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31. 发明授权

US07498146B2 Stable factor VIII/von willebrand factor complex 有权
标题翻译：稳定因子VIII / von willebrand因子复合物
公开(公告)号：US07498146B2
公开(公告)日：2009-03-03
申请号：US11132326
申请日：2005-05-19
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
IPC分类号： C12Q1/56
CPC分类号： C07K14/755 , Y10S514/834 , Y10T436/25375
摘要： There are disclosed a stable factor VIII/vWF-complexes, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation products, as well as methods of producing these complexes.
摘要翻译：公开了一种稳定的因子VIII / vWF-复合物，特别是包含高分子vWF多聚体，不含低分子vWF分子和蛋白水解vWF降解产物，以及生产这些复合物的方法。

32. 发明申请

US20070183949A1 Hydrocarbon reformer system including a pleated static mixer 审中-公开
标题翻译：碳氢重整器系统包括打褶式静态混合器
公开(公告)号：US20070183949A1
公开(公告)日：2007-08-09
申请号：US11350366
申请日：2006-02-08
申请人： Bernhard Fischer
发明人： Bernhard Fischer
IPC分类号： B01J19/00 , B01J8/02 , B01F5/06
CPC分类号： B01F5/0475 , B01F2215/0098 , H01M8/0625 , H01M2008/1293
摘要： A hydrocarbon reformer system for a fuel cell system comprising a feedstream delivery unit (FDU) and a hydrocarbon catalytic reformer (CR). The reformer includes a catalyst disposed in a housing. Ahead of the catalyst is the FDU including a static mixer for receiving any or all of air, hydrocarbon fuel, anode tailgas, and steam. The mixer is pleated and perforated, forming a plurality of flow passages between first and second sides of the mixer. Fuel flows through the perforations and is jetted into the reactants at a very large number of flow passage locations, wherein mixing occurs instantly. Homogenized fuel/reactants leave the mixer in a sheet flow nearly uniform in temperature that enters the reformer catalyst and allows uniform catalysis over the entire catalyst surface.
摘要翻译：一种用于燃料电池系统的烃重整器系统，包括进料流输送单元（FDU）和烃催化重整器（CR）。重整器包括设置在壳体中的催化剂。在催化剂之前，FDU包括用于接收任何或全部空气，烃燃料，阳极尾气和蒸汽的静态混合器。混合器被打褶和穿孔，在混合器的第一和第二面之间形成多个流动通道。燃料流过穿孔，并在非常大量的流动通道位置处喷射到反应物中，其中立即进行混合。均质燃料/反应物使混合器在进入重整器催化剂的温度下几乎均匀的片材流中，并允许在整个催化剂表面上均匀催化。

33. 发明授权

US07195182B2 Dosing device for fluids, especially a motor vehicle injection valve 有权
标题翻译：液体加药装置，特别是机动车辆注射阀
公开(公告)号：US07195182B2
公开(公告)日：2007-03-27
申请号：US11003265
申请日：2004-12-03
申请人： Bernhard Fischer , Bernhard Gottlieb , Andreas Kappel , Enrico Ulivieri
发明人： Bernhard Fischer , Bernhard Gottlieb , Andreas Kappel , Enrico Ulivieri
IPC分类号： B05B1/30 , B05B1/34 , F02M59/00 , F02M61/00 , F02M47/02
CPC分类号： F02M61/08 , F02M51/0603 , F02M61/12 , F02M61/16 , F02M61/168 , F02M2200/16
摘要： A dosing device comprises a housing (1) provided with an actuator, a dosing opening (8), a guiding shaft (6) which surrounds part of the valve needle (7) and forms a valve chamber (10) with the same, and a fluid chamber module (4) which is welded to the housing (1) in the form of a duct for guiding the valve needle (7) into the housing (9). The fluid chamber module (4) and the housing (1) are assembled along a separation surface (13) which is subjected to pressure by the dosing liquid and is formed almost only by axial cylinder wall surface parts (13) in order to reduce the pressure load on the weld seam (13).
摘要翻译：配量装置包括设置有致动器的壳体（1），配量开口（8），围绕阀针（7）的一部分并且形成与其相连的阀室（10）的引导轴（6），以及流体室模块（4），其以管道形式焊接到壳体（1），用于将阀针（7）引导到壳体（9）中。流体室模块（4）和壳体（1）沿着分离表面（13）组装，分离表面（13）受到计量液体的压力，几乎仅由轴向气缸壁表面部分（13）形成，以便减少焊缝上的压力载荷（13）。

34. 发明申请

US20070065687A1 Method and apparatus for light internal reforming in a solid oxide fuel cell system 有权
标题翻译：固体氧化物燃料电池系统中轻内部重整的方法和装置
公开(公告)号：US20070065687A1
公开(公告)日：2007-03-22
申请号：US11231703
申请日：2005-09-21
申请人： Sean Kelly , Bernhard Fischer
发明人： Sean Kelly , Bernhard Fischer
IPC分类号： H01M8/06 , H01M8/12
CPC分类号： H01M8/04097 , H01M8/04022 , H01M8/0618 , H01M8/0637 , H01M2008/1293 , Y02E60/566
摘要： In an SOFC stack system, wherein a CPOx reformer supplies reformate to the stack, a portion of the anode tail gas is recycled directly into the anode inlet of the stack, such that the fuel reaching the anodes is a mixture of fresh reformate and recycled anode tail gas and is present at a sufficiently high temperature that endothermic reforming of residual hydrocarbons from the CPOx reformer occurs within the stack. Preferably, an amount of secondary non-reformed fuel is also added to optimize the fuel mixture presented for internal reforming. The anode tail gas is hot, at the stack temperature of 750-800° C., which allows for the mixture of anode tail gas and secondary fuel to be mixed and reacted in a clean-up catalyst to react higher hydrocarbons in the secondary fuel, without additional oxygen, prior to being mixed with reformate and sent to the stack.
摘要翻译：在SOFC堆叠系统中，其中CPOx重整器将重整产物提供给堆叠，一部分阳极尾气直接再循环到堆叠的阳极入口中，使得到达阳极的燃料是新鲜重整产物和再循环阳极的混合物并且以足够高的温度存在，来自CPOx重整器的残余烃的吸热重整发生在堆内。优选地，还加入一定量的次级非重整燃料以优化用于内部重整的燃料混合物。阳极尾气是在750-800℃的叠层温度下是热的，这允许阳极尾气和二次燃料的混合物在清理催化剂中混合和反应，以使第二燃料中的高级烃反应，没有额外的氧气，在与重整产物混合并送到堆垛机之前。

35. 发明授权

US07044407B2 Fluid dosing device with a throttle point 有权
标题翻译：具有节流点的流体计量装置
公开(公告)号：US07044407B2
公开(公告)日：2006-05-16
申请号：US10428613
申请日：2003-05-02
申请人： Bernhard Fischer , Bernhard Gottlieb , Andreas Kappel , Randolf Mock , Enrico Ulivieri
发明人： Bernhard Fischer , Bernhard Gottlieb , Andreas Kappel , Randolf Mock , Enrico Ulivieri
IPC分类号： F02M61/08
CPC分类号： F02M51/0603 , F02M61/08 , F02M61/16 , F02M2200/16
摘要： A fluid dosing device for a pressurized liquid is disclosed, which comprises a chamber (35) which is supplied with pressurized liquid by means of a liquid supply line (17, 19); a valve needle (9) which is guided through the chamber (35), the first end section of said valve needle being able to be lifted and the second end section thereof forming a valve in conjunction with a valve seat disposed on the housing (3). Metal bellows (33) are provided as a leadthrough element for the first end section of the valve needle (9). The metal bellows seal the chamber in said region in a tight manner. A throttle point (37, 39) is provided between the valve needle (9) and the inner wall of the chamber between the metal bellows (33) and the mouth (18) of the liquid supply line (17) leading into the chamber.
摘要翻译：公开了一种用于加压液体的流体计量装置，其包括通过液体供应管线（17,19）供应加压液体的腔室（35）。被引导通过所述室（35）的阀针（9），所述阀针的第一端部能够被提升，并且所述第二端部与配置在所述壳体（3）上的阀座一起形成阀）。金属波纹管（33）设置为用于阀针（9）的第一端部的穿通元件。金属波纹管以紧密的方式密封所述区域中的腔室。在阀针（9）和金属波纹管（33）与通向腔室的液体供应管线（17）的口（18）之间的腔室内壁处设有节流点（37,39）。

36. 发明申请

US20050103587A1 Dosing device for fluids, especially a motor vehicle injection valve 有权
标题翻译：液体加药装置，特别是机动车辆注射阀
公开(公告)号：US20050103587A1
公开(公告)日：2005-05-19
申请号：US10967384
申请日：2004-10-18
申请人： Bernhard Fischer , Bernhard Gottlieb , Andreas Kappel , Enrico Ulivieri
发明人： Bernhard Fischer , Bernhard Gottlieb , Andreas Kappel , Enrico Ulivieri
IPC分类号： F02M51/06 , F02M61/08 , F02M61/16 , F02M61/20 , F02M63/00 , F16K31/00 , F16F5/00
CPC分类号： F02M61/167 , F02M51/0603 , F02M61/08 , F02M2200/16 , F16K31/007
摘要： An actuator (4) is connected, on one side, to a valve needle (3), and on the opposite side, to a hydraulic piston (6) pertaining to a hydraulic length compensator. A working chamber (5) is divided by a tight separating membrane (9), into an actuator chamber (10) containing the actuator (4) and a fluid chamber (11) which can be filled with the fluid to be dosed in a pressurized manner while the actuator chamber (10) and the hydraulic chamber (7) are filled with a hydraulic fluid. A base pressure can be produced in the hydraulic fluid by means of the pressure of the fluid to be dosed, which is transmitted through the separating membrane (9).
摘要翻译：致动器（4）在一侧连接到阀针（3），并且在相对侧连接到与液压长度补偿器相关的液压活塞（6）。工作室（5）由紧密分隔膜（9）分隔成包含致动器（4）的致动器室（10）和流体室（11），流体室可以填充加压的流体同时致动器室（10）和液压室（7）填充有液压流体。在液压流体中可以通过被分配的膜（9）传递的待计量流体的压力产生基础压力。

37. 发明授权

US06676030B2 Compensator assembly having a flexible diaphragm for a fuel injector and method 有权
标题翻译：具有用于燃料喷射器的柔性隔膜的补偿器组件和方法
公开(公告)号：US06676030B2
公开(公告)日：2004-01-13
申请号：US09973933
申请日：2001-10-11
申请人： Jack Lorraine , Andreas Kappel , Enrico Ulivieri , Bernhard Gottlieb , Bernhard Fischer
发明人： Jack Lorraine , Andreas Kappel , Enrico Ulivieri , Bernhard Gottlieb , Bernhard Fischer
IPC分类号： F02D700
CPC分类号： F02M51/0603 , F02M61/08 , F02M61/167
摘要： A fuel injector comprises a body having a longitudinal axis, a length-changing actuator that has first and second ends, a closure member coupled to the first end of the length-changing actuator, and a compensator assembly coupled the second end of the actuator. The length-changing actuator includes first and second ends. The closure member is movable between a first configuration permitting fuel injection and a second configuration preventing fuel injection. And the compensator assembly axially positions the actuator with respect to the body in response to temperature variation. The compensator assembly utilizes a configuration of at least one spring disposed between two pistons so as to reduce the use of elastomer seals to thereby reduce a slip stick effect. Also, a method of compensating for thermal expansion or contraction of the fuel injector comprises providing fuel from a fuel supply to the fuel injector; and adjusting the actuator with respect to the body in response to temperature variation.
摘要翻译：燃料喷射器包括具有纵向轴线的本体，具有第一和第二端的长度改变的致动器，联接到长度改变致动器的第一端的闭合构件和联接在致动器的第二端的补偿器组件。长度改变致动器包括第一和第二端。封闭构件可以在允许燃料喷射的第一配置和防止燃料喷射的第二配置之间移动。并且补偿器组件响应于温度变化将致动器相对于主体轴向定位。补偿器组件利用设置在两个活塞之间的至少一个弹簧的构造，以便减少弹性体密封的使用，从而减少滑动棒效应。此外，补偿燃料喷射器的热膨胀或收缩的方法包括从燃料供给燃料喷射器提供燃料; 以及响应于温度变化相对于身体调节致动器。

38. 发明授权

US6010844A Methods of preparing and recovering proteins 失效
标题翻译：制备和回收蛋白质的方法
公开(公告)号：US6010844A
公开(公告)日：2000-01-04
申请号：US752892
申请日：1996-11-20
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
IPC分类号： C12P21/00 , A61K38/43 , A61K38/46 , A61K38/55 , A61P7/00 , A61P7/02 , C07K1/04 , C07K1/22 , C07K14/745 , C07K19/00 , C12N9/50 , C12N9/64 , C12N9/74 , C12P21/06 , C12Q1/00 , A61K38/00 , C07K1/00 , G01N33/53
CPC分类号： C12N9/6429 , C12N9/50 , C12N9/6432 , C12P21/06 , C12Y304/21005 , C12Y304/21006
摘要： There is disclosed the preparation and recovery of proteins, in particular of enzymes, by controlled proteolytic cleavage of pro-proteins, in particular pro-enzymes, in a single method step, wherein a pro-protein-containing solution is contacted with a protease and with a solid carrier which has a higher affinity to the protein than to the pro-protein or to the functionally inactive degradation products thereof, the pro-protein being proteolytically cleaved to said protein, and the protein being selectively separated by absorption on the solid carrier.
摘要翻译：公开了通过在单一方法步骤中通过对前蛋白特别是前酶的受控蛋白水解切割来蛋白质，特别是酶的制备和回收，其中将含前蛋白的溶液与蛋白酶接触，具有与蛋白质相比对前蛋白或其功能无活性降解产物具有更高亲和力的固体载体，所述前蛋白质被蛋白水解切割至所述蛋白质，并且所述蛋白质通过固体载体上的吸收选择性分离。

39. 发明授权

US5880265A Method for isolation of highly pure von willebrand factor 失效
公开(公告)号：US5880265A
公开(公告)日：1999-03-09
申请号：US898129
申请日：1997-07-22
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K38/43 , A61P7/04 , C07K1/18 , C07K1/22 , C07K14/47 , C07K14/755 , C12P21/00
CPC分类号： C07K14/755 , A61K38/00
摘要： The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt.The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant vWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active.Further, the invention relates to a pharmaceutical preparation that contains rvWF, which is comprised of multimers with a high structural integrity.

40. 发明授权

US5687718A Device for continuously detecting blood parameters 失效
标题翻译：用于连续检测血液参数的装置
公开(公告)号：US5687718A
公开(公告)日：1997-11-18
申请号：US490320
申请日：1995-06-14
申请人： Bernhard Fischer , Martin Zoll , Joachim Wender , Frank Rochlitzer
发明人： Bernhard Fischer , Martin Zoll , Joachim Wender , Frank Rochlitzer
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/14539 , A61B5/1473 , A61B5/01
摘要： Disclosed is a device for continuing detecting blood parameters. The device includes a catheter adapted to be introduced into the artery of a patient. A sensor is arranged in the catheter. A tube us adapted to be coupled to a vein of a patient and is also connected to the first catheter. A device controllably maintains blood flow across the sensor, the device being controlled such that initially the flow of blood to the first catheter via the tube is prevented so long as the detective blood parameters indicated a sufficient amount of fresh arterial blood is flowing around the sensor. In the event that a detective blood parameters indicate that an insufficient amount of blood flows around the sensor, then blood flow through the first catheter to the vein of the patient via the tube is then established.
摘要翻译：公开了一种用于继续检测血液参数的装置。该装置包括适于引入患者动脉的导管。传感器布置在导管中。管子适于联接到患者的静脉并且还连接到第一导管。一种装置可控制地维持穿过传感器的血液流量，该装置被控制，使得首先防止经由管道到达第一导管的血液流动，只要检测血液参数指示足够数量的新鲜动脉血流在传感器周围流动。如果检测血液参数表明传感器周围流动的血液量不足，则建立通过第一导管的血液经由管道流过患者静脉的血液。

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