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31. 发明申请

US20080044854A1 SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES 失效
标题翻译：氨基酸进入分子的特定地点
公开(公告)号：US20080044854A1
公开(公告)日：2008-02-21
申请号：US11682272
申请日：2007-03-05
申请人： Pin Wang , Inchan Kwon , Soojin Son , Yi Tang , David Tirrell
发明人： Pin Wang , Inchan Kwon , Soojin Son , Yi Tang , David Tirrell
IPC分类号： C12P21/00 , C07H21/00 , C07K2/00 , C12N1/00 , C12N15/63 , C12N9/00
CPC分类号： C12N9/93 , C12N15/67 , C12N15/70
摘要： The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.
摘要翻译：本发明提供了涉及将非天然氨基酸并入多肽或蛋白质的方法和组合物的某些实施方案，所述方法和组合物通过利用突变或修饰的氨酰-tRNA合成酶将非天然氨基酸加载至相应的tRNA。在某些实施方案中，tRNA也被修饰，使得复合物与通常与未修饰的tRNA /氨酰-tRNA合成酶对形成摆动碱基配对的密码子形成严格的沃森 - 克里克碱基配对。

32. 发明授权

US06735580B1 Artificial neural network based universal time series 有权
标题翻译：基于人工神经网络的通用时间序列
公开(公告)号：US06735580B1
公开(公告)日：2004-05-11
申请号：US09648878
申请日：2000-08-25
申请人： Liang Li , Yi Tang , Bin Li , Xiaohua Wu
发明人： Liang Li , Yi Tang , Bin Li , Xiaohua Wu
IPC分类号： G06F1518
CPC分类号： G06N3/049 , Y10S706/925
摘要： A neural network based universal time series prediction system for financial securities includes a pipelined recurrent ANN architecutre having a plurality of identical modules to first adjust internal weights and biases in response to a first training set representing a nonlinear financial time series of samples of a financial quantity and a target value, and then determine and store an estimated prediction error of the ANN in order to adjust short time stock price predictions in accordance with the stored prediction error. The prediction system is also designed to output upper and lower prediction bounds within a confidence region.
摘要翻译：一种用于金融证券的基于神经网络的通用时间序列预测系统包括具有多个相同模块的流水线复现ANN结构，以响应于代表财务数量样本的非线性财务时间序列的第一训练集来首先调整内部权重和偏差和目标值，然后确定并存储ANN的估计预测误差，以便根据存储的预测误差来调整短时股票价格预测。预测系统还被设计为在置信区域内输出上限和下限预测范围。

33. 发明授权

US09092736B2 Communication and synapse training method and hardware for biologically inspired networks 有权
标题翻译：生物灵感网络的通信和突触训练方法和硬件
公开(公告)号：US09092736B2
公开(公告)日：2015-07-28
申请号：US12831540
申请日：2010-07-07
申请人： Vladimir Aparin , Yi Tang
发明人： Vladimir Aparin , Yi Tang
IPC分类号： G06N3/08 , G06N3/063 , G06N99/00 , G06N3/02 , G06N3/06
CPC分类号： G06N3/0635 , G06N3/02 , G06N3/06 , G06N3/08 , G06N99/005
摘要： Certain embodiments of the present disclosure support techniques for training of synapses in biologically inspired networks. Only one device based on a memristor can be used as a synaptic connection between a pair of neurons. The training of synaptic weights can be achieved with a low current consumption. A proposed synapse training circuit may be shared by a plurality of incoming/outgoing connections, while only one digitally implemented pulse-width modulation (PWM) generator can be utilized per neuron circuit for generating synapse-training pulses. Only up to three phases of a slow clock can be used for both the neuron-to-neuron communications and synapse training. Some special control signals can be also generated for setting up synapse training events. By means of these signals, the synapse training circuit can be in a high-impedance state outside the training events, thus the synaptic resistance (i.e., the synaptic weight) is not affected outside the training process.
摘要翻译：本公开的某些实施例支持在生物启发网络中训练突触的技术。只有一个基于忆阻器的设备可以用作一对神经元之间的突触连接。突触体重的训练可以用低电流消耗来实现。所提出的突触训练电路可以由多个输入/输出连接共享，而每个神经元电路只能使用一个数字实现的脉宽调制（PWM）发生器来产生突触训练脉冲。只有三个阶段的慢时钟可以用于神经元到神经元通信和突触训练。还可以生成一些特殊的控制信号来设置突触训练事件。通过这些信号，突触训练电路可以在训练事件之外处于高阻抗状态，因此在训练过程之外不会影响突触电阻（即突触重量）。

34. 发明授权

US08518666B2 Site-specific incorporation of amino acids into molecules 失效
公开(公告)号：US08518666B2
公开(公告)日：2013-08-27
申请号：US11682272
申请日：2007-03-05
申请人： Pin Wang , Inchan Kwon , Soojin Son , Yi Tang , David Tirrell
发明人： Pin Wang , Inchan Kwon , Soojin Son , Yi Tang , David Tirrell
IPC分类号： C12N15/67 , C07H21/00 , C07K2/00
CPC分类号： C12N9/93 , C12N15/67 , C12N15/70
摘要： The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.

35. 发明申请

US20130181530A1 Power Converter Circuit with AC Output 有权
标题翻译：电源转换器电路与交流输出
公开(公告)号：US20130181530A1
公开(公告)日：2013-07-18
申请号：US13440572
申请日：2012-04-05
申请人： Gerald Deboy , Yi Tang
发明人： Gerald Deboy , Yi Tang
IPC分类号： H02J1/00
CPC分类号： H02J3/385 , H02J3/387 , H02J3/40 , Y02E10/58 , Y10T307/707
摘要： A power converter circuit includes output terminals configured to receive an external voltage. A series circuit includes a number of converter units, each including input terminals configured to be coupled to a DC power source and output terminals configured to provide an output current. The series circuit is connected between the output terminals of the power converter circuit. A synchronization circuit is configured to generate a synchronization signal. The power converter circuit can be operated in a normal operation mode. In the normal operation mode, the synchronization circuit is configured to generate the synchronization signal dependent on the external voltage. In the normal operation mode, at least one converter unit of the plurality of converter units is configured to receive the synchronization signal and to regulate a generation of the output current such that a frequency and/or a phase of the output current is dependent on the synchronization signal.
摘要翻译：电源转换器电路包括被配置为接收外部电压的输出端子。串联电路包括多个转换器单元，每个转换器单元包括被配置为耦合到DC电源的输入端子和被配置为提供输出电流的输出端子。串联电路连接在电源转换器电路的输出端子之间。同步电路被配置为产生同步信号。电源转换器电路可以在正常工作模式下工作。在正常操作模式中，同步电路被配置为根据外部电压产生同步信号。在正常操作模式中，多个转换器单元中的至少一个转换器单元被配置为接收同步信号并调节输出电流的产生，使得输出电流的频率和/或相位取决于同步信号

36. 发明申请

US20130181529A1 Power Converter Circuit with AC Output 有权
标题翻译：电源转换器电路与交流输出
公开(公告)号：US20130181529A1
公开(公告)日：2013-07-18
申请号：US13352202
申请日：2012-01-17
申请人： Yi Tang , Gerald Deboy
发明人： Yi Tang , Gerald Deboy
IPC分类号： H02M7/5387 , H02J1/00
CPC分类号： H02J3/383 , H02M7/53871 , H02M2001/0074 , H02M2001/0077 , Y02E10/563 , Y10T307/707
摘要： A power converter circuit includes output terminals configured to receive an external AC voltage. At least one series circuit has at least two converter units. Each converter unit includes input terminals configured to be coupled to a DC power source. Output terminals provide an AC output current. The at least one series circuit is connected between the output terminals of the power converter circuit. A voltage measurement circuit is connected between the output terminals of the power converter circuit and configured to provide at least one measurement signal that includes information related to phase and frequency of the external AC voltage. At least one of the converter units is configured to receive the at least one measurement signal and is configured to regulate the generation of the AC output current dependent on the at least one measurement signal.
摘要翻译：电力转换器电路包括被配置为接收外部AC电压的输出端子。至少一个串联电路具有至少两个转换器单元。每个转换器单元包括被配置为耦合到DC电源的输入端。输出端子提供交流输出电流。所述至少一个串联电路连接在所述电力转换器电路的输出端子之间。电压测量电路连接在功率转换器电路的输出端之间，并被配置为提供至少一个测量信号，其包括与外部AC电压的相位和频率有关的信息。所述转换器单元中的至少一个被配置为接收所述至少一个测量信号，并且被配置为根据所述至少一个测量信号来调节所述AC输出电流的产生。

37. 发明授权

US08329390B2 Detection of transmembrane potentials using N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols 有权
标题翻译：使用N，N，N'-三烷基硫代巴比妥酸衍生的聚甲硫氨酸氧杂多糖检测跨膜电位
公开(公告)号：US08329390B2
公开(公告)日：2012-12-11
申请号：US11212203
申请日：2005-08-25
申请人： Zhenjun Diwu , Jianjun He , Yi Tang
发明人： Zhenjun Diwu , Jianjun He , Yi Tang
IPC分类号： C12Q1/00 , C07D403/00 , C07D239/10 , C07D239/66
CPC分类号： C07D239/66 , G01N33/52
摘要： The present invention relates generally to the detection and measurement of transmembrane potentials using an N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonol (shown below). In particular, the present invention is directed to compositions and optical methods for determining transmembrane potentials across the plasma membrane of biological cells using a slightly hydrophobic N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols. The method comprises a slightly hydrophobic N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonol anion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in the potential of the membrane. In one aspect the method is used to identify compounds which modulate membrane potentials in biological membranes. wherein R1, R2, and R3 are independently selected from the group consisting of hydrogen, alkyl, haloalkyl and heteroalkyl; n is an integer from 1 to 3; Z is Na, K, ammonium or other biologically acceptable salt.
摘要翻译：本发明一般涉及使用N，N，N'-三烷基硫代巴比妥酸衍生的聚甲基氧杂多酚（如下所示）检测和测量跨膜电位。特别地，本发明涉及使用稍微疏水的N，N，N'-三烷基硫代巴比妥酸衍生的聚甲基氧杂多糖测定生物细胞质膜跨膜电位的组合物和光学方法。该方法包括一种稍微疏水的N，N，N'-三烷基硫代巴比妥酸衍生的聚甲基氧杂氮杂阴离子，其能够响应膜的电位变化而从膜的第一面再分配到膜的第二面。在一个方面，该方法用于鉴定调节生物膜中膜电位的化合物。其中R1，R2和R3独立地选自氢，烷基，卤代烷基和杂烷基; n为1〜3的整数， Z是Na，K，铵或其他生物可接受的盐。

38. 发明申请

US20120258514A1 Kits for analysis of biological samples 审中-公开
标题翻译：用于生物样品分析的试剂盒
公开(公告)号：US20120258514A1
公开(公告)日：2012-10-11
申请号：US13374994
申请日：2012-01-27
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C12N9/96 , C12N1/20 , C07H7/06 , C07H21/04 , C07K14/00 , C12N5/071 , C07K2/00
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

39. 发明授权

US08093404B2 Macrocyclic dyes having aryl moieties 有权
标题翻译：具有芳基部分的大环染料
公开(公告)号：US08093404B2
公开(公告)日：2012-01-10
申请号：US12583513
申请日：2009-08-20
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C07D403/06
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

40. 发明授权

US07985552B2 Dye conjugates of nucleotides and other biological substances 有权
标题翻译：核苷酸和其他生物物质的染料缀合物
公开(公告)号：US07985552B2
公开(公告)日：2011-07-26
申请号：US12807268
申请日：2010-09-01
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/53 , C07D225/00 , C07D209/56
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

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