专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US4663524A Apparatus for measuring parameters of light spots with a moving knife-edge mask 失效
标题翻译：用移动的刀刃掩模测量光斑参数的装置
公开(公告)号：US4663524A
公开(公告)日：1987-05-05
申请号：US823017
申请日：1986-01-27
申请人： Michael T. Gale , Heinrich Meier
发明人： Michael T. Gale , Heinrich Meier
IPC分类号： G01J1/42 , H01J3/14
CPC分类号： G01J1/4257
摘要： A two-dimensional knife edge mask comprised of an array of spaced periodic rectangular opaque regions (e.g., a chrome grating pattern layer deposited on one surface of a slide) separated by transparent different given spacing stripes between adjacent rectangular regions in each of the two orthogonal dimensions thereof, is linearly moved at a fixed velocity across an incident light spot, the direction of movement being oblique to the orthogonal dimensions of the rectangular regions and the distance of movement being sufficient to traverse at least one entire spacing strips in each of the two orthogonal dimensions. A photocell (which may be secured to the other side of the slide) senses the occulted light.
摘要翻译：二维刀刃掩模由两个间隔的周期性矩形不透明区域（例如，沉积在载玻片的一个表面上的镀铬光栅图案层）阵列组成，在两个正交的每一个中的相邻矩形区域之间分开的透明不同的给定间隔条纹其尺寸以穿过入射光点的固定速度线性移动，移动方向与矩形区域的正交尺寸倾斜，并且移动距离足以穿过两者中的每一个中的至少一个整个间隔条正交尺寸。光电管（其可以固定到幻灯片的另一侧）感测到隐蔽的光。

32. 发明授权

US4330213A Optical line width measuring apparatus and method 失效
标题翻译：光线宽度测量装置及方法
公开(公告)号：US4330213A
公开(公告)日：1982-05-18
申请号：US121529
申请日：1980-02-14
申请人： Hans P. Kleinknecht , Heinrich Meier
发明人： Hans P. Kleinknecht , Heinrich Meier
IPC分类号： G01B11/00 , G01B11/02 , G01B9/02
CPC分类号： G01B11/02 , Y10T74/18936
摘要： Optical monitoring of the lateral dimensions of a pattern disposed on a substrate in the form of a wafer or mask is accomplished by testing for the lateral dimensions of a diffraction grating test pattern disposed adjacent the pattern. A beam of monochromatic light such as from a laser is diffracted by the test pattern and detectors determine the intensity of the diffracted beams. The detectors are disposed in a plane orthogonal to the plane of the test pattern and to the direction of the grating lines. The detectors are selectively spaced from each other according to the periodicity d of the grating and the width of the grating lines a is determined from a relationship of the detected intensities of the beams.
摘要翻译：以晶片或掩模的形式设置在基板上的图案的横向尺寸的光学监测通过测试邻近图案设置的衍射光栅测试图案的横向尺寸来实现。来自激光的单色光束被测试图案衍射，检测器确定衍射光束的强度。检测器设置在与测试图案的平面正交并且与光栅线的方向垂直的平面中。检测器根据光栅的周期d选择性地间隔开，并且根据检测到的光束强度的关系确定光栅线a的宽度。

33. 发明申请

US20140155383A1 USE OF CATHEPSIN K INHIBITION FOR THE TREATMENT AND/OR PROPHYLAXIS OF PULMONARY HYPERTENSION AND/OR HEART FAILURE 有权
标题翻译：用于治疗和/或预防肺动脉高压和/或心脏衰竭的CATHEPSIN K抑制的用途
公开(公告)号：US20140155383A1
公开(公告)日：2014-06-05
申请号：US14118222
申请日：2012-05-11
申请人： Stefan Golz , Martina Delbeck , Heinrich Meier , Andreas Geerts , Thomas Mondritzki , Hubert Trübel
发明人： Stefan Golz , Martina Delbeck , Heinrich Meier , Andreas Geerts , Thomas Mondritzki , Hubert Trübel
IPC分类号： A61K31/55 , A61K31/165 , A61K31/415 , A61K31/336 , A61K31/495 , A61K31/496
CPC分类号： A61K31/55 , A61K31/165 , A61K31/277 , A61K31/336 , A61K31/40 , A61K31/415 , A61K31/495 , A61K31/496
摘要： The present invention relates to the use of cathepsin K and/or cathepsin S inhibitors in a method for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure.
摘要翻译：本发明涉及组织蛋白酶K和/或组织蛋白酶S抑制剂在治疗和/或预防肺动脉高压和/或心力衰竭的方法中的用途。

34. 发明授权

US08143411B2 Substituted 6-phenylnicotinic acids and their use 有权
标题翻译：取代的6-苯基烟酸及其用途
公开(公告)号：US08143411B2
公开(公告)日：2012-03-27
申请号：US12676568
申请日：2008-08-26
申请人： Lars Bärfacker , Barbara Albrecht-Küpper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
发明人： Lars Bärfacker , Barbara Albrecht-Küpper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
IPC分类号： C07D211/78 , A61K31/44
CPC分类号： C07D213/80
摘要： The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, in particular dyslipidaemias, arteriosclerosis and heart failure.
摘要翻译：本申请涉及新的取代的6-苯基烟酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化和心力衰竭。

35. 发明申请

US20100234432A1 Substituted 6-phenylnicotinic acids and their use 有权
标题翻译：取代的6-苯基烟酸及其用途
公开(公告)号：US20100234432A1
公开(公告)日：2010-09-16
申请号：US12676568
申请日：2008-08-26
申请人： Lars Baerfacker , Barbara Albrecht-Kuepper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
发明人： Lars Baerfacker , Barbara Albrecht-Kuepper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
IPC分类号： A61K31/44 , C07D213/55 , C07D213/78 , A61P9/10
CPC分类号： C07D213/80
摘要： The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, in particular dyslipidaemias, arteriosclerosis and heart failure.
摘要翻译：本申请涉及新的取代的6-苯基烟酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化和心力衰竭。

36. 发明授权

US07683076B2 Tetrahydro-quinolinylurea derivatives 失效
标题翻译：四氢 - 喹啉基脲衍生物
公开(公告)号：US07683076B2
公开(公告)日：2010-03-23
申请号：US10578413
申请日：2004-10-26
申请人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reiβmüller , Muneto Mogi , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto
发明人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reiβmüller , Muneto Mogi , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D215/38
摘要： This invention relates to tetrahydro-quinolinylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-quinolinylurea derivative of the present invention has vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).
摘要翻译：本发明涉及可用作药物制剂活性成分的四氢 - 喹啉基脲衍生物及其盐。本发明的四氢 - 喹啉基脲衍生物具有香草素受体（VR1）拮抗活性，可用于预防和治疗与VR1活性有关的疾病，特别是用于治疗泌尿系统疾病或障碍，例如逼尿肌过度活动膀胱过度活动），尿失禁，神经源性逼尿肌过度活动（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。

37. 发明申请

US20090312381A1 Substituted Arylimidazolone and Triazolone as Inhibitors of Vasopressin Receptors 有权
标题翻译：取代的芳基咪唑酮和三唑酮作为加压素受体的抑制剂
公开(公告)号：US20090312381A1
公开(公告)日：2009-12-17
申请号：US12301616
申请日：2007-05-21
申请人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
发明人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
IPC分类号： A61K31/4196 , C07D249/12 , C07D233/70 , C07D409/04 , A61K31/4164 , A61P9/00
CPC分类号： C07D249/12 , C07D233/70 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14
摘要： The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
摘要翻译：本申请涉及新的取代的4-芳基咪唑-2-酮和5-芳基-1,2,4-三唑烷酮，其制备方法，其单独使用或组合用于治疗和/或预防疾病以及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

38. 发明申请

US20050049240A1 Tetrahydroisochinolines, their production and the use thereof as analgesics 审中-公开
标题翻译：四氢异噻ol啶，其生产及其作为止痛剂的用途
公开(公告)号：US20050049240A1
公开(公告)日：2005-03-03
申请号：US10490193
申请日：2002-09-11
申请人： Nils Gribenow , Bernd Kalthof , Heinrich Meier , Stephan-Nicholas Wirtz , Peter Spreyer
发明人： Nils Gribenow , Bernd Kalthof , Heinrich Meier , Stephan-Nicholas Wirtz , Peter Spreyer
IPC分类号： A61K31/472 , A61K31/4725 , A61K31/496 , A61P25/04 , A61P29/00 , A61P43/00 , C07D217/26 , C07D401/12 , A61K31/55 , A61K31/4709 , C07D41/02 , C07D43/02
CPC分类号： C07D401/12 , C07D217/26
摘要： The invention relates to novel tetrahydroisoquinolines, to processes for their preparation and to their use for producing pharmaceuticals for the treatment and/or prophylaxis of diseases, in particular of states of pain.
摘要翻译：本发明涉及新型四氢异喹啉，其制备方法及其用于制备用于治疗和/或预防疾病，特别是疼痛状态的药物。

39. 发明授权

US6066655A 4-phenyl-3-substituted 1,4-dihydropyridine esters 失效
标题翻译： 4-苯基-3-取代的1,4-二氢吡啶酯
公开(公告)号：US6066655A
公开(公告)日：2000-05-23
申请号：US988114
申请日：1997-12-10
申请人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： A61K31/4427 , A61K31/455 , A61P9/08 , A61P25/24 , A61P25/26 , A61P25/28 , C07D211/90 , C07D401/12 , C07D211/86
CPC分类号： C07D401/12 , C07D211/90
摘要： 4-Phenyl-3-substituted 1,4-dihydropyridine esters are prepared by reaction of benzaldehydes with ketoesters and enamines, if appropriate with isolation of the ylidene intermediate products, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols.The new 4-phenyl-3-substituted 1,4-dihydropyridine esters can be employed as active compounds in medicaments for the treatment of the central nervous system, in particular as cerebral therapeutics.
摘要翻译：通过苯甲醛与酮酯和烯胺的反应制备4-苯基-3-取代的1,4-二氢吡啶酯，如果合适地分离亚基中间体产物，或通过相应的二氢吡啶羧酸与醇的酯化反应。新的4-苯基-3-取代的1,4-二氢吡啶酯可用作药物中的活性化合物，用于治疗中枢神经系统，特别是作为脑治疗剂。

40. 发明授权

US6001857A Heterocyclyl substituted dihydropyridines 失效
标题翻译：杂环取代的二氢吡啶
公开(公告)号：US6001857A
公开(公告)日：1999-12-14
申请号：US903508
申请日：1997-07-30
申请人： Bodo Junge , Wolfgang Hartwig , Heinrich Meier , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
发明人： Bodo Junge , Wolfgang Hartwig , Heinrich Meier , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
IPC分类号： C07D401/04 , C07D409/04 , A61K31/44
CPC分类号： C07D401/04 , C07D409/04
摘要： 4-Heterocyclyl-substituted dihydropyridines are prepared by reacting appropriate aldehydes with .beta.-keto esters and aminocrotonic acid esters, or by esterifying 4-heterocyclyl-substituted dihydropyridinecarboxylic acids. The 4-heterocyclyl-substituted dihydropyridines can be employed in medicaments, in particular for the treatment of disorders of the central nervous system.
摘要翻译：通过使适当的醛与β-酮酯和氨基巴豆酸酯反应，或通过酯化4-杂环基取代的二氢吡啶羧酸来制备4-杂环基取代的二氢吡啶。 4-杂环基取代的二氢吡啶可用于药物中，特别是用于治疗中枢神经系统疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式