cost of insurance, processing fees, or other associated costs. Insurance can be monitored and a determination can be made regarding whether a participant has adequate insurance to cover a proposed transaction. The present invention also provides for risk associated with online transactions to be categorized and transferred.
摘要翻译：本发明考虑了一种用于促进电子商务交易的风险管理系统，其中交易的参与者使用不同的货币进行商务。自动销售风险管理系统通过提供交易的价格来促成交易，该交易将与交易相关的综合成本纳入参与者可用的价格。货币风险管理系统可以收到与交易中涉及的交付品相关的金额，并确定交易的合计成本。总成本可以包括信用成本，货币兑换成本，保险成本，处理费用或其他相关费用。可以监控保险，并且可以确定参与者是否有足够的保险来支付拟议的交易。本发明还提供与要分类和转移的在线交易相关联的风险。

37. 发明申请

US20090305991A1 33 Human Secreted Proteins 审中-公开
标题翻译： 33人类分泌蛋白
公开(公告)号：US20090305991A1
公开(公告)日：2009-12-10
申请号：US12538668
申请日：2009-08-10
申请人： Daniel R. Soppet , Paul A. Moore , Yanggu Shi , Steven M. Ruben , Craig A. Rosen , David W. LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
发明人： Daniel R. Soppet , Paul A. Moore , Yanggu Shi , Steven M. Ruben , Craig A. Rosen , David W. LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
IPC分类号： A61K38/16 , C12N15/11 , C12N15/00 , C12N15/87 , C12N5/06 , C12N1/21 , C07K14/435 , C07K16/18 , C12P21/02 , C12Q1/68 , C12Q1/02 , G01N33/566
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to 33 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及33种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

38. 发明申请

US20090192046A1 Chemo-selective identification of therapeutics 审中-公开
标题翻译：化学选择性鉴定治疗
公开(公告)号：US20090192046A1
公开(公告)日：2009-07-30
申请号：US12309259
申请日：2007-07-09
申请人： Daniel R. Soppet , Stephen K. Horrigan , Paul Young , James Meade
发明人： Daniel R. Soppet , Stephen K. Horrigan , Paul Young , James Meade
IPC分类号： C40B30/02
CPC分类号： G16B25/00 , G16B35/00 , G16C20/60
摘要： Disclosed is the use of a therapeutic filter for simultaneous screening against multiple targets coupled with subsequent in silico drug discovery utilizing biologically active compounds for the identification and selection of gene sets having characteristic expression profiles for formation of an active compound database with subsequent identification of therapeutically effective agents by scanning and matching in said active compound database.
摘要翻译：公开了使用治疗性过滤器同时筛选多个靶标，并与随后的计算机药物发现相结合，利用生物活性化合物用于鉴定和选择具有形成活性化合物数据库的特征性表达谱的基因组，随后鉴定治疗有效代理通过在所述活动化合物数据库中进行扫描和匹配。

39. 发明申请

US20080050379A1 Cancer gene determination and therapeutic screening using signature gene sets 审中-公开
标题翻译：癌基因测定和使用签名基因组的治疗筛选
公开(公告)号：US20080050379A1
公开(公告)日：2008-02-28
申请号：US11881252
申请日：2007-07-26
申请人： Paul Young , Meena Augustus , Kenneth Carter , Reinhard Ebner , Gregory Endress , Stephen Horrigan , Daniel Soppet , Zoe Weaver
发明人： Paul Young , Meena Augustus , Kenneth Carter , Reinhard Ebner , Gregory Endress , Stephen Horrigan , Daniel Soppet , Zoe Weaver
IPC分类号： A61K39/395 , A61K31/00 , A61P43/00 , C07K16/18 , C12Q1/68 , C40B30/06 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/57407
摘要： Processes for assaying potential antitumor agents based on their modulation of the expression of specified genes, or sets, of suspected cancer cell genes are disclosed, along with methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, or sets of genes. Also disclosed are methods for determining functionally related genes, or gene sets, as well as methods for treating cancer based on targeting expression products of such genes, or gene sets, and determining genes involved in the cancerous process.
摘要翻译：本发明公开了基于对可疑癌细胞基因的特定基因或组的表达调节的潜在抗肿瘤剂的方法，以及用于诊断由于表达的结果而导致的癌性或潜在癌性病症的方法表达这些基因或一组基因。还公开了用于确定功能相关基因或基因组的方法，以及基于这些基因或基因组的靶向表达产物以及确定参与癌症过程的基因来治疗癌症的方法。

40. 发明申请

US20070203070A1 28 HUMAN SECRETED PROTEINS 失效
标题翻译： 28人类分泌蛋白
公开(公告)号：US20070203070A1
公开(公告)日：2007-08-30
申请号：US11744695
申请日：2007-05-04
申请人： Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
发明人： Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
IPC分类号： A61K38/17 , C07H21/04 , C07K16/00 , C07K4/00 , C12N15/00 , C12N15/09 , C12N5/00 , C12N5/08 , C12Q1/00 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

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