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31. 发明申请

US20090117166A1 Sequential coupling of biomolecule layers to polymers 审中-公开
标题翻译：生物分子层与聚合物的顺序耦合
公开(公告)号：US20090117166A1
公开(公告)日：2009-05-07
申请号：US12228884
申请日：2008-08-15
申请人： David Myung , Stayce Beck , Jaan Noolandi , Christopher N. Ta , Jennifer R. Cochran , Curtis W. Frank
发明人： David Myung , Stayce Beck , Jaan Noolandi , Christopher N. Ta , Jennifer R. Cochran , Curtis W. Frank
IPC分类号： A61F2/04 , A61K9/10 , A61K38/39 , A61K38/30 , A61K38/18
CPC分类号： A61L27/34 , A61L15/32 , A61L27/14 , A61L27/48 , C08L89/00
摘要： A bio-mimetic or bio-implantable material based on a sequential process of coupling biomolecule layers to a polymer layer is provided. In general, the material could be based on two or more biomolecule layers starting with one of the layers covalently linked to the polymer layer via cross-linkers and the other layers sequentially and covalently linked using cross-linkers to the previously added layer. The polymer layer could be a hydrogel or an interpenetrating polymer network hydrogel. The first layer of biomolecules could be a collagen type, fibronectin, laminin, extracellular matrix protein, or any combinations thereof. The second layer of biomolecules typically is a growth factor, protein or stimulant. The cross-linkers are either water soluble or insoluble bifunctional cross-linkers or azide-active-ester crosslinkers. The material and process as taught in this invention are useful in the field of tissue engineering and wound healing.
摘要翻译：提供了基于将生物分子层耦合到聚合物层的顺序方法的生物模拟或生物可植入材料。通常，该材料可以基于两个或更多个生物分子层，其起始于通过交联剂共价连接到聚合物层的层之一，并且其它层使用交联剂顺序并共价连接到先前添加的层。聚合物层可以是水凝胶或互穿聚合物网络水凝胶。第一层生物分子可以是胶原型，纤连蛋白，层粘连蛋白，细胞外基质蛋白或其任何组合。第二层生物分子通常是生长因子，蛋白质或兴奋剂。交联剂是水溶性或不溶性双功能交联剂或叠氮化物 - 活性酯交联剂。本发明教导的材料和方法可用于组织工程和伤口愈合领域。

32. 发明申请

US20080269370A1 Strain-hardened interpenetrating polymer network hydrogel 有权
标题翻译：应变硬化互穿聚合物网络水凝胶
公开(公告)号：US20080269370A1
公开(公告)日：2008-10-30
申请号：US12070336
申请日：2008-02-15
申请人： David Myung , Laura Hartman , Jean Noolandi , Christopher N. Ta , Curtis W. Frank
发明人： David Myung , Laura Hartman , Jean Noolandi , Christopher N. Ta , Curtis W. Frank
IPC分类号： G02B1/04
CPC分类号： A61K47/48784 , A61K47/58 , A61K47/60 , A61K47/6903 , A61L27/38 , A61L27/52
摘要： A strain-hardened interpenetrating polymer network (IPN) hydrogel is provided. The interpenetrating polymer network hydrogel is based on two different networks. The first network is a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups. The second network is a non-silicone network of ionizable monomers. The second network has been polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. An aqueous salt solution having a neutral pH is used to ionize and swell the second network in the interpenetrating polymer network. The swelling of the second network is constrained by the first network, and this constraining effect results in an increase in effective physical cross-links within the interpenetrating polymer network, and, in turn, an increase its elastic modulus. The strain-hardened interpenetrating polymer network hydrogel is attractive and useful for medical, industrial, and personal hygiene purposes.
摘要翻译：提供了应变硬化的互穿聚合物网络（IPN）水凝胶。互穿聚合物网络水凝胶基于两个不同的网络。第一个网络是通过其端基聚合化学交联的预制亲水非离子遥爪大分子单体的非硅氧烷网络。第二个网络是可离子化单体的无硅网络。第二网络已经在第一网络的存在下被聚合和化学交联，并且与第一网络形成了物理交叉连接。使用具有中性pH的盐水溶液使互穿聚合物网络中的第二网络离子化并溶胀。第二网络的膨胀由第一网络约束，并且这种约束效应导致互穿聚合物网络内的有效物理交联的增加，并且进而增加其弹性模量。应变硬化的互穿聚合物网络水凝胶对于医疗，工业和个人卫生目的是有吸引力和有用的。

33. 发明申请

US20120277807A1 Methods, Devices and Compositions for Adhering Hydrated Polymer Implants to Bone 审中-公开
标题翻译：用于将水合聚合物植入物粘附到骨的方法，装置和组合物
公开(公告)号：US20120277807A1
公开(公告)日：2012-11-01
申请号：US13542464
申请日：2012-07-05
申请人： David Myung , Lampros Kourtus , Michael J. Jaasma
发明人： David Myung , Lampros Kourtus , Michael J. Jaasma
IPC分类号： A61B17/84
CPC分类号： A61L33/0094 , A61L27/34 , A61L27/50 , A61L33/068 , A61L2400/18 , C08L75/04
摘要： A method of attaching an implant to a bone, the implant comprising a hydrated polymer comprising a lubricious hydrated surface and an attachment surface comprising accessible chemical functional groups. The method includes the steps of treating the implant or the bone with an isocyanate-containing compound; placing the attachment surface in apposition to the bone; and allowing the isocyanate-containing compound to cure to bond the implant to the bone. The invention also includes a medical implant having a hydrated polymer comprising an attachment surface comprising a thermoplastic material, the hydrated polymer having an interpenetrating polymer network with at least two polymers, the hydrated polymer having a low coefficient of friction on at least one surface.
摘要翻译：一种将植入物附着到骨骼上的方法，所述植入物包括包含光滑水合表面的水合聚合物和包含可接近的化学官能团的附着表面。该方法包括用含异氰酸酯的化合物处理植入物或骨骼的步骤; 将附着表面放置在骨骼上; 并允许含异氰酸酯的化合物固化以将植入物粘合到骨上。本发明还包括具有包含热塑性材料的附着表面的水合聚合物的医用植入物，所述水合聚合物具有至少两种聚合物的互穿聚合物网络，所述水合聚合物在至少一个表面上具有低摩擦系数。

34. 发明申请

US20060287721A1 Artificial cornea 审中-公开
标题翻译：人造角膜
公开(公告)号：US20060287721A1
公开(公告)日：2006-12-21
申请号：US11409218
申请日：2006-04-20
申请人： David Myung , Christopher Ta , Nabeel Farooqui , Curtis Frank , Won-Gun Koh , Jungmin Ko , Jaan Noolandi , Michael Carrasco
发明人： David Myung , Christopher Ta , Nabeel Farooqui , Curtis Frank , Won-Gun Koh , Jungmin Ko , Jaan Noolandi , Michael Carrasco
IPC分类号： A61F2/14
CPC分类号： A61F2/142 , A61F2/15 , A61K35/12
摘要： The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxyethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.
摘要翻译：本发明提供了一种人造角膜植入物，其具有光学透明的中心纤芯和围绕中心纤芯的多孔，亲水的，生物相容的裙部。在一个实施方案中，中心芯由互穿双网络水凝胶制成，裙部由聚（丙烯酸2-羟乙酯）（PHEA）制成。在另一个实施例中，中心芯和裙部均由互穿双网络水凝胶制成。人造角膜植入物也可以具有相互扩散区域，其中裙部组件与芯部件互穿，反之亦然。在优选的实施方案中，生物分子连接到裙部，中心芯或两者。这些生物分子可以是任何类型的生物分子，但优选支持上皮和/或成纤维细胞存活和生长的生物分子。优选地，生物分子以空间选择性方式连接。本发明还提供了使用光刻法制造人造角膜植入物的方法。

35. 发明申请

US20070179605A1 Interpenetrating polymer network hydrogel corneal prosthesis 有权
标题翻译：互穿聚合物网络水凝胶角膜假体
公开(公告)号：US20070179605A1
公开(公告)日：2007-08-02
申请号：US11639049
申请日：2006-12-13
申请人： David Myung , Christopher Ta , Curtis Frank , Won-Gun Koh , Jaan Noolandi
发明人： David Myung , Christopher Ta , Curtis Frank , Won-Gun Koh , Jaan Noolandi
IPC分类号： A61F2/14 , C12N5/08
CPC分类号： C12N5/0621 , A61F2/142 , A61F2/15 , A61L27/00 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2430/16 , C12N2533/30 , C12N2533/54 , C08L71/02 , C08L33/08
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译：本发明提供具有高葡萄糖和透氧性，强度，含水量和抗蛋白质吸附性的材料。这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。该材料设计用作角膜假体。

36. 发明申请

US20060083773A1 Artificial corneal implant 有权
标题翻译：人造角膜植入物
公开(公告)号：US20060083773A1
公开(公告)日：2006-04-20
申请号：US11243952
申请日：2005-10-04
申请人： David Myung , Jaan Noolandi , Alan Smith , Curtis Frank , Christopher Ta , Yin Hu , Won-Gun Koh , Michael Carrasco
发明人： David Myung , Jaan Noolandi , Alan Smith , Curtis Frank , Christopher Ta , Yin Hu , Won-Gun Koh , Michael Carrasco
IPC分类号： A61K35/30 , A61F2/14
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，其中第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附于生物分子。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

37. 发明申请

US20170035975A1 VACUUM-ASSISTED DRUG DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：真空辅助药物递送装置和方法
公开(公告)号：US20170035975A1
公开(公告)日：2017-02-09
申请号：US15331603
申请日：2016-10-21
申请人： David Myung , Edward E. Manche , Donald J. Eaton , Anthony J. Abbate
发明人： David Myung , Edward E. Manche , Donald J. Eaton , Anthony J. Abbate
IPC分类号： A61M5/42 , A61M37/00 , A61F9/00 , A61M5/158 , A61M5/20
CPC分类号： A61M37/00 , A61F9/0008 , A61M5/158 , A61M2037/0007
摘要： This invention relates to a device and method for the vacuum-assisted delivery of drugs through an intact surface membrane of an organ.
摘要翻译：本发明涉及通过器官的完整表面膜真空辅助递送药物的装置和方法。

38. 发明申请

US20070233240A1 Intraocular lens implant 审中-公开
标题翻译：人工晶状体植入物
公开(公告)号：US20070233240A1
公开(公告)日：2007-10-04
申请号：US11725190
申请日：2007-03-16
申请人： Curtis Frank , Christopher Ta , David Myung , Jaan Noolandi , Michael Carrasco , Won-Gun Koh
发明人： Curtis Frank , Christopher Ta , David Myung , Jaan Noolandi , Michael Carrasco , Won-Gun Koh
IPC分类号： A61F2/16
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： The present invention provides a hydrogel-based intraocular lens (IOL) implant that can covalently attach to a lens capsule on implantation into an eye. The inventive IOL has a high refractive index, high elasticity, and is of a similar size to a naturally occurring lens. In addition, the IOL can be implanted in a smaller, dehydrated state, allowing the IOL to be placed in the lens capsule with a small incision (up to about 1/10 the volume of the IOL). Exposure to fluid can then initiate rapid swelling of the dried polymer to the shape and dimensions of a natural lens, with full occupation of the lens capsule. Upon equilibrium swelling, the IOL can then make contact with the inner aspect of the lens capsule and covalently bind to it. By this attachment process, the IOL may accommodate in a manner identical to that of the natural lens.
摘要翻译：本发明提供一种水凝胶型眼内透镜（IOL）植入物，其可以植入眼睛中共价连接到晶状体囊。本发明的IOL具有高折射率，高弹性，并且具有与天然存在的透镜相似的尺寸。此外，IOL可以植入较小的脱水状态，允许IOL以小切口（高达IOL体积的约1/10）放置在晶状体囊中。然后暴露于流体可以引发干燥的聚合物快速膨胀到天然晶状体的形状和尺寸，完全占据晶状体囊。在平衡肿胀时，IOL然后可以与镜片胶囊的内部部分接触并共价结合。通过该附接过程，IOL可以以与天然镜片相同的方式容纳。

39. 发明申请

US20070126982A1 Interpenetrating polymer network hydrogel contact lenses 有权
标题翻译：互穿聚合物网络水凝胶隐形眼镜
公开(公告)号：US20070126982A1
公开(公告)日：2007-06-07
申请号：US11636114
申请日：2006-12-07
申请人： David Myung , Jaan Noolandi , Christopher Ta , Curtis Frank
发明人： David Myung , Jaan Noolandi , Christopher Ta , Curtis Frank
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , C08L51/08
摘要： The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要翻译：本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网状水凝胶。水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。遥爪大分子单体的分子量优选为约575Da至约20,000Da。也可以使用分子量的混合物。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。该材料被设计成用作隐形眼镜。

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