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31. 发明申请

US20180243893A1 Safety Hammer 审中-公开
公开(公告)号：US20180243893A1
公开(公告)日：2018-08-30
申请号：US15445980
申请日：2017-02-28
申请人： George John
发明人： George John
IPC分类号： B25D1/02 , B25D1/04
CPC分类号： B25D1/045 , B25D2250/005 , B25D2250/105 , B25D2250/141 , B25D2250/351 , B25G1/10 , B25G3/16 , B25G3/32
摘要： A safety hammer is provided that may be designed to prevent injuries caused by flying nails when users accidentally fail to strike nails on their heads. The present invention may provide for a wooden handle with finger grooves. The wooden handle may be reinforced with a steel rod to add strength and attach the handle to the tempered steel head. Close to the end used for striking nails, the present invention may provide for a pin configured to attach the metal shield to the end used for striking nails. The track in the shield may fit over the pin to ensure the pin is positioned correctly around the face of the present invention's hammer face. In some embodiments, the shield may be secured by magnets, which may be embedded around the present invention's hammer head. The present invention may also provide for a fulcrum point that may be oriented above the nail removal portion of the present invention.

32. 发明授权

US07911161B2 Automotive power inverter with reduced capacitive coupling 有权
标题翻译：具有降低电容耦合的汽车电源逆变器
公开(公告)号：US07911161B2
公开(公告)日：2011-03-22
申请号：US11769772
申请日：2007-06-28
申请人： Terence G. Ward , Gregory Scott Smith , George John , Tilak Gopalarathnam , David F. Nelson
发明人： Terence G. Ward , Gregory Scott Smith , George John , Tilak Gopalarathnam , David F. Nelson
IPC分类号： H02P1/00
CPC分类号： B60K6/485 , B60K6/405 , H01L2924/0002 , Y02T10/6226 , H01L2924/00
摘要： An automotive power inverter is provided. The power inverter includes a chassis, a microelectronic die coupled to the chassis and having an integrated circuit formed thereon, and an insulating region between the chassis and the microelectronic die.
摘要翻译：提供汽车电源逆变器。功率逆变器包括底盘，耦合到底盘并且具有形成在其上的集成电路的微电子管芯，以及底架和微电子管芯之间的绝缘区域。

33. 发明申请

US20100129451A1 Method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery 有权
标题翻译：通过生物催化从二糖制备水/有机胶凝剂的方法及其在酶触发药物递送中的应用
公开(公告)号：US20100129451A1
公开(公告)日：2010-05-27
申请号：US12313784
申请日：2008-11-24
申请人： George John , Praveen Kumar Vemula
发明人： George John , Praveen Kumar Vemula
IPC分类号： A61K9/10 , A61K31/05
CPC分类号： A61K9/48 , A61K8/0216 , A61K8/11 , A61K8/60 , A61K9/06 , A61K31/05 , A61K31/12 , A61K47/26 , A61K2800/10 , A61K2800/56 , A61Q19/00
摘要： A method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery. Controlled delivery of an anti-inflammatory, chemopreventive drug is achieved by an enzyme-triggered drug release mechanism via degradation of encapsulated hydrogels. The hydro- and organo-gelators are synthesized in high yields from renewable resources by using a regioselective enzyme catalysis and a known chemopreventive and anti-inflammatory drug, curcumin, is encapsulated in the gel matrix and released by enzyme triggered delivery. The release of the drug occurs at the physiological temperature and control of the drug release rate is achieved by manipulating the enzyme concentration and temperature. The by-products formed after the gel degradation clearly demonstrated the site specificity of degradation of the gelator by enzyme catalysis. The present invention has applications in developing cost effective, controlled drug delivery vehicles from renewable resources, with a potential impact on pharmaceutical research and molecular design and delivery strategies.
摘要翻译：通过生物催化从二糖制备水/有机胶凝剂的方法及其在酶触发药物递送中的应用。通过酶引发的药物释放机制通过封装的水凝胶的降解来实现抗炎化学预防药物的控制递送。通过使用区域选择性酶催化和已知的化学预防和抗炎药物姜黄素包封在凝胶基质中并通过酶触发递送释放水合和有机胶凝剂以可再生资源的高收率合成。药物的释放发生在生理温度下，通过操作酶浓度和温度来实现药物释放速率的控制。在凝胶降解后形成的副产物清楚地证明了通过酶催化降解胶凝剂的位点特异性。本发明在从可再生资源开发具有成本效益的，可控制的药物递送载体中具有应用，对药物研究和分子设计和递送策略具有潜在的影响。

34. 发明授权

US07698410B2 Context-sensitive, self-adjusting targeting models 有权
标题翻译：上下文相关的自调整目标模型
公开(公告)号：US07698410B2
公开(公告)日：2010-04-13
申请号：US11741301
申请日：2007-04-27
申请人： Amitabh Seth , Shu-Yao Chien , George John
发明人： Amitabh Seth , Shu-Yao Chien , George John
IPC分类号： G06F15/173 , G06F9/455 , G06F17/00 , G10L21/00 , G01R31/08 , G06F11/30
CPC分类号： H04L67/20 , G06F17/30899 , H04L67/02
摘要： In an embodiment, new traffic pattern data is received pertaining to a first time period having a first time increment. The traffic pattern data may be received as, or converted to, count information reflecting the probabilities that the user will select particular links services. An incremental table is accessed to determine stale traffic pattern count data, which is the traffic pattern count data in the incremental table over a second time period having the first time increment, wherein the second time period covers the oldest traffic pattern count data in the incremental table. Then a count table is updated to reflect removal of the stale traffic pattern count data, wherein the count table contains global count data at a higher level of granularity than the incremental table. The incremental table and count table are updated to reflect addition of the new traffic pattern data.
摘要翻译：在一个实施例中，接收关于具有第一时间增量的第一时间段的新的业务模式数据。业务模式数据可以被接收为反映用户将选择特定链路服务的概率的计数信息或转换为计数信息。访问增量表以确定陈旧的业务模式计数数据，其是具有第一时间增量的第二时间段中的增量表中的业务模式计数数据，其中第二时间段覆盖增量中的最旧的业务模式计数数据表。然后更新计数表以反映陈旧的流量模式计数数据的删除，其中计数表包含比增量表更高的粒度级别的全局计数数据。更新增量表和计数表以反映新的流量模式数据的添加。

35. 发明授权

US07580261B2 Semiconductor cooling system for use in electric or hybrid vehicle 有权
标题翻译：用于电动或混合动力汽车的半导体冷却系统
公开(公告)号：US07580261B2
公开(公告)日：2009-08-25
申请号：US11685726
申请日：2007-03-13
申请人： Gregory Scott Smith , George John , Terence G. Ward , Edward P Yankoski , David F. Nelson
发明人： Gregory Scott Smith , George John , Terence G. Ward , Edward P Yankoski , David F. Nelson
IPC分类号： H05K7/20 , F28F7/00 , F25D17/02
CPC分类号： H01L23/4735 , H01L2924/0002 , H01L2924/00
摘要： A cooling system is provided for use in conjunction with a semiconductor assembly including a first semiconductor device and a second semiconductor device electrically coupled to the first semiconductor device by an elongated electrical connection. The cooling system includes a flow passage, a pump fluidly coupled to the flow passage, and an outlet array fluidly coupled to the flow passage and configured to direct a coolant fluid over the second semiconductor device. The outlet array has an interconnect feature formed therein configured to receive the elongated electrical connection there through.
摘要翻译：提供冷却系统以与半导体组件结合使用，所述半导体组件包括通过细长的电连接与第一半导体器件电连接的第一半导体器件和第二半导体器件。冷却系统包括流动通道，流体地联接到流动通道的泵以及流体耦合到流动通道并被配置为将冷却剂流体引导到第二半导体器件上的出口阵列。出口阵列具有形成在其中的互连特征，其构造成在其中接收细长的电连接。

36. 发明申请

US20060174642A1 Cooling arrangements for integrated electric motor-inverters 有权
标题翻译：集成电动机 - 逆变器的冷却装置
公开(公告)号：US20060174642A1
公开(公告)日：2006-08-10
申请号：US11054483
申请日：2005-02-09
申请人： James Nagashima , Karl Conroy , Eric Ostrom , Gregory Smith , George John , David Tang , Terence Ward
发明人： James Nagashima , Karl Conroy , Eric Ostrom , Gregory Smith , George John , David Tang , Terence Ward
IPC分类号： F25B1/00 , F25D15/00 , F25B49/00 , F25D23/12 , F28D5/00
CPC分类号： F28D15/00 , B60K6/26 , B60K2001/003 , F28D15/0266 , H02K9/19 , H02K11/33 , H05K7/20936
摘要： In order to provide a modular arrangement, an inverter for an electric traction motor used to drive an automotive vehicle is positioned in proximity with the traction motor. The inverter is located within a compartment adjacent to one end of the electric traction motor and is cooled in a closed system by spraying a liquid coolant directly onto the inverter. The liquid coolant absorbs heat from the inverter and is cooled by a heat exchange arrangement comprising a reservoir with pipes carrying a second coolant from the radiator of the automotive vehicle. In a preferred embodiment, the coolant is collected from the inverter in an annular reservoir that is integral with the compartment containing the inverter. In accordance with one embodiment of the cooling arrangement, heat from the inverter vaporizes the liquid coolant by absorbing heat from the inverter during a phase change from a liquid to a vapor. The vaporized coolant is condensed by a circulating second coolant in pipes connected to the vehicle's radiator through a condenser that is preferably coaxial with the motor and the annular reservoir, which annular reservoir in the second embodiment collects overspray liquid coolant. In order to avoid degrading the inverter, the coolant is a dielectric fluid.
摘要翻译：为了提供模块化布置，用于驱动机动车辆的电动牵引电动机的逆变器位于牵引电动机附近。逆变器位于与电力牵引电动机的一端相邻的隔室内，并通过将液体冷却剂直接喷射到逆变器上而在封闭系统中冷却。液体冷却剂从逆变器吸收热量，并且通过热交换装置来冷却，所述热交换装置包括具有从机动车辆的散热器承载第二冷却剂的管道的储存器。在优选实施例中，冷却剂从与逆变器的隔室成一整体的环形容器中从逆变器收集。根据冷却装置的一个实施例，来自逆变器的热量在从液体到蒸汽的相变期间通过吸收来自逆变器的热量来蒸发液体冷却剂。蒸发的冷却剂通过连接到车辆散热器的管道中的循环第二冷却剂冷凝，该冷凝器优选地与电动机和环形储存器同轴，该第二实施例中的环形储存器收集过喷液体冷却剂。为了避免降低变频器，冷却剂是介质流体。

37. 发明申请

US20150189859A1 Animal Waste Collecting Device 审中-公开
标题翻译：动物废物收集装置
公开(公告)号：US20150189859A1
公开(公告)日：2015-07-09
申请号：US14465011
申请日：2014-08-21
申请人： George John
发明人： George John
IPC分类号： A01K23/00 , A01K27/00
CPC分类号： A01K23/00
摘要： Disclosed is an animal waste collecting device. The device includes a harness that includes an adjustable waist strap that is attached to a back strap and a pair of leg straps. The leg straps are connected by means of a connecting rod of a receptacle holder, wherein the receptacle holder is positioned adjacent to an animal's buttocks. The connecting rod includes a rotatable rod attached thereto, wherein the rotatable rod includes a pair of bag attachment rods for holding a disposable bag thereon. The connecting rod is connected to the pull straps so that when the pull straps are actuated, the connecting rod moves the rotatable rod and the bag attachment rods. In this way, the disposable bag can be automatically positioned to collect animal waste as the animal defecates, thereby eliminating the need for an animal owner to pick up animal waste by hand.
摘要翻译：公开了一种动物废物收集装置。该装置包括线束，其包括附接到背带和一对腿带的可调节腰带。腿带通过容器保持器的连杆连接，其中容器保持器邻近动物的臀部定位。所述连杆包括安装在其上的可旋转杆，其中所述可转动杆包括用于在其上保持一次性袋的一对袋附接杆。连接杆连接到拉带，以便当拉带被致动时，连杆移动可旋转杆和袋附件杆。以这种方式，随着动物排便，一次性袋可以自动定位以收集动物废物，从而消除了动物所有者用手拾取动物废物的需要。

38. 发明申请

US20110229565A1 Drug Delivery Composition Comprising a Self-Assembled Gelator 审中-公开
标题翻译：包含自组装胶凝剂的药物输送组合物
公开(公告)号：US20110229565A1
公开(公告)日：2011-09-22
申请号：US13119304
申请日：2009-09-17
申请人： Jeffrey M. Karp , Praveen Kumar Vemula , George John , Greg Cruikshank
发明人： Jeffrey M. Karp , Praveen Kumar Vemula , George John , Greg Cruikshank
IPC分类号： A61K38/43 , A61K31/167 , A61K31/7034 , A61K31/405 , A61K9/48 , A61K47/16 , C07C233/01 , C07C215/18 , C07D209/26 , A61K31/225 , A61K38/16 , A61K38/10 , A61K38/08 , A61K38/06 , A61K38/05 , A61K38/07 , C07C69/34 , C07H15/26 , C07K14/00 , C07K7/00 , C07K7/06 , C07K5/00 , A61K31/133 , A61P25/04 , A61P29/00 , A61P11/00 , A61P31/06 , C12P7/62 , C12P19/00
CPC分类号： A61K47/48038 , A61K9/06 , A61K31/12 , A61K31/167 , A61K31/22 , A61K31/405 , A61K31/43 , A61K31/555 , A61K31/7034 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/55 , A61K47/555 , A61K2300/00
摘要： This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be used to release the drugs.
摘要翻译：本发明公开了药物递送组合物，制备前药的方法，以及使用自组装凝胶剂的药物递送方法。凝胶剂的骨架可以含有药物或前药，如对乙酰氨基酚或水杨苷。另外的药物或药剂可以包封在凝胶剂中。酶或水解裂解可用于释放药物。

39. 发明申请

US20060182364A1 System and method for sharpening vector-valued digital images 审中-公开
标题翻译：用于锐化矢量值数字图像的系统和方法
公开(公告)号：US20060182364A1
公开(公告)日：2006-08-17
申请号：US11059009
申请日：2005-02-16
申请人： George John
发明人： George John
IPC分类号： G06K9/40
CPC分类号： G06T5/004
摘要： Sharpening multi-spectral digital images without increasing noise is accomplished by filtering vector values rather than independent scalar values. A low-pass filter is performed on image A to obtain a blurred image B1 with noise and signal suppressed. The resulting blurred image B1 is subtracted from the original image A to produce a high frequency band C1 that contains noise and signal. Vector difference mean filtering is performed on the original image A to produce a filtered image B2 with noise suppressed. The filtered image B2 is subtracted from the original image A to produce a noise band C2 that contains noise with very little signal. The noise band C2 is subtracted from the high frequency band C1 to produce a signal band D that contains the signal. The signal band D is then added to the filtered image B2 to further enhance detail in the noise filtered band.
摘要翻译：通过过滤矢量值而不是独立的标量值来实现锐化多光谱数字图像而不增加噪声。在图像A上执行低通滤波器以获得具有噪声和信号抑制的模糊图像B 1。从原始图像A中减去所得到的模糊图像B 1，以产生包含噪声和信号的高频带C 1。对原始图像A执行矢量差分平均滤波以产生噪声抑制的滤波图像B 2。从原始图像A中减去滤波图像B 2，以产生包含非常小信号的噪声的噪声频带C2。从高频带C 1中减去噪声频带C 2，以产生包含该信号的信号频带D. 然后将信号频带D加到滤波图像B 2，以进一步增强噪声滤波频带中的细节。

40. 发明授权

US08968784B2 Method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery 有权
标题翻译：通过生物催化从二糖制备水/有机胶凝剂的方法及其在酶触发药物递送中的应用
公开(公告)号：US08968784B2
公开(公告)日：2015-03-03
申请号：US12313784
申请日：2008-11-24
申请人： George John , Praveen Vemula
发明人： George John , Praveen Vemula
IPC分类号： A61K9/14 , A61K31/05 , A01N31/08 , A61K9/06 , A61K47/26
CPC分类号： A61K9/48 , A61K8/0216 , A61K8/11 , A61K8/60 , A61K9/06 , A61K31/05 , A61K31/12 , A61K47/26 , A61K2800/10 , A61K2800/56 , A61Q19/00
摘要： A method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery. Controlled delivery of an anti-inflammatory, chemopreventive drug is achieved by an enzyme-triggered drug release mechanism via degradation of encapsulated hydrogels. The hydro- and organo-gelators are synthesized in high yields from renewable resources by using a regioselective enzyme catalysis and a known chemopreventive and anti-inflammatory drug, curcumin, is encapsulated in the gel matrix and released by enzyme triggered delivery. The release of the drug occurs at the physiological temperature and control of the drug release rate is achieved by manipulating the enzyme concentration and temperature. The by-products formed after the gel degradation clearly demonstrated the site specificity of degradation of the gelator by enzyme catalysis. The present invention has applications in developing cost effective, controlled drug delivery vehicles from renewable resources, with a potential impact on pharmaceutical research and molecular design and delivery strategies.
摘要翻译：通过生物催化从二糖制备水/有机胶凝剂的方法及其在酶触发药物递送中的应用。通过酶引发的药物释放机制通过封装的水凝胶的降解来实现抗炎化学预防药物的控制递送。通过使用区域选择性酶催化和已知的化学预防和抗炎药物姜黄素包封在凝胶基质中并通过酶触发递送释放水合和有机胶凝剂以可再生资源的高收率合成。药物的释放发生在生理温度下，通过操作酶浓度和温度来实现药物释放速率的控制。在凝胶降解后形成的副产物清楚地证明了通过酶催化降解胶凝剂的位点特异性。本发明在从可再生资源开发具有成本效益的，可控制的药物递送载体中具有应用，对药物研究和分子设计和递送策略具有潜在的影响。

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