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31. 发明授权

US4786440A Detergent compositions using an aminocarboxylic acid as builder 失效
标题翻译：使用氨基羧酸作为助洗剂的洗涤剂组合物
公开(公告)号：US4786440A
公开(公告)日：1988-11-22
申请号：US752707
申请日：1985-07-08
申请人： Lance A. Cooper , Jaime Simon , David A. Wilson
发明人： Lance A. Cooper , Jaime Simon , David A. Wilson
IPC分类号： C11D3/33 , C11D3/30
CPC分类号： C11D3/33
摘要： Triethylenetetraminehexaacetic acid is used as a builder in combination with a surfactant or mixture of surfactants to provide a detergent composition having excellent properties. In the series of ethyleneaminopolycarboxylic acids triethylenetetraminehexaacetic acid was found unexpectedly superior as a substitute for nitrilotriacetic acid as a builder in detergent formulations.
摘要翻译：三亚乙基四胺六乙酸用作与表面活性剂或表面活性剂混合物组合的助洗剂，以提供具有优异性能的洗涤剂组合物。在一系列的乙烯基氨基多羧酸中，三亚乙基四胺六乙酸被意外地优于替代次氮基三乙酸作为洗涤剂配方中的助洗剂。

32. 发明授权

US4770791A Control of metal ions using bis(aminoalkyl) piperazine derivatives 失效
标题翻译：使用双（氨基烷基）哌嗪衍生物控制金属离子
公开(公告)号：US4770791A
公开(公告)日：1988-09-13
申请号：US34310
申请日：1987-04-03
申请人： Druce K. Crump , Jaime Simon , David A. Wilson
发明人： Druce K. Crump , Jaime Simon , David A. Wilson
IPC分类号： C02F5/14 , C04B24/00 , C07D295/13 , C07F9/6509 , C08G12/40
CPC分类号： C07D295/13 , C02F5/14 , C04B24/003 , C07F9/650958 , C08G12/40
摘要： It has now been found that certain phosphonate derivatives of bis(aminoalkyl) piperazines are good threshold agents to prevent metal ion precipitation in aqueous solutions. They also function as sequestering and/or chelating agents as do those which do not contain the phosphonate group.
摘要翻译：现在已经发现，双（氨基烷基）哌嗪的某些膦酸酯衍生物是防止水溶液中的金属离子沉淀的良好阈值剂。它们也用作螯合剂和/或螯合剂，如不含膦酸酯基团的那些。

33. 发明授权

US4680396A Bis(aminoalkyl)piperazine derivatives and their use as metal ion control agents 失效
标题翻译：双（氨烷基）哌嗪衍生物及其作为金属离子控制剂的用途
公开(公告)号：US4680396A
公开(公告)日：1987-07-14
申请号：US583526
申请日：1984-02-24
申请人： Druce K. Crump , Jaime Simon , David A. Wilson
发明人： Druce K. Crump , Jaime Simon , David A. Wilson
IPC分类号： C02F5/14 , C04B24/00 , C07D295/13 , C07F9/6509 , C08G12/40 , C07D295/12
CPC分类号： C07D295/13 , C02F5/14 , C04B24/003 , C07F9/650958 , C08G12/40
摘要： It has now been found that certain phosphonate derivatives of bis(aminoalkyl) piperazines are good threshold agents to prevent metal ion precipitation in aqueous solutions. They also function as sequestering and/or chelating agents as do those which do not contain the phosphonate group.
摘要翻译：现在已经发现，双（氨基烷基）哌嗪的某些膦酸酯衍生物是防止水溶液中的金属离子沉淀的良好阈值剂。它们也用作螯合剂和/或螯合剂，如不含膦酸酯基团的那些。

34. 发明授权

US4568468A Use of norbornane derived compounds as threshold agents 失效
标题翻译：使用降冰片烷衍生化合物作为阈值剂
公开(公告)号：US4568468A
公开(公告)日：1986-02-04
申请号：US695604
申请日：1985-01-28
申请人： Jaime Simon , Druce K. Crump , David A. Wilson
发明人： Jaime Simon , Druce K. Crump , David A. Wilson
IPC分类号： C02F5/12 , C02F5/14 , C07F9/38
CPC分类号： C07F9/3817 , C02F5/12 , C02F5/14 , A61K2123/00 , C02F2101/006
摘要： A process of preventing precipitation of scale producing metal ions, e.g. calcium, from their aqueous solutions by adding an effective amount of a methylenephosphonic acid derivative of bis(methylamine)-norbornane. These compounds are effective in threshold amounts.
摘要翻译：防止产生鳞屑的沉淀产生金属离子的过程，例如，钙，从其水溶液中加入有效量的双（甲胺） - 降冰片烷的亚甲基膦酸衍生物。这些化合物的阈值量是有效的。

35. 发明授权

US4500469A Metal ion control compounds based on norbornane 失效
标题翻译：基于降冰片烷的金属离子控制化合物
公开(公告)号：US4500469A
公开(公告)日：1985-02-19
申请号：US584071
申请日：1984-02-27
申请人： Jaime Simon , Druce K. Crump , David A. Wilson
发明人： Jaime Simon , Druce K. Crump , David A. Wilson
IPC分类号： C02F5/12 , C02F5/14 , C07F9/38 , C07C61/12 , C07C87/40 , C07C143/21
CPC分类号： C07F9/3817 , C02F5/12 , C02F5/14 , A61K2123/00 , C02F2101/006
摘要： The bis(methylamine) of norbornane compounds which have at least one of the amine hydrogens substituted with hydroxyalkyl, methylenephosphonic, alkylenesulfonic, carboxylic acid radicals and salts of any of the acid radicals are useful as chelating, sequestering agents. The phosphonate substituted compounds are also useful as threshold agents.
摘要翻译：具有至少一个被羟基烷基，亚甲基膦酸，烷基磺酸，羧酸基团取代的胺氢和任何酸基的盐的降冰片烷化合物的双（甲胺）可用作螯合螯合剂。膦酸酯取代的化合物也可用作阈剂。

36. 发明授权

US06861044B2 Radioiodinated sulfonated phenols and process therefore 失效
标题翻译：因此，放射性碘化磺化酚和过程
公开(公告)号：US06861044B2
公开(公告)日：2005-03-01
申请号：US10022885
申请日：2001-12-18
申请人： Jaime Simon , R. Keith Frank , Alan D. Strickland
发明人： Jaime Simon , R. Keith Frank , Alan D. Strickland
IPC分类号： A61K47/10 , A61K47/12 , A61K47/16 , A61K47/20 , A61K47/42 , A61K51/00 , A61K51/04 , A61P35/00
CPC分类号： A61K51/04 , A61K51/0406
摘要： The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, or a carboxyl group, and I* is 123I, 131I or 125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.
摘要翻译：本发明涉及式（Ⅰ）的放射性碘化酚类化合物的用途：m和n分别独立地为0,1,2或3，X为在生理pH值为负或带正电的基团，R 1，R 1，R 2 R 2和R 3独立地是氢，C 1 -C 4烷基或羧基，I *是123 I，131 I或125 I及其药学上可接受的盐。该化合物在可植入导管中的近距离放射治疗的动物体内被配制和使用。此外，由于这些化合物的肾脏清除速度快，因此可用于研究肾功能。还公开了制备这些化合物的方法。

37. 发明申请

US20050031680A1 In vivo use of water absorbent polymers 失效
标题翻译：体内使用吸水性聚合物
公开(公告)号：US20050031680A1
公开(公告)日：2005-02-10
申请号：US10840112
申请日：2004-05-06
申请人： Jaime Simon , Alan Strickland
发明人： Jaime Simon , Alan Strickland
IPC分类号： A61K31/715 , A61K31/716 , A61K31/74 , A61K31/78 , A61K47/32 , A61K9/48 , A61K9/14 , A61K9/24
CPC分类号： A61K31/78 , A61K9/00 , A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
摘要翻译：本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。优选的聚合物包括优选以珠粒形式提供的超吸收性丙烯酸聚合物。聚合物可以包括用于选择性地去除血液传播的废物的功能基团，例如。尿素，来自G.I. 道。

38. 发明授权

US06670456B2 Actinium-225 complexes and conjugates for targeted radiotherapy 失效
标题翻译：锕-225复合物和共轭物用于靶向放射治疗
公开(公告)号：US06670456B2
公开(公告)日：2003-12-30
申请号：US10085930
申请日：2002-02-27
申请人： R. Keith Frank , Garry E. Kiefer , Jaime Simon
发明人： R. Keith Frank , Garry E. Kiefer , Jaime Simon
IPC分类号： C07F500
CPC分类号： A61K51/0497 , A61K51/0482
摘要： Actinium-225 complexes comprising functionalized polyazamacrocyclic chelant compounds are disclosed. Such complexes show improved stability and can be conjugated to a biological carrier.
摘要翻译：公开了包含官能化的多氮杂环螯合剂化合物的锕-225络合物。这样的复合物显示出改善的稳定性并且可以与生物载体缀合。

39. 发明申请

US20120251442A1 Methods for Treatment of Tumors by Direct Administration of a Radioisotope 审中-公开
标题翻译：通过直接施用放射性同位素治疗肿瘤的方法
公开(公告)号：US20120251442A1
公开(公告)日：2012-10-04
申请号：US13469677
申请日：2012-05-11
申请人： R. Keith Frank , Kenneth McMillan , Edna Sue McMillian , Jaime Simon , H. Max Loy, JR. , Stanley D. Stearns
发明人： R. Keith Frank , Kenneth McMillan , Edna Sue McMillian , Jaime Simon , H. Max Loy, JR. , Stanley D. Stearns
IPC分类号： A61K51/00 , A61P35/00
CPC分类号： A61K51/1217
摘要： This invention provides a safer and more effective treatment for non-intracavitary undesirable tissue masses, especially bone cancer and soft tissue tumors. The method involves the direct administration of a therapeutically-effective dose of a formulated radioisotope composition nearby or directly into the tissue mass. Small volumes of the composition are used.Administration of the dose for bone cancer may be done through a hole or multiple holes created in the bone using a miniature drill. Delivery of the dose directly into a tumor may be accomplished using a microsyringe or a miniature pump capable of accurately delivering microliter amounts of material.
摘要翻译：本发明为非腔内不期望的组织块，特别是骨癌和软组织肿瘤提供更安全和更有效的治疗。该方法包括在组织块中直接施用治疗有效剂量的配制的放射性同位素组合物或直接施用于组织块。使用小体积的组合物。可以通过使用微型钻头在骨头中产生的孔或多个孔来进行骨癌剂量的施用。可以使用能够精确地递送微量的材料的微量注射器或微型泵来将剂量直接递送到肿瘤中。

40. 发明授权

US08263112B2 In vivo use of water absorbent polymers 失效
标题翻译：体内使用吸水性聚合物
公开(公告)号：US08263112B2
公开(公告)日：2012-09-11
申请号：US10840112
申请日：2004-05-06
申请人： Jaime Simon , Alan D. Strickland
发明人： Jaime Simon , Alan D. Strickland
IPC分类号： A61K9/16
CPC分类号： A61K31/78 , A61K9/00 , A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
摘要翻译：本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。优选的聚合物包括优选以珠粒形式提供的超吸收性丙烯酸聚合物。聚合物可以包括用于选择性地去除血液传播的废物的功能基团，例如。尿素，来自G.I. 道。

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