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31. 发明授权

US07322938B2 Breast biopsy system and methods 有权
标题翻译：乳腺活检系统及方法
公开(公告)号：US07322938B2
公开(公告)日：2008-01-29
申请号：US09929371
申请日：2001-08-13
申请人： Fred H. Burbank , Michael L. Jones , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Paul Lubock
IPC分类号： A61B10/00 , A61B18/18
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possibly cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen. The specimen may be encapsulated and removed as an intact piece.
摘要翻译：提供了一种用于精确地分离患者体内组织中的靶病变的装置和方法，导致当其被去除用于诊断和/或治疗时，对病变的“清洁”边缘的高可能性。这种方法有利地经常导致仅使用单一经皮手术来诊断和治疗恶性病变的能力，而不需要随访的经皮或外科手术，同时最小化可能的癌细胞从病变迁移到周围的风险组织或血液。特别地，该装置包括具有适于进入患者身体的远端的活检器械，纵向轴和沿轴设置的切割元件。切割元件可在径向缩回位置和径向延伸位置之间致动。有利地，仪器可以在其径向延伸位置中绕其轴线旋转，以通过围绕组织样本限定周边边界来将期望的组织样本与周围组织隔离。样品可以作为完整的片段被包封和去除。

32. 发明授权

US06725083B1 Tissue site markers for in VIVO imaging 有权
标题翻译：用于VIVO成像的组织位点标记
公开(公告)号：US06725083B1
公开(公告)日：2004-04-20
申请号：US09717909
申请日：2000-11-20
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B1900
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
摘要翻译：本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区分开来。本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。标记可以具有不均匀的表面轮廓以增强声学特征。标记具有在医学成像期间可识别人造的特征形式。可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后移动或操纵标记的组织时抵抗活组织腔的迁移。

33. 发明授权

US06508773B2 Tissue specimen encapsulation device and method thereof 有权
公开(公告)号：US06508773B2
公开(公告)日：2003-01-21
申请号：US10032083
申请日：2001-12-21
申请人： Fred H. Burbank , Richard L. Quick , Jacob Frank Louw , Michael L. Jones , Paul Lubock
发明人： Fred H. Burbank , Richard L. Quick , Jacob Frank Louw , Michael L. Jones , Paul Lubock
IPC分类号： A61B500
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00234 , A61B17/221 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2017/00287 , A61B2017/2212 , A61B2017/320064 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： A device for encapsulating tissue specimens includes a wand assembly, a sheath, and a guide assembly. The guide assembly pulls, draws, or otherwise moves the sheath about the tissue specimen. The wand assembly is disposed proximate to the tissue specimen, typically either adjacent or through the specimen. In an aspect of the encapsulating device, the guide assembly has sheath deployment members that are disposed about the tissue specimen. The sheath, which is attached to ends of the sheath deployment members and the wand assembly, is drawn over the tissue specimen as the sheath deployment members are pushed or pulled. In another aspect of the device, the guide assembly is an arm or a housing that rotates about the tissue specimen. The sheath, which is secured at one end to the guide assembly and at another end to the wand assembly, is drawn over the tissue specimen as the guide assembly rotates. The sheath may be made up of porous material, non-porous material, selectively permeable material, woven material, braided material, knit material, web material, mesh material, a film material, a flexible laminate material, or of an elastic material.

34. 发明授权

US06347241B2 Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it 有权
标题翻译：超声和X射线检测活检部位标记及其应用的装置
公开(公告)号：US06347241B2
公开(公告)日：2002-02-12
申请号：US09343975
申请日：1999-06-30
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
IPC分类号： A61B1900
CPC分类号： A61K49/006 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3933 , A61B2090/395 , A61B2090/3987 , A61M37/0069
摘要： A biopsy site marker comprises small bodies or pellets of gelatin which enclose substantially in their interior a radio (X-ray) opaque object. The gelatin pellets are deposited into the biopsy site, typically a cylindrical opening in the tissue created by the recent use of a vacuum assisted large core biopsy device, by an applicator device that includes an elongated cylindrical body that forms a flexible tube and a piston slidable in the tube. One end of the tube is placed into the biopsy site. Typically, several gelatin pellets, only some of which typically do, but all of which may contain the radio opaque object, are deposited sequentially into the site through the tube. The radio opaque objects contained in the gelatin bodies are of a non-biological configuration and readily identifiable as man-made object, so that in observation by typical mammography equipment they do not assume the shape of a line, whereby they are readily distinguishable from granules and lines of calcification.
摘要翻译：活检部位标记物包括明胶的小体或小丸，其基本上在其内部封闭无线电（X射线）不透明物体。凝胶颗粒沉积到活检部位，通常是通过最近使用真空辅助的大芯活检装置产生的组织中的圆柱形开口，该施用装置包括形成柔性管的细长圆柱形主体和可滑动的活塞在管中。将管的一端放入活检部位。通常，几个明胶丸粒，其中仅一些通常可以，但都可以包含无线电不透明物体，通过管子依次沉积到该部位。包含在明胶体中的无线电不透明物体具有非生物构型，并且易于被识别为人造物体，因此在通过典型的乳房X射线摄影术设备的观察中，它们不呈现线的形状，由此它们容易与颗粒区分开和钙化线。

35. 发明授权

US6161034A Methods and chemical preparations for time-limited marking of biopsy sites 有权
公开(公告)号：US6161034A
公开(公告)日：2000-12-12
申请号：US241936
申请日：1999-02-02
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
IPC分类号： A61B8/08 , A61B10/00 , A61B10/02 , A61B17/00 , A61B19/00 , A61K49/00
CPC分类号： A61B90/39 , A61B10/02 , A61B2017/00004 , A61B2090/3788 , A61B2090/3908 , A61B2090/3925 , A61B2090/3929 , A61B2090/3933 , A61B2090/395 , A61B2090/3975 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61M37/0069
摘要： Detectable markers that may be introduced into a cavity created by removal of a biopsy specimen to mark the location of the biopsy site so that it may be located in a subsequent medical/surgical procedure. The markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.

36. 发明申请

US20120253189A1 CAVITY-FILLING BIOPSY SITE MARKERS 有权
公开(公告)号：US20120253189A1
公开(公告)日：2012-10-04
申请号：US13495408
申请日：2012-06-13
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.
摘要翻译：本发明提供用于在有限时间内标记活检部位的材料，装置和方法。活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。系统可以包括含有粉末的管和含有无菌盐水的注射器。管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

37. 发明申请

US20100324416A1 CAVITY-FILLING BIOPSY SITE MARKERS 有权
公开(公告)号：US20100324416A1
公开(公告)日：2010-12-23
申请号：US12852286
申请日：2010-08-06
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.
摘要翻译：本发明提供用于在有限时间内标记活检部位的材料，装置和方法。活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。系统可以包括含有粉末的管和含有无菌盐水的注射器。管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

38. 发明申请

US20090287078A1 Marker or filler forming fluid 审中-公开
标题翻译：标记或填料成型液
公开(公告)号：US20090287078A1
公开(公告)日：2009-11-19
申请号：US12214947
申请日：2008-06-24
申请人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
IPC分类号： A61B6/00 , A61M5/00
CPC分类号： A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3933 , A61B2090/3987 , A61K49/226
摘要： A solution for forming a marker or filler mass for an intracorporeal site. The solution contains a polar, water soluble non-aqueous solvent such as dimethyl sulfoxide and a bioabsorbable, essentially water insoluble polymer such as polylactic acid, or copolymers of lactic acid and glycolic acid. The solution may be delivered to the biopsy site by a suitable syringe and delivery tube. The delivery tube is preferably provided with a releasable radiopaque element on the distal tip which can be released within the polymeric marker mass formed in the biopsy cavity.
摘要翻译：用于形成体内部位的标记物或填充剂块的溶液。该溶液含有极性的水溶性非水溶剂如二甲基亚砜和生物可吸收的，基本上不溶于水的聚合物如聚乳酸，或乳酸和乙醇酸的共聚物。溶液可以通过合适的注射器和输送管递送到活检部位。输送管优选地设置在远端上的可释放的不透射线元件，其可以在形成于活检腔内的聚合物标记块内释放。

39. 发明授权

US07565191B2 Tissue site markers for in vivo imaging 有权
标题翻译：用于体内成像的组织位点标记
公开(公告)号：US07565191B2
公开(公告)日：2009-07-21
申请号：US11238201
申请日：2005-09-29
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B19/00
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
摘要翻译：本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区别开来。本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。标记可以具有不均匀的表面轮廓以增强声学特征。标记具有在医学成像期间可识别人造的特征形式。可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后移动或操纵标记的组织时抵抗活组织腔的迁移。

40. 发明授权

US07404821B2 Treatment for post partum hemorrhage 有权
公开(公告)号：US07404821B2
公开(公告)日：2008-07-29
申请号：US10355809
申请日：2003-01-30
申请人： Fred H. Burbank , Michael L. Jones , Jill Uyeno
发明人： Fred H. Burbank , Michael L. Jones , Jill Uyeno
IPC分类号： A61B17/00
CPC分类号： A61B17/12 , A61B17/2812 , A61B17/42 , A61B2017/00057 , A61B2017/2837 , A61B2090/064 , A61B2090/378
摘要： The invention is directed to instruments and procedures using such instruments for temporarily reducing or terminating blood flow through a female patient's uterine artery to treat post partum hemorrhage (PPH). The uterine artery is occluded by a clamping device which includes a pair of pivotally connected clamping members, with each of the clamping members having a handle and a clamping element at the distal end of the handle. The clamping elements are inclined with respect to the longitudinal axes of the handles at an included obtuse angle between about 120° and about 170°, preferably between about 130° and 160°. An artery locating sensor is provided on the distal end of at least one of the clamping elements. Preferably, the artery locating sensor is a Doppler ultrasound blood flow sensor. After birth, the clamping device is inserted into the female patient's post partum vaginal canal and advanced therein until one of the clamping elements Is in the patient's uterine cervix and the other clamping element is on the exterior of the uterine cervix. The clamping element on the exterior of the patient's uterine cervix is pressed against the patient's vaginal fornix and the clamping device closed so as to occlude the uterine artery disposed within tissue grasped by the clamping device. The clamping device is locked in the closed configuration and maintained in the condition until the patient's uterus is sufficiently clotted up to ensure termination of the hemorrhaging, typically about 5 minutes to about 7 hours.

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