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31. 发明申请

US20110142771A1 Photostabilization of Retinoids with Alkoxycrylene Compounds 有权
标题翻译：类视黄醇与烷氧基化合物的光稳定化
公开(公告)号：US20110142771A1
公开(公告)日：2011-06-16
申请号：US13032215
申请日：2011-02-22
申请人： Craig A. Bonda , Anna Pavlovic , Jean Zhang
发明人： Craig A. Bonda , Anna Pavlovic , Jean Zhang
IPC分类号： A61K8/40 , A61K8/49 , A61K31/07 , A61K31/11 , A61K31/203 , A61K31/215 , A61K31/192 , A61K31/382 , A61K31/122 , A61Q17/00 , A61Q19/00 , A61Q19/08 , A61P17/00 , A61P17/10
CPC分类号： A61Q19/08 , A61K8/361 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/49 , A61K8/671 , A61K2800/52 , A61Q17/04 , A61Q19/00
摘要： The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) α-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the retinoid compound is concentration dependent, with the amount of retinoid photostabilization increasing with the concentration of the alkoxycrylene compound.
摘要翻译：已经发现光稳定化电子激发态能量 - 特别是来自类视黄醇化合物的单态态能够容易地转移到（接受）在四（对）位置具有烷氧基的α-氰基二苯基丙烯酸酯化合物（以下称为“烷氧基烯”）的具有式（I）的苯环：其中R 1和R 2中的一个是直链或支链C 1 -C 30烷氧基，优选C 1 -C 8，更优选甲氧基，并且非烷氧基R 1或R 2是氢; 并且R 3是直链或支链C 1 -C 30烷基，优选C 2 -C 20。式（I）的烷氧基化亚烷基化合物显着地将组合物中类视色素化合物的光稳定性提高至少3倍和10倍或更高。氧化烯化合物稳定类视黄醇化合物的能力是浓度依赖性的，随着烷氧基化合物浓度的增加，类视黄醇光稳定化的量增加。

32. 发明申请

US20100021403A1 DISPERSIONS OF INORGANIC PARTICULATES CONTAINING ALKOXYCRYLENE 有权
标题翻译：含有烷氧基的无机颗粒的分散体
公开(公告)号：US20100021403A1
公开(公告)日：2010-01-28
申请号：US12554329
申请日：2009-09-04
申请人： Craig A. Bonda , Anna Pavlovic , Jean Zhang
发明人： Craig A. Bonda , Anna Pavlovic , Jean Zhang
IPC分类号： A61K8/27 , A61K8/29 , A61Q17/04
CPC分类号： A61K8/40 , A61K2800/52 , A61Q17/04
摘要： A composition comprising an inorganic particulate material in an amount of about 20 wt % to about 70 wt %, a carrier for the particulate material comprising a compound of formula (I) in an amount of about 1 wt % to about 70 wt %, a particulate material coating material in an amount of about 0 wt % to about 5 wt %, and a dispersing agent for the particulate material in an amount of about 0 wt % to about 5 wt %, based on the total weight of the composition, wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, and the non-alkoxy R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical.
摘要翻译：一种组合物，其包含约20重量％至约70重量％的无机颗粒材料，所述颗粒材料的载体包含约1重量％至约70重量％的量的式（I）化合物，约0重量％至约5重量％的颗粒材料涂料，和基于组合物总重量的约0重量％至约5重量％的颗粒材料分散剂，其中 R1和R2之一是直链或支链C1-C30烷氧基，非烷氧基R1或R2是氢; 且R 3为直链或支链C 1 -C 30烷基。

33. 发明申请

US20090324835A1 UV-ABSORBING AND PHOTOSTABILIZING POLYMERS 有权
标题翻译： UV吸收和光聚合聚合物
公开(公告)号：US20090324835A1
公开(公告)日：2009-12-31
申请号：US12163222
申请日：2008-06-27
申请人： Craig A. Bonda , Anna Pavlovic , Jean Zhang
发明人： Craig A. Bonda , Anna Pavlovic , Jean Zhang
IPC分类号： B05D3/02 , C08F222/04 , C08K5/07 , C08K5/10 , C08F118/02
CPC分类号： C08F218/10 , C08F222/06
摘要： Polymers comprising monomers having 2-cyano-3,3-diphenyl-prop-2-enoic acid moieties having the formula are disclosed. Compositions comprising said polymers and methods for increasing the UV-absorbing, water resistance, and photostabilizing properties of compositions comprising such polymers also are disclosed.
摘要翻译：公开了包含具有下式的具有2-氰基-3,3-二苯基 - 丙-2-烯酸部分的单体的聚合物。还公开了包含所述聚合物的组合物和用于增加包含这种聚合物的组合物的UV吸收，耐水性和光稳定性能的方法。

34. 发明申请

US20090291054A1 METHOD OF QUENCHING ELECTRONIC EXCITATION OF CHROMOPHORE-CONTAINING ORGANIC MOLECULES IN PHTOACTIVE COMPOSITIONS 有权
标题翻译：电化学组合物中包含有机分子的电子激发的方法
公开(公告)号：US20090291054A1
公开(公告)日：2009-11-26
申请号：US12432542
申请日：2009-04-29
申请人： Craig A. Bonda , Anna Pavlovic
发明人： Craig A. Bonda , Anna Pavlovic
IPC分类号： A61K8/40 , A61Q17/04
CPC分类号： A61K8/40 , A61K2800/52 , A61Q17/04
摘要： The photostabilizing electronic excited state energy—particularly singlet state energy from a UV-absorbing molecule has been found to be readily transferred to (accepted by) α-cyanodiphenylacrylate compounds of formulas (I) and (V) having an alkoxy radical preferably in the four (para) position (hereinafter methoxycrylenes) on one or both of the phenyl rings: wherein at least one of R1 and R2 is a straight or branched chain C1-C12 alkoxy radical, preferably C1-C8, more preferably C1-C4, and most preferably methoxy, and any non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C24 alkyl radical, preferably C12-C24, more preferably C20; wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heteroaryl, heterocycloalkyl, substituted heteroaryl and substituted heterocycloalkyl; R2 is selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkyl, C3-C8 substituted cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne; R4, R5, R6 and R7 are the same or different and are selected from the group consisting of C1-C30 alkoxy straight chin on branched and a, b, c and d are each either 0 or 1, and a, b, c and d add up to 1, 2, 3, or 4.
摘要翻译：已经发现光稳定化电子激发态能量 - 特别是来自紫外线吸收分子的单态能量已经被发现容易地转移到具有烷氧基的式（I）和（V）的α-氰基二苯基丙烯酸酯化合物（接受）（对位）位置（以下为甲氧基）;其中R 1和R 2中的至少一个为直链或支链C 1 -C 12烷氧基，优选C 1 -C 8，更优选C 1 -C 4，最优选优选甲氧基，任何非烷氧基R 1或R 2为氢; 并且R 3是直链或支链C 1 -C 24烷基，优选C 12 -C 24，更优选C 20; 其中A和B相同或不同，并且选自氧，氨基和硫; R 1和R 3相同或不同，选自C 1 -C 30烷基，C 2 -C 30亚烷基，C 2 -C 30炔基，C 3 -C 8环烷基，C 1 -C 30取代的亚烷基，C 2 -C 30取代的炔基，芳基，取代的芳基，杂芳基，杂环烷基，取代的杂芳基和取代的杂环烷基; R 2选自C 1 -C 30烷基，C 2 -C 30亚烷基，C 2 -C 30炔基，C 3 -C 8环烷基，C 1 -C 30取代的烷基，C 3 -C 8取代的环烷基，C 1 -C 30取代的亚烷基，C 2 -C 30取代的炔烃 R4，R5，R6和R7相同或不同，选自支链上的C1-C30烷氧基直链，a，b，c和d各自为0或1，a，b，c和 d加起来1，2，3或4。

35. 发明申请

US20090069466A1 PHOTOSTABILIZING SILICONE FLUIDS 有权
标题翻译：光敏硅胶
公开(公告)号：US20090069466A1
公开(公告)日：2009-03-12
申请号：US12205546
申请日：2008-09-05
申请人： Craig A. Bonda , Anna Pavlovic , Anthony J. O'Lenick, JR.
发明人： Craig A. Bonda , Anna Pavlovic , Anthony J. O'Lenick, JR.
IPC分类号： C08K5/3437 , C07C69/76 , C08F283/12 , C08L83/04 , C08K5/07 , C08K5/17 , C08K5/3492 , C08K5/09 , C08K5/42 , C08K5/1545 , C08K5/3472
CPC分类号： A61K8/40 , A61K8/898 , A61K2800/52 , A61Q17/04 , C08K5/315 , C09B69/103
摘要： A silicone fluid comprising a chromophore-substituted polyorganosiloxane having a formula (2): wherein x is an integer in the range of 60 to 2000; y is an integer in the range of 5 to 100; a ratio x:y is in a range of about 10:1 to about 20:1; and X is a photostabilizing chromophore.
摘要翻译：包含具有式（2）的发色团取代的聚有机硅氧烷的硅氧烷流体：其中x是在60至2000的范围内的整数; y为5〜100的整数，比例x：y在约10:1至约20:1的范围内; X是光稳定发色团。

36. 发明授权

US06962692B2 Photostabilizers, UV absorbers, and methods of photostabilizing a sunscreen composition 有权
标题翻译：光稳定剂，紫外线吸收剂和防晒组合物的光稳定化方法
公开(公告)号：US06962692B2
公开(公告)日：2005-11-08
申请号：US10385833
申请日：2003-03-11
申请人： Craig A. Bonda , Anna Pavlovic , Urvil B. Shah
发明人： Craig A. Bonda , Anna Pavlovic , Urvil B. Shah
IPC分类号： A61K8/00 , A61K8/35 , A61K8/37 , A61K8/40 , A61Q17/04 , C08G63/54 , C08G63/547 , C08G63/91 , C08K5/00 , C08K5/103 , C08K5/315 , C08L67/02 , C08L67/06 , C08L67/07 , A61K7/64
CPC分类号： C08L67/02 , A61K8/35 , A61K8/37 , A61K8/40 , A61K2800/52 , A61Q17/04 , C08G63/54 , C08G63/916 , C08K5/0008 , C08K5/005 , C08K5/103 , C08K5/315 , C08L67/06 , C08L67/07 , C08L2666/18
摘要： Polymers and compounds including a diphenylmethylene or a 9H-fluorene moiety; and sunscreen compositions including a mixture of a photoactive compound and any one of the foregoing derivatives are disclosed herein. Also disclosed are methods for stabilizing a sunscreen composition by the addition of one or more of the foregoing derivatives, methods of filtering out ultra-violet light from a substrate by the use of one or more such derivatives, and methods for terminating a polymerization reaction by the addition of derivatives of diphenylmethylene and/or 9H-fluorene. Synergistic combinations of the polymer with (1) diesters or polyesters of a naphthalene dicarboxylic acid, or (2) oxybenzone enhance the photostability of sunscreen compositions containing a photodegradable sunscreen active compound, such as avobenzone.
摘要翻译：包括二苯基亚甲基或9H-芴部分的聚合物和化合物; 并且包括光活性化合物和任何前述衍生物的混合物的防晒组合物在本文中公开。还公开了通过添加一种或多种前述衍生物来稳定防晒组合物的方法，通过使用一种或多种此类衍生物从底物过滤出紫外光的方法，以及通过使用一种或多种此类衍生物终止聚合反应的方法加入二苯基亚甲基和/或9H-芴衍生物。聚合物与（1）萘二羧酸的二酯或聚酯或（2）羟基苯酮的协同组合增强了含有可光降解防晒活性化合物如阿伏苯宗的防晒组合物的光稳定性。

37. 发明授权

US06899866B2 Photostabilization of a sunscreen composition with a combination of an α-cyano-β, β-diphenylacrylate compound and a dialkyl naphithalate 失效
标题翻译：使用α-氰基-β，β-二苯基丙烯酸酯化合物和二烷基萘甲酸酯的组合的防晒组合物的光稳定化
公开(公告)号：US06899866B2
公开(公告)日：2005-05-31
申请号：US10785271
申请日：2004-02-24
申请人： Craig A. Bonda
发明人： Craig A. Bonda
IPC分类号： A61K8/35 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/85 , A61K8/86 , A61Q17/04 , A61K7/00 , A61K7/42 , A61K7/44
CPC分类号： A61K8/37 , A61K8/35 , A61K8/40 , A61K8/85 , A61K8/86 , A61K2800/52 , A61Q17/04
摘要： Sunscreen compositions including a dibenzoylmethane derivative, such as avobenzone, that are made more stable by the addition of (a) an α-cyano-β,β-diphenylacrylate compound, e.g., octocrylene and (b) a diester or polyester of naphthalene dicarboxylic acid (diethylhexyl 2,6-naphthalate), having a weight ratio of (a)/(b) of at least 0.95, preferably at least about 1.0. More particularly, the invention relates to sunscreen compositions which utilize a combination of octocrylene and diethylhexyl 2,6-naphthalate to stabilize other photoactive compounds present in a sunscreen composition and, in particular, to stabilize dibenzoylmethane derivatives, without, or with levels less than 0.5% by weight of, a methoxy-substituted benzophenone derivative, such as benzophenone-3.
摘要翻译：通过添加（a）α-氰基-β-二苯基丙烯酸酯化合物（例如，八亚甲基）和（b）萘二羧酸的二酯或聚酯来制备包含二苯甲酰甲烷衍生物如阿伏苯宗的防晒组合物，（a）/（b）的重量比为至少0.95，优选至少约1.0的（2,6-萘二甲酸二乙基己酯）。更具体地说，本发明涉及防晒组合物，其使用辛基苯二酚和2,6-萘二甲酸二乙基己酯的组合来稳定存在于防晒组合物中的其它光活性化合物，特别是稳定二苯甲酰甲烷衍生物，不含或低于0.5 重量％的甲氧基取代的二苯甲酮衍生物，例如二苯甲酮-3。

38. 发明授权

US06355261B1 Ultraviolet radiation absorbing waxes useful in cosmetic compositions 失效
标题翻译：用于化妆品组合物的紫外线吸收蜡
公开(公告)号：US06355261B1
公开(公告)日：2002-03-12
申请号：US09452929
申请日：1999-12-02
申请人： Craig A. Bonda , Urvil B. Shah , Peter J. Marinelli
发明人： Craig A. Bonda , Urvil B. Shah , Peter J. Marinelli
IPC分类号： A61K600
CPC分类号： A61Q19/00 , A61K8/375 , A61Q1/02 , A61Q1/06 , A61Q5/006 , A61Q17/04 , A61Q19/02 , A61Q19/08
摘要： The compounds of formula (I), suitable solvents for the compounds, and use of the compounds as waxes, UV absorbers, and skin conditioners is disclosed. A compound of formula (I) is a wax at room temperature, absorbs UVA and UVB radiation, and boosts the sun protection factor of sunscreen compositions. The compounds of formula (I) have utility in a variety of cosmetics and other compositions including waxes for coating, polishing, and sealing, textile and leather manufacture, adhesives, and crafts. The compounds of formula (I) also have utility in the treatment of skin conditions including acne, psoriasis, seborrheic dermatitis, dandruff, warts, corns, calluses, ringworm infection, wrinkling, yellowing, leatheriness, mottling, and hyperpigmentation.
摘要翻译：公开了式（I）化合物，化合物的合适溶剂以及化合物作为蜡，UV吸收剂和皮肤调理剂的用途。式（I）化合物在室温下为蜡，吸收UVA和UVB辐射，并提高防晒组合物的防晒系数。式（I）化合物可用于各种化妆品和其它组合物，包括用于涂布，抛光和密封的蜡，纺织品和皮革制造，粘合剂和工艺品。式（I）化合物还可用于治疗皮肤病，包括痤疮，牛皮癣，脂溢性皮炎，头皮屑，疣，玉米，愈伤组织，癣感染，起皱，泛黄，皮质，斑驳和色素沉着过度。

39. 发明授权

US06350894B1 STABLE SUNSCREEN COMPOSITION CONTAINING DIBENZOYLMETHANE DERIVATIVE, E.G., PARSOL 1789, AND C12, C16, C18 BRANCHED CHAIN HYDROXYBENZOATE AND/OR C12, C16 BRANCHED CHAIN BENZOATE STABILIZERS/SOLUBILIZERS 有权
标题翻译：含有二苯甲基甲基衍生物的稳定的SUNCREEN组合物，E.G.，PARSOL 1789和C12，C16，C18分支链羟基苯甲酸酯和/或C12，C16分支链苯甲酸酯稳定剂/溶剂
公开(公告)号：US06350894B1
公开(公告)日：2002-02-26
申请号：US09523336
申请日：2000-03-10
申请人： Craig A. Bonda , Steven P. Hopper
发明人： Craig A. Bonda , Steven P. Hopper
IPC分类号： C07C6988
CPC分类号： C07C69/96 , A61K8/35 , A61K8/368 , A61K8/37 , A61Q17/04 , C07C69/88
摘要： A sunscreen composition containing a UV-B dibenzoylmethane derivative, such as 4-(1,1-dimethylethyl)-4′-methoxydibenzoylmethane (PARSOL 1789), and a stabilizer/solubilizer for the dibenzoylmethane derivative selected from formula (I) and formula (II), and mixtures thereof: wherein m=5, 7, 9 or mixtures and n=4, 6, 8 or mixtures; wherein p1 m=5, 7 or mixtures and n=4, 6 or mixtures. These long branched chain alkyl hydroxybenzoates and long branched chain benzoates having a C4+ branch at the 2 position are quite effective in stabilizing the dibenzoylmethane derivative UV-B filter compounds making them more effective; effective for longer periods of time.
摘要翻译：含有UV-B二苯甲酰甲烷衍生物如4-（1,1-二甲基乙基）-4'-甲氧基二苯甲酰甲烷（PARSOL 1789）的防晒组合物和选自式（I）和式（I）的二苯甲酰甲烷衍生物的稳定剂/增溶剂 II）及其混合物：其中m = 5,7,9或混合物，并且= 4,6,8或混合物;其中p1 m = 5,7或混合物，n = 4,6或其混合物。这些长支链烷基羟基苯甲酸酯和在2位具有C4 +分支的长支链苯甲酸酯在稳定二苯甲酰甲烷衍生物UV-B过滤器化合物方面非常有效，使得它们更有效; 有效期较长。

40. 发明授权

US5783173A Stable sunscreen composition containing dibenzoylmethane derivative, E. G., PARSOL 1789, and C12, C16, C18, branched chain hydroxybenzoate and/or C12, C16, branched chain benzoate stabilizers/solubilizers 失效
标题翻译：包含二苯甲酰甲烷衍生物，E.G.，PARSOL 1789和C12，C16，C18支链羟基苯甲酸酯和/或C 12，C 16支链苯甲酸酯稳定剂/增溶剂的稳定防晒组合物
公开(公告)号：US5783173A
公开(公告)日：1998-07-21
申请号：US752585
申请日：1996-11-21
申请人： Craig A. Bonda , Steven P. Hopper
发明人： Craig A. Bonda , Steven P. Hopper
IPC分类号： A61K8/35 , A61K8/368 , A61K8/37 , A61Q17/04 , C07C69/88 , C07C69/96 , A61K7/42 , A61K31/12 , A61K31/24
CPC分类号： C07C69/96 , A61K8/35 , A61K8/368 , A61K8/37 , A61Q17/04 , C07C69/88
摘要： A sunscreen composition containing a UV-B dibenzoylmethane derivative, such as 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane (PARSOL 1789), and a stabilizer/solubilizer for the dibenzoylmethane derivative selected from formula (I) and formula (II), and mixtures thereof: ##STR1## wherein m=5, 7, 9 or mixtures and n=4, 6, 8 or mixtures; ##STR2## wherein m=5, 7 or mixtures and n=4, 6 or mixtures. These long branched chain alkyl hydroxybenzoates and long branched chain benzoates having a C.sub.4.sup.+ branch at the 2 position are quite effective in stabilizing the dibenzoylmethane derivative UV-B filter compounds making them more effective; effective for longer periods of time.
摘要翻译：含有UV-B二苯甲酰甲烷衍生物如4-（1,1-二甲基乙基）-4'-甲氧基二苯甲酰甲烷（PARSOL 1789）的防晒组合物和选自式（I）和式（I）的二苯甲酰甲烷衍生物的稳定剂/增溶剂 II）及其混合物：其中m = 5,7,9或混合物，n = 4,6,8或其混合物; ，6或混合物。这些长支链烷基羟基苯甲酸酯和在2位具有C4 +分支的长支链苯甲酸酯在稳定二苯甲酰甲烷衍生物UV-B过滤器化合物方面非常有效，使得它们更有效; 有效期较长。

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