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31. 发明申请

US20110171739A1 LIGANDS FOR AGGREGATED TAU MOLECULES 有权
标题翻译：用于聚集的TAU分子的配体
公开(公告)号：US20110171739A1
公开(公告)日：2011-07-14
申请号：US13063525
申请日：2009-09-23
申请人： Steven John Kemp , Lynda Jane Storey , John Mervyn David , Janet Richard , Charles Robert Harrington , Claude Michael Wischik , Scott Clunas , Tobias Kerst Heinrich
发明人： Steven John Kemp , Lynda Jane Storey , John Mervyn David , Janet Richard , Charles Robert Harrington , Claude Michael Wischik , Scott Clunas , Tobias Kerst Heinrich
IPC分类号： G01N33/50 , C07D277/66 , C07D417/12 , C07D513/04 , C07D471/04
CPC分类号： G01N33/6896 , C07D277/66 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04 , G01N2333/4709 , G01N2800/2821 , Y10T436/14 , Y10T436/147777 , Y10T436/17 , Y10T436/18
摘要： Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.
摘要翻译：提供某些苯并噻唑，咪唑并噻唑，咪唑并嘧啶和咪唑并吡啶化合物，包括例如：式（I）及其药学上和生理上可接受的盐，水合物和溶剂化物。此类化合物可用作tau蛋白和PHF的诊断配体或标记。

32. 发明授权

US5827960A Bi-directional mass air flow sensor having mutually-heated sensor elements 失效
标题翻译：具有相互加热的传感器元件的双向质量空气流量传感器
公开(公告)号：US5827960A
公开(公告)日：1998-10-27
申请号：US919644
申请日：1997-08-28
申请人： Michel Farid Sultan , Charles Robert Harrington , Michael James O'Rourke , Antonio Buddy Catalan
发明人： Michel Farid Sultan , Charles Robert Harrington , Michael James O'Rourke , Antonio Buddy Catalan
IPC分类号： G01F1/684 , G01F1/68
CPC分类号： G01F1/6845 , G01F1/684
摘要： A low cost, bi-directional manifold air flow sensing device based on sensed temperature differential due to airflow achieves improved sensitivity and frequency response by eliminating the heater element of the conventional sensor topology, and operating the sensor elements at a relatively higher current so that each temperature sensing element heats both itself and the other temperature sensing element. The sensitivity is significantly increased due to the increased current in the sensor elements, and the frequency response is significantly increased due to closer spacing of the sensor elements. With this new topology, the sensor elements are said to be mutually heated. In a particularly advantageous mechanization, the sensing device includes two separate pairs of upstream and downstream sensing elements, and the sensing elements are connected in the four legs of a Wheatstone bridge. The sensitivity is doubled since sensor elements are connected in each of the bridge legs, and performance and cost are improved through the elimination of off-chip bridge components. A simple, low cost, temperature compensation circuit compensates for ambient temperature variations.
摘要翻译：基于由气流感测到的温度差异的低成本双向歧管空气流量感测装置通过消除常规传感器拓扑的加热器元件来实现改善的灵敏度和频率响应，并以相对较高的电流操作传感器元件，使得每个温度感测元件本身和另一温度感测元件加热。由于传感器元件中的电流增加，灵敏度显着增加，并且由于传感器元件的间隔更近，频率响应显着增加。通过这种新的拓扑结构，传感器元件被认为是相互加热的。在特别有利的机械化中，感测装置包括两对独立的上游和下游感测元件，并且传感元件连接在惠斯通电桥的四条腿中。传感器元件连接在每个桥脚中时，灵敏度增加了一倍，通过消除芯片外部桥式组件，可以提高性能和成本。简单，低成本的温度补偿电路补偿环境温度变化。

33. 发明授权

US06880392B2 Method and apparatus for determining an approximation for fuel volatility on-board a vehicle 失效
标题翻译：用于确定车载燃料挥发性的近似值的方法和装置
公开(公告)号：US06880392B2
公开(公告)日：2005-04-19
申请号：US10150675
申请日：2002-05-17
申请人： Han-Sheng Lee , David K. Lambert , Charles Robert Harrington , Rick Daniel Kerr
发明人： Han-Sheng Lee , David K. Lambert , Charles Robert Harrington , Rick Daniel Kerr
IPC分类号： F02D41/00 , F02D41/06 , G01M19/00
CPC分类号： F02D41/0025 , F02D19/0628 , F02D19/087 , F02D41/06 , F02D2200/0611 , Y02T10/36
摘要： An apparatus and method for determining an approximation to a measure of the volatility of fuel on-board a vehicle having an internal combustion engine. The method includes the steps of measuring at least one characteristic of the fuel corresponding to a temperature of the fuel, a volume of the fuel, and a concentration of oxygenates within the fuel; determining an approximation of the a measure of the volatility of the sample volume of fuel using a linear function based on the at least one measured characteristic of the fuel corresponding to temperature, volume, and concentration of oxygenates of the fuel. Preferably, at least one temperature measurement is associated with a predetermined volume of the sample as the sample is evaluated. The method can include determining whether a fuel contains ethanol, and if not, whether the fuel is a winter blend of fuel or a summer blend of fuel. The method to determine whether ethanol is present can include the steps of bringing the fuel into contact with a sensing element; measuring a characteristic of the fuel corresponding to concentration of oxygenates, such as the change in capacitance or resistance of the sensing element; and calculating the dielectric constant or the conductivity of the sample respectively. The method to determine the type of non-ethanol containing fuel can be based on two temperature measurements taken at two predetermined volumes during the evaporation process.
摘要翻译：一种用于确定对具有内燃机的车辆上的燃料的挥发性的量度的近似值的装置和方法。该方法包括以下步骤：测量与燃料的温度，燃料的体积以及燃料内的含氧化合物的浓度对应的燃料的至少一种特性; 使用基于对应于燃料的含氧化合物的温度，体积和浓度的燃料的至少一个测量特性的线性函数来确定燃料的样品体积的挥发性的量度的近似值。优选地，当评估样品时，至少一个温度测量与样品的预定体积相关联。该方法可以包括确定燃料是否含有乙醇，如果不是，燃料是燃料的混合物还是燃料的夏季混合物。确定乙醇是否存在的方法可以包括使燃料与感测元件接触的步骤; 测量对应于含氧化合物浓度的燃料的特性，例如感测元件的电容或电阻的变化; 并分别计算样品的介电常数或电导率。确定含有非乙醇的燃料的类型的方法可以基于在蒸发过程期间以两个预定体积进行的两次温度测量。

34. 发明授权

US6131453A Bi-directional mass airflow sensor having integral wheatstone bridge 失效
标题翻译：具有整体惠斯通电桥的双向质量气流传感器
公开(公告)号：US6131453A
公开(公告)日：2000-10-17
申请号：US106542
申请日：1998-06-29
申请人： Michel Farid Sultan , Charles Robert Harrington
发明人： Michel Farid Sultan , Charles Robert Harrington
IPC分类号： G01F1/684 , G01F1/68
CPC分类号： G01F1/6845 , G01F1/684
摘要： A low cost, bi-directional airflow sensing device based on sensed temperature differential due to airflow achieves improved sensitivity and accuracy, and reduced manufacturing cost, by providing two separate pairs of upstream and downstream sensing elements on the same substrate, and connecting the sensing elements as the four legs of an on-chip Wheatstone bridge. The sensitivity is at least doubled since sensor elements are connected in each of the bridge legs, and accuracy and cost are improved through the elimination of off-chip bridge resistors. Additional improvements in the susceptibility to electromagnetic interference (EMI) are realized since the bridge is fully closed on the sensor substrate, and the bridge resistors are located in close proximity.
摘要翻译：基于由气流感测到的温度差异的低成本双向气流感测装置通过在同一衬底上提供两组分离的上游和下游感测元件并连接感测元件，从而提高了灵敏度和精度并降低了制造成本作为片上惠斯通电桥的四条腿。传感器元件连接在每个桥脚中时，灵敏度至少增加了一倍，通过消除片外桥式电阻可以提高精度和成本。实现了电磁干扰（EMI）敏感性的进一步改善，因为桥接器在传感器基板上完全关闭，并且桥接电阻器位于紧邻处。

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