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31. 发明申请

US20110214621A1 HIGH EFFICIENCY GAS-FIRED WATER HEATER 有权
标题翻译：高效燃气加热器
公开(公告)号：US20110214621A1
公开(公告)日：2011-09-08
申请号：US12974186
申请日：2010-12-21
申请人： Jozef Boros , Qian Zhang , Yoshiki Semba , Subbu Thenappan
发明人： Jozef Boros , Qian Zhang , Yoshiki Semba , Subbu Thenappan
IPC分类号： F24H1/18
CPC分类号： F24H1/18
摘要： The efficiencies of illustrative embodiments of vertical center flue type fuel-fired base water heaters are improved by installing in the water heaters variously configured tubular condensing type secondary heat exchangers of smaller diameters than the associated center flues. The efficiency increases are achieved with components and manufacturing processes similar to those utilized in the base water heaters and secondary heat exchanger materials similar to those in the tank portions of the base water heaters.
摘要翻译：通过安装在具有比相关联的中心烟道更小的直径的各种配置的管状冷凝型二次热交换器的热水器中，提高了垂直中心烟道式燃料基础热水器的说明性实施例的效率。与基础热水器和二次热交换器材料中使用的部件和制造工艺类似于基础热水器的罐部分中的部件和制造工艺类似的部件和制造工艺实现效率提高。

32. 发明申请

US20110214347A1 Methods and Apparatuses for Plant Aeration 审中-公开
标题翻译：植物曝气的方法和装置
公开(公告)号：US20110214347A1
公开(公告)日：2011-09-08
申请号：US13061448
申请日：2009-08-28
申请人： Qian Zhang
发明人： Qian Zhang
IPC分类号： A01G31/02 , A01G1/00
CPC分类号： A01G31/02 , A01G7/00 , A01G33/00 , Y02P60/216
摘要： Plant-aeration systems, methods for plant aeration, plant-aeration cells, methods of environmental remediation, systems for algae cultivation, and apparatuses for algae aeration.
摘要翻译：植物曝气系统，植物曝气方法，植物曝气池，环境修复方法，藻类培养系统和藻类曝气装置。

33. 发明授权

US07985857B2 Usage of poly-3-hydroxybutyrates in preparation of β-lactam compounds 有权
标题翻译：聚-3-羟基丁酸酯在制备β-内酰胺化合物中的用途
公开(公告)号：US07985857B2
公开(公告)日：2011-07-26
申请号：US12280781
申请日：2006-10-16
申请人： Weichuan Lu , Qian Zhang , Xin Cheng
发明人： Weichuan Lu , Qian Zhang , Xin Cheng
IPC分类号： C07D205/08 , C07F7/18
CPC分类号： C07D205/08 , C07F7/188
摘要： A method for preparing compounds having the formula(I) by using P(3HB), wherein R is R1, R2, R3 are lower linear or branched C1-C4 alkyl, comprising the steps of: a: obtaining (3R)-3-RO—CH(CH3)CH2COOCH3 by pyrolysis of P(3HB) and protection; b: obtaining (3R)-3-RO—CH(CH3)CH2CHO by reduction of (3R)-3-RO—CH(CH3)CH2COOCH3 ; c: enolizing (3R)-3-RO—CH(CH3)CH2CHO and then reacting with chlorosulfonyl isocyanate, at last getting the final product by reduction; wherein (3R)-3-RO—CH(CH3)CH2CHO is enolized by reacting (3R)-3-RO—CH(CH3)CH2CHO with isopropenyl acetate and p-toluenesulfonic acid by heating under reflux.
摘要翻译：通过使用P（3HB）制备具有式（I）的化合物的方法，其中R为R 1，R 2，R 3为低级直链或支链C 1 -C 4烷基，包括以下步骤：a：获得（3R）-3- RO-CH（CH3）CH2COOCH3通过热解P（3HB）和保护; b：通过还原（3R）-3 -OR-CH（CH3）CH2COOCH3获得（3R）-3 -OR-CH（CH 3）CH 2 CHO; c：烯化（3R）-3 -OR-CH（CH 3）CH 2 CHO，然后与氯磺酰基异氰酸酯反应，最后通过还原得到最终产物; 其中通过在回流下加热使（3R）-3 -OR-CH（CH 3）CH 2 CHO与乙酸异丙烯酯和对甲苯磺酸反应来使（3R）-3 -OR-CH（CH 3）CH 2 CHO烯醇化。

34. 发明申请

US20110086043A1 STAT5a AND ITS FUNCTIONAL TUMOR SUPPRESSOR ANALOGS FOR TREATMENT OF MALIGNANCIES EXPRESSING NPM/ALK AND OTHER ONCOGENIC KINASES 有权
标题翻译： STAT5a及其功能性肿瘤抑制剂类似物，用于治疗表达NPM / ALK和其他ONCGENIC KINASES的恶性肿瘤
公开(公告)号：US20110086043A1
公开(公告)日：2011-04-14
申请号：US12681327
申请日：2008-09-29
申请人： Mariusz A. Wasik , Qian Zhang
发明人： Mariusz A. Wasik , Qian Zhang
IPC分类号： A61K39/395 , C12N5/00 , A61P35/00 , A61P35/02 , A61K31/7105 , A61K31/713 , A61K31/7068 , A61K38/02 , A61K35/12 , C12Q1/48 , C12Q1/68
CPC分类号： A61K31/706 , A61K31/5355 , A61K38/1709 , A61K39/3955 , C07K16/18 , C07K16/3061 , C07K2317/76 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12Q1/485 , G01N33/57484 , G01N2333/91011 , G01N2800/52
摘要： The invention provides methods of inhibiting epigenetic gene silencing in a cell expressing NPM/ALK or decreasing NPM/ALK content in a cell, by contacting a cell with an agent capable of increasing the concentration of Stat5a protein or its functional analog. Further, the invention provides a method of treating malignancies expressing oncogenic kinase by administering to a patient affected with a malignancy an agent capable of increasing the concentration of Stat5a protein or its epigenetically silenced functional tumor suppressor analog in a malignant cell. Finally, it provides a method to diagnose malignancy and monitor patient's response to therapy by analysis of the degree of DNA methylation of the gene encoding for Stat5a or its analog, their mRNA, or protein.
摘要翻译：本发明提供了通过使细胞与能够增加Stat5a蛋白或其功能类似物的浓度的试剂接触来抑制表达NPM / ALK的细胞中表观遗传学基因沉默或降低细胞中NPM / ALK含量的方法。此外，本发明提供了一种通过向恶性肿瘤患者施用能增加恶性细胞中Stat5a蛋白或其表观遗传学上沉默的功能性肿瘤抑制型类似物的浓度的试剂来治疗表达致癌激酶的恶性肿瘤的方法。最后，它提供了一种通过分析编码Stat5a或其类似物，mRNA或蛋白质的基因的DNA甲基化程度来诊断恶性肿瘤并监测患者对治疗反应的方法。

35. 发明申请

US20110085517A1 METHOD AND DEVICE FOR DETACHING USER EQUIPMENT 有权
标题翻译：用于分离用户设备的方法和设备
公开(公告)号：US20110085517A1
公开(公告)日：2011-04-14
申请号：US12971612
申请日：2010-12-17
申请人： Yijun Yu , Qian Zhang
发明人： Yijun Yu , Qian Zhang
IPC分类号： H04W36/00
CPC分类号： H04W60/06 , H04W36/0022 , H04W36/14 , H04W76/30 , H04W76/32 , H04W76/34
摘要： A method and device for detaching a user equipment (UE) are disclosed in the present invention. The UE is registered with a mobility management entity (MME) in a packet switched (PS) network and a mobile switching center (MSC) in a circuit switched (CS) network. When the UE needs to detach from the PS network, the MSC receives a Detach Request with a Detach Type indicating the detaching from the PS network only; after receiving the Detach Request, the MSC deletes the context of the PS core network entity and clears the connection between the MSC and the MME. An MME for performing UE detachment is also disclosed in the present invention. The present invention helps reduce the time delay during the subsequent handover and quickly provide users with communications services, so as to improve user's experience and meet the carriers' requirements.
摘要翻译：在本发明中公开了一种用于分离用户设备（UE）的方法和设备。 UE被分配交换（PS）网络中的移动性管理实体（MME）和电路交换（CS）网络中的移动交换中心（MSC））注册。当UE需要从PS网络分离时，MSC接收到具有分离类型的分离请求，指示仅从PS网络分离; MSC收到分离请求后，删除PS核心网实体的上下文，并清除MSC与MME之间的连接。在本发明中还公开了用于执行UE分离的MME。本发明有助于减少后续切换期间的时延，并迅速为用户提供通信服务，从而提高用户体验并满足运营商的需求。

36. 发明申请

US20100312899A1 DETERMINING AN EFFICIENT KEEP-ALIVE INTERVAL FOR A NETWORK CONNECTION 有权
标题翻译：确定网络连接的有效保持间隔
公开(公告)号：US20100312899A1
公开(公告)日：2010-12-09
申请号：US12480560
申请日：2009-06-08
申请人： Shai Herzog , Rashid Qureshi , Jorge Raastroem , Xuemei Bao , Rajeev Bansal , Qian Zhang , Scott Michael Bragg
发明人： Shai Herzog , Rashid Qureshi , Jorge Raastroem , Xuemei Bao , Rajeev Bansal , Qian Zhang , Scott Michael Bragg
IPC分类号： G06F15/16 , G06F11/00
CPC分类号： H04L65/1066 , H04L67/14 , H04L67/141 , H04L67/145 , H04L67/28 , H04L67/2842 , H04L69/16 , H04L69/163 , H04L69/28
摘要： Systems and methods for use in communication between a client and a server, via a networking device, are provided. The method may include sending a request to establish a data connection from the client to the server via the networking device, setting a data connection keep-alive interval for the data connection to a predetermined safe value, and sending a request to establish a test connection between the client and the server. The method may further include determining an efficient keep-alive interval for communication between the client and server via the networking device, using the test connection, setting the data connection keep-alive interval to the efficient keep-alive interval determined using the test connection, and uploading the efficient keep-alive interval from the client to the server in an efficient keep-alive interval notification message, for communication to other clients connected to the server.
摘要翻译：提供了通过网络设备在客户端和服务器之间的通信中使用的系统和方法。该方法可以包括通过网络设备发送建立从客户端到服务器的数据连接的请求，将数据连接的数据连接保持间隔设置为预定的安全值，以及发送建立测试连接的请求在客户端和服务器之间。该方法可以进一步包括：使用测试连接，经由网络设备确定用于客户端和服务器之间的通信的有效保持间隔，将数据连接保持间隔设置为使用测试连接确定的有效保持间隔，并且在有效的保持活动间隔通知消息中将高效的保持活动间隔从客户端上传到服务器，以便与连接到服务器的其他客户端进行通信。

37. 发明申请

US20100260337A1 Context-Free Protocol for Enforcing Data Forwarding in Wireless Ad Hoc Networks 有权
标题翻译：在无线Ad Hoc网络中执行数据转发的无上下文协议
公开(公告)号：US20100260337A1
公开(公告)日：2010-10-14
申请号：US12422722
申请日：2009-04-13
申请人： Chengqi Song , Qian Zhang
发明人： Chengqi Song , Qian Zhang
IPC分类号： H04L9/00 , H04L9/30
CPC分类号： H04W12/04 , H04L9/0827 , H04L63/062 , H04L2209/80 , H04L2463/062 , H04W12/02
摘要： Described herein is a context-free protocol (i.e., the COFFEE protocol) for stimulating cooperation among selfish nodes. Various embodiments have the ability to transmit a packet over the path successfully without the dependency on the information of other packets' transmissions. It is assumed that every node in the network is rational, and therefore during the packet forwarding stage, if the intermediate nodes can not clearly tell whether the packet is destined to them or not, they do not simply drop the packet. Thus, in the COFFEE protocol, by introducing several techniques, for a packet received by a node, the node thinks the packet could potentially be destined to itself and forwards the packet to find out the answer. Detailed analysis and performance evaluations have been conducted to demonstrate the effectiveness of the COFFEE protocol.
摘要翻译：这里描述了用于刺激自私节点之间的协作的无上下文协议（即，COFFEE协议）。各种实施例具有在路径上成功传送分组的能力，而不依赖于其他分组传输的信息。假设网络中的每个节点都是合理的，因此在分组转发阶段，如果中间节点不能清楚地知道分组是否指定给它们，则它们不会简单地丢弃分组。因此，在COFFEE协议中，通过引入几种技术，对于由节点接收的分组，节点认为分组可能潜在地注定到自身并转发分组以找出答案。已经进行了详细的分析和绩效评估，以证明COFFEE协议的有效性。

38. 发明申请

US20100008946A1 Microorganisms for therapy 有权
公开(公告)号：US20100008946A1
公开(公告)日：2010-01-14
申请号：US12462074
申请日：2009-07-28
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/12 , C12N7/01 , A61P35/00
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

39. 发明申请

US20090155287A1 Modified vaccinia virus strains for use in diagnostic and therapeutic methods 有权
标题翻译：用于诊断和治疗方法的改良的痘苗病毒株
公开(公告)号：US20090155287A1
公开(公告)日：2009-06-18
申请号：US12080766
申请日：2008-04-04
申请人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
发明人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/00 , A61K35/76 , A61K39/395 , A61K39/00 , A61P35/04
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
摘要翻译：提供了修饰的病毒和用于制备修饰的病毒的方法。提供含有病毒的疫苗。病毒可以用于治疗诸如增殖性和炎性疾病（包括癌症）的疾病的方法，以及作为抗肿瘤和/或抗血管生成剂。病毒也可用于诊断方法。

40. 发明申请

US20070181081A1 High efficiency, wet-base, downfired multi-pass water heater 有权
标题翻译：高效率，湿碱，低温多功能热水器
公开(公告)号：US20070181081A1
公开(公告)日：2007-08-09
申请号：US11350443
申请日：2006-02-09
申请人： Ozzie Missoum , Gregory Welk , Qian Zhang
发明人： Ozzie Missoum , Gregory Welk , Qian Zhang
IPC分类号： F24H1/00
CPC分类号： F24H1/206 , F24H8/00 , Y02B30/102
摘要： A fuel-fired water heater has a three-pass condensing type heat exchanger disposed within its tank and having a central vertical first pass flue pipe separated into upper and lower portions by an internal dividing structure. Respectively coupled to the upper and lower first pass flue pipe portions are circumferentially spaced series of vertical second and third pass flue pipes which circumscribe the central flue pipe within the tank. During firing of the water heater, combustion gases from a power burner are sequentially forced downwardly through the upper portion of the first pass flue pipe, upwardly through the second pass flue pipes to an upper plenum external to the tank, and then downwardly through the third pass flue pipes and the lower central pipe portion into a bottom plenum external to the tank for discharge from the water heater.
摘要翻译：燃料热水器具有设置在其罐内的三通冷凝型热交换器，并具有通过内部分隔结构分离成上部和下部的中央垂直第一通道烟道。分别耦合到上，下第一通道烟道管部分是圆周间隔的一系列垂直的第二和第三通道烟道管，其围绕罐内的中央烟道管。在热水器的燃烧期间，来自动力燃烧器的燃烧气体依次被迫向下通过第一通道烟道管的上部，向上通过第二通道烟道管，到罐外部的上部通风室，然后向下通过第三通道通过烟道管和下中心管部分进入罐外部的底部增压室，以从热水器排出。

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