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31. 发明授权

US08048627B2 Method and compositions for detection and enumeration of genetic variations 有权
标题翻译：用于检测和计数遗传变异的方法和组合物
公开(公告)号：US08048627B2
公开(公告)日：2011-11-01
申请号：US10562840
申请日：2004-06-09
申请人： Devin Dressman , Hai Yan , Kenneth W Kinzler , Bert Vogelstein
发明人： Devin Dressman , Hai Yan , Kenneth W Kinzler , Bert Vogelstein
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C12Q1/6858 , C07H21/04 , C12N15/1075 , C12Q1/686 , C12Q2565/537 , C12Q2563/149 , C12Q2563/143
摘要： Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to which thousands of copies of DNA identical in sequence to the original are bound. This population of beads then corresponds to a one-to-one representation of the starting DNA molecules. Variation within the original population of DNA molecules can then be simply assessed by counting fluorescently-labeled particles via flow cytometry. Millions of individual DNA molecules can be assessed in this fashion with standard laboratory equipment. Moreover, specific variants can be isolated by flow sorting and employed for further experimentation. This approach can be used for the identification and quantification of rare mutations as well as to study variations in gene sequences or transcripts in specific populations or tissues.
摘要翻译：生物医学研究的许多领域取决于对个别基因或转录本中不常见变异的分析。在这里，我们描述一种可以量化这种变化的方法，其规模和容易度迄今为止是无法实现的。将这样的分子的集合中的每个DNA分子转化成单个颗粒，其中与原始序列顺序相同的数千个拷贝的DNA被结合。这种珠子群对应于起始DNA分子的一对一表示。然后可以通过流式细胞术对荧光标记的颗粒进行计数，简单地评估原始DNA分子群体内的变异。可以用标准实验室设备以这种方式评估数百万个单独的DNA分子。此外，可以通过流动分选分离特定的变体并用于进一步的实验。该方法可用于鉴定和定量稀有突变，并研究特定群体或组织中基因序列或转录本的变异。

32. 发明授权

US08035433B2 Process insensitive delay line 有权
标题翻译：过程不敏感的延迟线
公开(公告)号：US08035433B2
公开(公告)日：2011-10-11
申请号：US12690124
申请日：2010-01-20
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H03L7/06
CPC分类号： H03H11/265
摘要： A delay line including a phase detector having two inputs and one output. The first input of the phase detector is connected to an input of the delay line. The second input of the phase detector is connected to an output of the delay line. The output of the phase detector is connected to a control circuit which controls current flow at a control node to produce a control voltage at the node. A voltage-controlled delay unit is responsible to the control voltage to control a delay applied to a signal at an input of the delay line.
摘要翻译：延迟线包括具有两个输入和一个输出的相位检测器。相位检测器的第一输入端连接到延迟线的输入端。相位检测器的第二输入端与延迟线的输出相连。相位检测器的输出连接到控制电路，该控制电路控制控制节点处的电流，以在节点处产生控制电压。电压控制延迟单元负责控制电压以控制施加到延迟线输入端的信号的延迟。

33. 发明授权

US07947809B2 Compositions and methods relating to glucagon receptor antibodies 有权
标题翻译：与胰高血糖素受体抗体相关的组合物和方法
公开(公告)号：US07947809B2
公开(公告)日：2011-05-24
申请号：US11903481
申请日：2007-09-20
申请人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
发明人： Hai Yan , Shaw-Fen Sylvia Hu , Thomas C. Boone , Richard A. Lindberg
IPC分类号： C12P21/08
CPC分类号： C07K16/2869 , A61K2039/505 , C07K14/723 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies including methods of treating and preventing type 2 diabetes and related disorders by administering such antibodies to a subject in need of such treatment.
摘要翻译：本公开提供了与抗原结合蛋白特别是特异性结合人胰高血糖素受体的抗体相关的组合物和方法。本公开提供了编码这种抗原结合蛋白的核酸和抗体，以及制备和使用这些抗体的方法，包括通过向需要这种治疗的受试者施用此类抗体来治疗和预防2型糖尿病和相关疾病的方法。

34. 发明授权

US07659928B2 Apparatus and method for providing anti-eclipse operation for imaging sensors 有权
标题翻译：用于为成像传感器提供防食操作的装置和方法
公开(公告)号：US07659928B2
公开(公告)日：2010-02-09
申请号：US11110874
申请日：2005-04-21
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H04N5/217 , H04N3/14 , H04N5/335 , H01L27/00
CPC分类号： H04N5/3598
摘要： An anti-eclipse circuit of an image pixel includes an output line for receiving a reset output signal from a pixel and a circuit coupled to the output line for detecting when a pixel reset voltage at a pixel output is below a predetermined level, and, in response, for increasing a reset voltage at the pixel output to a value above the predetermined level. The detecting and increasing circuit comprises a charge amplifier circuit for receiving the reset output signal at the output line and a voltage generating circuit coupled to the output line responsive to the output of the charge amplifier circuit.
摘要翻译：图像像素的日食电路包括用于接收来自像素的复位输出信号的输出线和耦合到输出线的电路，用于检测像素输出处的像素复位电压何时低于预定水平，并且在响应，用于将像素输出处的复位电压增加到高于预定电平的值。检测和增加电路包括用于在输出线处接收复位输出信号的电荷放大器电路和响应于电荷放大器电路的输出耦合到输出线的电压产生电路。

35. 发明授权

US07642846B2 Apparatuses and methods for providing offset compensation for operational amplifier 有权
标题翻译：为运算放大器提供偏移补偿的装置和方法
公开(公告)号：US07642846B2
公开(公告)日：2010-01-05
申请号：US11978602
申请日：2007-10-30
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H03F1/02
CPC分类号： H03F3/45188 , H03F3/45183 , H03F3/45475 , H03F3/45968 , H03F2200/405 , H03F2203/45066 , H03F2203/45212 , H03F2203/45422 , H03F2203/45424 , H03F2203/45536 , H03F2203/45551 , H03F2203/45618 , H03F2203/45681 , H04N5/357 , H04N5/378
摘要： Apparatuses and methods for providing offset compensation include a primary amplifier which includes a first output, a second output, a first load input, and a second load input, a first feedback loop connected to the primary amplifier and which includes a first switch located between the first output of the primary amplifier and the first load input, and a first sampling capacitor coupled to the first switch between the first switch and the first load input and a second feedback loop connected to the primary amplifier and which includes a second switch located between the second output of the primary amplifier and the second load input, and a second sampling capacitor coupled to the second switch between the second switch and the second load input.
摘要翻译：用于提供偏移补偿的装置和方法包括主放大器，其包括第一输出，第二输出，第一负载输入和第二负载输入，连接到主放大器的第一反馈环路，并且包括位于初级放大器和第一负载输入的第一输出以及耦合到第一开关和第一负载输入之间的第一开关的第一采样电容器和连接到主放大器的第二反馈环路，并且包括位于第一开关所述主放大器和所述第二负载输入的第二输出以及耦合到所述第二开关和所述第二负载输入之间的所述第二开关的第二采样电容器。

36. 发明申请

US20090286687A1 Method and Compositions for Detection and Enumeration of Genetic Variations 审中-公开
标题翻译：遗传变异检测和计数的方法和组合
公开(公告)号：US20090286687A1
公开(公告)日：2009-11-19
申请号：US12361690
申请日：2009-01-29
申请人： Devin DRESSMAN , Hai Yan , Kenneth Kinzler , Bert Volgelstein
发明人： Devin DRESSMAN , Hai Yan , Kenneth Kinzler , Bert Volgelstein
IPC分类号： C40B20/00
CPC分类号： C12Q1/6858 , C07H21/04 , C12N15/1075 , C12Q1/686 , C12Q2565/537 , C12Q2563/149 , C12Q2563/143
摘要： Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to which thousands of copies of DNA identical in sequence to the original are bound. This population of beads then corresponds to a one-to-one representation of the starting DNA molecules. Variation within the original population of DNA molecules can then be simply assessed by counting fluorescently-labeled particles via flow cytometry. Millions of individual DNA molecules can be assessed in this fashion with standard laboratory equipment. Moreover, specific variants can be isolated by flow sorting and employed for further experimentation. This approach can be used for the identification and quantification of rare mutations as well as to study variations in gene sequences or transcripts in specific populations or tissues.
摘要翻译：生物医学研究的许多领域取决于对个别基因或转录本中不常见变异的分析。在这里，我们描述一种可以量化这种变化的方法，其规模和容易度迄今为止是无法实现的。将这样的分子的集合中的每个DNA分子转化成单个颗粒，其中与原始序列顺序相同的数千个拷贝的DNA被结合。这种珠子群对应于起始DNA分子的一对一表示。然后可以通过流式细胞术对荧光标记的颗粒进行计数，简单地评估原始DNA分子群体内的变异。可以用标准实验室设备以这种方式评估数百万个单独的DNA分子。此外，可以通过流动分选分离特定的变体并用于进一步的实验。该方法可用于鉴定和定量稀有突变，并研究特定群体或组织中基因序列或转录本的变异。

37. 发明申请

US20080204294A1 Analog-to-digital converter apparatus, systems, and methods 有权
标题翻译：模数转换器装置，系统和方法
公开(公告)号：US20080204294A1
公开(公告)日：2008-08-28
申请号：US11710798
申请日：2007-02-26
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H03M1/12
CPC分类号： H03M1/124 , H03M1/146 , H03M1/361
摘要： Various embodiments disclose apparatus, systems, and methods operating with a first circuit branch with transistors coupled in series between first and second supply nodes, and a second circuit branch with second transistors coupled in series between the first and second supply nodes. The second circuit branch may include a resistive unit coupled in series with the second transistors. The first and second circuit branches may receive analog information and to provide digital output information. The digital output information may include output values based on a relationship between a voltage across the first resistive unit and a voltage difference between first and second components of the analog input information. Other embodiments disclose additional apparatus, systems, and methods.
摘要翻译：各种实施例公开了利用在第一和第二供应节点之间串联耦合的晶体管的第一电路支路操作的装置，系统和方法，以及具有串联连接在第一和第二供应节点之间的第二晶体管的第二电路支路。第二电路支路可以包括与第二晶体管串联耦合的电阻单元。第一和第二电路分支可以接收模拟信息并提供数字输出信息。数字输出信息可以包括基于第一电阻单元两端的电压与模拟输入信息的第一和第二分量之间的电压差之间的关系的输出值。其他实施例公开了附加的装置，系统和方法。

38. 发明申请

US20080180559A1 Apparatus, methods and systems for amplifier 有权
标题翻译：放大器的装置，方法和系统
公开(公告)号：US20080180559A1
公开(公告)日：2008-07-31
申请号：US11700487
申请日：2007-01-31
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H04N3/14 , H04N5/335 , H03F1/36 , H03F3/68
CPC分类号： H04N5/3741 , H03F3/45188 , H04N5/378
摘要： Various embodiments comprise apparatus, methods, and systems that include an amplification apparatus comprising a first input, a second input, and an output, a first plurality of series-connected transistors including a first transistor having a first channel ratio and a first gate coupled to the first input, and a second plurality of series-connected transistors including a second transistor having a second channel ratio that is greater than the first channel ratio, the second transistor including a second gate coupled to the second input.
摘要翻译：各种实施例包括包括包括第一输入，第二输入和输出的放大装置的装置，方法和系统，第一多个串联连接的晶体管，其包括具有第一沟道比的第一晶体管和耦合到所述第一输入端和所述第二多个串联连接的晶体管包括具有大于所述第一沟道比的第二沟道比的第二晶体管，所述第二晶体管包括耦合到所述第二输入的第二栅极。

39. 发明授权

US07310252B2 Closed-loop high voltage booster 有权
公开(公告)号：US07310252B2
公开(公告)日：2007-12-18
申请号：US11414365
申请日：2006-05-01
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H02M3/18 , G05F1/00
CPC分类号： H02M3/073 , H04N5/335
摘要： A voltage boosting circuit with a closed-loop control mechanism and a controllable slew rate. A tracking capacitor and a control current form the closed-loop and are used to adjust the slew rate of the boosting circuit. The closed-loop control and adjustable slew rate improve the accuracy and predictability of the boosting circuit's final boosted output voltage.

40. 发明申请

US20070010662A1 VGF fusion polypeptides 审中-公开
标题翻译： VGF融合多肽
公开(公告)号：US20070010662A1
公开(公告)日：2007-01-11
申请号：US11329372
申请日：2006-01-10
申请人： Hai Yan , Thomas Boone
发明人： Hai Yan , Thomas Boone
IPC分类号： C07K14/475 , C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention provides novel VGF polypeptides and selective binding agents. The invention also provides host cells and methods for producing VGF polypeptides. The invention further provides VGF pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, conditions, and disorders associated with VGF polypeptides.
摘要翻译：本发明提供新型VGF多肽和选择性结合剂。本发明还提供用于产生VGF多肽的宿主细胞和方法。本发明还提供用于诊断，治疗，改善和/或预防与VGF多肽相关的疾病，病症和病症的VGF药物组合物和方法。

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