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31. 发明授权

US07924425B2 Spatially selective fixed-optics multicolor fluorescence detection system for a multichannel microfluidic device, and method for detection 有权
标题翻译：用于多通道微流体装置的空间选择性固定光学多色荧光检测系统及其检测方法
公开(公告)号：US07924425B2
公开(公告)日：2011-04-12
申请号：US11993852
申请日：2006-06-26
申请人： Nicole Y. Morgan , Paul Smith , Ed Wellner
发明人： Nicole Y. Morgan , Paul Smith , Ed Wellner
IPC分类号： G01N21/00
CPC分类号： G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6478 , G01N2021/6484
摘要： A system for spatially selective, fixed-optics fluorescence detection in a multichannel polymeric microfluidic device, and a method for performing spatially selective, fixed-optics fluorescence detection.
摘要翻译：用于多通道聚合微流体装置中的空间选择性，固定光学荧光检测的系统以及用于执行空间选择性固定光学荧光检测的方法。

32. 发明授权

US07914045B2 Buckle support assembly and manfacturing method and system 有权
标题翻译：带扣支撑装配及制造方法及系统
公开(公告)号：US07914045B2
公开(公告)日：2011-03-29
申请号：US12405375
申请日：2009-03-17
申请人： Thomas Messner , Richard Jodts , Steve Marzi , Marco Amaya , Juan Espinosa , Carlos Camarillo , Paul Smith
发明人： Thomas Messner , Richard Jodts , Steve Marzi , Marco Amaya , Juan Espinosa , Carlos Camarillo , Paul Smith
IPC分类号： B60R22/00
CPC分类号： B60R22/12 , B60R22/03 , B60R22/18 , B60R2022/021 , B60R2022/1806 , Y10T24/45623
摘要： A support assembly is disclosed generally including a buckle component or components and a positioning member of flexible material that is arranged and configured to support the buckle component in a predetermined elevated position or predetermined positions for multiple components while also allowing for resilient shifting thereof. In the preferred form, the flexible material is belt webbing that has a plurality of fold portions folded and sewn together in a specific manner. Sew patterns are disclosed as well as methods and fixtures for forming the belt webbing positioning member.
摘要翻译：公开了一种支撑组件，其通常包括带扣部件和柔性材料的定位构件，其被布置和构造成将带扣部件支撑在预定的升高位置或多个部件的预定位置，同时还允许其弹性移位。在优选形式中，柔性材料是带状织带，其具有以特定方式折叠和缝合在一起的多个折叠部分。公开了缝合图案以及用于形成带织带定位构件的方法和固定装置。

33. 外观设计

USD624061S1 Electronic display mount with folding wall plate 有权
标题翻译：电子显示屏带折叠墙板
公开(公告)号：USD624061S1
公开(公告)日：2010-09-21
申请号：US29343133
申请日：2009-09-08
申请人： Paul Smith , Jeff Bremmon , Nathan Bohl
设计人： Paul Smith , Jeff Bremmon , Nathan Bohl

34. 发明授权

US07763666B2 Plug-flow regeneration process 有权
标题翻译：插管再生过程
公开(公告)号：US07763666B2
公开(公告)日：2010-07-27
申请号：US11572905
申请日：2005-07-28
申请人： Gregory Mark Vero , Paul Smith
发明人： Gregory Mark Vero , Paul Smith
IPC分类号： C08J5/20
CPC分类号： C02F1/42 , B01J49/05 , B01J49/50 , C02F2303/16
摘要： A process for the regeneration of loaded ion-exchange resin comprising (a) providing loaded resin for regeneration; (b) providing first stage and third stage regenerant suitable for regenerating loaded resin; (c) providing a plurality of regeneration vessels; (d) filling a regeneration vessel with a desired amount of the loaded resin before filling another regeneration vessel; (e) once a regeneration vessel has been filled, contacting the loaded resin within the vessel with first stage regenerant in a plug flow to provide a first stage regenerated resin; (f) contacting the first stage regenerated resin with third stage regenerant in a plug flow to provide regenerated resin and (g) removing and collecting third stage regenerant from a vessel containing regenerated resin and adding the collected regenerant to the first stage regenerant.
摘要翻译：一种负载离子交换树脂的再生方法，包括：（a）提供用于再生的负载树脂; （b）提供适于再生负载树脂的第一级和第三级再生剂; （c）提供多个再生容器; （d）在填充另一个再生容器之前，用所需量的负载树脂填充再生容器; （e）一旦已经填充了再生容器，使容器内的负载树脂与活塞流中的第一级再生剂接触以提供第一级再生树脂; （f）使第一级再生树脂与活塞流中的第三级再生剂接触以提供再生树脂，（g）从含有再生树脂的容器中除去和收集第三级再生剂，并将收集的再生剂加入到第一级再生剂中。

35. 发明申请

US20100165339A1 SPATIALLY SELECTIVE FIXED-OPTICS MULTICOLOR FLUORESCENCE DETECTION SYSTEM FOR A MULTICHANNEL MICROFLUIDIC DEVICE, AND METHOD FOR DETECTION 有权
标题翻译：用于多通道微流体装置的空间选择性固定化多功能荧光检测系统及其检测方法
公开(公告)号：US20100165339A1
公开(公告)日：2010-07-01
申请号：US11993852
申请日：2006-06-26
申请人： Nicole Y. Morgan , Paul Smith , Ed Wellner
发明人： Nicole Y. Morgan , Paul Smith , Ed Wellner
IPC分类号： G01J3/28 , G01J1/58
CPC分类号： G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6478 , G01N2021/6484
摘要： A fixed-optics system for detecting fluorescence light emitted from one or more spatially selected volumes (S), e.g., in one or more microfluidic channels, comprises a detection optical fiber (60) corresponding to each selected volume and a ball lens (110) adjacent to one end of each optical fiber, wherein the ball lens has a diameter (D) larger than the diameter of the optical fiber and a distance (d1) between the ball lens and the optical fiber is in a range of 3 to 40 times the diameter of the optical fiber, so that due to a quasi-focusing configuration light emitted from the spatially selected volume and received by the ball lens converges onto the end (60a) of the optical fiber.
摘要翻译：用于检测从一个或多个空间选择的体积（S）发射的荧光的固定光学系统，例如在一个或多个微流体通道中，包括对应于每个选定体积的检测光纤（60）和球透镜（110）邻近各光纤的一端，其中，所述球透镜的直径（D）大于所述光纤的直径，并且所述球透镜与所述光纤之间的距离（d1）在3〜40倍的范围内光纤的直径，使得由于准聚焦配置，从空间选择的体积发射并由球透镜接收的光会聚到光纤的端部（60a）上。

36. 发明申请

US20090277138A1 Clothing Packing Apparatus 有权
标题翻译：服装包装设备
公开(公告)号：US20090277138A1
公开(公告)日：2009-11-12
申请号：US12440356
申请日：2007-09-07
申请人： Paul Smith , Wai Kwon Tang
发明人： Paul Smith , Wai Kwon Tang
IPC分类号： A41H33/00 , B65B5/04
CPC分类号： D06F89/02 , D06F89/005
摘要： A clothing packing apparatus for folding a clothing article, such as a suit, comprising a spacing material to separate parts of the folded clothing article comprises a parts that partial overlay a fold line in the aligned sleeves and the body of an article of clothing; a slit for folding the sleeves independently; gripping surfaces to engage the clothing article; rounded/tapered edges to eliminate pressure compressions; pre-formed bands to improve folding performance; and a casing for storage and transit. The spacing material is preferably formed of foam capable of forming a continuous U-shaped curve along the fold lines and an anti-collapsible structure when folded with the clothing article.
摘要翻译：一种衣服包装装置，用于折叠诸如衣服的衣服制品，其包括用于分离折叠的衣服制品的部分的间隔材料，其包括部分地覆盖对齐的袖子中的折叠线和衣服的身体的部分; 用于独立地折叠套筒的狭缝; 抓握表面以接合衣物; 圆形/锥形边缘消除压力压缩; 预先形成的乐队，以提高折叠表演; 和一个用于存储和运输的套管。间隔材料优选由能够沿折线形成连续的U形曲线的泡沫形成，并且当与服装物品折叠时具有防折叠结构。

37. 发明申请

US20080245531A1 DOWNHOLE DEPLOYMENT VALVES 有权
标题翻译：井下部分阀
公开(公告)号：US20080245531A1
公开(公告)日：2008-10-09
申请号：US12098264
申请日：2008-04-04
申请人： Joe Noske , David Iblings , David Pavel , David J. Brunnert , Paul Smith , Michael Brian Grayson
发明人： Joe Noske , David Iblings , David Pavel , David J. Brunnert , Paul Smith , Michael Brian Grayson
IPC分类号： E21B34/06
CPC分类号： E21B34/14 , E21B21/08 , E21B21/10 , E21B2034/005 , Y10T137/7898
摘要： Methods and apparatus enable reliable and improved isolation between two portions of a bore extending through a casing string disposed in a borehole. A downhole deployment valve (DDV) may provide the isolation utilizing a valve member such as a flapper that is disposed in a housing of the DDV and is designed to close against a seat within the housing. The DDV includes an operating mechanism for opening/closing the DDV. In use, pressure in one portion of a well that is in fluid communication with a well surface may be bled off and open at well surface while maintaining pressure in another portion of the casing string beyond the DDV.
摘要翻译：方法和装置能够在延伸穿过设置在钻孔中的套管柱的孔的两个部分之间实现可靠和改进的隔离。井下展开阀（DDV）可以利用诸如挡板的阀构件来提供隔离，所述阀构件设置在DDV的壳体中并被设计成抵靠壳体内的座。 DDV包括用于打开/关闭DDV的操作机构。在使用中，与井表面流体连通的井的一部分中的压力可以在井表面被排出并打开，同时保持套管柱的另一部分中的压力超过DDV。

38. 发明授权

US07276287B2 Melt-processible poly(tetrafluoroethylene) 有权
公开(公告)号：US07276287B2
公开(公告)日：2007-10-02
申请号：US10736771
申请日：2003-12-17
申请人： Paul Smith , Jeroen F. Visjager , Cees Bastiaansen , Theodorus Tervoort
发明人： Paul Smith , Jeroen F. Visjager , Cees Bastiaansen , Theodorus Tervoort
IPC分类号： B32B27/00
CPC分类号： D01F6/32 , C08F14/26 , H05K1/034 , Y10T428/31544
摘要： Melt-processible, thermoplastic poly(tetrafluoroethylene) (PTFE) compositions are disclosed and methods for making and processing same. Additionally, products comprising these compositions are described.

39. 发明申请

US20070208085A1 Potent cytotoxicity and inhibition of pan-cell cycle progression by an alkylating anthraquinone 审中-公开
标题翻译：通过烷基化蒽醌对细胞周期进程的有效细胞毒性和抑制作用
公开(公告)号：US20070208085A1
公开(公告)日：2007-09-06
申请号：US11655043
申请日：2007-01-17
申请人： Agamemnon Epenetos , Klaus Pors , Paul Smith , Laurence Patterson
发明人： Agamemnon Epenetos , Klaus Pors , Paul Smith , Laurence Patterson
IPC分类号： A61K31/137
CPC分类号： A61K31/137
摘要： The present invention generally relates to chemotherapeutic treatment of proliferative disorders, such as cancer. The invention more specifically relates to inhibition of pan-cell cycle progression with alkylating anthraquinones, which may inhibit mitotic commitment, lead to limited expression of G2 arrest and force cells to enter polyploidy via an aberrant mitosis. The methods of the invention are particularly useful in the treatment of chemotherapy-resistant cancers.
摘要翻译：本发明一般涉及增生性疾病如癌症的化学治疗。本发明更具体地涉及用烷基化蒽醌抑制泛细胞周期进程，其可抑制有丝分裂承诺，导致G2阻滞的有限表达，并且通过异常有丝分裂使强制细胞进入多倍体。本发明的方法在化疗耐药性癌症的治疗中特别有用。

40. 发明授权

US07250772B2 Method and apparatus for characterizing a signal path carrying an operational signal 有权
标题翻译：用于表征携带操作信号的信号路径的方法和装置
公开(公告)号：US07250772B2
公开(公告)日：2007-07-31
申请号：US11198900
申请日：2005-08-04
申请人： Cynthia Furse , Paul Smith
发明人： Cynthia Furse , Paul Smith
IPC分类号： G01R31/11 , G01R23/16
CPC分类号： H04B1/707 , G01R31/008 , G01R31/11 , H04B2201/709709 , H04L1/242 , H04L25/085
摘要： A method of characterizing a signal path includes (i) generating a reference spread-spectrum signal; (ii) coupling the reference spread-spectrum signal into the signal path while the signal path is carrying an operational signal; (iii) receiving a reflected spread-spectrum signal from the signal path generated in response to the reference spread-spectrum signal; and (iv) correlating the reflected spread-spectrum signal with the reference spread-spectrum signal to produce a correlation result corresponding to a characteristic of the signal path.
摘要翻译：表征信号路径的方法包括：（i）生成参考扩展频谱信号; （ii）当信号路径携带操作信号时，将参考扩展频谱信号耦合到信号路径中; （iii）从响应于参考扩频信号产生的信号路径接收反射的扩频信号; 和（iv）将反射的扩频信号与参考扩频信号相关，以产生与信号路径的特性对应的相关结果。

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