专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20130071416A1 IMMUNOGENIC PROTEINS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF STREPTOCOCCUS AGALACTIAE 有权
标题翻译：免疫原性蛋白质和组合物治疗和预防结核病
公开(公告)号：US20130071416A1
公开(公告)日：2013-03-21
申请号：US13637929
申请日：2011-04-01
申请人： Guido Grandi , Domenico Maione , Cira Daniela Rinaudo
发明人： Guido Grandi , Domenico Maione , Cira Daniela Rinaudo
IPC分类号： A61K39/00 , A61P31/04 , C07H21/04 , C07K14/00 , A61K38/16
CPC分类号： A61K39/092 , A61K2039/55 , A61K2039/57 , A61K2039/575 , C07K14/315 , C07K16/1275 , C07K2317/734 , C07K2319/40
摘要： The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS)
摘要翻译：本发明提供了用于治疗和预防无乳链球菌（B族链球菌; GBS）的蛋白质和组合物，

32. 发明授权

US08147849B2 Protective antigens for group B Streptococcus hypervirulent strains 有权
标题翻译： B组链球菌高毒力株的保护性抗原
公开(公告)号：US08147849B2
公开(公告)日：2012-04-03
申请号：US12706387
申请日：2010-02-16
申请人： Francesco Doro , Nathalie Norais , Domenico Maione , Sabrina Liberatori , Guido Grandi
发明人： Francesco Doro , Nathalie Norais , Domenico Maione , Sabrina Liberatori , Guido Grandi
IPC分类号： A61K39/09 , C12P21/06 , C07K14/315 , C12N15/09
CPC分类号： C07K14/315 , A61K39/00
摘要： The invention provides protective antigens for Group B streptococcus hypervirulent strains. The fragments are useful in vaccine compositions to induce protection against S. agalactiae, particularly against hypervirulent strains.
摘要翻译：本发明提供了B组链球菌高毒力菌株的保护性抗原。这些片段可用于疫苗组合物中，以诱导针对无精子症的保护，特别是针对高毒力菌株。

33. 发明申请

US20110195409A1 STREPTOCOCCUS PYOGENES CLASSIFICATION 审中-公开
标题翻译： STREPTOCOCCUS PYOGENES分类
公开(公告)号：US20110195409A1
公开(公告)日：2011-08-11
申请号：US12741514
申请日：2008-11-06
申请人： Guido Grandi , Marirosa Mora , John L. Telford , Chiara Zingaretti , Fabiana Falugi
发明人： Guido Grandi , Marirosa Mora , John L. Telford , Chiara Zingaretti , Fabiana Falugi
IPC分类号： C12Q1/68 , C07K7/06 , C07K14/315 , C07H21/00 , C07K16/12 , C09K3/00
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： The difference Lancefield T-serotypes correlate with the sequence of the pilus backbone protein (Pbp) in Streptococcus pyogenes (GAS). We have sequenced Pbp for over 50 GAS strains, representing the major disease-associated serotypes, and have identified 15 Pbp variants. These 15 variants have been shown to determine the specificity of the T-serotyping, such that sequencing of the Pbp from a given GAS strain reliably predicts that strain's T-serotype. thus the invention permits the t-serotype of a GAS strain to be determined based on genotype.
摘要翻译：不同的Lancefield T型血清型与化脓链球菌（GAS）中的菌毛骨架蛋白（Pbp）的序列相关。我们已经为超过50种GAS菌株测序了Pbp，代表了主要的疾病相关血清型，并确定了15种Pbp变体。已经显示了这15种变体来确定T血清型的特异性，使得来自给定GAS菌株的Pbp的测序可靠地预测该菌株的T血清型。因此本发明允许基于基因型确定GAS株的t-血清型。

34. 发明授权

US09206399B2 Immunogenic bacterial vesicles with outer membrane proteins 有权
标题翻译：具有外膜蛋白的免疫原性细胞囊泡
公开(公告)号：US09206399B2
公开(公告)日：2015-12-08
申请号：US11666786
申请日：2005-10-28
申请人： Jeannette Adu-Bobie , Mariagrazia Pizza , Nathalie Norais , Germano Ferrari , Guido Grandi
发明人： Jeannette Adu-Bobie , Mariagrazia Pizza , Nathalie Norais , Germano Ferrari , Guido Grandi
IPC分类号： A61K39/095 , C12N9/10 , A61K39/108
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K39/095 , C07K14/22 , C12N9/1051 , Y02A50/474
摘要： Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.
摘要翻译：脑膜炎球菌mltA同系物的敲除使细菌自发释放富含免疫原性外膜蛋白的囊泡，并且能够以比正常生产过程制备的OMV更高的杀菌滴度引发交叉保护性抗体应答。因此，本发明提供了具有其mltA基因的敲除突变的细菌。本发明还提供了一种细菌，其中所述细菌：（i）具有包含肽聚糖的细胞壁; 和（ii）不表达具有MltA蛋白的裂解转糖苷酶活性的蛋白质。本发明还提供包含囊泡的组合物，其在本发明的细菌培养期间释放到培养基中。

35. 发明授权

US09067987B2 Neisserial antigenic peptides 有权
标题翻译： Neisserial抗原肽
公开(公告)号：US09067987B2
公开(公告)日：2015-06-30
申请号：US13405213
申请日：2012-02-24
申请人： Cesira Galeotti , Guido Grandi , Vega Masignani , Marirosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人： Cesira Galeotti , Guido Grandi , Vega Masignani , Marirosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号： C07K14/22 , A61K39/095 , A61K39/00 , A61K48/00
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
摘要翻译：本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质，多肽和其片段。还提供编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸，例如，反义核酸）。另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。还提供了用组合物制备组合物和处理方法的方法。本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

36. 发明授权

US08481057B2 Chlamydial antigens 失效
标题翻译：衣原体抗原
公开(公告)号：US08481057B2
公开(公告)日：2013-07-09
申请号：US12086571
申请日：2006-12-19
申请人： Guido Grandi , Lehutova Livia
发明人： Guido Grandi , Giulio Ratti
IPC分类号： A61K39/118 , C07K14/295
CPC分类号： A61K39/118
摘要： The invention is in the field of immunology and vaccinology. In particular, it relates to antigens derived from Chlamydia trachomatis that are expressed on the cell surface and so are ideal for use in immunization as well as combinations of these antigens.
摘要翻译：本发明在免疫学和疫苗学领域。特别地，本发明涉及在细胞表面表达的来自沙眼衣原体的抗原，因此是用于免疫的理想用途以及这些抗原的组合。

37. 发明申请

US20120276129A1 NEISSERIAL ANTIGENIC PEPTIDES 有权
标题翻译： NEISSERIAL抗原肽
公开(公告)号：US20120276129A1
公开(公告)日：2012-11-01
申请号：US13405213
申请日：2012-02-24
申请人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号： A61K39/095 , A61P37/04 , C07K14/22
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
摘要翻译：本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质，多肽和其片段。还提供编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸，例如，反义核酸）。另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。还提供了用组合物制备组合物和处理方法的方法。本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

38. 发明申请

US20120219578A1 NEISSERIAL ANTIGENIC PEPTIDES 有权
公开(公告)号：US20120219578A1
公开(公告)日：2012-08-30
申请号：US13405162
申请日：2012-02-24
申请人： Cesira GALEOTTI , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人： Cesira GALEOTTI , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号： A61K39/095 , A61P31/04 , A61P37/04 , C07K14/22
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

39. 发明授权

US08133973B2 Immunogenic compositions for Chlamydia trachomatis 失效
标题翻译：沙眼衣原体的免疫原性组合物
公开(公告)号：US08133973B2
公开(公告)日：2012-03-13
申请号：US11920230
申请日：2006-05-12
申请人： Guido Grandi , Giulio Ratti
发明人： Guido Grandi , Giulio Ratti
IPC分类号： C07K14/295 , A61K38/04 , A61K39/118
CPC分类号： C07K14/295 , Y10T436/143333
摘要： The present invention provides variant LcrE sequences and/or combinations of variant LcrE sequences across the Chlamydia trachomatis serovars. Such changes in LcrE genotypes across the Chlamydia trachomatis serovars are likely to correspond with changes in LcrE phenotypes, in particular, with changes in immunogenicity. The present invention also provides peptides surrounding or associated with the amino acid substitutions, in particular, peptides surrounding or associated with high frequency mutated amino acid positions or hypervariable regions, which are likely to be B and/or T cell epitopic regions capable of eliciting Chlamydia specific cell mediated immune responses. The variant LcrE sequences and/or combinations of the variant LcrE sequences and/or epitope regions associated with the variant LcrE sequences are useful as immunogens and/or in the preparation of immunogenic compositions for preventing and/or treating and/or, diagnosing Chlamydia infections.
摘要翻译：本发明提供了穿过沙眼衣原体血清型沙眼衣原体的变体LcrE序列和/或变体LcrE序列的组合。沙眼衣原体血清型的LcrE基因型的这种变化可能与LcrE表型的变化相一致，特别是随着免疫原性的变化。本发明还提供了与氨基酸取代相关的肽，特别是与高频突变的氨基酸位置或高变区相关的肽，其可能是能诱导衣原体的B和/或T细胞表位区特异性细胞介导的免疫应答。与变体LcrE序列相关的变体LcrE序列和/或变体LcrE序列和/或表位区域的变体的变体LcrE序列和/或组合可用作免疫原和/或用于预防和/或治疗和/或诊断衣原体感染的免疫原性组合物。

40. 发明授权

US08128936B2 Immunogenic compositions for Streptococcus pyogenes 有权
标题翻译：化脓性链球菌的免疫原性组合物
公开(公告)号：US08128936B2
公开(公告)日：2012-03-06
申请号：US12715912
申请日：2010-03-02
申请人： Guido Grandi , John Telford , Giuliano Bensi
发明人： Guido Grandi , John Telford , Giuliano Bensi
IPC分类号： A61K39/09 , C07K14/315 , C12P21/04
CPC分类号： C07K14/315 , A61K39/092 , C07K2319/00
摘要： The invention includes a GAS antigen, GAS 40, which is particularly suitable for use either alone or in combinations with additional GAS antigens, such as GAS 117, GAS 130, GAS 277, GAS 236, GAS 40, GAS 389, GAS 504, GAS 509, GAS 366, GAS 159, GAS 217, GAS 309, GAS 372, GAS 039, GAS 042, GAS 058, GAS 290, GAS 511, GAS 533, GAS 527, GAS 294, GAS 253, GAS 529, GAS 045, GAS 095, GAS 193, GAS 137, GAS 084, GAS 384, GAS 202, and GAS 057.
摘要翻译：本发明包括GAS抗原GAS40，其特别适用于单独使用或与额外的GAS抗原如GAS 117，GAS 130，GAS 277，GAS 236，GAS 40，GAS 389，GAS 504，GAS 509，GAS 366，GAS 159，GAS 217，GAS 309，GAS 372，GAS 039，GAS 042，GAS 058，GAS 290，GAS 511，GAS 533，GAS 527，GAS 294，GAS 253，GAS 529，GAS 045， GAS 095，GAS 193，GAS 137，GAS 084，GAS 384，GAS 202和GAS 057。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式