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31. 发明授权

US08620452B2 Selecting electrode combinations for stimulation therapy 有权
标题翻译：选择电极组合进行刺激治疗
公开(公告)号：US08620452B2
公开(公告)日：2013-12-31
申请号：US11810943
申请日：2007-06-07
申请人： Gary W. King , Gabriela C. Miyazawa , Jordan J. Greenberg , Steven M. Goetz
发明人： Gary W. King , Gabriela C. Miyazawa , Jordan J. Greenberg , Steven M. Goetz
IPC分类号： A61N1/05
CPC分类号： A61N1/37247 , A61N1/0529 , A61N1/0534 , A61N1/0553 , A61N1/36185 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： Techniques for selecting electrode combinations for stimulation therapy include delivering stimulation via each of at least five combination groups. A first group of electrode combinations is characterized by the presence of a caudal anode. A second group of electrode combinations is characterized by the presence of a rostral anode. A third group of electrode combinations is characterized by the presence of a single anode above and a single anode below the cathode(s) of the combination. A fourth group of electrode combinations is characterized by the presence of multiple anodes above and below the cathode(s) of the combination. A fifth group of electrode combinations is characterized by the presence of transverse anodes. A sixth group of electrode combination is characterized by at least one off-center cathode. One or more preferred electrode combinations groups, and/or a number of leads to implant within the patient, may by selected based on patient feedback.
摘要翻译：用于选择用于刺激治疗的电极组合的技术包括通过至少五个组合组中的每一个递送刺激。第一组电极组合的特征在于尾部阳极的存在。第二组电极组合的特征在于存在罗氏阳极。第三组电极组合的特征在于在组合的阴极下方存在单个阳极和单个阳极。第四组电极组合的特征在于在组合的阴极上方和下方存在多个阳极。第五组电极组合的特征在于存在横向阳极。第六组电极组合的特征在于至少一个偏心阴极。可以通过基于患者反馈来选择一个或多个优选的电极组合组和/或在患者体内植入的多个引线。

32. 发明授权

US08744597B2 Selecting electrode combinations for stimulation therapy 有权
标题翻译：选择电极组合进行刺激治疗
公开(公告)号：US08744597B2
公开(公告)日：2014-06-03
申请号：US11810967
申请日：2007-06-07
申请人： Gary W. King , Kevin K. Tidemand , Wilbert A. Wesselink , Gabriela C. Miyazawa , Jordan J. Greenberg
发明人： Gary W. King , Kevin K. Tidemand , Wilbert A. Wesselink , Gabriela C. Miyazawa , Jordan J. Greenberg
IPC分类号： A61N1/05
CPC分类号： A61N1/37247 , A61N1/0529 , A61N1/0534 , A61N1/0553 , A61N1/36185 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： Techniques for selecting electrode combinations for stimulation therapy include delivering stimulation via each of at least two electrode combination classes during a therapy evaluation period. A first one of the classes comprises one or more electrode combinations that include electrodes within one or two columns of an implantable array of electrodes. The array may include at least three electrode columns. A second one of the classes comprises one or more electrode combinations that include electrodes within at least three electrode columns of the implantable array of electrodes. A preferred one of the electrode combination classes for a patient, and/or a number of leads to implant within the patient, may by selected based on feedback collected from the patient during the therapy evaluation period.
摘要翻译：用于选择用于刺激治疗的电极组合的技术包括在治疗评价期间通过至少两个电极组合类别中的每一个递送刺激。这些类别中的第一个包括一个或多个电极组合，其包括在可植入的电极阵列的一列或两列内的电极。阵列可以包括至少三个电极柱。第二类包括一个或多个电极组合，其包括在可植入电极阵列的至少三个电极列内的电极。可以通过基于在治疗评估期间从患者收集的反馈来选择用于患者的电极组合类别中的优选的一个，和/或患者内的植入物的数量。

33. 发明申请

US20080004675A1 Selecting electrode combinations for stimulation therapy 有权
标题翻译：选择电极组合进行刺激治疗
公开(公告)号：US20080004675A1
公开(公告)日：2008-01-03
申请号：US11810967
申请日：2007-06-07
申请人： Gary W. King , Kevin K. Tidemand , Wilbert A. Wesselink , Gabriela C. Miyazawa , Jordan J. Greenberg
发明人： Gary W. King , Kevin K. Tidemand , Wilbert A. Wesselink , Gabriela C. Miyazawa , Jordan J. Greenberg
IPC分类号： A61N1/05
CPC分类号： A61N1/37247 , A61N1/0529 , A61N1/0534 , A61N1/0553 , A61N1/36185 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： Techniques for selecting electrode combinations for stimulation therapy include delivering stimulation via each of at least two electrode combination classes during a therapy evaluation period. A first one of the classes comprises one or more electrode combinations that include electrodes within one or two columns of an implantable array of electrodes. The array may include at least three electrode columns. A second one of the classes comprises one or more electrode combinations that include electrodes within at least three electrode columns of the implantable array of electrodes. A preferred one of the electrode combination classes for a patient, and/or a number of leads to implant within the patient, may by selected based on feedback collected from the patient during the therapy evaluation period.
摘要翻译：用于选择用于刺激治疗的电极组合的技术包括在治疗评价期间通过至少两个电极组合类别中的每一个递送刺激。这些类别中的第一个包括一个或多个电极组合，其包括在可植入的电极阵列的一列或两列内的电极。阵列可以包括至少三个电极柱。第二类包括一个或多个电极组合，其包括在可植入电极阵列的至少三个电极列内的电极。可以通过基于在治疗评估期间从患者收集的反馈来选择用于患者的电极组合类别中的优选的一个，和/或患者内的植入物的数量。

34. 发明授权

US09084872B2 Introducer for therapy delivery elements 有权
标题翻译：介绍治疗传递要素
公开(公告)号：US09084872B2
公开(公告)日：2015-07-21
申请号：US12869891
申请日：2010-08-27
申请人： Ethan A. Rooney , Gary W. King , Thomas E. Cross, Jr. , Richard T. Stone
发明人： Ethan A. Rooney , Gary W. King , Thomas E. Cross, Jr. , Richard T. Stone
IPC分类号： A61N1/00 , A61M25/06 , A61N1/05 , A61N1/372 , A61N1/375
CPC分类号： A61M25/0662 , A61N1/0551 , A61N1/0553 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： The disclosure describes an introducer for facilitating implantation of therapy elements into a patient. The introducer has an elongated body that defines a lumen for advancement of a therapy element to an implant site, and includes a curved portion medially located between substantially straight proximal and distal portions. As an example, the shape of the introducer may allow a clinician to more easily, and without substantially damaging surrounding tissue, find the correct tissue depth and follow that tissue depth to the implant site. For example, the introducer may facilitate implantation of a therapy element within or between desired layers of tissue of the patient. In some embodiments, fluid may be injected through the introducer to create a space within the tissue to implant the therapy element. Fluid may also be evacuated through the introducer prior to implantation.
摘要翻译：本公开描述了一种用于促进将治疗元件植入患者体内的导引器。引导器具有限定用于使治疗元件前进到植入部位的内腔的细长主体，并且包括中间位于基本上直的近端部分和远端部分之间的弯曲部分。作为示例，引导器的形状可以允许临床医生更容易地且不会基本上损伤周围的组织，找到正确的组织深度并且将该组织深度跟随到植入部位。例如，导引器可以有助于将治疗元件植入患者组织的期望的层之内或之间。在一些实施例中，流体可以通过导引器注入，以在组织内产生植入治疗元件的空间。在植入之前，流体也可以通过引入器排空。

35. 发明授权

US08597042B2 Connector for implantable medical lead 有权
标题翻译：可植入医用铅的连接器
公开(公告)号：US08597042B2
公开(公告)日：2013-12-03
申请号：US13262998
申请日：2010-04-09
申请人： Gary W. King
发明人： Gary W. King
IPC分类号： H01R4/28
CPC分类号： A61N1/3752 , H01R13/6275 , H01R24/58 , H01R2107/00 , H01R2201/12
摘要： A connector (500) for operably coupling a medical lead to an implantable medical device includes first and second pivotably coupled elongate members (510, 520). Each of the first and second elongate members has (i) a proximal end portion (512, 522), and (ii) a distal end portion (514, 524) for engaging the lead. The lead has a proximal end portion having a shoulder. The first and second elongate members are pivotably coupled such that the distal end portions of the first and second elongate members are moveable to allow insertion of the lead proximally past the distal end portions of the elongate members and to allow the distal end portions to engage the lead distal the shoulder.
摘要翻译：用于将医用引线可操作地连接到可植入医疗装置的连接器（500）包括第一和第二可枢转耦合的细长构件（510,520）。第一和第二细长构件中的每一个具有（i）近端部分（512,522）和（ii）用于接合引线的远端部分（514,524）。引线具有具有肩部的近端部分。第一和第二细长构件可枢转地联接，使得第一和第二细长构件的远端部分可移动以允许引线向近侧插入穿过细长构件的远端部分并且允许远端部分接合引导远离肩膀。

36. 发明授权

US08204607B2 Implantable medical lead 有权
标题翻译：可植入医用铅
公开(公告)号：US08204607B2
公开(公告)日：2012-06-19
申请号：US11450148
申请日：2006-06-09
申请人： Ethan A. Rooney , Carl D. Wahlstrand , Gary W. King , Thomas E. Cross, Jr. , Richard T. Stone
发明人： Ethan A. Rooney , Carl D. Wahlstrand , Gary W. King , Thomas E. Cross, Jr. , Richard T. Stone
IPC分类号： A61N1/36
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/36071 , A61N1/37211
摘要： The disclosure describes an implantable medical lead for delivering stimulation to a patient. Electrodes may be located on two or more surfaces of the lead to, for example, selectively deliver stimulation to one or more tissue layers within the patient. The lead may be implanted within or between intra-dermal, deep dermal, or subcutaneous tissue layers, and may be used to, for example, deliver peripheral nerve field stimulation to treat pain experienced by the patient at the site at which the lead is implanted. The lead may comprise a paddle lead or a multiple level lead, e.g., a lead having a plurality of flat or paddle shaped lead bodies arranged in substantially parallel planes. Further, the lead may include fixation structures on the distal end, proximal end, or both ends to prevent migration.
摘要翻译：本公开描述了用于将刺激递送给患者的可植入医疗引线。电极可以位于引线的两个或更多个表面上，以例如选择性地将刺激递送到患者体内的一个或多个组织层。铅可以植入在真皮内，深层皮肤或皮下组织层之内或之间，并且可以用于例如递送周围神经域刺激，以治疗患者在植入铅的部位所经历的疼痛。引线可以包括桨引线或多级引线，例如具有布置在基本上平行的平面中的多个扁平或桨状引线的引线。此外，引线可以包括远端，近端或两端的固定结构，以防止迁移。

37. 发明授权

US08165681B2 Method for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated 失效
标题翻译：阻止组织激活或动作电位传导而其他组织被治疗激活的方法
公开(公告)号：US08165681B2
公开(公告)日：2012-04-24
申请号：US11930725
申请日：2007-10-31
申请人： Gary W. King
发明人： Gary W. King
IPC分类号： A61N1/36
CPC分类号： A61N1/3962 , A61N1/36007 , A61N1/36071
摘要： A desired effect is produced by therapeutically activating tissue at a first site within a patient's body and a corresponding undesired side effect is reduced by blocking activation of tissue or conduction of action potentials at a second site within the patient's body by applying high frequency stimulation and/or direct current pulses at or near the second site. Time-varying DC pulses may be used before or after a high frequency blocking signal. The high frequency stimulation may begin before and continue during the therapeutic activation. The high frequency stimulation may begin with a relatively low amplitude, and the amplitude may be gradually increased. The desired effect may be promotion of micturition or defecation and the undesired side effect may be sphincter contraction.
摘要翻译：通过在患者体内的第一部位进行治疗活化的组织产生期望的效果，并且通过施加高频刺激和/或使患者的身体内的第二部位阻止组织的激活或动作电位的传导来减少相应的不期望的副作用，和/ 或在第二位置处或附近的直流脉冲。可以在高频阻塞信号之前或之后使用时变DC脉冲。高频刺激可以在治疗激活期间开始并且在治疗激活期间继续。高频刺激可以以相对低的幅度开始，并且幅度可能逐渐增加。期望的效果可以是排尿或排便的促进，并且不期望的副作用可以是括约肌收缩。

38. 发明授权

US08121702B2 Impedance-based stimulation adjustment 有权
标题翻译：基于阻抗的刺激调整
公开(公告)号：US08121702B2
公开(公告)日：2012-02-21
申请号：US12717484
申请日：2010-03-04
申请人： Gary W. King
发明人： Gary W. King
IPC分类号： A61N1/18
CPC分类号： A61N1/36185 , A61N1/08 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Techniques for adjusting stimulation are disclosed. A medical device measures an impedance associated with one or more electrodes, e.g., the impedance presented to the medical device by a total electrical circuit that includes the one or more electrodes, the conductors associated with the electrodes, and tissue proximate to the electrodes. The medical device stores at least one patient-specific relationship between impedance and a stimulation parameter, and adjusts the value of the stimulation parameter based on the measured impedance according to the relationship. The medical device may store multiple relationships, and select one the relationships based on, for example, an activity level of the patient, posture of the patient, or a current stimulation program or electrode combination used to deliver stimulation. By adjusting a stimulation parameter, such as amplitude, according to such a relationship, the stimulation intensity as perceived by the patient may be kept substantially constant.
摘要翻译：公开了用于调节刺激的技术。医疗设备测量与一个或多个电极相关联的阻抗，例如通过包括一个或多个电极，与电极相关联的导体和靠近电极的组织的总电路呈现给医疗装置的阻抗。医疗装置存储阻抗和刺激参数之间的至少一个患者特异性关系，并且根据关系根据所测量的阻抗来调整刺激参数的值。医疗设备可以存储多个关系，并且基于例如患者的活动水平，患者的姿势或用于递送刺激的当前刺激程序或电极组合来选择一个关系。通过根据这样的关系调整诸如振幅的刺激参数，可以将患者感觉到的刺激强度保持基本上恒定。

39. 发明申请

US20100161007A1 IMPEDANCE-BASED STIMULATION ADJUSTMENT 有权
标题翻译：基于阻抗的刺激调整
公开(公告)号：US20100161007A1
公开(公告)日：2010-06-24
申请号：US12717484
申请日：2010-03-04
申请人： Gary W. King
发明人： Gary W. King
IPC分类号： A61N1/08
CPC分类号： A61N1/36185 , A61N1/08 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Techniques for adjusting stimulation are disclosed. A medical device measures an impedance associated with one or more electrodes, e.g., the impedance presented to the medical device by a total electrical circuit that includes the one or more electrodes, the conductors associated with the electrodes, and tissue proximate to the electrodes. The medical device stores at least one patient-specific relationship between impedance and a stimulation parameter, and adjusts the value of the stimulation parameter based on the measured impedance according to the relationship. The medical device may store multiple relationships, and select one the relationships based on, for example, an activity level of the patient, posture of the patient, or a current stimulation program or electrode combination used to deliver stimulation. By adjusting a stimulation parameter, such as amplitude, according to such a relationship, the stimulation intensity as perceived by the patient may be kept substantially constant.
摘要翻译：公开了用于调节刺激的技术。医疗设备测量与一个或多个电极相关联的阻抗，例如通过包括一个或多个电极，与电极相关联的导体和靠近电极的组织的总电路呈现给医疗装置的阻抗。医疗装置存储阻抗和刺激参数之间的至少一个患者特异性关系，并且根据关系根据所测量的阻抗来调整刺激参数的值。医疗设备可以存储多个关系，并且基于例如患者的活动水平，患者的姿势或用于递送刺激的当前刺激程序或电极组合来选择一个关系。通过根据这样的关系调整诸如振幅的刺激参数，可以将患者感觉到的刺激强度保持基本上恒定。

40. 发明授权

US07734342B2 Techniques for positioning therapy delivery elements within a spinal cord or brain 有权
标题翻译：用于在脊髓或脑内定位治疗递送元件的技术
公开(公告)号：US07734342B2
公开(公告)日：2010-06-08
申请号：US11669758
申请日：2007-01-31
申请人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N1/00
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

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