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31. 发明授权

US07229439B2 Apparatus and method for accessing a body site 有权
标题翻译：用于访问身体部位的装置和方法
公开(公告)号：US07229439B2
公开(公告)日：2007-06-12
申请号：US10851342
申请日：2004-05-21
申请人： Fred H. Burbank , Paul Lubock , Martin Shabaz , Frank Louw
发明人： Fred H. Burbank , Paul Lubock , Martin Shabaz , Frank Louw
IPC分类号： A61F18/18
CPC分类号： A61B10/0266 , A61B10/02 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2010/0208 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00291 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1455 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： A device and method of using the device to access a desired tissue site within a patient's body and separating a tissue specimen from the tissue site suitable for evaluation. The device includes a probe member having an arcuate tissue-cutting RF powered electrode secured to and distally spaced from the distal end of the probe and a small dimensioned distal extremity which when an inner lumen thereof is subjected to a vacuum, secured tissue for the specimen to the surface of the distal extremity. A circular tissue-cutting blade preferably secured to the distal end of a supporting tube is configured to rotate and move longitudinally along the shaft of the probe member effective to sever a tissue specimen from tissue secured to the surface of the distal extremity of the probe member. The supporting tube covers the separated specimen, and may be disposed within an accessing cannula.
摘要翻译：一种使用该装置来访问患者体内期望的组织部位并将组织标本与适于评估的组织部位分离的装置和方法。该装置包括探针构件，该探针构件具有固定到探针的远端并远离间隔开的弓形组织切割RF供电的电极，以及小尺寸的远端，当其内腔经受真空时，用于样本的固定的组织到远端的表面。优选地固定到支撑管的远端的圆形组织切割刀片构造成沿着探针构件的轴线旋转并纵向移动，其有效地从固定到探针构件的远端的表面的组织切断组织样本。支撑管覆盖分离的样本，并且可以设置在进入的插管内。

32. 发明授权

US06758848B2 Apparatus and method for accessing a body site 有权
公开(公告)号：US06758848B2
公开(公告)日：2004-07-06
申请号：US10179933
申请日：2002-06-21
申请人： Fred H. Burbank , Paul Lubock , Martin Shabaz , Frank Louw
发明人： Fred H. Burbank , Paul Lubock , Martin Shabaz , Frank Louw
IPC分类号： A61B1818
CPC分类号： A61B10/0266 , A61B10/02 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2010/0208 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00291 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1455 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： A device and method of using the device to access a desired tissue site within a patient's body and separating a tissue specimen from the tissue site suitable for evaluation. The device includes a probe member having an arcuate tissue-cutting RF powered electrode secured to and distally spaced from the distal end of the probe and a small dimensioned distal extremity which when an inner lumen thereof is subjected to a vacuum, secured tissue for the specimen to the surface of the distal extremity. A circular tissue-cutting blade preferably secured to the distal end of a supporting tube is configured to rotate and move longitudinally along the shaft of the probe member effective to sever a tissue specimen from tissue secured to the surface of the distal extremity of the probe member. The supporting tube covers the separated specimen, and may be disposed within an accessing cannula.

33. 发明授权

US06725083B1 Tissue site markers for in VIVO imaging 有权
标题翻译：用于VIVO成像的组织位点标记
公开(公告)号：US06725083B1
公开(公告)日：2004-04-20
申请号：US09717909
申请日：2000-11-20
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B1900
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
摘要翻译：本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区分开来。本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。标记可以具有不均匀的表面轮廓以增强声学特征。标记具有在医学成像期间可识别人造的特征形式。可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后移动或操纵标记的组织时抵抗活组织腔的迁移。

34. 发明授权

US5707389A Side branch occlusion catheter device having integrated endoscope for performing endoscopically visualized occlusion of the side branches of an anatomical passageway 失效
标题翻译：具有用于进行解剖通道的侧分支的内窥镜可视化闭塞的集成内窥镜的侧分支闭塞导管装置
公开(公告)号：US5707389A
公开(公告)日：1998-01-13
申请号：US486038
申请日：1995-06-07
申请人： Frank Louw , Stephen A. Sosnowski , David Rosenthal
发明人： Frank Louw , Stephen A. Sosnowski , David Rosenthal
IPC分类号： A61B17/12 , A61B29/00
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/1214 , A61B2017/22097 , A61M2025/018
摘要： The device for blocking (e.g., embolizing) the side branches of an anatomical passageway under endoscopic guidance. The device comprises an elongate catheter body having a side branch blocking apparatus, such as an embolization catheter, disposed therein and further incorporating an endoscope (e.g., an angioscope). The incorporated endoscope is useable to A) visually locate side branches which emanate from the anatomical passageway and b) visually observe the operation of the side branch blocking apparatus. Also disclosed are methods for utilizing a device of the forgoing character, including methods for performing in situ embolization of the side branches of a vein, under angioscopic visualization. The endoscopic component of the device may also be utilized to visually observe the use and/or effect of one or more separate device, such as valvulotome(s) used for cutting venous valves located within the lumen of a vein.
摘要翻译：用于在内窥镜引导下阻塞（例如，栓塞）解剖通道的侧分支的装置。该装置包括细长导管体，其具有设置在其中并进一步结合内窥镜（例如，血管造影仪）的侧分支阻塞装置，例如栓塞导管。所配置的内窥镜可用于A）可视地定位从解剖通道发出的侧分支，以及b）目视观察侧支阻断装置的操作。还公开了用于利用前述特征的装置的方法，包括在血管视觉可视化下进行静脉侧枝的原位栓塞的方法。该装置的内窥镜部件也可以用于目视观察一个或多个分离装置（例如用于切割位于静脉内腔内的静脉瓣）的瓣膜切开的使用和/或效果。

35. 发明授权

US06178968B2 Method of endoscopically visualized occlusion of the side branches of an anatomical passageway 有权
标题翻译：解剖通道侧枝的内窥镜可视化闭塞的方法
公开(公告)号：US06178968B2
公开(公告)日：2001-01-30
申请号：US09306863
申请日：1999-05-07
申请人： Frank Louw , Stephen A. Sosnowski , David Rosenthal
发明人： Frank Louw , Stephen A. Sosnowski , David Rosenthal
IPC分类号： A61M2900
CPC分类号： A61B17/1214 , A61B17/12022 , A61B17/12109 , A61B17/12145 , A61B17/12172 , A61M2025/018
摘要： Methods for utilizing a device for blocking (e.g., embolizing) the side branches of an anatomical passageway under endoscopic guidance. The device comprises an elongate catheter body having a side branch blocking apparatus, such as an embolization catheter, disposed therein and further incorporating an endoscope (e.g., an angioscope). The incorporated endoscope is useable to a) visually locate side branches which emanate from the anatomical passageway and b) visually observe the operation of the side branch blocking apparatus. Disclosed are methods for performing in situ embolization of the side branches of a vein, under angioscopic visualization. The endoscopic component of the device may also be utilized to visually observe the use and/or effect of one or more separate device, such as valvulotome(s) used for cutting venous valves located within the lumen of a vein.
摘要翻译：用于在内窥镜引导下利用用于阻塞（例如栓塞）解剖通道的侧分支的装置的方法。该装置包括细长导管体，其具有设置在其中并进一步结合内窥镜（例如，血管造影仪）的侧分支阻塞装置，例如栓塞导管。内置的内窥镜可用于a）目视定位从解剖通道发出的侧分支，以及b）目视观察侧支阻断装置的操作。公开了在血管腔视觉下进行静脉侧支的原位栓塞的方法。该装置的内窥镜部件也可以用于目视观察一个或多个分离装置（例如用于切割位于静脉内腔内的静脉瓣）的瓣膜切开的使用和/或效果。

36. 发明授权

US5947994A Endoscopically-assisted device for endoluminal occlusion of anatomical passageway side branches 失效
标题翻译：内窥镜辅助装置用于解剖通道侧枝的腔内闭塞
公开(公告)号：US5947994A
公开(公告)日：1999-09-07
申请号：US910944
申请日：1997-08-08
申请人： Frank Louw , Stephen A. Sosnowski , David Rosenthal
发明人： Frank Louw , Stephen A. Sosnowski , David Rosenthal
IPC分类号： A61B17/12 , A61B29/00
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/1214 , A61B2017/22097 , A61M2025/018
摘要： The device for blocking (e.g., embolizing) the side branches of an anatomical passageway under endoscopic guidance. The device comprises an elongate catheter body having a side branch blocking apparatus, such as an embolization catheter, disposed therein and further incorporating an endoscope (e.g., an angioscope). The incorporated endoscope is useable to A) visually locate side branches which emanate from the anatomical passageway and b) visually observe the operation of the side branch blocking apparatus. Also disclosed are methods for utilizing a device of the forgoing character, including methods for performing in situ embolization of the side branches of a vein, under angioscopic visualization. The endoscopic component of the device may also be utilized to visually observe the use and/or effect of one or more separate device, such as valvulotome(s) used for cutting venous valves located within the lumen of a vein.
摘要翻译：用于在内窥镜引导下阻塞（例如，栓塞）解剖通道的侧分支的装置。该装置包括细长导管体，其具有设置在其中并进一步结合内窥镜（例如，血管造影仪）的侧分支阻塞装置，例如栓塞导管。所配置的内窥镜可用于A）可视地定位从解剖通道发出的侧分支，以及b）目视观察侧支阻断装置的操作。还公开了用于利用前述特征的装置的方法，包括在血管视觉可视化下进行静脉侧枝的原位栓塞的方法。该装置的内窥镜部件也可以用于目视观察一个或多个分离装置（例如用于切割位于静脉内腔内的静脉瓣）的瓣膜切开的使用和/或效果。

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