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31. 发明申请

US20060078592A1 Drug delivery systems 审中-公开
标题翻译：药物输送系统
公开(公告)号：US20060078592A1
公开(公告)日：2006-04-13
申请号：US11210124
申请日：2005-08-23
申请人： Jay Kunzler , Dharmendra Jani , Joseph Salamone
发明人： Jay Kunzler , Dharmendra Jani , Joseph Salamone
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61F9/0017
摘要： A method for making an ocular drug delivery device involves subjecting the device to a supercritical fluid to remove contaminants from the device. The supercritical fluid includes supercritical carbon dioxide. The contaminants include unreacted monomers or oligomers present in the polymeric material used to form the device.
摘要翻译：用于制造眼药物递送装置的方法包括使装置经受超临界流体以从装置中去除污染物。超临界流体包括超临界二氧化碳。污染物包括存在于用于形成该装置的聚合物材料中的未反应的单体或低聚物。

32. 发明申请

US20070159594A9 Photochromic blue light filtering materials and ophthalmic devices 审中-公开
标题翻译：光致变色蓝光过滤材料和眼科装置
公开(公告)号：US20070159594A9
公开(公告)日：2007-07-12
申请号：US11121960
申请日：2005-05-04
申请人： Dharmendra Jani , Jay Kunzler , Joseph Salamone
发明人： Dharmendra Jani , Jay Kunzler , Joseph Salamone
IPC分类号： G02C7/04 , G02C7/10
CPC分类号： G02B5/23 , A61L27/50 , A61L2430/16 , G02B1/043 , G02C7/102 , G03C1/73
摘要： Polymeric compositions have photochromic and blue-light filtering ability and are useful in the manufacture of ophthalmic medical devices. The polymeric compositions comprise a photochromic material incorporated into polymeric host materials and are activatable by blue light having a first wavelength range to become photochromic, and are thereby capable of absorbing blue light in a second wavelength range. Methods of making the compositions comprise incorporating a photochromic material into a polymeric host material.
摘要翻译：聚合物组合物具有光致变色和蓝光过滤能力，并且可用于制造眼科医疗装置。聚合物组合物包含并入聚合物主体材料中的光致变色材料，并且可通过具有第一波长范围的蓝光激发而变为光致变色，从而能够吸收第二波长范围内的蓝光。制备组合物的方法包括将光致变色材料掺入聚合物主体材料中。

33. 发明申请

US20050031669A1 Rate controlled release of a pharmaceutical agent in a biodegradable device 审中-公开
标题翻译：在可生物降解的装置中速率控制药剂的释放
公开(公告)号：US20050031669A1
公开(公告)日：2005-02-10
申请号：US10887381
申请日：2004-07-08
申请人： Afshin Shafiee , Joseph Salamone , Dharmendra Jani , Stephen Bartels , Jay Kunzler
发明人： Afshin Shafiee , Joseph Salamone , Dharmendra Jani , Stephen Bartels , Jay Kunzler
IPC分类号： A61K9/00 , A61K9/16 , A61P27/02 , C12N5/02
CPC分类号： A61K9/0051 , A61K9/1647
摘要： Chemical erosion drug delivery systems are provided that allow sustained release of therapeutic agents within a treated area for a prolonged period of time.
摘要翻译：提供化学腐蚀药物递送系统，其允许治疗剂在处理区域内持续释放较长时间。

34. 发明申请

US20060223727A1 Polysaccharide and polyol composition for treating dry eye and related methods of manufacture and methods of use 审中-公开
标题翻译：用于治疗干眼的多糖和多元醇组合物及其制备方法和使用方法
公开(公告)号：US20060223727A1
公开(公告)日：2006-10-05
申请号：US11391060
申请日：2006-03-28
申请人： Joseph Salamone , Erning Xia , X. Liu
发明人： Joseph Salamone , Erning Xia , X. Liu
IPC分类号： C11D3/00
CPC分类号： A61K47/10 , A61K9/0048 , A61K47/38
摘要： The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
摘要翻译：本发明涉及一种用于治疗干眼症的组合物，在一个实施方案中包括羧甲基纤维素和多元醇。已经发现这样的组合物可以缓解干眼症状并长期保留在眼睛中。

35. 发明申请

US20050266095A1 Gentle preservative compositions 审中-公开
标题翻译：温和的防腐剂组合物
公开(公告)号：US20050266095A1
公开(公告)日：2005-12-01
申请号：US10858116
申请日：2004-06-01
申请人： Erning Xia , Joseph Salamone
发明人： Erning Xia , Joseph Salamone
IPC分类号： A61K33/40 , A61L2/18 , A61L12/12 , A61L12/14 , C01B15/037 , C11D3/00 , C11D3/32 , C11D3/39
CPC分类号： A61L2/186 , A61L12/124 , A61L12/143 , A61L2202/24 , C01B15/037 , C11D3/0078 , C11D3/323 , C11D3/3947
摘要： Compositions are described which are useful in preserving any topically applied solution. Compositions including urea-hydrogen peroxide complex in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions. A hydrogen peroxide component of such solutions, when introduced into the eye, is converted to oxygen and water, leaving only the natural product, urea.
摘要翻译：描述了可用于保存任何局部施用的溶液的组合物。还描述了包括有效保护隐形眼镜的量的溶液中的脲 - 过氧化氢络合物的组合物，以及制备和使用这些溶液的方法。这种溶液的过氧化氢组分当被引入眼睛时被转化成氧和水，只剩下天然产物尿素。

36. 发明授权

US08114420B2 Composition for treating dry eye and related methods of manufacture and methods of use 有权
标题翻译：用于治疗干眼症的组合物及其相关制造方法和使用方法
公开(公告)号：US08114420B2
公开(公告)日：2012-02-14
申请号：US11391056
申请日：2006-03-28
申请人： Erning Xia , Joseph Salamone , X. Michael Liu
发明人： Erning Xia , Joseph Salamone , X. Michael Liu
IPC分类号： A61K9/00
CPC分类号： A61K31/047 , A61K9/0048 , A61K31/715 , A61K31/717 , A61K31/737 , A61K31/765 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/38 , A61K2300/00
摘要： The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
摘要翻译：本发明涉及一种用于治疗干眼症的组合物，在一个实施方案中包括羧甲基纤维素和多元醇。已经发现这样的组合物可以缓解干眼症状并长期保留在眼睛中。

37. 发明申请

US20060292189A1 Ophthalmic solution with a flavoring agent as a dosing indicator and method for indicating dosage of an ophthalmic solution 审中-公开
标题翻译：具有调味剂作为剂量指示剂的眼科溶液和用于指示眼用溶液剂量的方法
公开(公告)号：US20060292189A1
公开(公告)日：2006-12-28
申请号：US11431950
申请日：2006-05-11
申请人： Erning Xia , Joseph Salamone
发明人： Erning Xia , Joseph Salamone
IPC分类号： A61K9/00
CPC分类号： A61K31/415 , A61K9/0048 , A61K31/4402 , A61K31/498 , A61L12/141
摘要： The invention provides an ophthalmic solution with a flavoring agent as a dosing indicator and a method for indicating dosage of an ophthalmic solution. To indicate dosage, a flavoring agent is added to an ophthalmic solution in an amount correlated to the dosage of the ophthalmic solution to be used. The flavoring agent can be a sweet flavoring agent (sweetener), or combinations of a sweetener with a sour flavoring agent or a bitter flavoring agent or mixtures thereof. The flavoring agent may also be natural flavors, natural fruit flavors, artificial flavors, artificial fruit flavors, flavor enhancers and mixtures thereof, which may be combined with a sweetener, a sour flavoring agent, a bitter flavoring agent, and mixtures thereof. The invention may be utilized as a contact lens solution, an eye drop formulation, and a pharmaceutical composition containing at least one active pharmaceutical ingredient for the treatment of eye diseases. The invention also provides to a method of administering a dose of an ophthalmic solution to the person's eye.
摘要翻译：本发明提供了一种具有调味剂作为剂量指示剂的眼用溶液和用于指示眼用溶液剂量的方法。为了表示剂量，将调味剂以与所使用的眼用溶液的剂量相关的量加入到眼用溶液中。调味剂可以是甜味调味剂（甜味剂）或甜味剂与酸味调味剂或苦味调味剂或其混合物的组合。调味剂还可以是天然香料，天然水果香料，人造香料，人造水果香料，风味增强剂及其混合物，其可与甜味剂，酸味调味剂，苦味调味剂及其混合物组合。本发明可以用作隐形眼镜溶液，滴眼剂制剂和含有至少一种用于治疗眼部疾病的活性药物成分的药物组合物。本发明还提供了向眼睛施用眼用溶液剂量的方法。

38. 发明申请

US20060222623A1 Composition for treating dry eye and related methods of manufacture and methods of use 有权
标题翻译：用于治疗干眼症的组合物及其相关制造方法和使用方法
公开(公告)号：US20060222623A1
公开(公告)日：2006-10-05
申请号：US11391056
申请日：2006-03-28
申请人： Erning Xia , Joseph Salamone , X. Liu
发明人： Erning Xia , Joseph Salamone , X. Liu
IPC分类号： A61K31/717 , A61K31/765 , A61K31/737 , A61K31/715
CPC分类号： A61K31/047 , A61K9/0048 , A61K31/715 , A61K31/717 , A61K31/737 , A61K31/765 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/38 , A61K2300/00
摘要： The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
摘要翻译：本发明涉及一种用于治疗干眼症的组合物，在一个实施方案中包括羧甲基纤维素和多元醇。已经发现这样的组合物可以缓解干眼症状并长期保留在眼睛中。

39. 发明申请

US20050202983A1 Prevention of loss of tight cell junctions using carbohydrate-containing compositions 审中-公开
标题翻译：使用含碳水化合物的组合物预防紧密细胞连接的损失
公开(公告)号：US20050202983A1
公开(公告)日：2005-09-15
申请号：US10799521
申请日：2004-03-12
申请人： Erning Xia , Joseph Salamone , David McCanna
发明人： Erning Xia , Joseph Salamone , David McCanna
IPC分类号： A61K9/00 , A61K31/70 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/723 , A61K31/726 , A61K31/728 , A61K31/729 , A61K31/731 , A61K31/732 , A61K31/734 , A61K31/736 , C11D3/00 , C11D3/22 , G02B1/12
CPC分类号： A61K31/70 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/723 , A61K31/726 , A61K31/728 , A61K31/729 , A61K31/731 , A61K31/732 , A61K31/734 , A61K31/736 , C11D3/0078 , C11D3/222
摘要： Compositions are described which are useful in preventing the loss of tight epithelial cell junctions upon topical application. Such compositions include one or more carbohydrates in an amount effective to prevent the loss of tight cell junctions and hence improve the management of tissue health.
摘要翻译：描述了可用于在局部施用时防止紧密上皮细胞连接丧失的组合物。这样的组合物包括一种或多种碳水化合物，其量有效地防止紧密细胞连接的丧失，从而改善组织健康的管理。

40. 发明申请

US20050118058A1 Gentle preservative compositions for self-preserving solutions 审中-公开
标题翻译：用于自我保护溶液的温和防腐剂组合物
公开(公告)号：US20050118058A1
公开(公告)日：2005-06-02
申请号：US10725049
申请日：2003-12-01
申请人： Erning Xia , Joseph Salamone
发明人： Erning Xia , Joseph Salamone
IPC分类号： A01N43/16 , A61L12/08 , A61L12/14 , C11D3/00 , C11D3/22 , C11D3/48
CPC分类号： C11D3/48 , A01N43/16 , A61L12/08 , A61L12/143 , C11D3/0078 , C11D3/227
摘要： Compositions are described which are useful in preserving any topically applied solution. Compositions including one or more cationic polysaccharides in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions.
摘要翻译：描述了可用于保存任何局部施用的溶液的组合物。还描述了包含一种或多种有效保护隐形眼镜的量的溶液中的阳离子多糖的组合物，以及制备和使用这些溶液的方法。

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